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Simon Hammann et al.
Analytical and bioanalytical chemistry, 407(30), 9019-9028 (2015-10-07)
Triacylglycerols represent the major part (>90%) in most plant oils and have to be eliminated, when the minor compounds such as phytosterols or tocopherols should be analyzed. Here, we used an all liquid-liquid chromatographic technique, countercurrent chromatography (CCC), to fractionate
Sławomir Oszwałdowski et al.
Journal of chromatography. A, 1412, 139-150 (2015-08-25)
Capillary electrophoresis coupled with contactless conductivity detector was applied to characterize BGE/segment/segment/BGE and BGE/segment/electrolyte/segment/BGE systems, where segment is the phase of mixed micelles migrating surrounded by BGE and composition of the first segment≠second segment. It was established that both systems
Jin Fu Peng et al.
Biomolecules & therapeutics, 23(5), 400-406 (2015-09-04)
MicroRNAs (miRNAs) are a family of non-coding RNA that are able to adjust the expression of many proteins, including ATP-binding cassette transporter and organic cation transporter. We sought to evaluate the effect of miR-511 on the regulation of OATP1B1 expression
Simon C Boehme et al.
Nano letters, 15(5), 3056-3066 (2015-04-09)
Charge trapping is an ubiquitous process in colloidal quantum-dot solids and a major limitation to the efficiency of quantum dot based devices such as solar cells, LEDs, and thermoelectrics. Although empirical approaches led to a reduction of trapping and thereby
Myeong-Hoon Kim et al.
Macromolecular bioscience, 14(7), 943-952 (2014-04-18)
Oleyl dextran-coated magnetic nanoclusters (ODMCs) are fabricated for the accurate detection of macrophage-rich atherosclerotic plaques using magnetic resonance (MR) imaging. Dextran is introduced to the cluster surface of magnetic nanocrystals (MNCs) through self-assembly using amphiphilic oleic acid-conjugated dextran (ODex) to
H Yeşim Karasulu et al.
Journal of drug targeting, 23(6), 525-537 (2015-03-05)
The aim of this study was to develop aprotinin-loaded microemulsion (MA) for intravenous administration and evaluate the biodistribution and therapeutic potential of developed formulation in acute pancreatitis models in rats. Phase diagrams were constructed to identify microemulsion region and the
Philip Carsten Christophersen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 232-239 (2013-09-24)
The present study aims at evaluating the ability of a gastro-intestinal in vitro lipolysis model to predict the performance of two lipid formulations and a conventional tablet containing a poorly soluble drug, cinnarizine, in dogs, both in the fasted and
ARDS: clinical lessons from the oleic acid model of acute lung injury.
D P Schuster
American journal of respiratory and critical care medicine, 149(1), 245-260 (1994-01-01)
Joong-Seok Min et al.
Lipids in health and disease, 14, 77-77 (2015-07-24)
Cholesterol oxidation products (COPs) are produced during thermal processing of animal origin foods and are considered to have negative health impacts. The model systems are helpful to understand the impact of various factors on oxidation changes in foods during cooking
Sharon Janssens et al.
American journal of physiology. Endocrinology and metabolism, 309(10), E874-E883 (2015-10-01)
Insulin resistance is associated with ectopic lipid accumulation. Physical activity improves insulin sensitivity, but the impact of exercise on lipid handling in insulin-resistant tissues remains to be elucidated. The present study characterizes the effects of acute exercise on lipid content
Young Mi Song et al.
Autophagy, 11(1), 46-59 (2014-12-09)
Metformin activates both PRKA and SIRT1. Furthermore, autophagy is induced by either the PRKA-MTOR-ULK1 or SIRT1-FOXO signaling pathways. We aimed to elucidate the mechanism by which metformin alleviates hepatosteatosis by examining the molecular interplay between SIRT1, PRKA, and autophagy. ob/ob
Yuri Kashima et al.
PloS one, 9(8), e105073-e105073 (2014-08-22)
Royal jelly (RJ) intake lowers serum cholesterol levels in animals and humans, but the active component in RJ that lowers serum cholesterol level and its molecular mechanism are unclear. In this study, we set out to identify the bile acid-binding
Muiris T Kennedy et al.
BMC pulmonary medicine, 8, 9-9 (2008-07-10)
Hypertonic saline (HTS) reduces the severity of lung injury in ischemia-reperfusion, endotoxin-induced and ventilation-induced lung injury. However, the potential for HTS to modulate the resolution of lung injury is not known. We investigated the potential for hypertonic saline to modulate
N B Cater et al.
The American journal of clinical nutrition, 73(1), 41-44 (2000-12-22)
Dietary behenic acid (22:0) is poorly absorbed. Because of its low bioavailability compared with other fatty acids and because of its very long chain length, the effect of dietary behenic acid (behenate) on serum lipid concentrations in humans is assumed
Choumini Balasanthiran et al.
Journal of colloid and interface science, 459, 63-69 (2015-08-12)
The surface of oleic acid stabilized rod-shape anatase TiO2 nanocrystals was modified by adsorption of Eu(3+) ions. The Eu(3+) attachment showed Langmuir adsorption behavior, thus the loading of Eu(3+) could be controlled precisely up to surface saturation coverage. The Eu(3+)-TiO2
Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1.
Alvarez-Garcia O, Rogers NH, Smith RG, et al.
Arthritis & Rheumatology (Hoboken, N.J.), 66(7), 1779-1788 (2014)
Andrew D Southam et al.
Cancer research, 75(12), 2530-2540 (2015-05-07)
The redeployed drug combination of bezafibrate and medroxyprogesterone acetate (designated BaP) has potent in vivo anticancer activity in acute myelogenous leukemia (AML) and endemic Burkitt lymphoma (eBL) patients; however, its mechanism-of-action is unclear. Given that elevated fatty acid biosynthesis is
Takako Miyamae et al.
Redox report : communications in free radical research, 18(1), 12-19 (2013-02-12)
Fibromyalgia (FM) is characterized by generalized pain and chronic fatigue of unknown etiology. To evaluate the role of oxidative stress in this disorder, we measured plasma levels of ubiquinone-10, ubiquinol-10, free cholesterol (FC), cholesterol esters (CE), and free fatty acids
Kent Sakai et al.
Journal of lipid research, 55(10), 2033-2040 (2014-05-29)
Hydrolysis of intracellular cholesteryl ester (CE) is the rate-limiting step in the efflux of cholesterol from macrophage foam cells. In mouse peritoneal macrophages (MPMs), this process is thought to involve several enzymes: hormone-sensitive lipase (Lipe), carboxylesterase 3 (Ces3), neutral CE
Chih-Sheng Chiang et al.
Advanced healthcare materials, 5(16), 2131-2141 (2016-06-24)
A new therapeutic strategy of combining multistage short-term magnetic guidance with optimized ligand-mediated targeting in a newly developed nanodelivery system is investigated to promote accumulation and modulate intratumoral distribution behavior of the nanocarriers for enhanced tumor therapy. The multifunctional magnetic
Myungsuk Kim et al.
Journal of agricultural and food chemistry, 63(44), 9729-9739 (2015-10-13)
The aim of our study is to investigate the molecular mechanism of gomisin J from Schisandra chinensis on the oleic acid (OA)-induced lipid accumulation in HepG2 cells. Gomisin J attenuated lipid accumulation in OA-induced HepG2 cells. It also suppressed the
Christopher Lipina et al.
Cellular signalling, 27(9), 1742-1750 (2015-05-30)
The plasma membrane-associated enzyme NEU3 sialidase functions to cleave sialic acid residues from the ganglioside GM3 thereby promoting its degradation, and has been implicated in the modulation of insulin action. Herein, we report for the first time that impaired insulin
Elwira Sieniawska et al.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 24(6), 527-532 (2015-09-19)
The aim of this study was to evaluate the antimycobacterial activity of the essential oil (EO) of Mutellina purpurea L. and its main constituents against the M. tuberculosis H37Ra strain. The M. purpurea EO was obtained by hydrodistillation, while its
Di Zhang et al.
Food chemistry, 141(1), 347-356 (2013-06-19)
The existing cellular antioxidant activity (CAA) assays always use chemical stressors [e.g. 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)] to initiate oxidative stress (OS), which is not accordance with the pathology of OS-related diseases. In contrast to previous cell models, an oleic acid
Hongxin Zhang et al.
Physical chemistry chemical physics : PCCP, 19(27), 17756-17764 (2017-06-29)
We report optical depletion of upconversion luminescence (UCL) in NaYF
Finn Purcell-Milton et al.
ACS nano, 11(9), 9207-9214 (2017-08-19)
Core/shell quantum dots (QDs) are of high scientific and technological importance as these nanomaterials have found a number of valuable applications. In this paper, we have investigated the dependence of optical activity and photoluminescence upon CdS shell thickness in a
Birgit Ploier et al.
The Journal of biological chemistry, 288(50), 36061-36072 (2013-11-05)
Saccharomyces cerevisiae, as well as other eukaryotes, preserves fatty acids and sterols in a biologically inert form, as triacylglycerols and steryl esters. The major triacylglycerol lipases of the yeast S. cerevisiae identified so far are Tgl3p, Tgl4p, and Tgl5p (Athenstaedt
Yingying Li et al.
Frontiers in chemistry, 8, 832-832 (2020-11-12)
The rare-earth nanocrystals containing Er3+ emitters offer very promising tools for imaging applications, as they can not only exhibit up-conversion luminescence but also down-conversion luminescence in the second near-infrared window (NIR II). Doping non-lanthanide cations into host matrix was demonstrated
Shiou-Wah Gouk et al.
The British journal of nutrition, 111(7), 1174-1180 (2013-11-30)
In the present study, we investigated the effect of long-acyl chain SFA, namely palmitic acid (16:0) and stearic acid (18:0), at sn-1, 3 positions of TAG on obesity. Throughout the 15 weeks of the experimental period, C57BL/6 mice were fed
Jong-Suep Baek et al.
International journal of pharmaceutics, 495(2), 701-709 (2015-10-02)
Tadalafil is a phosphodiesterase-5 inhibitor indicated for the treatment of erectile dysfunction. In this study, we prepared and evaluated transdermal nanostructured lipid carriers (NLC) to improve the skin permeability of tadalafil. Tadalafil-loaded NLC dispersions were prepared using glyceryl monostearate as
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