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Melissa J Parker et al.
Critical care medicine, 41(9), 2188-2195 (2013-06-14)
To evaluate the preferences and self-reported practices of pediatric acute care physicians with respect to sodium bicarbonate administration to infants and children in shock or cardiac arrest. National survey study utilizing a self-administered questionnaire. Thirteen Canadian pediatric tertiary care centers.
Saravanan Gowrisankar et al.
ChemSusChem, 6(1), 85-91 (2013-01-03)
New benzoyl- and naphthoyl-substituted phosphines have been synthesized, which are stable to air and moisture. Testing these so-called phosphomide ligands in the presence of different ruthenium precursors, the hydrogenation of sodium bicarbonate (NaHCO(3)) to sodium formate (NaHCO(2)) proceeded with good
G Cave et al.
Clinical toxicology (Philadelphia, Pa.), 51(5), 394-397 (2013-05-25)
The use of intravenous lipid emulsion (ILE) as an antidote in non-local, anaesthetic drug toxicity has generated considerable interest. Flecainide is a lipophilic anti-arrhythmic with a significant cardiotoxic profile, with blockade of sodium and potassium channels causing arrhythmias and shock
Mark J Neavyn et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 9(3), 250-254 (2013-05-03)
Sodium bicarbonate is central to the treatment of many poisonings. When it was placed on the FDA drug shortage list in 2012, alternative treatment strategies to specific poisonings were considered. Many hospital pharmacies, poison centers, and medical toxicologists proposed sodium
Nimrit Goraya et al.
Current opinion in nephrology and hypertension, 22(2), 193-197 (2013-02-06)
Most patients with chronic kidney disease (CKD) have progressive decline in glomerular filtration rate (GFR), despite current treatment practices. Recent studies support that dietary acid reduction with oral sodium based alkali or base-inducing food types add kidney protection to that
James J Barber et al.
Journal of strength and conditioning research, 27(1), 252-258 (2012-12-21)
Creatine and sodium bicarbonate supplementation independently increase exercise performance, but it remains unclear whether combining these 2 supplements is more beneficial on exercise performance. The purpose of this study was to evaluate the impact of combining creatine monohydrate and sodium
Judy L Aschner et al.
Pediatrics, 122(4), 831-835 (2008-10-03)
Common clinical practices often are unsupported by experimental evidence. One example is the administration of sodium bicarbonate to neonates. Despite a long history of widespread use, objective evidence that administration of sodium bicarbonate improves outcomes for patients in cardiopulmonary arrest
Antonio Lacquaniti et al.
Radiology, 267(1), 86-93 (2013-01-09)
To evaluate the utility of serum and urinary neutrophil gelatinase-associated lipocalin (NGAL) in depicting an event of contrast material-induced nephropathy (CIN) in patients who received iodinated contrast media, gadoterate meglumine, or radiopharmaceutical technetium-99m ((99m)Tc) and to evaluate the protective effect
Oesophageal bezoar induced by black beans successfully removed by associating endoscopy and oral sodium bicarbonate.
Miao-Yan Chen et al.
Acta gastro-enterologica Belgica, 76(3), 347-347 (2013-11-23)
Ashwati Raghunath
BMJ case reports, 2013, doi:10-doi:10 (2013-01-04)
The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laboratory findings were unremarkable. He did not have any extra-pyramidal side
Anna Ohradanova et al.
Bioorganic & medicinal chemistry letters, 22(3), 1314-1316 (2012-01-10)
An α-carbonic anhydrase (CA, EC 4.2.1.1) isolated from the living fossil sponge Astrosclera willeyana, Astrosclerin, was investigated for its inhibition profile with simple inorganic anions, complex anions and other small molecules known to interact with these zinc enzymes. Astrosclerin is
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 15(3), 573-578 (2005-01-25)
A detailed inhibition study of five carbonic anhydrase (CA, EC 4.2.1.1) isozymes with carboxylates including aliphatic (formate, acetate), dicarboxylic (oxalate, malonate), hydroxy/keto acids (l-lactate, l-malate, pyruvate), tricarboxylic (citrate), or aromatic (benzoate, tetrafluorobenzoate) representatives, some of which are important intermediates in
Effect of oral care solutions in reducing ventilator-associated pneumonia: review of current evidence.
E Balamurugan et al.
The Nursing journal of India, 103(6), 282-284 (2013-08-09)
J Do Valle Bargieri et al.
The Journal of sports medicine and physical fitness, 53(5), 470-476 (2013-08-02)
Decrease in peripheral oxygen delivery may impact exercise performance in athletes with exercise-related arterial oxygen desaturation (ERD). We evaluated whether sodium bicarbonate ingestion would be effective to reduce ERD and what is the consequences upon exercise performance. Seventy highly trained
Jonathan Hewitt et al.
The Cochrane database of systematic reviews, 6(6), CD009204-CD009204 (2012-06-15)
Acute kidney injury (AKI) is a common, serious, but potentially treatable condition. Because AKI is often associated with acidosis, it has become common practice to recommend administration of sodium bicarbonate to correct acid imbalance. To assess the benefits and harms
Jeremiah R Brown et al.
JACC. Cardiovascular interventions, 2(11), 1116-1124 (2009-11-21)
We sought to conduct a meta-analysis to compare N-acetylcysteine (NAC) in combination with sodium bicarbonate (NaHCO(3)) for the prevention of contrast-induced acute kidney injury (AKI). Contrast-induced AKI is a serious consequence of cardiac catheterizations and percutaneous coronary interventions (PCI). Despite
Elizabeth J Scharman et al.
The Annals of pharmacotherapy, 47(1), 90-105 (2013-01-18)
To conduct a systematic literature review to evaluate evidence-based recommendations for the prevention of rhabdomyolysis-associated acute renal failure (ARF). PubMed (1966-December 2012), International Pharmaceutical Abstracts, Science Citation Index, and Cochrane databases (1970-December 2012) were searched. There were no language restrictions.
Daniela Vullo et al.
Bioorganic & medicinal chemistry letters, 21(12), 3591-3595 (2011-05-17)
Two new β-carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogen Salmonella enterica serovar Typhimurium, stCA 1 and stCA 2, were characterized kinetically. The two enzymes possess appreciable activity as catalysts for the hydration of CO(2) to bicarbonate, with k(cat)
Eric A J Hoste et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 25(3), 747-758 (2009-08-26)
There have been conflicting reports on the use of intravenous administration of sodium bicarbonate for prevention of contrast-induced acute kidney injury (CI-AKI). The aim of this study was to evaluate the use of sodium bicarbonate for prevention of CI-AKI. This
Stephen J Traub et al.
Annals of emergency medicine, 62(5), 511-520 (2013-06-19)
We test the hypothesis that N-acetylcysteine plus normal saline solution is more effective than normal saline solution alone in the prevention of contrast-induced nephropathy. The design was a randomized, double blind, 2-center, placebo-controlled interventional trial. Inclusion criteria were patients undergoing
Nigel Greene et al.
Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential
Mark D Parker et al.
Physiological reviews, 93(2), 803-959 (2013-04-17)
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1-3), five Na(+)-coupled HCO3(-) transporters (NCBTs), and two other unusual members (AE4, BTR1). In this review
Peter Burghout et al.
Bioorganic & medicinal chemistry, 19(1), 243-248 (2010-12-18)
The Gram-positive bacterium Streptococcus pneumoniae is a human respiratory tract pathogen that contributes significantly to global mortality and morbidity. It was recently shown that this bacterial pathogen depends on a conserved β-carbonic anhydrase (CA, EC 4.2.1.1) for in vitro growth
Best evidence topic report. Treatment of jellyfish stings in UK coastal waters: vinegar or sodium bicarbonate?
Heather Prestwich et al.
Emergency medicine journal : EMJ, 24(9), 664-664 (2007-08-23)
Sally M Bradberry et al.
Toxicological reviews, 24(3), 195-204 (2006-01-05)
Experimental studies suggest that both alkalinisation and sodium loading are effective in reducing cardiotoxicity independently. Species and experimental differences may explain why sodium bicarbonate appears to work by sodium loading in some studies and by a pH change in others.
Sophia Zoungas et al.
Annals of internal medicine, 151(9), 631-638 (2009-11-04)
Intravenous sodium bicarbonate has been proposed to reduce the risk for contrast-induced nephropathy (CIN). To determine the effect of sodium bicarbonate on the risk for CIN. MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from 1950 to
Sodium bicarbonate--the swings and roundabouts will not stop without randomized evidence.
Burkhard Simma et al.
Critical care medicine, 41(9), 2242-2243 (2013-08-28)
Daniel J Peart et al.
Journal of strength and conditioning research, 26(7), 1975-1983 (2012-04-17)
Sodium bicarbonate (NaHCO3) is a buffering agent that is suggested to improve performance by promoting the efflux of hydrogen ions from working cells and tissues. Research surrounding its efficacy as an ergogenic aid is conflicting, making it difficult to draw
U Ozgul et al.
Anaesthesia and intensive care, 41(4), 501-504 (2013-07-03)
The aim of this study was to determine whether pretreatment with alkalinised lignocaine reduced the incidence and severity of pain during propofol injection. This prospective, randomised, double-blind study included 300 adult, American Society of Anesthesiologists physcial status I to II
Sodium bicarbonate use in acute kidney injury.
Mark D Uniacke et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 61(3), 523-523 (2013-01-08)
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