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Veronica Estrella et al.
Cancer research, 73(5), 1524-1535 (2013-01-05)
The pH of solid tumors is acidic due to increased fermentative metabolism and poor perfusion. It has been hypothesized that acid pH promotes local invasive growth and metastasis. The hypothesis that acid mediates invasion proposes that H(+) diffuses from the
Michael Haase et al.
PLoS medicine, 10(4), e1001426-e1001426 (2013-04-24)
Preliminary evidence suggests a nephroprotective effect of urinary alkalinization in patients at risk of acute kidney injury. In this study, we tested whether prophylactic bicarbonate-based infusion reduces the incidence of acute kidney injury and tubular damage in patients undergoing open
Sankar D Navaneethan et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 53(4), 617-627 (2008-11-26)
Optimal hydration measures to prevent contrast-induced nephropathy are controversial. We conducted a systematic review and meta-analysis using the MEDLINE database (1966 to January 2008), EMBASE (January 2008), and abstracts from conference proceedings. Adult patients undergoing contrast procedures. Randomized controlled trials
Lars R McNaughton et al.
Current sports medicine reports, 7(4), 230-236 (2008-07-09)
Athletes use many different strategies to enhance their performance, including clothing and footwear, training regimes, diets, and ergogenic aids. The use of ergogenic aids is believed to be widespread, with a variety of legal as well as illegal substances being
John H Boyd et al.
Current opinion in critical care, 14(4), 379-383 (2008-07-11)
Bicarbonate therapy for severe lactic acidosis remains a controversial therapy. The most recent 2008 Surviving Sepsis guidelines strongly recommend against the use of bicarbonate in patients with pH at least 7.15, while deferring judgment in more severe acidemia. We review
Barak Cohen et al.
The American journal of emergency medicine, 31(12), 1703-1706 (2013-09-24)
Urine alkalinization is indicated for various medical conditions. Alkalinization is usually achieved by intravenous administration of alkali substances titrated by repeated urinalyses. Some situations such as mass casualty events might require urine alkalinization by the oral route. We evaluated the
Nilufar Mohebbi et al.
PloS one, 8(1), e55286-e55286 (2013-02-06)
The renal handling of salt and protons and bicarbonate are intricately linked through shared transport mechanisms for sodium, chloride, protons, and bicarbonate. In the collecting duct, the regulated fine-tuning of salt and acid-base homeostasis is achieved by a series of
Sodium bicarbonate--the swings and roundabouts will not stop without randomized evidence.
Burkhard Simma et al.
Critical care medicine, 41(9), 2242-2243 (2013-08-28)
Stephen J Traub et al.
Annals of emergency medicine, 62(5), 511-520 (2013-06-19)
We test the hypothesis that N-acetylcysteine plus normal saline solution is more effective than normal saline solution alone in the prevention of contrast-induced nephropathy. The design was a randomized, double blind, 2-center, placebo-controlled interventional trial. Inclusion criteria were patients undergoing
Daniel J Peart et al.
Journal of strength and conditioning research, 26(7), 1975-1983 (2012-04-17)
Sodium bicarbonate (NaHCO3) is a buffering agent that is suggested to improve performance by promoting the efflux of hydrogen ions from working cells and tissues. Research surrounding its efficacy as an ergogenic aid is conflicting, making it difficult to draw
Eric A J Hoste et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 25(3), 747-758 (2009-08-26)
There have been conflicting reports on the use of intravenous administration of sodium bicarbonate for prevention of contrast-induced acute kidney injury (CI-AKI). The aim of this study was to evaluate the use of sodium bicarbonate for prevention of CI-AKI. This
Oesophageal bezoar induced by black beans successfully removed by associating endoscopy and oral sodium bicarbonate.
Miao-Yan Chen et al.
Acta gastro-enterologica Belgica, 76(3), 347-347 (2013-11-23)
Anna Ohradanova et al.
Bioorganic & medicinal chemistry letters, 22(3), 1314-1316 (2012-01-10)
An α-carbonic anhydrase (CA, EC 4.2.1.1) isolated from the living fossil sponge Astrosclera willeyana, Astrosclerin, was investigated for its inhibition profile with simple inorganic anions, complex anions and other small molecules known to interact with these zinc enzymes. Astrosclerin is
Ashwati Raghunath
BMJ case reports, 2013, doi:10-doi:10 (2013-01-04)
The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laboratory findings were unremarkable. He did not have any extra-pyramidal side
Rashmi Aggarwal et al.
Indian journal of experimental biology, 50(11), 826-832 (2013-01-12)
The present study reports molecular characterization of small heat shock protein gene in Indian isolates of Chaetomium globosum, C. perlucidum, C. reflexum, C. cochlioides and C. cupreum. Six isolates of C. globosum and other species showed a band of 630bp
Sodium bicarbonate use in acute kidney injury.
Mark D Uniacke et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 61(3), 523-523 (2013-01-08)
U Ozgul et al.
Anaesthesia and intensive care, 41(4), 501-504 (2013-07-03)
The aim of this study was to determine whether pretreatment with alkalinised lignocaine reduced the incidence and severity of pain during propofol injection. This prospective, randomised, double-blind study included 300 adult, American Society of Anesthesiologists physcial status I to II
Nigel Greene et al.
Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential
Antonio Lacquaniti et al.
Radiology, 267(1), 86-93 (2013-01-09)
To evaluate the utility of serum and urinary neutrophil gelatinase-associated lipocalin (NGAL) in depicting an event of contrast material-induced nephropathy (CIN) in patients who received iodinated contrast media, gadoterate meglumine, or radiopharmaceutical technetium-99m ((99m)Tc) and to evaluate the protective effect
Mark D Parker et al.
Physiological reviews, 93(2), 803-959 (2013-04-17)
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1-3), five Na(+)-coupled HCO3(-) transporters (NCBTs), and two other unusual members (AE4, BTR1). In this review
Peter Burghout et al.
Bioorganic & medicinal chemistry, 19(1), 243-248 (2010-12-18)
The Gram-positive bacterium Streptococcus pneumoniae is a human respiratory tract pathogen that contributes significantly to global mortality and morbidity. It was recently shown that this bacterial pathogen depends on a conserved β-carbonic anhydrase (CA, EC 4.2.1.1) for in vitro growth
Best evidence topic report. Treatment of jellyfish stings in UK coastal waters: vinegar or sodium bicarbonate?
Heather Prestwich et al.
Emergency medicine journal : EMJ, 24(9), 664-664 (2007-08-23)
Antoine Kimmoun et al.
Anesthesiology, 120(4), 926-934 (2013-11-23)
Lactic acidosis is associated with cardiovascular failure. Buffering with sodium bicarbonate is proposed in severe lactic acidosis. Bicarbonate induces carbon dioxide generation and hypocalcemia, both cardiovascular depressant factors. The authors thus investigated the cardiovascular and metabolic effects of an adapted
Alessandra Cincinelli et al.
Bioorganic & medicinal chemistry, 19(6), 1847-1851 (2011-03-08)
A high activity α-carbonic anhydrase (CA, EC 4.2.1.1) has been purified from various tissues of the Antarctic seal Leptonychotes weddellii. The new enzyme, denominated lwCA, has a catalytic activity for the physiologic CO(2) hydration to bicarbonate reaction, similar to that
Ruth M Hobson et al.
International journal of sports physiology and performance, 9(1), 139-144 (2013-04-13)
The ability to buffer H+ could be vital to exercise performance, as high concentrations of H+ contribute to the development of fatigue. The authors examined the effect of sodium bicarbonate (SB) supplementation on 2000-m rowing-ergometer performance. Twenty male rowers (age
Sally M Bradberry et al.
Toxicological reviews, 24(3), 195-204 (2006-01-05)
Experimental studies suggest that both alkalinisation and sodium loading are effective in reducing cardiotoxicity independently. Species and experimental differences may explain why sodium bicarbonate appears to work by sodium loading in some studies and by a pH change in others.
Vivian Barbosa Pinheiro et al.
Urology, 82(1), 33-37 (2013-04-23)
To evaluate the effects of oral sodium bicarbonate (NaBic) supplementation upon urinary citrate excretion in calcium stone formers (CSFs). Sixteen adult calcium stone formers with hypocitraturia were enrolled in a randomized, double-blind, crossover protocol using 60 mEq/day of NaBic during
Denis Fourches et al.
Chemical research in toxicology, 23(1), 171-183 (2009-12-18)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this
G Christodoulopoulos et al.
The Veterinary record, 172(4), 100-100 (2012-12-27)
'Salivary abomasum disease' is a common syndrome in Greece affecting lambs and kids from three to 17 days of age. In this case series, we present clinical and laboratory findings from 37 affected lambs presented alive and subsequently euthanased for
Xiao-juan Ma et al.
Journal of the science of food and agriculture, 93(13), 3209-3215 (2013-04-05)
Ovalbumin (OVA) is a major allergen in hen egg. During thermal processing, reducing sugars contained in the hen egg white might easily undergo glycation with OVA, but few studies have been conducted on its corresponding immunoreactivity changes. The aim of
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