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Cladribine, cytarabine, filgrastim, and mitoxantrone (CLAG-M) compared to standard induction in acute myeloid leukemia from myelodysplastic syndrome after azanucleoside failure.

Michael V Jaglal et al.

Leukemia research, 38(4), 443-446 (2014-01-21)

For patients with acute myeloid leukemia from antecedent myelodysplastic syndrome particularly after azanucleoside treatment failure, outcome is poor. Here, we conducted a case-control study in these patients to compare the efficacy of CLAG-M induction (28 patients) versus standard 3+7 induction

PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers.

Filip Janku et al.

PloS one, 6(7), e22769-e22769 (2011-08-11)

Oncogenic mutations of PIK3CA, RAS (KRAS, NRAS), and BRAF have been identified in various malignancies, and activate the PI3K/AKT/mTOR and RAS/RAF/MEK pathways, respectively. Both pathways are critical drivers of tumorigenesis. Tumor tissues from 504 patients with diverse cancers referred to

Impact of diabetes on clinical outcome among elderly patients with acute coronary syndrome treated with percutaneous coronary intervention: insights from the ELDERLY ACS 2 trial.

Giuseppe De Luca et al.

Journal of cardiovascular medicine (Hagerstown, Md.), 21(6), 453-459 (2020-05-02)

Despite recent improvements in percutaneous coronary revascularization and antithrombotic therapies for the treatment of acute coronary syndromes, the outcome is still unsatisfactory in high-risk patients, such as the elderly and patients with diabetes. The aim of the current study was

Nitrite, a novel method to decrease ischemia/reperfusion injury in the rat liver.

Bergthor Björnsson et al.

World journal of gastroenterology, 21(6), 1775-1783 (2015-02-17)

To investigate whether nitrite administered prior to ischemia/reperfusion (I/R) reduces liver injury. Thirty-six male Sprague-Dawley rats were randomized to 3 groups, including sham operated (n = 8), 45-min segmental ischemia of the left liver lobe (IR, n = 14) and

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