369497

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Poly-phosphocholinated Liposomes Form Stable Superlubrication Vectors.

Weifeng Lin et al.

Langmuir : the ACS journal of surfaces and colloids, 35(18), 6048-6054 (2019-04-18)

We have prepared phosphatidylcholine (PC) vesicles (liposomes) incorporating a novel lipid/poly-phosphocholine conjugate. This both stabilizes the liposomes against aggregation (for example, during storage or when being delivered) and allows them to act as very efficient lubricating elements readily attaining superlubric

Co-delivery of Metformin and Paclitaxel Via Folate-Modified pH-Sensitive Micelles for Enhanced Anti-tumor Efficacy.

Yu Xiao et al.

AAPS PharmSciTech, 19(5), 2395-2406 (2018-06-06)

Single chemotherapeutic agent like paclitaxel (PTX) has shown some limitations in anti-tumor treatment, such as undesirable side effects, multidrug resistance, and high toxicity. In order to reduce the toxicity of PTX and increase the anti-tumor effect, folate-modified amphiphilic and biodegradable

New Photoresponsive Poly(meth)acrylates Bearing Azobenzene Moieties Obtained via ATRP Polymerization Exhibiting Liquid-Crystalline Behavior.

Piotr Cieciórski et al.

Polymers, 13(13) (2021-07-03)

Here, we report our studies on photoresponsive poly(meth)acrylates containing azobenzene groups connected to a polymer backbone via a short methylene linker. A series of side-chain azobenzene polymers was synthesized via the atom transfer radical polymerization (ATRP) technique using several catalytic

ATRP Fabricated and Short Chain Polyethylenimine Grafted Redox Sensitive Polymeric Nanoparticles for Codelivery of Anticancer Drug and siRNA in Cancer Therapy.

Chetan Nehate et al.

ACS applied materials & interfaces, 9(45), 39672-39687 (2017-10-20)

To overcome the limitations of conventional chemotherapy, nanoparticle-mediated combinatorial delivery of siRNA and drugs represents a new approach to overcome its associated side effects. Designing safe and efficient vehicles for their codelivery has emerged as a potential challenge in the

Nanopatterned polystyrene-b-poly(acrylic acid) surfaces to modulate cell-material interaction.

Erlantz Lizundia et al.

Materials science & engineering. C, Materials for biological applications, 75, 229-236 (2017-04-19)

In this work we explore the effect of surface nanoarchitecture of polystyrene (PS) and polystyrene-b-poly(acrylic acid) (PS-b-PAA) diblock copolymer films on cell viability. PS and PS-b-PAA have been nanopatterned at temperatures of 110, 120 and 140°C using nanoporous aluminium oxide

Robust superhydrophobic and superoleophilic filter paper via atom transfer radical polymerization for oil/water separation.

Hui Wu et al.

Carbohydrate polymers, 181, 419-425 (2017-12-20)

Robust superhydrophobic and superoleophilic cellulose-g-PFOEMA filter paper membranes were fabricated via surface grafting of poly(perfluorooctylethyl methacrylate) (PFOEMA) using atom transfer radical polymerization (ATRP). The surface chemical compositions, morphologies and wettability of cellulose-g-PFOEMA with different degree of graft ratio (DG) were

Molecularly imprinted protein recognition thin films constructed by controlled/living radical polymerization.

Shogo Sasaki et al.

Journal of bioscience and bioengineering, 119(2), 200-205 (2014-07-26)

We demonstrated the synthesis of molecularly imprinted polymers (MIPs) with binding affinity toward a target protein, ribonuclease A (RNase) by atom transfer radical polymerization (ATRP) of acrylic acid, acrylamide, and N,N'-methylenebisacrylamide in the presence of RNase. The binding activity of

ROP and ATRP Fabricated Dual Targeted Redox Sensitive Polymersomes Based on pPEGMA-PCL-ss-PCL-pPEGMA Triblock Copolymers for Breast Cancer Therapeutics.

Arun Kumar et al.

ACS applied materials & interfaces, 7(17), 9211-9227 (2015-04-04)

To minimize cardiotoxicity and to increase the bioavailability of doxorubicin, polymersomes based on redox sensitive amphiphilic triblock copolymer poly(polyethylene glycol methacrylate)-poly(caprolactone)-s-s-poly(caprolactone)-poly(polyethylene glycol methacrylate) (pPEGMA-PCL-ss-PCL-pPEGMA) with disulfide linkage were designed and developed. The polymers were synthesized by ring opening polymerization (ROP)

Design and Synthesis of a Cyclic Double-Grafted Polymer Using Active Ester Chemistry and Click Chemistry via A "Grafting onto" Method.

Meng Liu et al.

Polymers, 11(2) (2019-04-10)

Combing active ester chemistry and click chemistry, a cyclic double-grafted polymer was successfully demonstrated via a "grafting onto" method. Using active ester chemistry as post-functionalized modification approach, cyclic backbone (c-P2) was synthesized by reacting propargyl amine with cyclic precursor (poly(pentafluorophenyl

Ion-Conducting Redox-Active Polymer Gels Based on Stable Nitroxide Radicals.

Fadoi Boujioui et al.

Polymers, 11(8) (2019-08-10)

Redox-active polymer networks based on stable nitroxide radicals are a very promising class of materials to be used in the so-called organic radical batteries. In order to obtain fast-charging and high power electrodes, however, excellent ionic conductivity inside the electrode

Synthesis and characterization of a novel water-soluble cationic diblock copolymer with star conformation by ATRP.

Shuzhao Li et al.

Materials science & engineering. C, Materials for biological applications, 43, 350-358 (2014-09-02)

A water-soluble cationic diblock copolymer, CD-PAM-b-PMeDMA, was synthesized through atom transfer radical polymerization (ATRP) from a β-cyclodextrin (CD) macroinitiator with 10-active sites (10Br-β-CD). In order to reduce the cytotoxicity of the CD-PAM-b-PMeDMA, biocompatible polyacrylamide (PAM) was first introduced onto the

A complementary density gradient of zwitterionic polymer brushes and NCAM peptides for selectively controlling directional migration of Schwann cells.

Tanchen Ren et al.

Biomaterials, 56, 58-67 (2015-05-03)

Selective enhancement of directional migration of Schwann cells (SCs) over fibroblasts (FIBs) plays a significant role in peripheral nerve regeneration, because this behavior facilitates neuron repair and avoids fibrosis. Herein a complementary density gradient of poly(3-dimethyl-methacryloyloxyethyl ammonium propane sulfonate) (PDMAPS

High retreatability and dimensional stability of polymer grafted waterlogged archaeological wood achieved by ARGET ATRP.

Yihang Zhou et al.

Scientific reports, 9(1), 9879-9879 (2019-07-10)

To explore new methods to maintain the dimensional stability of waterlogged archaeological wood after drying and keep the natural cell lumens unaltered for future retreatments, activator regenerated by electron transfer (ARGET) atom transfer radical polymerization (ATRP) is employed to consolidate

Preparation of multifunctional Janus nanoparticles on the basis of SPIONs as targeted drug delivery system.

Behrad Shaghaghi et al.

International journal of pharmaceutics, 559, 1-12 (2019-01-22)

Passing the Blood-Brain-Barrier (BBB) is a challenging aspect in nanomedicine. Utilizing surfactant particles is reported to be a potent strategy for easier BBB penetration. On the other hand, loading different functional molecules on a single particle is therapeutically and economically

Journal of the American Chemical Society, 112, 6190-6190 (1990)

Effect of Structure of Polymers Grafted from Graphene Oxide on the Compatibility of Particles with a Silicone-Based Environment and the Stimuli-Responsive Capabilities of Their Composites.

Monika Zygo et al.

Nanomaterials (Basel, Switzerland), 10(3) (2020-03-28)

This study reports the utilization of controlled radical polymerization as a tool for controlling the stimuli-responsive capabilities of graphene oxide (GO) based hybrid systems. Various polymer brushes with controlled molecular weight and narrow molecular weight distribution were grafted from the

Synthesis and Antibacterial Study of Sulfobetaine/Quaternary Ammonium-Modified Star-Shaped Poly[2-(dimethylamino)ethyl methacrylate]-Based Copolymers with an Inorganic Core.

Yuji Pu et al.

Biomacromolecules, 18(1), 44-55 (2016-12-24)

Cationic polymethacrylates are interesting candidates for bacterial disinfectants since they can be made in large-scale by various well-established polymerization techniques such as atom transfer radical polymerization (ATRP). However, they are usually toxic or ineffective in serum and various strategies to

Amphiphilic PEO-b-PBLG diblock and PBLG-b-PEO-b-PBLG triblock copolymer based nanoparticles: doxorubicin loading and in vitro evaluation.

Dipti Kakkar et al.

Macromolecular bioscience, 15(1), 124-137 (2015-01-06)

Huisgen's 1,3-dipolar cycloaddition ("Click Chemestry") has been used to prepare amphiphilic PEO-b-PBLG diblock and PBLG-b-PEO-b-PBLG triblock copolymers as potential carriers of anticancer drugs. Spherical and flower shaped micelles (D ≈ 100 nm) were obtained from diblock and triblock copolymers respectively.

Mesoporous silica nanoparticles (MSNs)-based organic/inorganic hybrid nanocarriers loading 5-Fluorouracil for the treatment of colon cancer with improved anticancer efficacy.

Gang Pan et al.

Colloids and surfaces. B, Biointerfaces, 159, 375-385 (2017-08-19)

Novel methods to improve the anticancer performance of 5-fluorouracil (5-FU) is quite necessary for clinical medicines. In the present work, we fabricated a novel type of mesoporous silica nanoparticles (MSNs)-based inorganic/organic hybrid nanoparticles covalently attached with poly(oligo(ethylene glycol) monomethyl ether

Glass transition temperature of single-chain polystyrene particles end-grafted to oxide-coated silicon.

Yawei Li et al.

The Journal of chemical physics, 152(6), 064904-064904 (2020-02-18)

A method based on the PeakForce QNM atomic force microscopic (AFM) adhesion measurement is employed to investigate the glassy dynamics of polystyrene (PS) single-chain particles end-grafted to SiO2-Si substrates with different diameters, D0, of 3.4 nm-8.8 nm and molar masses

A Highly Selective Poly(thiophene)-graft-Poly(methacrylamide) Polymer Modified ITO Electrode for Neuron Specific Enolase Detection in Human Serum.

Muhammet Aydın et al.

Macromolecular bioscience, 19(8), e1900109-e1900109 (2019-06-22)

In this study, an impedimetric immunosensor based on polymer poly(thiophene)-graft-poly(methacrylamide) polymer (P(Thi-g-MAm)) modified indium tin oxide (ITO) electrode is developed for the detection of the Neuron Specific Enolase (NSE) cancer biomarker. First, the P(Thi-g-MAm) polymer is synthesized and coated on

Stretching of collapsed polymers causes an enhanced dissipative response of PNIPAM brushes near their LCST.

Yunlong Yu et al.

Soft matter, 11(43), 8508-8516 (2015-09-16)

Poly(N-isopropyl acrylamide) (PNIPAM) is a stimulus-responsive polymer that can switch in water from an expanded state below the lower critical solution temperature (LCST) of 32 °C to a globular state above the LCST. It was recently shown that, as a

Spider-silk inspired polymeric networks by harnessing the mechanical potential of β-sheets through network guided assembly.

Nicholas Jun-An Chan et al.

Nature communications, 11(1), 1630-1630 (2020-04-04)

The high toughness of natural spider-silk is attributed to their unique β-sheet secondary structures. However, the preparation of mechanically strong β-sheet rich materials remains a significant challenge due to challenges involved in processing the polymers/proteins, and managing the assembly of

Surface-Induced ARGET ATRP for Silicon Nanoparticles with Fluorescent Polymer Brushes.

Chun-Na Yan et al.

Polymers, 11(7) (2019-07-26)

Well-defined polymer brushes attached to nanoparticles offer an elegant opportunity for surface modification because of their excellent mechanical stability, functional versatility, high graft density as well as controllability of surface properties. This study aimed to prepare hybrid materials with good

Ionic Polypeptide Polymers with Unusual β-Sheet Stability.

Michel Nguyen et al.

Biomacromolecules, 19(10), 4068-4074 (2018-09-12)

Incorporating charged amino acid side chains in polypeptide polymer backbones to improve solubility usually leads to reduced secondary structuring. Here we show that highly water soluble (>15 mg.mL-1) β-sheets can be obtained via nucleotide monophosphate grafting onto simple poly(γ-propargyl- L-glutamate) backbone.

PEO-b-PS Block Copolymer Templated Mesoporous Carbons: A Comparative Study of Nitrogen and Sulfur Doping in the Oxygen Reduction Reaction to Hydrogen Peroxide.

Valentina Perazzolo et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 27(3), 1002-1014 (2020-09-22)

Carbon materials slightly doped with heteroatoms such as nitrogen (N-RFC) or sulfur (S-RFC) are investigated as active catalysts for the electrochemical bielectronic oxygen reduction reaction (ORR) to H2 O2 . Mesoporous carbons with wide, accessible pores were prepared by pyrolysis

Electrical monitoring of photoisomerization of block copolymers intercalated into graphene sheets.

Semin Kim et al.

Nature communications, 11(1), 1324-1324 (2020-03-14)

Insulating polymers have received little attention in electronic applications. Here, we synthesize a photoresponsive, amphiphilic block copolymer (PEO-b-PVBO) and further control the chain growth of the block segment (PVBO) to obtain different degrees of polymerization (DPs). The benzylidene oxazolone moiety

Polystyrene Chain Growth Initiated from Dialkylzinc for Synthesis of Polyolefin-Polystyrene Block Copolymers.

Tae Jin Kim et al.

Polymers, 12(3) (2020-03-07)

Polyolefins (POs) are the most abundant polymers. However, synthesis of PO-based block copolymers has only rarely been achieved. We aimed to synthesize various PO-based block copolymers by coordinative chain transfer polymerization (CCTP) followed by anionic polymerization in one-pot via conversion

Hydrogen Peroxide and Glutathione Dual Redox-Responsive Nanoparticles for Controlled DOX Release.

Runhai Chen et al.

Macromolecular bioscience, 20(2), e1900331-e1900331 (2019-12-20)

Polymer nanoparticulate drug delivery systems that respond to reactive oxygen species (ROS) and glutathione (GSH) simultaneously at biologically relevant levels hold great promise to improve the therapeutic efficacy to cancer cells with reduced side effects of chemo drugs. Herein, a

Aptamer-immobilized open tubular capillary column to capture circulating tumor cells for proteome analysis.

Lukuan Liu et al.

Talanta, 175, 189-193 (2017-08-27)

Circulating tumor cells hold the key to predicting the prognosis and discovering the therapeutic targets. Herein, we proposed a strategy to develop an aptamer-immobilized open tubular capillary column by which SMMC-7721 human hepatoma cells (SMMC-7721 cells) could be captured with

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