372072

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A Proton Wire Mediates Proton Coupled Electron Transfer from Hydroxyurea and Other Hydroxamic Acids to Tyrosyl Radical in Class Ia Ribonucleotide Reductase.

Adam R Offenbacher et al.

The journal of physical chemistry. B, 124(2), 345-354 (2020-01-07)

Proton-coupled electron transfer (PCET) is fundamental to many important biological reactions, including solar energy conversion and DNA synthesis. For example, class Ia ribonucleotide reductases (RNRs) contain a tyrosyl radical-diiron cofactor with one aspartate ligand, D84. The tyrosyl radical, Y122•, in

Enzyme architecture: the effect of replacement and deletion mutations of loop 6 on catalysis by triosephosphate isomerase.

Xiang Zhai et al.

Biochemistry, 53(21), 3486-3501 (2014-05-16)

Two mutations of the phosphodianion gripper loop in chicken muscle triosephosphate isomerase (cTIM) were examined: (1) the loop deletion mutant (LDM) formed by removal of residues 170-173 [Pompliano, D. L., et al. (1990) Biochemistry 29, 3186-3194] and (2) the loop

Quantitative measures of myo-IP6 in soil using solution 31P NMR spectroscopy and spectral deconvolution fitting including a broad signal.

Jolanda E Reusser et al.

Environmental science. Processes & impacts, 22(4), 1084-1094 (2020-03-20)

Inositol phosphates, particularly myo-inositol hexakisphosphate (myo-IP6), are an important pool of soil organic phosphorus (P) in terrestrial ecosystems. To measure concentrations of myo-IP6 in alkaline soil extracts, solution 31P nuclear magnetic resonance (NMR) spectroscopy is commonly used. However, overlap of

Molecular insights on the interaction and preventive potential of epigallocatechin-3-gallate in Celiac Disease.

Ricardo Dias et al.

International journal of biological macromolecules, 112, 1029-1037 (2018-02-16)

Celiac Disease (CD) is now recognized as a worldwide epidemic. Although a gluten free diet usually induces clinical improvements within days or weeks, adhering to this routine is still troublesome. Therefore, new solutions are needed for quality-of-life improvement of CD

Stepwise Hydrogen Atom and Proton Transfers in Dioxygen Reduction by Aryl-Alcohol Oxidase.

Juan Carro et al.

Biochemistry, 57(11), 1790-1797 (2018-02-28)

The mechanism of dioxygen reduction by the flavoenzyme aryl-alcohol oxidase was investigated with kinetic isotope, viscosity, and pL (pH/pD) effects in rapid kinetics experiments by stopped-flow spectrophotometry of the oxidative half-reaction of the enzyme. Double mixing of the enzyme in

Impurity profiling of carbocisteine by HPLC-CAD, qNMR and UV/vis spectroscopy.

Oliver Wahl et al.

Journal of pharmaceutical and biomedical analysis, 95, 1-10 (2014-03-19)

For the impurity profiling of the mucolytic and anti-inflammatory drug carbocisteine a high performance liquid chromatographic (HPLC) method using corona charged aerosol detection (CAD) was developed and fully validated following the ICH guideline Q2(R1). The response was linear (R²>0.995) over

Mary Jo Weiss-Errico et al.

The journal of physical chemistry. B, 121(35), 8359-8366 (2017-08-12)

Legacy perfluoroalkyl substances (PFASs) are known environmental pollutants with serious adverse health effects. Perfluoroethercarboxylic acids (PFECAs), emerging PFASs now being substituted for legacy PFASs, have recently been detected in the environment. Cyclodextrins (CDs) have been proposed as agents for the

Tuning Cerium(IV)-Assisted Hydrolysis of Phosphatidylcholine Liposomes under Mildly Acidic and Neutral Conditions.

Dominique E Williams et al.

Chembiochem : a European journal of chemical biology, 16(10), 1474-1482 (2015-05-09)

With the goal of designing a lysosomal phospholipase mimic, we optimized experimental variables to enhance Ce(IV) -assisted hydrolysis of phosphatidylcholine (PC) liposomes. Our best result was obtained with the chelating agent bis-tris propane (BTP). Similar to the hydrolytic enzyme, Ce(IV)

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