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J Hadrévi et al.
Scientific reports, 5, 15925-15925 (2015-11-03)
Chronic musculoskeletal pain exists either as localised to a single region or as widespread to multiple sites in several quadrants of the body. Prospective studies indicate that widespread pain could act as a far end of a continuum of musculoskeletal
Carbolithiation of conjugated enynes with aryllithiums in microflow system and applications to synthesis of allenylsilanes
Tomida Y, et al.
Organic Letters, 11(16), 3614-3617 (2009)
Suganthagunthalam Dhakshinamoorthy et al.
Molecular bioSystems, 11(9), 2406-2416 (2015-07-16)
Altered metabolism is increasingly acknowledged as an important aspect of cancer, and thus serves as a potentially fertile area for the identification of therapeutic targets or leads. Our recent work using transcriptional data to predict metabolite levels in cancer cells
Hanna N Wetzel et al.
International immunopharmacology, 23(2), 387-390 (2014-12-03)
The chimeric human/mouse anti-cocaine monoclonal antibody (mAb) 2E2 and its further humanized variant h2E2 have been reported to sequester a significant portion of cocaine in plasma and decrease cocaine concentrations in the brain in mice and rats. However, many cocaine
Keyvan Dastmalchi et al.
Journal of agricultural and food chemistry, 63(30), 6810-6822 (2015-07-15)
The cultivation, storage, and distribution of potato tubers are compromised by mechanical damage and suboptimal healing. To investigate wound-healing progress in cultivars with contrasting russeting patterns, metabolite profiles reported previously for polar tissue extracts were complemented by GC/MS measurements for
Urszula Czyżewska et al.
Journal of medicinal food, 18(5), 584-591 (2014-09-10)
Propolis is a resin that is collected by honeybees from various plant sources. Due to its pharmacological properties, it is used in commercial production of nutritional supplements in pharmaceutical industry. In this study, gas chromatography-mass spectrometry was applied for quality
Jie Shen et al.
Scientific reports, 5, 8651-8651 (2015-03-04)
It is technically challenging to investigate the function of secreted protein in real time by supply of conditioned medium that contains secreted protein of interest. The internalization of anthrax toxin is facilitated by a secreted protein Dickkopf-1 (DKK1) and its
Jun-ichi Ito et al.
Inorganic chemistry, 47(9), 3763-3771 (2008-03-19)
The reaction of trithiomolybdate [PPh 4] 2[MoOS 3] ( 1) with 2 equiv of trimethylchlorosilane generated trithio-chloro molybdate [PPh 4][MoClS 3] ( 2) in high yield, by way of a siloxy complex [PPh 4][Mo(OSiMe 3)S 3] ( 3). This intriguing
Devin H Currie et al.
BMC systems biology, 9, 30-30 (2015-06-27)
Thermoanaerobacterium saccharolyticum is a hemicellulose-degrading thermophilic anaerobe that was previously engineered to produce ethanol at high yield. A major project was undertaken to develop this organism into an industrial biocatalyst, but the lack of genome information and resources were recognized
Yu-Xuan Lu et al.
PloS one, 9(6), e99948-e99948 (2014-06-14)
A strategy known as diapause (developmental arrest) has evolved in insects to increase their survival rate under harsh environmental conditions. Diapause causes a dramatic reduction in the metabolic rate and drastically extends lifespan. However, little is known about the mechanisms
Xianqin Wang et al.
Biological & pharmaceutical bulletin, 38(3), 470-475 (2015-03-12)
Numerous people die of paraquat (PQ) poisoning every year in the world. Although several studies regarding paraquat (PQ) poisoning have been conducted, the metabolic changes in plasma remain unknown. In this study, the metabolomics of 15 PQ poisoned patients with
Kai Lun Chang et al.
PloS one, 9(8), e104621-e104621 (2014-08-08)
Findings from epidemiology, preclinical and clinical studies indicate that consumption of coffee could have beneficial effects against dementia and Alzheimer's disease (AD). The benefits appear to come from caffeinated coffee, but not decaffeinated coffee or pure caffeine itself. Therefore, the
Na Huang et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(9), 1785-1792 (2014-05-28)
Composite hydrogels--macroscopic hydrogels with embedded microgel particles--are expected to respond to external stimuli quickly because microgels swell much faster than bulky gels. In this work, the kinetics of the pH-induced swelling of a composite hydrogel are studied using turbidity measurements.
Amanda Ruprecht et al.
Journal of bacteriology, 197(8), 1360-1367 (2015-02-04)
The acyl coenzyme A (acyl-CoA) dehydrogenases (ACADs) FadE34 and CasC, encoded by the cholesterol and cholate gene clusters of Mycobacterium tuberculosis and Rhodococcus jostii RHA1, respectively, were successfully purified. Both enzymes differ from previously characterized ACADs in that they contain
Siddharth Jambhrunkar et al.
Molecular pharmaceutics, 11(10), 3642-3655 (2014-08-29)
Mesoporous silica nanoparticles (MCM-41) with different surface chemistry were used as carrier system to study its influence on drug delivery and anticancer activity of curcumin (CUR). CUR was encapsulated in pristine MCM-41 (hydrophilic and negatively charged), amino functionalized MCM-41 (MCM-41-NH2
Hanne Roberg-Larsen et al.
Steroids, 99(Pt B), 125-130 (2015-02-11)
Due to their non-charged character, liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) measurements of oxysterols are often performed after derivatization with e.g. charged Girard reagents. However, derivatization reactions are time-consuming and may require numerous steps to remove excess reagent. In addition, extensive
Qiao Zhao et al.
Phytochemistry, 112, 170-178 (2014-08-12)
Pinoresinol reductase (PrR) catalyzes the conversion of the lignan (-)-pinoresinol to (-)-lariciresinol in Arabidopsis thaliana, where it is encoded by two genes, PrR1 and PrR2, that appear to act redundantly. PrR1 is highly expressed in lignified inflorescence stem tissue, whereas
Nai-Dong Chen et al.
International journal of analytical chemistry, 2015, 713410-713410 (2015-11-06)
GC-MS method combined with FTIR techniques by the analysis of polysaccharide was applied to evaluate the similarity between wild (W) and tissue-cultured (TC) Dendrobium huoshanense (DHS), Dendrobium officinale (DO), and Dendrobium moniliforme (DM) as well as 3 wild Dendrobium spp.:
Alexandr N Simonov et al.
PloS one, 10(11), e0141252-e0141252 (2015-11-21)
Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or two physiological enzymatic activities differentially regulated by
Michael Englert et al.
Analytical and bioanalytical chemistry, 407(18), 5503-5511 (2015-05-07)
Purification of individual fatty acids from vegetable oils by preparative liquid chromatography techniques such as countercurrent chromatography (CCC) is a challenging task due to the equivalent-chain-length (ECL) rule. It implies that one double bond equals two carbon atoms in the
Mihi Yang et al.
BMC complementary and alternative medicine, 14, 265-265 (2014-07-27)
Korean red ginseng (KRG) is a processed ginseng from raw ginseng to enhance safety, preservation and efficacy, known having beneficial effects on women's health due to its estrogen like function. While estrogen supplementation showed some modulation of endocrine disrupting chemicals
Minghua Nie et al.
Chemosphere, 127, 109-116 (2015-02-14)
The occurrence and distribution of six selected estrogen compounds were investigated in samples of surface water, suspended particulate matter (SPM), and sediment in the Yangtze Estuary and its coastal areas over four seasons. With the exception of 17α-ethinylestradiol (EE2), all
Andrii Piatkivskyi et al.
European journal of mass spectrometry (Chichester, England), 20(4), 337-344 (2014-11-26)
Gas-phase ion-molecule reactions [IMR] of various boron- and silicon-containing neutrals were investigated as a potential route for detecting phosphorylation within peptides in the negative ion mode. Trimethyl borate (TMB), triethyl borate (TEB) and N,O- Bis(trimethylsilyl)acetamide (TMSA), unlike diethylmethoxyborane (DEMB), diisopropoxymethylborane
Greg M Kowalski et al.
Biochemical and biophysical research communications, 463(4), 818-824 (2015-06-19)
Cardiac metabolism is thought to be altered in insulin resistance and type 2 diabetes (T2D). Our understanding of the regulation of cardiac substrate metabolism and insulin sensitivity has largely been derived from ex vivo preparations which are not subject to the
Andreas Üllen et al.
Biochemical pharmacology, 93(4), 470-481 (2015-01-13)
Hypochlorous acid added as reagent or generated by the myeloperoxidase (MPO)-H2O2-Cl(-) system oxidatively modifies brain ether-phospholipids (plasmalogens). This reaction generates a sn2-acyl-lysophospholipid and chlorinated fatty aldehydes. 2-Chlorohexadecanal (2-ClHDA), a prototypic member of chlorinated long-chain fatty aldehydes, has potent neurotoxic potential
Yiwei Li et al.
Lab on a chip, 15(15), 3203-3210 (2015-07-02)
Active control over the cell gradient is essential for understanding biological systems and the reconstitution of the functionality of many types of tissues, particularly for organ-on-a-chip. Here, we propose a three-dimensional (3D) microfluidic strategy for generating controllable cell gradients. In
Minghua Nie et al.
The Science of the total environment, 487, 785-791 (2013-12-25)
The occurrence and multi-phase distribution of six environmental estrogen compounds were investigated in a drinking water reservoir area by analyzing estrogens in suspended particulate matter (SPM), filtrate (conventional dissolved phase, <1 μm), permeate (truly soluble phase, <1 kDa) and retentate
Roksana Wierzbicka et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1000, 120-129 (2015-07-29)
High throughput GC-MS methods for quantification of alkylresorcinols (AR), biomarkers of whole grain wheat and rye intake, in plasma and adipose tissue and their metabolites in urine were developed and optimised. Alkylresorcinols in plasma (200μL) and adipose tissues (10-50mg) were
Bartholomaeus Pieber et al.
Journal of chromatography. A, 1217(42), 6555-6561 (2010-09-18)
A new method was developed for the quantitative analysis of steryl glycosides in biodiesel (fatty acid methyl esters). This method is much more sensitive than existing methods and has minimum limits of quantification of 50 μg/kg, compared to previously published
Magda Caban et al.
Journal of chromatography. A, 1346, 107-116 (2014-05-13)
This paper discusses a new silylating reagent - dimethyl(3,3,3-trifluoropropyl)silyldiethylamine (DIMETRIS) - for the derivatisation of non-steroidal anti-inflammatory drugs (NSAIDs) prior to GC-MS analysis. DIMETRIS reacts with seven target compounds (diclofenac, ibuprofen, ketoprofen, naproxen, flurbiprofen and paracetamol, as well as salicylic
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