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Samata Mehta et al.
International journal of pharmaceutics, 426(1-2), 44-53 (2012-01-24)
For any new vaginal dosage form, the distribution and retention in the vagina has to be assessed by in vivo evaluation. We evaluated the vaginal distribution and retention of starch-based pellets in sheep as live animal model by gamma scintigraphy
J Sýkora et al.
Biochimica et biophysica acta, 1788(2), 324-332 (2008-12-17)
The effect of non-ionic detergents on baclofen (GABAB-R agonist)-stimulated G-protein activity was measured as a [(35)S]GTPgammaS binding assay in the plasma membranes (PM) isolated from the brain tissue. The effect was clearly biphasic--a decrease in the activity was followed by
Yuxun Zhang et al.
Protein expression and purification, 59(2), 249-257 (2008-04-01)
Obtaining sufficient amount of purified G-protein coupled receptors (GPCRs) is almost always one of the major challenges for their structural studies. CB2(271-326), a human cannabinoid receptor 2 (CB2) fragment comprising part of the third extracellular loop (EL3), the seventh transmembrane
Mika Kaakinen et al.
Experimental cell research, 314(2), 237-245 (2007-11-15)
The relationship between the endoplasmic reticulum (ER) and the sarcoplasmic reticulum (SR) of skeletal muscle cells has remained obscure. In this study, we found that ER- and SR-specific membrane proteins exhibited diverse solubility properties when extracted with mild detergents. Accordingly
Xue Li et al.
Chemosphere, 78(6), 752-759 (2009-12-17)
Currently, soil contamination by polybrominated diphenyl ethers (PBDEs) at e-waste recycling sites in China is of significant environmental concern and requires the identification of appropriate remediation technologies. In this paper, photodestruction of a model PBDE congener (BDE-99) in selected UV/surfactant
Lucia Montenegro et al.
Drug development and industrial pharmacy, 37(6), 737-746 (2011-01-06)
Solid lipid nanoparticles (SLN) are regarded as interesting drug delivery systems and their preparation techniques have gained a great deal of attention. To evaluate the feasibility of preparing idebenone (IDE) loaded SLN from O/W microemulsions by the phase-inversion temperature (PIT)
Yuji Ishii et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(11), 2081-2089 (2012-08-02)
We have suggested that adenine-related compounds are allosteric inhibitors of UGT in rat liver microsomes (RLM) treated with detergent. To clarify whether the same occurs with a pore-forming peptide, alamethicin, the effects of adenine-related compounds on 4-metylumbelliferone (4-MU) glucuronidation were
H Yeşim Karasulu et al.
AAPS PharmSciTech, 9(2), 342-348 (2008-04-24)
The purpose of this research was to develop an emulsion formulation of indomethacin (IND) suitable for nasal delivery. IND was incorporated into the oil phases of oil in water (O/W) and water in oil (W/O) emulsions. For this purpose, different
Woraporn Sukhumavasi et al.
Journal of immunology (Baltimore, Md. : 1950), 181(5), 3464-3473 (2008-08-21)
TLR adaptor MyD88 activation is important in host resistance to Toxoplasma gondii during i.p. infection, but the function of this signaling pathway during oral infection, in which mucosal immunity assumes a predominant role, has not been examined. In this study
Anja Heins et al.
Lipids, 42(6), 561-572 (2007-04-21)
The location and the resulting chemical microenvironment of the antioxidant propyl gallate (PG) was studied in micellar solutions using the cationic emulsifier cetyl trimethyl ammonium bromide (CTAB), the anionic emulsifier sodium dodecyl sulphate (SDS) and the non-ionic emulsifier Brij 58
Electrodeposited Mesoporous Pt for Direct Ethanol Fuel Cells Anodes
Doan N
International Journal of Electrochemical Science, 11(4), 7631-7643 (2016)
Sreekhar Cheboyina et al.
International journal of pharmaceutics, 359(1-2), 167-173 (2008-05-23)
A novel freeze pelletization technique was evaluated for the preparation of wax-based sustained release matrix pellets. Pellets containing water-soluble drugs were successfully prepared using a variety of waxes. The drug release significantly depended on the wax type used and the
Strategy for preparation of transparent organic thin film transistors with PEDOT:PSS electrodes and a polymeric gate dielectric
Albrecht G, et al.
Materials Science in Semiconductor Processing, 40, 772-776 (2015)
G Tataru et al.
International journal of pharmaceutics, 404(1-2), 83-93 (2010-11-16)
Magnetic micro- and nanoparticles based on ferrofluid (maghemite) were elaborated by inverse emulsion crosslinking of sodium salt of carboxymethylcellulose (CMCNa) and gelatin. Crosslinking was carried out with glutaric aldehyde within aqueous droplets dispersed into toluene in presence of surfactants. The
Sayan Gupta et al.
Biochemistry, 46(35), 9886-9898 (2007-08-09)
Recombinant full-length Saccharomyces cerevisiae TATA binding protein (TBP) and its isolated C-terminal conserved core domain (TBPc) were prepared with measured high specific DNA-binding activities. Direct, quantitative comparison of TATA box binding by TBP and TBPc reveals greater affinity by TBPc
Lucia Montenegro et al.
International journal of pharmaceutics, 434(1-2), 169-174 (2012-06-05)
Idebenone (IDE), a synthetic derivative of ubiquinone, shows a potent antioxidant activity that could be beneficial in the treatment of skin oxidative damages. In this work, the feasibility of targeting IDE into the upper layers of the skin by topical
William Bragg et al.
Journal of chromatography. A, 1218(48), 8691-8700 (2011-11-01)
A novel procedure was developed for the fabrication of a fritless packed column for the coupling of capillary electrochromatography (CEC) to mass spectrometry (MS). The process involved the formation of internal tapers on two separate columns. Once the internal tapers
Prasun Bandyopadhyay et al.
The journal of physical chemistry. B, 114(35), 11462-11467 (2010-08-19)
The fluorescence response of pyrene has been studied in the presence of nonionic brij micelles and poly(acrylic acid) (PAA) with benzophenone (BP) as a neutral hydrophobic quencher. Pyrene emission is quenched ("off" state) in the presence of BP in brij
Anders Pedersen et al.
Protein expression and purification, 77(2), 220-223 (2011-02-15)
The anti-apoptotic B cell CLL/lymphoma-2 (Bcl-2) protein is a key player in the regulation of programmed cell death and is linked to various types of cancer and their resistance to drug treatment. Biophysical and structural studies of the full-length intact
Yuying Xue et al.
Journal of applied toxicology : JAT, 32(7), 480-487 (2011-03-10)
Accidental ingestion or injection of household products sometimes occurs due to their accessibility, but the toxic manifestations have not been well characterized when they are internally administered. The aim of this study was to investigate the toxic effects induced by
Scalable synthesis of sub-100 nm hollow carbon nanospheres for energy storage applications
Zhao H, et al.
Nano Research, 11(4), 1822-1833 (2018)
Vishwas Rai et al.
International journal of pharmaceutics, 411(1-2), 92-97 (2011-03-30)
The objective of this pre-formulation study was to systematically investigate the effects of two surfactants (Brij 58(®) and Tween 80(®)) and change in solution pH on in vitro permeation of naltrexone HCl (NTX-HCl) across tissue engineered human buccal mucosa. For
Jason J Emer et al.
Journal of drugs in dermatology : JDD, 10(7), 735-743 (2011-07-02)
Corticosteroids are the mainstay of therapy for atopic dermatitis, but long-term use is associated with adverse effects. We sought to evaluate the clinical efficacy of two steroid-sparing creams for atopic dermatitis. Twenty patients were enrolled in an investigator-blinded, bilateral comparison
Patricia L Foley et al.
Biochemical and biophysical research communications, 395(1), 42-47 (2010-03-30)
The shape and compaction of the bacterial nucleoid may affect the accessibility of genetic material to the transcriptional machinery in natural and synthetic systems. To investigate this phenomenon, the nature and contribution of RNA and protein to the compaction of
Chuanyu Yang et al.
PloS one, 10(7), e0133826-e0133826 (2015-07-25)
Huanglongbing (HLB) is the most serious disease affecting the citrus industry worldwide to date. The causal agent, Candidatus Liberibacter asiaticus (Las), resides in citrus phloem, which makes it difficult to effectively treat with chemical compounds. In this study, a transcuticular
Anja Heins et al.
Lipids, 42(6), 573-582 (2007-05-03)
To characterize parameters influencing the antioxidant activity at interfaces a novel ESR approach was developed, which facilitates the investigation of the reaction stoichiometry of antioxidants towards stable radicals. To relate the activity of antioxidants towards the location of radicals at
Linnéa Isaksson et al.
Protein expression and purification, 82(1), 218-225 (2012-01-25)
Detailed biophysical studies of integral membrane proteins are often hampered by sample preparation difficulties. Membrane proteins are typically difficult to express in sufficient amounts to enable the use of demanding techniques such as nuclear magnetic resonance and X-ray crystallography for
S Fall et al.
Journal of physics. Condensed matter : an Institute of Physics journal, 22(47), 474005-474005 (2011-03-10)
The structural optimization of highly mesoporous silica thin film templated with Brij58 is reported in this paper. The best conditions for obtaining well organized films are studied as a function of the concentration of surfactant, the relative humidity (RH) and
Gülten Kantarci et al.
AAPS PharmSciTech, 8(4), E91-E91 (2008-01-10)
The aim of the present study was to make a comparison of the in vitro release rate of diclofenac sodium (DS) from microemulsion (M) vehicles containing soybean oil, nonionic surfactants (Brij 58 and Span 80), and different alcohols (ethanol [E]
James Chen Yong Kah et al.
Langmuir : the ACS journal of surfaces and colloids, 28(24), 8834-8844 (2012-03-01)
The stability of gold nanorods (NRs) coated with amphiphilic ligands (ALs) was investigated. NRs coated with cetyltrimethylammonium bromide (CTAB) were ligand exchanged with polyoxyethylene [10] cetyl ether (Brij56), Oligofectamine (OF), and phosphatidylserine (PS). An aggregation index based on the longitudinal
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