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关键词:'39133'
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Karolina Stępniak et al.
Nature communications, 12(1), 3621-3621 (2021-06-17)
Chromatin structure and accessibility, and combinatorial binding of transcription factors to regulatory elements in genomic DNA control transcription. Genetic variations in genes encoding histones, epigenetics-related enzymes or modifiers affect chromatin structure/dynamics and result in alterations in gene expression contributing to
Synthesis of ?-Substituted 3-Ulosonic Acids from Aldonolactones.
Csuk, R., et al.
Tetrahedron, 59, 7887-7895 (2003)
Aimee Iberg-Badeaux et al.
Molecular and cellular biology, 37(4) (2016-12-07)
Short-term and long-term transcriptional memory is the phenomenon whereby the kinetics or magnitude of gene induction is enhanced following a prior induction period. Short-term memory persists within one cell generation or in postmitotic cells, while long-term memory can survive multiple
Rebecca S Treger et al.
Immunity, 50(2), 334-347 (2019-02-03)
Elevated endogenous retrovirus (ERV) transcription and anti-ERV antibody reactivity are implicated in lupus pathogenesis. Overproduction of non-ecotropic ERV (NEERV) envelope glycoprotein gp70 and resultant nephritis occur in lupus-prone mice, but whether NEERV mis-expression contributes to lupus etiology is unclear. Here
Yuanyuan Li et al.
Genome biology, 19(1), 18-18 (2018-02-10)
Previous studies showed that the majority of developmental genes are devoid of DNA methylation at promoters even when they are repressed. Such hypomethylated regions at developmental genes are unusually large and extend well beyond proximal promoters, forming DNA methylation valleys
Rong Wang et al.
Nature communications, 11(1), 4607-4607 (2020-09-16)
Drug tolerance is the basis for acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) including osimertinib, through mechanisms that still remain unclear. Here, we show that while AXL-low expressing EGFR mutated lung cancer (EGFRmut-LC) cells are more sensitive
Carbon-branched carbohydrate chirons: practical access to both enantiomers of 2-C-methyl-ribono-1,4-lactone and 2-C-methyl-arabinonolactone.
Booth, K. V., et al.
Tetrahedron Asymmetry, 20, 2357-2367 (2009)
H S Bleeg et al.
European journal of biochemistry, 127(2), 391-396 (1982-10-01)
An enzyme from Saccharomyces cerevisiae which catalyzes the reaction: L-galactonolactone + O2 leads to L-ascorbate + H2O2 has been purified 466-fold from the mitochondrial fraction of a yeast homogenate. The enzyme has several properties that are different from the L-galactonolactone
Wen Shan Yew et al.
Biochemistry, 45(49), 14582-14597 (2006-12-06)
Many members of the mechanistically diverse enolase superfamily have unknown functions. In this report we use both genome (operon) context and screening of a library of acid sugars to assign the L-fuconate dehydratase (FucD) function to a member of the
Dana Koludrovic et al.
PLoS genetics, 11(10), e1005555-e1005555 (2015-10-07)
MIcrophthalmia-associated Transcription Factor (MITF) regulates melanocyte and melanoma physiology. We show that MITF associates the NURF chromatin-remodelling factor in melanoma cells. ShRNA-mediated silencing of the NURF subunit BPTF revealed its essential role in several melanoma cell lines and in untransformed
Viktoriia Korniienko et al.
Materials (Basel, Switzerland), 13(18) (2020-09-10)
High strength, excellent corrosion resistance, high biocompatibility, osseointegration ability, and low bacteria adhesion are critical properties of metal implants. Additionally, the implant surface plays a critical role as the cell and bacteria host, and the development of a simultaneously antibacterial
Christine Feld et al.
Nucleic acids research, 46(7), 3412-3428 (2018-02-23)
SKI is a transcriptional co-regulator and overexpressed in various human tumors, for example in acute myeloid leukemia (AML). SKI contributes to the origin and maintenance of the leukemic phenotype. Here, we use ChIP-seq and RNA-seq analysis to identify the epigenetic
Biosynthesis of Vitamin B6: Origin of Pyridoxine by the Union of Two Acyclic Precursors, 1-Deoxy-D-xylulose and 4-Hydroxy-L-threonine.
Kennedy, I.A., et al.
Journal of the American Chemical Society, 117, 1661-1662 (1995)
Kyunghee Lee et al.
Oncogenesis, 9(1), 2-2 (2020-01-05)
PI3K Interacting Protein 1 (PIK3IP1) is a suppressor of the PI3K/Akt/mTOR pathway. We previously reported that activated Ras suppresses PIK3IP1 expression to positively regulate the PI3K pathway in cancer cells. Using doxycycline-inducible PIK3IP1, here we confirm that reversing the effect
M Lavit et al.
Arzneimittel-Forschung, 50(7), 640-644 (2000-08-31)
A simple and sensitive HPLC method has been developed to measure trimebutine (CAS 39133-31-8, maleate: CAS 34140-59-5) and its main metabolite desmethyl-trimebutine in human plasma. The method was validated according to the Washington Consensus Conference on the Validation of Analytical
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