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Dorottya Hajdu et al.
International journal of biological macromolecules, 129, 511-522 (2019-02-11)
Small, cysteine-rich and cationic antifungal proteins from natural sources are promising candidates for the development of novel treatment strategies to prevent and combat infections caused by drug-resistant fungi. However, limited information about their structure and antifungal mechanism hampers their future
Rishikesh Kumar et al.
Drug delivery, 22(3), 383-388 (2014-03-08)
Drug delivery systems are a promising technology to increase poor solubility and bioavailability of compounds. Therefore we have developed PLGA-PEG encapsulated amphotericin B nanoparticles (NPs) drug delivery technology to increase the solubility of amphotericin B and target the macrophage of
Emanuela Iaccarino et al.
The Biochemical journal, 477(8), 1391-1407 (2020-03-28)
Bicyclic peptides assembled around small organic scaffolds are gaining an increasing interest as new potent, stable and highly selective therapeutics because of their uncommon ability to specifically recognize protein targets, of their small size that favor tissue penetration and of
Delynn M Moss et al.
The American journal of tropical medicine and hygiene, 98(5), 1408-1412 (2018-03-28)
Blood samples from 805 students attending 42 elementary schools in Mopti, Sikasso, and Koulikoro regions, and Bamako district in Mali participated in a school water, sanitation, and hygiene intervention. Immunoglobulin (Ig) G responses to several antigens/pathogens were assessed by a
Xiuli Han et al.
Journal of experimental botany, 68(11), 2951-2962 (2017-06-06)
Plasma membrane (PM) H+-ATPase is essential for plant growth and development. Various environmental stimuli regulate its activity, a process that involves many protein cofactors. However, whether endogenous small molecules play a role in this regulation remains unknown. Here, we describe
Vanessa K Berner et al.
Cellular immunology, 298(1-2), 104-114 (2015-11-10)
Microparticulate β-glucan (MG) conjugated to vaccine antigen has been shown to serve as an effective adjuvant in vivo. To further study antigen presentation by MG:vaccine conjugates, bone marrow-derived dendritic cells (BMDC) were treated with MG conjugated to ovalbumin (OVA), then
Tengteng Ni et al.
Food chemistry, 286, 234-240 (2019-03-05)
Avermectins (AVMs) are a group of anti-parasitic agents that have been widely used in food-producing animals. To monitor the residue of the AVMs, an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) was developed with a simple sample preparation procedure. Conjugates of
Yuting Zhao et al.
Analytica chimica acta, 1057, 44-50 (2019-03-06)
In this paper, an immunosensor using CdTe@SiO2 core-shell nanoparticles as labels was constructed for highly sensitive detection of prostate-specific antigen (PSA). In this approach, CdTe@SiO2 core-shell nanoparticles were synthesized using the sol-gel method. The additional Cd ions and sulfur source
Jonathan Visentin et al.
Molecular immunology, 108, 34-44 (2019-02-19)
Although the Luminex single antigen flow beads (SAFB) and the flow cytometry crossmatch (FCXM) are the most sensitive assays used for anti-HLA antibodies characterization in transplant recipients, their semi-quantitative fluorescence read-out is not closely linked to graft outcome. Surface plasmon
Santanu Rana et al.
Antioxidants & redox signaling, 30(5), 713-732 (2018-04-11)
Metabolic remodeling of cardiac muscles during pathological hypertrophy is characterized by downregulation of fatty acid oxidation (FAO) regulator, peroxisome proliferator-activated receptor alpha (PPARα). Thereby, we hypothesized that a cardiac-specific induction of PPARα might restore the FAO-related protein expression and resultant
Margaret C Schneider et al.
Journal of materials chemistry. B, 8(14), 2775-2791 (2020-03-11)
Enzyme-sensitive hydrogels containing encapsulated chondrocytes are a promising platform for cartilage tissue engineering. However, the growth of neotissue is closely coupled to the degradation of the hydrogel and is further complicated due to the encapsulated cells serving as the enzyme
Gavin T Knight et al.
eLife, 7 (2018-10-30)
Human pluripotent stem cell (hPSC)-derived neural organoids display unprecedented emergent properties. Yet in contrast to the singular neuroepithelial tube from which the entire central nervous system (CNS) develops in vivo, current organoid protocols yield tissues with multiple neuroepithelial units, a.k.a.
Yan Huang et al.
Mikrochimica acta, 184(11), 4287-4294 (2017-12-05)
The authors describe a rapid, low-cost and sensitive approach for the determination of carbohydrate antigen 19-9 (CA 19-9) in whole blood by using magnetized carbon nanotube (MCNT) and lateral flow strip biosensor (LFSB). MCNTs were synthesized by depositing magnetite (Fe
J Catja Warmelink et al.
Midwifery, 55, 45-52 (2017-09-20)
Inter-professional collaboration is considered essential in effective maternity care. National projects are being undertaken to enhance inter-professional relationships and improve communication between all maternity care providers in order to improve the quality of maternity care in the Netherlands. However, little
Jinfeng Zhang et al.
Nanoscale, 7(32), 13503-13510 (2015-07-23)
The use of different nanocarriers for delivering hydrophobic pharmaceutical agents to tumor sites has garnered major attention. Despite the merits of these nanocarriers, further studies are needed to improve their drug loading capacities (which are typically <10%) and reduce their
Birol Ay et al.
Journal of biomedical materials research. Part A, 105(3), 879-890 (2016-10-23)
The reconstruction of skeletal muscle tissue is currently performed by transplanting a muscle tissue graft from local or distant sites of the patient's body, but this practice leads to donor site morbidity in case of large defects. With the aim
Yuki Takagi et al.
Thrombosis and haemostasis, 116(6), 1022-1031 (2016-09-09)
Antithrombin (AT) and thrombomodulin (TM) play important roles in the process of natural anticoagulation in vivo. Recently, we reported that the prothrombin Yukuhashi mutation (p.Arg596Leu) was associated with AT and TM resistance-related thrombophilia. To assess the AT and TM resistances
Somasekhar R Chinnadayyala et al.
Sensors (Basel, Switzerland), 21(1) (2021-01-01)
Rheumatoid arthritis (RA) is a chronic autoimmune disease that produces a progressive inflammatory response that leads to severe pain, swelling, and stiffness in the joints of hands and feet, followed by irreversible damage of the joints. The authors developed a
Liang Dong et al.
Journal of tissue engineering and regenerative medicine, 11(5), 1479-1489 (2015-06-30)
Hair follicle morphogenesis and regeneration depend on intensive but well-orchestrated interactions between epithelial and mesenchymal components. Therefore, an alternative strategy to reproduce the process of epithelial-mesenchymal interaction in vitro could use a 3D system containing appropriate cell populations. The 3D
Immobilization of laccase on polymer grafted polytetrafluoroethylene membranes for biosensor construction.
Tastan E
Talanta, 84(2), 524-530 (2011)
Michael J Taylor et al.
Journal of biomedical materials research. Part A, 107(10), 2195-2204 (2019-05-23)
Scaffolds composed of synthetic polymers such as poly(caprolactone) (PCL) are widely used for the support and repair of tissues in biomedicine. Pores are common features in scaffolds as they facilitate cell penetration. Various surface modifications can be performed to promote
Vinod Kumar et al.
Scientific reports, 7(1), 1665-1665 (2017-05-12)
Hedgehog (Hh) pathway is involved in epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) maintenance resulting in tumor progression. GDC-0449, an inhibitor of Hh pathway component smoothened (Smo) has shown promise in the treatment of various cancers including pancreatic cancer.
Md Shakir Uddin Ahmed et al.
International journal of nanomedicine, 12, 6973-6984 (2017-10-17)
As an alternative therapeutic treatment to reduce or eliminate the current side effects associated with advanced prostate cancer (PCa) chemotherapy, a multifunctional double-receptor-targeting iron oxide nanoparticles (IONPs) (luteinizing hormone-releasing hormone receptor [LHRH-R] peptide- and urokinase-type plasminogen activator receptor [uPAR] peptide-targeted
Sirinart Aromseree et al.
Journal of medical virology, 86(11), 1911-1919 (2014-08-06)
To understand the potential role in cervical cancer development of the three most common high-risk human papillomavirus (HR-HPVs) in Thai women, HPV genotypes and viral genome statuses in different cervical lesions were investigated. Cervical tissues consisting of no cervical intraepithelial
R Usha et al.
Colloids and surfaces. B, Biointerfaces, 90, 83-90 (2011-10-25)
This paper reports the effect of L-lysine on the conformational, rheological, and thermal properties of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS) cross linked collagen and investigates the influence of l-lysine on the self assembly processes of collagen. In the absence of
Keiichi Kimura et al.
Tissue engineering. Part A, 25(5-6), 457-467 (2018-08-25)
Although oxygen is a vital nutrient for the hepatocytes in vitro, few reports have focused on its effect during hepatic differentiation of induced pluripotent stem cells (iPSCs). In this report, we performed the hepatic differentiation of human iPSCs (hiPSCs) under
Kalline L Ribeiro et al.
Colloids and surfaces. B, Biointerfaces, 169, 72-81 (2018-05-12)
The use of central venous catheters (CVC) is highly associated with nosocomial blood infections and its use largely requires a systematic assessment of benefits and risks. Bacterial contamination of these tubes is frequent and may result in development of microbial
Hua Li et al.
PloS one, 10(6), e0129013-e0129013 (2015-06-04)
The technology of virus-based genetic modification in tissue engineering has provided the opportunity to produce more flexible and versatile biomaterials for transplantation. Localizing the transgene expression with increased efficiency is critical for tissue engineering as well as a challenge for
Identification of miRNAs and their targets in maize in response to Sugarcane mosaic virus infection.
Zihao Xia et al.
Plant physiology and biochemistry : PPB, 125, 143-152 (2018-02-18)
MicroRNAs (miRNAs) are endogenous non-coding small RNAs that play essential regulatory roles in plant development and environmental stress responses. Maize (Zea mays L.) is a global economically important food and forage crop. To date, a number of maize miRNAs have
Michael D Raleigh et al.
The Journal of pharmacology and experimental therapeutics, 368(2), 282-291 (2018-11-10)
Fentanyl is an extremely potent synthetic opioid that has been increasingly used to adulterate heroin, cocaine, and counterfeit prescription pills, leading to an increase in opioid-induced fatal overdoses in the United States, Canada, and Europe. A vaccine targeting fentanyl could
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