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Qian Ren et al.
International journal of biological macromolecules, 130, 845-852 (2019-03-08)
Hyaluronic acid (HA) is a natural biopolymer that can target to tumor cells due to CD44 receptors overexpressed in tumor cells. Here, a theranostic nanoparticle HA-Ce6 (DOX) with enzyme and pH dual-responsive is presented, which combined HA and a highly
Yan Yan et al.
Drug design, development and therapy, 13, 681-694 (2019-03-13)
Budesonide (Bud) is a nonhalogenated glucocorticoid with high anti-inflammatory potency and low systemic side effects. However, the poor water solubility of Bud affects its dissolution and release behavior, thus influencing its anti-inflammatory effect. This study was aimed at synthesizing and
Wei Yang et al.
International journal of biological macromolecules, 130, 58-67 (2019-02-25)
To mimic the natural structure of tissue extracellular matrix, a novel silk fibroin (SF)/hyaluronic acid (HA)/sodium alginate (SA) composite scaffold (92% in porosity) was prepared by freeze-drying. Fourier-transform infrared spectroscopy and Raman spectra indicated interactions among SF, HA, and SA
William Marcondes Facchinatto et al.
International journal of biological macromolecules, 124, 828-837 (2018-12-07)
Methoxypoly(ethyleneglycol)-graft-chitosan (PEG-g-Ch) was prepared by grafting polyethyleneglycol into chitosans (Ch) exhibiting different average degree of deacetylation (60% < DD¯ < 95%). 1H NMR showed that PEG-g-Ch derivatives presented high average degree of N-substitution (DS¯ ≈ 40%) and such derivatives exhibited full water solubility at 1.0 < pH < 11.0. The
Elena Iuliana Bîru et al.
Polymers, 12(10) (2020-10-25)
The covalent functionalization of graphene oxide (GO) surface with hyperbranched benzoxazine (BZ) structures has been achieved using poly(amidoamine) dendrimers (PAMAM) of different generations. By increasing the PAMAM generation, multiple benzoxazine rings were synthesized decorating the GO layers. The polymerization process
Sanjay Tiwari et al.
International journal of pharmaceutics, 531(1), 281-291 (2017-08-29)
Nanoparticles of cationized polyacrylamide (CPAA NP), decorated with the recognition peptide VRPMPLQ (to produce CPAA-Pep NP), were prepared, characterized and tested biologically. They were designed to target dysplasia regions in the colon, characterized by overexpressed sialic acid. This targetability was
Jiling Yi et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(6), 1700876-1700876 (2018-06-26)
Neuroma formation after amputation as a long-term deficiency leads to spontaneous neuropathic pain that reduces quality of life of patients. To prevent neuroma formation, capping techniques are implemented as effective treatments. However, an ideal, biocompatible material covering the nerves is
Tulin Ibsirlioglu et al.
Methods (San Diego, Calif.), 171, 97-107 (2019-05-06)
Here, the in vitro engineering of a cartilage-like tissue by using decellularized extracellular matrix scaffold (hECM) seeded with human adipose stem cells (hASCs) which can both be isolated from the human waste adipose tissue is described. Cell-free, highly fibrous and
Henrique V Almeida et al.
Advanced healthcare materials, 4(7), 1043-1053 (2015-02-07)
An alternative strategy to the use of in vitro expanded cells in regenerative medicine is the use of freshly isolated stromal cells, where a bioactive scaffold is used to provide an environment conducive to proliferation and tissue-specific differentiation in vivo.
Junseok Yeom et al.
Advanced healthcare materials, 4(2), 237-244 (2014-08-08)
Synthetic hydrogels have been extensively investigated as artificial extracellular matrices (ECMs) for tissue engineering in vitro and in vivo. Crucial challenges for such hydrogels are sustaining long-term cytocompatible encapsulation and providing appropriate cues at the right place and time for
Tomasz Guszcz et al.
Oncology letters, 19(1), 562-568 (2020-01-04)
Bladder cancer (BCa) is the ninth most common cancer in the world and its early detection is crucial for successful therapy. Unfortunately, there are no satisfactory tools to detect BCa at early stages and BCa's confirmation muscle-invasive. The search for
Arash Shams et al.
Artificial cells, nanomedicine, and biotechnology, 47(1), 2562-2568 (2019-06-20)
Brucellosis has always been a threat to the health and economics of societies. We report a new colorimetric immunoassay based on colored silica nanoparticles for detection of Brucella abortus. An immunosensor was designed based on blue-SiNPs and paramagnetic nanoparticles (PMNPs).
Hauke S Hillen et al.
Cell, 171(5), 1082-1093 (2017-10-17)
In human mitochondria, transcription termination events at a G-quadruplex region near the replication origin are thought to drive replication of mtDNA by generation of an RNA primer. This process is suppressed by a key regulator of mtDNA-the transcription factor TEFM.
Nitin Bhardwaj et al.
Nanotoxicology, 9(8), 1032-1040 (2015-04-02)
Administration of poly-dispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs, 10 µg intravenously on alternate days) induced a sustained anemia in mice. Using a modified double in vivo biotinylation (DIB) technique, blood counts of reticulocytes and erythrocytes of different age groups were simultaneously
Jihye Choi et al.
Journal of biomedical optics, 19(5), 051203-051203 (2013-12-04)
Biomarker-specific photothermal nanoparticles that can efficiently sense markers that are overexpressed in distinguished adenocarcinomas have attracted much interest in an aspect of efficacy increase of cancer treatment. We demonstrated a promising prospect of a smart photothermal therapy agent employing anti-epidermal
Gun-Woo Oh et al.
Journal of biomaterials science. Polymer edition, 32(3), 355-371 (2020-10-17)
Three-dimensional (3 D) printing is an effective technology that has shown considerable potential for use in tissue regeneration. Of the many materials that have been proposed for this purpose, poly (ε-caprolactone) (PCL) 3 D scaffolds have been received significant attention in the
Folic acid-conjugated organically modified silica nanoparticles for enhanced targeted delivery in cancer cells and tumor in vivo.
Yin F
Journal of Material Chemistry B: Materials for Biology and Medicine, 3(29), 6081-6093 (2015)
Daniela Barros et al.
Biomaterials, 192, 601-611 (2018-12-05)
Laminin immobilization into diverse biological and synthetic matrices has been explored to replicate the microenvironment of stem cell niches and gain insight into the role of extracellular matrix (ECM) on stem cell behavior. However, the site-specific immobilization of this heterotrimeric
Xuan Gao et al.
Journal of pharmaceutical sciences, 104(2), 368-377 (2014-09-02)
The long serum half-lives of mAbs are conferred by pH-dependent binding of IgG-Fc to the neonatal Fc receptor (FcRn). The Fc region of human IgG1 has three conserved methionine residues, Met252, Met358, and Met428. Recent studies showed oxidation of these
Yubo Qin et al.
Biomedical microdevices, 21(3), 54-54 (2019-06-17)
Aptamers have been widely used to recognize and capture their targets in sensitive detection applications, such as in detections of circulating tumor cells. In this study, we investigate the effects of different lengths of oligo-T spacers on surface tethered sgc8
Bryan Hoang et al.
International journal of pharmaceutics, 471(1-2), 224-233 (2014-05-24)
Docetaxel (DTX) remains the only effective drug for prolonging survival and improving quality of life of metastatic castration resistant prostate cancer (mCRPC) patients. Despite some clinical successes with DTX-based therapies, advent of cumulative toxicity and development of drug resistance limit
Jasper Van Hoorick et al.
Advanced healthcare materials, 9(16), e2000760-e2000760 (2020-07-01)
Corneal blindness is the fourth leading cause of visual impairment. Of specific interest is blindness due to a dysfunctional corneal endothelium which can only be treated by transplanting healthy tissue from a deceased donor. Unfortunately, corneal supply does not meet
Monica Boffito et al.
PloS one, 13(7), e0199896-e0199896 (2018-07-07)
Scaffolds populated with human cardiac progenitor cells (CPCs) represent a therapeutic opportunity for heart regeneration after myocardial infarction. In this work, square-grid scaffolds are prepared by melt-extrusion additive manufacturing from a polyurethane (PU), further subjected to plasma treatment for acrylic
Vaidyanathan Vinoth Kumar et al.
Bioresource technology, 200, 81-89 (2015-10-18)
The present study investigated the applicability of a laccase based bioprocess for the treatment of a mixture containing 13 selected pharmaceuticals. To do so, laccase was immobilized as cross-linked enzyme aggregates (MAC-CLEAs) on amine functionalized magnetic nanoparticles using chitosan/1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride
Comparison of the mucoadhesive properties of thiolated polyacrylic acid to thiolated polyallylamine.
Sarah Duggan et al.
International journal of pharmaceutics, 498(1-2), 245-253 (2015-12-26)
Synthetic polymers, polyacrylic acid (PAA) and polyallylamine (PAAm), were thiolated using different methods of thiolation. Both polymers resulted in comparable thiol contents, thus allowing for the direct comparison of mucoadhesive and cohesive properties between the well-established thiolated PAA and the
Rishi K Wadhera et al.
Annals of internal medicine, 174(1), 86-92 (2020-10-13)
The Hospital Readmissions Reduction Program (HRRP) has penalized hospitals with higher 30-day readmission rates more than $3 billion to date. Clinicians and policy experts have raised concerns that the 30-day readmission measure used in this program provides an incomplete picture
Shao-Peng Pang et al.
Scientific reports, 7(1), 4224-4224 (2017-06-28)
Dynamical processes occurring on the edges in complex networks are relevant to a variety of real-world situations. Despite recent advances, a framework for edge controllability is still required for complex networks of arbitrary structure and interaction strength. Generalizing a previously
Yuming Lai et al.
Analytical and bioanalytical chemistry, 410(23), 5993-6000 (2018-07-01)
Tumor necrosis factor alpha (TNF-α) is a cytokine with significance in early diagnosis of cardiovascular diseases, obesity and insulin resistance. We demonstrate the proof of concept for a rapid and sensitive detection of TNF-α using a magnetic bead pull-down assay
Jing Gao et al.
Bioorganic chemistry, 83, 154-160 (2018-10-27)
Docetaxel is one of the most effective anticancer drugs. However, the current formulation of docetaxel contains Tween 80 and ethanol as the solvent, which can cause severe side effects. Consequently, the development of new type of formulation of docetaxel with
Yan Liang et al.
Artificial cells, nanomedicine, and biotechnology, 48(1), 1114-1124 (2020-09-04)
In this paper, we developed a novel strategy of preparing doxorubicin (DOX) nanocrystal (NC) exerting spherical particles with a diameter of 102 nm, which experienced following coating of chondroitin sulphate derivative (CSOA) shell via electrostatic and hydrophobic interactions. Such multifunctional outerwear
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