400-38-4

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The association of HLA-DRB1 alleles with antineutrophil cytoplasmic antibody-associated systemic vasculitis in Chinese patients.

Huan Luo et al.

Human immunology, 72(5), 422-425 (2011-03-01)

Antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis (AASV) is a group of autoimmune diseases. The human leukocyte antigen (HLA) system is devoted to the pathogenesis of these autoimmune diseases. The present study aimed to investigate the distribution of HLA-DRB1 alleles in

The effects of salinity on the growth and biochemical properties of Chlamydomonas mexicana GU732420 cultivated in municipal wastewater.

El-Sayed Salama et al.

Environmental technology, 35(9-12), 1491-1498 (2014-04-08)

A freshwater microalga Chlamydomonas mexicana was grown on municipal wastewater with different levels of salinity up to 400 mmol/L NaCl, and the biochemical properties were characterized after 10 days of cultivation. C. mexicana showed the higher specific growth rates for

Combined versus sequential diuretic treatment of ascites in non-azotaemic patients with cirrhosis: results of an open randomised clinical trial.

P Angeli et al.

Gut, 59(1), 98-104 (2009-07-03)

The aim of the study was to compare sequential versus combined diuretic therapy in patients with cirrhosis, moderate ascites and without renal failure. One hundred patients were randomly assigned to the two diuretic treatments. The sequential treatment provided potassium canrenoate

Myo-inositol therapy for poor-responders during IVF: a prospective controlled observational trial.

Francesca Caprio et al.

Journal of ovarian research, 8, 37-37 (2015-06-13)

The overall incidence of poor ovarian response in IVF cycles has been reported to be between 9 and 24%. The management of these patients remains a significant challenge in assisted reproduction. The aim of the present study was to evaluate

Phase II NCCTG trial of RT + irinotecan and adjuvant BCNU plus irinotecan for newly diagnosed GBM.

Kurt A Jaeckle et al.

Journal of neuro-oncology, 99(1), 73-80 (2010-01-12)

Irinotecan has radiosensitizing effects and shows synergism with nitrosoureas. We performed a Phase II study of RT and irinotecan, followed by BCNU plus irinotecan in newly-diagnosed GBM. The MTD for patients receiving enzyme-inducing anticonvulsants (EIAC) was as follows: irinotecan 400

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial.

M William Audeh et al.

Lancet (London, England), 376(9737), 245-251 (2010-07-09)

Olaparib is a novel, orally active poly(ADP-ribose) polymerase (PARP) inhibitor that induces synthetic lethality in homozygous BRCA-deficient cells. We aimed to assess the efficacy and safety of olaparib for treatment of advanced ovarian cancer in patients with BRCA1 or BRCA2

Celecoxib plus chemoradiotherapy for locally advanced rectal cancer: a phase II TCOG study.

Ling-Wei Wang et al.

Journal of surgical oncology, 109(6), 580-585 (2014-01-01)

To report the results of a phase II trial combining celecoxib and preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer. Patients with clinical stage II or III rectal cancer were treated with radiotherapy of 44 Gy in 22 fractions. Concurrent chemotherapy

Modification of pepsinogen I levels and their correlation with gastrointestinal injury after administration of dexibuprofen, ibuprofen or diclofenac: a randomized, open-label, controlled clinical trial.

B J Gómez et al.

International journal of clinical pharmacology and therapeutics, 44(4), 154-162 (2006-04-22)

To assess the effect of a 2-week treatment with dexibuprofen, in comparison with ibuprofen and diclofenac, on pepsinogen plasma concentrations and gastrointestinal mucosa, as well as the correlation of these changes with gastrointestinal mucosal injury. 60 patients with rheumatologic disease

Psoralen-mediated virus photoinactivation in platelet concentrates: enhanced specificity of virus kill in the absence of shorter UVA wavelengths.

H Margolis-Nunno et al.

Photochemistry and photobiology, 62(5), 917-922 (1995-11-01)

Treatments with psoralens and long-wavelength ultraviolet radiation (UVA, 320-400 nm; PUVA) have shown efficacy for virus sterilization of platelet concentrates (PC). Our laboratory has employed the psoralen derivative 4'-aminomethyl-4,5',8-trimethylpsoralen (AMT), and we have found that platelet integrity is best preserved

Detection of early cleavage embryos improves pregnancy and delivery rates of Day 3 embryo transfer during in vitro fertilization.

Chun-I Lee et al.

Taiwanese journal of obstetrics & gynecology, 55(4), 558-562 (2016-09-04)

This study established a simple criterion for improving the pregnancy and delivery rates of Day 3 embryo transfer for in vitro fertilization (IVF) by assessing the early cleavage of two-cell stage embryos. In total, 258 cycle patients undergoing an IVF and

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors.

Dorota Łażewska et al.

International journal of molecular sciences, 21(10) (2020-05-16)

Dual target ligands are a promising concept for the treatment of Parkinson's disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with histamine H3 receptor (H3R) antagonism could have positive effects on dopamine regulation. Thus, a series of

Discovery of p1736, a novel antidiabetic compound that improves peripheral insulin sensitivity in mice models.

Jessy Anthony et al.

PloS one, 8(10), e77946-e77946 (2013-11-07)

Insulin resistance is a characteristic feature of Type 2 diabetes. Insulin resistance has also been implicated in the pathogenesis of cardiovascular disease. Currently used thiazolidinedione (TZD) insulin sensitizers although effective, have adverse side effects of weight gain, fluid retention and

Efficacy and safety of flupirtine modified release for the management of moderate to severe chronic low back pain: results of SUPREME, a prospective randomized, double-blind, placebo- and active-controlled parallel-group phase IV study.

Michael A Uberall et al.

Current medical research and opinion, 28(10), 1617-1634 (2012-09-14)

To demonstrate non-inferior/superior efficacy of flupirtine modified release (MR) compared with tramadol/placebo for the management of moderate to severe chronic low back pain (LBP). Randomized, double-blind, active-/placebo-controlled double-dummy multicenter study, performed in 31 German study centers. LBP patients (n = 363) with

Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase-A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects.

I Berlin et al.

British journal of clinical pharmacology, 30(6), 805-816 (1990-12-01)

1. The effects of two reversible, predominantly monoamine oxidase-A (MAO-A) inhibitors, moclobemide (150 mg three times daily) and toloxatone (400-200-400 mg day-1) on monoamine metabolites and psychometric performance were compared in a double-blind placebo controlled crossover study in 12 healthy

The safety, pharmacokinetics and pharmacodynamics of a combination of fluticasone furoate and vilanterol in healthy Japanese subjects.

Norie Nakahara et al.

International journal of clinical pharmacology and therapeutics, 51(8), 660-671 (2013-06-06)

To evaluate the safety, pharmacokinetics and pharmacodynamics of fluticasone furoate (FF) and vilanterol (VI) administered alone or in combination in three Phase I studies in healthy Japanese male subjects. FF, VI and FF/VI inhalation powder in a novel dry powder

Potent combination therapy for human breast tumors with high doses of 5-fluorouracil: remission and lack of host toxicity.

Omar N Al Safarjalani et al.

Cancer chemotherapy and pharmacology, 69(6), 1449-1455 (2012-03-01)

The purpose of this investigation was to evaluate the effectiveness of oral 5-(phenylthio)acyclouridine (PTAU) in reducing 5-fluorouracil (FUra) host toxicity and enhancing its chemotherapeutic efficacy against human breast tumors. PTAU is a potent and specific inhibitor of uridine phosphorylase (UP

Iron casein succinylate-chitosan coacervate for the liquid oral delivery of iron with bioavailability and stability enhancement.

Kyoung Ah Min et al.

Archives of pharmacal research, 39(1), 94-102 (2015-12-01)

Iron casein succinylate (ICS) liquid oral preparation as iron supplement has uncomfortable taste after a long period of storage because of its stability, and poor bioavailability of iron compared to any other iron preparations. To improve the chemical stability of

Preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with locally advanced resectable rectal cancer: a multicenter Phase II study.

Sun Young Kim et al.

International journal of radiation oncology, biology, physics, 81(3), 677-683 (2010-10-05)

To evaluate the efficacy and safety of preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with rectal cancer. Forty patients with locally advanced, nonmetastatic, and mid- to lower rectal cancer were enrolled. Radiotherapy was delivered at a dose of

β-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis.

Frederic Tissot et al.

American journal of respiratory and critical care medicine, 188(9), 1100-1109 (2013-06-21)

Life-threatening intraabdominal candidiasis (IAC) occurs in 30 to 40% of high-risk surgical intensive care unit (ICU) patients. Although early IAC diagnosis is crucial, blood cultures are negative, and the role of Candida score/colonization indexes is not established. The aim of

Elevated levels of macrophage inflammatory protein 2 in severe murine peritonitis increase neutrophil recruitment and mortality.

K R Walley et al.

Infection and immunity, 65(9), 3847-3851 (1997-09-01)

We hypothesized that chemokines may play important roles in a cecal ligation and puncture (CLP) model of septic peritonitis in CD-1 mice. Concentrations of C-X-C (macrophage inflammatory protein 2 [MIP-2] and ENA-78) and C-C (MIP-1alpha and JE) chemokines were measured

Lipid complex effect on fatty acid profile and chemical composition of cow milk and cheese.

R Bodkowski et al.

Journal of dairy science, 99(1), 57-67 (2015-10-28)

The effect of administration of lipid complex (LC) on cow milk and cheese characteristics was studied. Lipid complex was elaborated based on grapeseed oil with synthesized conjugated linoleic acid (CLA) and Atlantic mackerel oil enriched in n-3 fatty acids. The

Effective 2D-RPLC/RPLC enrichment and separation of micro-components from Hedyotis diffusa Willd. and characterization by using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

Cunman Li et al.

Journal of pharmaceutical and biomedical analysis, 99, 35-44 (2014-07-26)

An effective method aiming at enrichment and analysis of micro-components in traditional Chinese medicine (TCM) was developed. One fraction (fraction E) from the extract of Hedyotis diffusa Willd. was selected as test sample, which was isolated by using the XAD-4

Efficacy of rifaximin versus lactulose for reducing the recurrence of overt hepatic encephalopathy and hopitalizations in cirrhosis.

Roxana Irimia et al.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 116(4), 1021-1027 (2013-05-25)

Both rifaximin and lactulose have been reported to be effective for maintenance of remission from hepatic encephalopathy (HE) in patients with cirrhosis. The aim of this study was to compare the efficacy of different treatment strategies for preventing recurrences and

Carcinogenic activity associated with halogenated acetones and acroleins in the mouse skin assay.

M Robinson et al.

Cancer letters, 48(3), 197-203 (1989-12-01)

Several chlorinated acetones have been identified in drinking water and these, as well as a number of chlorinated acroleins, are produced by chlorination of humic acid solutions. Many of these chlorinated compounds and the brominated acrolein analog were positive in

Futile cycling between 4-methylumbelliferone and its conjugates in perfused rat liver.

S Ratna et al.

Hepatology (Baltimore, Md.), 17(5), 838-853 (1993-05-01)

Futile cycling between 4-methylumbelliferone and its sulfate and glucuronide conjugates was examined in the single-pass perfused rat liver preparation. The steady-state hepatic extraction ratio of 4-methylumbelliferone was found to be high (0.97) at a low input concentration of 0.005 mumol/L

A specific adenylyl cyclase inhibitor (DDA) and a cyclic AMP-dependent protein kinase inhibitor (H-89) block the action of equine growth hormone on in vitro maturation of equine oocytes.

Gabriel Ribas Pereira et al.

Zygote (Cambridge, England), 23(6), 795-801 (2014-09-27)

The objectives of this study were firstly to determine whether the stimulatory function of equine growth hormone (eGH) on equine oocyte maturation in vitro is mediated via cyclic adenosine monophosphate (cAMP); and secondly if the addition of eGH in vitro

Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia.

Farhad Ravandi et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28(11), 1856-1862 (2010-03-10)

PURPOSE To determine the efficacy and toxicity of the combination of sorafenib, cytarabine, and idarubicin in patients with acute myeloid leukemia (AML) younger than age 65 years. PATIENTS AND METHODS In the phase I part of the study, 10 patients

Liposomal amphotericin B for complicated visceral leishmaniasis (kala-azar) in eastern Sudan: how effective is treatment for this neglected disease?

Niven A Salih et al.

Tropical medicine & international health : TM & IH, 19(2), 146-152 (2014-01-18)

The aim of this study was to report the patient profile and treatment outcomes, including relapses, of patients with visceral leishmaniasis (VL) treated with liposomal amphotericin B (AmBisome) in Gedaref, Sudan. AmBisome was offered to two groups of patients: primary

Efficacy and Safety of Bavituximab in Combination with Sorafenib in Advanced Hepatocellular Carcinoma: A Single-Arm, Open-Label, Phase II Clinical Trial.

Ali A Mokdad et al.

Targeted oncology, 14(5), 541-550 (2019-08-21)

Bavituximab, an immunomodulator, targets phosphatidylserine (PS), a membrane lipid externalized on tumor and endothelial cells in response to sorafenib. The objective of this phase II study was to assess the efficacy of combination bavituximab and sorafenib in advanced hepatocellular carcinoma

Sorafenib in combination with capecitabine: an oral regimen for patients with HER2-negative locally advanced or metastatic breast cancer.

José Baselga et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 30(13), 1484-1491 (2012-03-14)

Sorafenib is a multikinase inhibitor with antiangiogenic/antiproliferative activity. A randomized, double-blind, placebo-controlled phase IIB trial assessed sorafenib with capecitabine for locally advanced or metastatic human epidermal growth factor receptor 2 (HER2) -negative breast cancer. Patients were randomly assigned to first-

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