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Ki-Dong Kwon et al.
BJU international, 114(6), 926-936 (2014-05-21)
To examine the therapeutic effect of adenovirus encoding histone deacetylase 2 (HDAC2) small hairpin RNA (Ad-HDAC2 shRNA) in a rat model of Peyronie's disease (PD) and to determine the mechanisms by which HDAC2 knockdown ameliorates fibrotic responses in primary fibroblasts
Yoshihide Ogawa et al.
Frontiers in bioscience : a journal and virtual library, 9, 2901-2908 (2004-09-09)
Ascorbic acid overload and vitamin B6 deficiency have been implicated in the development of hyperoxalemia in dialysis patients, but there is still disagreement about this. Hemodialysis patients who are exposed long-term hyperoxalemia may develop secondary oxalosis with an increased risk
M A Raskind et al.
Biological psychiatry, 46(6), 756-765 (1999-09-24)
High cerebrospinal fluid (CSF) norepinephrine (NE) concentrations in aging and Alzheimer's disease (AD) could reflect decreased NE clearance from central nervous system (CNS) extracellular fluid or increased release of NE into CNS extracellular fluid. Measuring CSF concentrations of the intraneuronal
M O Kristensen et al.
Acta neurologica Scandinavica, 87(6), 475-481 (1993-06-01)
The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20). Supplementing serum cobalamin we measured methylmalonic acid (MMA), a metabolite
K Koike et al.
Biological & pharmaceutical bulletin, 23(1), 101-103 (2000-03-08)
Hydroxyproline (Hyp) content in biological fluids is used as a parameter of collagen catabolism, especially bone resorption. In this paper, we examined the relationship between aging and serum free 4-Hyp and proline (Pro) content using a newly introduced analytical technique
Ankit A Chaturvedi et al.
The Journal of surgical research, 192(2), 432-439 (2014-07-02)
Ultrapure alginate gel is promising in terms of adhesion prevention. Because anti-adhesive barriers have been shown to disturb healing of bowel anastomoses, the effect of ultrapure alginate gel on the repair of colon anastomoses was studied. In 102 male Wistar
S Díaz et al.
Human reproduction (Oxford, England), 14(10), 2499-2505 (1999-10-21)
Bone density and turnover was assessed in a longitudinal study of healthy lactating women who initiated use of Norplant((R)) implants (NOR, n = 29), progesterone vaginal rings (PVR, n = 28) or Copper T 380A intrauterine devices (T-Cu, n =
J E Baldwin et al.
Bioorganic & medicinal chemistry letters, 10(17), 1927-1929 (2000-09-15)
The potent neuroexcitatory activity of kainoid amino acids in the mammalian CNS places new analogues in high demand as tools for neuropharmacological research. A range of 4-arylsulfanyl-substituted kainoids has been synthesised in a parallel fashion via mesylate displacement by a
Jibing Yang et al.
American journal of physiology. Lung cellular and molecular physiology, 306(8), L786-L796 (2014-02-11)
Fibrogenesis involves a pathological accumulation of activated fibroblasts and extensive matrix remodeling. Profibrotic cytokines, such as TGF-β, stimulate fibroblasts to overexpress fibrotic matrix proteins and induce further expression of profibrotic cytokines, resulting in progressive fibrosis. Connective tissue growth factor (CTGF)
Yan-Yan Tao et al.
Experimental biology and medicine (Maywood, N.J.), 238(11), 1284-1296 (2013-09-06)
Salvianolic acid B (Sal B) is a major water soluble component extracted from Radix Salviae miltiorrhizae, a traditional Chinese herb widely used for treating cardiovascular and hepatic diseases. Sal B has been reported to inhibit transforming growth factor (TGF)-β1-stimulated hepatic
Georgios Galanopoulos et al.
The Journal of surgical research, 189(1), 22-31 (2014-03-04)
The aim of this study was to investigate the effects of iloprost, on colonic anastomotic healing in rats, under obstructive ileus conditions. Eighty male Albino rats were randomized into four groups of 20 animals each. They underwent colonic resection followed
J Adelmeijer et al.
The British journal of surgery, 100(11), 1498-1504 (2013-09-17)
Fibrin sealants are used in pancreatic surgery to prevent leakage of pancreatic fluid and reduce associated complications. The efficacy of this approach is unclear. Fibrin clots were generated in vitro from two commercially available liquid fibrin sealants (Tissucol Duo® and
Lihua Jian et al.
Biochemical and biophysical research communications, 446(4), 1022-1028 (2014-04-01)
The extracellular matrix (ECM) is an essential element of mammalian organisms, and its cross-linking formation plays a vital role in ECM development and postnatal homeostasis. Defects in cross-link formation caused by aging, genetic, or environmental factors are known to cause
Benedetto Natalini et al.
Methods in molecular biology (Clifton, N.J.), 970, 191-208 (2013-01-04)
Chiral ligand-exchange chromatography (CLEC) first described in the late 1960s to early 1970s by Davankov and Rogozhin can be still considered as an elective choice for the direct enantioseparation of compounds endowed with chelating moieties. Among the numerous chelating species
H U Shetty et al.
Clinical chemistry, 42(2), 298-302 (1996-02-01)
Previous studies suggest the presence of increased concentrations of cerebral myo-inositol in Alzheimer disease (AD). To characterize this abnormality further, we quantified myo-inositol and several other polyols in cerebrospinal fluid (CSF) and plasma from 10 AD subjects and 10 healthy
Debarati Basu et al.
The Journal of biological chemistry, 288(14), 10132-10143 (2013-02-23)
Although plants contain substantial amounts of arabinogalactan proteins (AGPs), the enzymes responsible for AGP glycosylation are largely unknown. Bioinformatics indicated that AGP galactosyltransferases (GALTs) are members of the carbohydrate-active enzyme glycosyltransferase (GT) 31 family (CAZy GT31) involved in N- and
M Ia Spivak et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(2), 23-30 (2013-07-05)
It was investigated the effect of probiotic strains Bifidobacterium animalis VKL and VKB and their mixture on erosive and ulcerative lesions in the gastric mucosa (GM) of rats induced by water immersion restraint stress. It was found that separate prophylactic
Sezgin Zeren et al.
Anesthesia and analgesia, 116(2), 495-499 (2013-01-11)
Local anesthetic infiltration along the incision may be used to provide surgical anesthesia or postoperative analgesia. However, the effect of local anesthetics on wound healing remains controversial. In this investigation, we evaluated the effects of levobupivacaine on wound healing. Sixty
István Ilisz et al.
Journal of chromatography. A, 1363, 169-177 (2014-07-20)
Two chiral stationary phases containing a quinine- or a quinidine-based zwitterionic ion-exchanger as chiral selector were applied for the enantioseparation of 27 unusual cyclic secondary α-amino acids. The effects of the nature and concentration of the bulk solvent, the acid
Arun Sreekumar et al.
Nature, 457(7231), 910-914 (2009-02-13)
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have
Paulo De Sa Peixoto et al.
The Journal of biological chemistry, 288(11), 7528-7535 (2013-01-24)
In vivo, collagen I, the major structural protein in human body, is found assembled into fibrils. In the present work, we study a high concentrated collagen sample in its soluble, fibrillar, and denatured states using one and two dimensional {(1)H}-(13)C
Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis.
Ksenija Bernau et al.
Respiratory research, 16, 45-45 (2015-04-18)
Fibrosing disorders of the lung, such as idiopathic pulmonary fibrosis, are characterized by progressive extracellular matrix accumulation that is driven by myofibroblasts. The transcription factor megakaryoblastic leukemia-1 (MKL1) mediates myofibroblast differentiation in response to several profibrotic stimuli, but the role
Gengxia Yang et al.
Toxicology letters, 220(2), 103-108 (2013-05-04)
Bone morphogenetic protein-7 (BMP-7) has been shown to inhibit liver and renal fibrosis in in vivo and vitro studies. There is no study to investigate BMP-7's role in the development of pulmonary fibrosis induced by silica. In the current study
Yuanyuan Shi et al.
American journal of respiratory and critical care medicine, 188(7), 831-841 (2013-08-09)
Alveolar transforming growth factor (TGF)-β1 signaling and expression of TGF-β1 target genes are increased in patients with idiopathic pulmonary fibrosis (IPF) and in animal models of pulmonary fibrosis. Internalization and degradation of TGF-β receptor TβRI inhibits TGF-β signaling and could
Xiaolei Li et al.
European journal of pharmacology, 703(1-3), 42-45 (2013-02-21)
The study was to compare the preventive effects of the local application of mitomycin C (MMC) and 10-hydroxycamptothecin (HCPT) on reducing intraarticular adhesion after knee surgery in rabbit model. Thirty-six New-Zealand rabbits were randomly and equally divided into three groups:
Stefano Fiorucci et al.
The Journal of pharmacology and experimental therapeutics, 315(1), 58-68 (2005-06-28)
The nuclear receptors farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR)gamma exert counter-regulatory effects on hepatic stellate cells (HSCs) and protect against liver fibrosis development in rodents. Here, we investigated whether FXR ligands regulate PPARgamma expression in HSCs and
Jacob Kofoed et al.
Chemical communications (Cambridge, England), (14)(14), 1482-1484 (2006-04-01)
The aldol reaction of acetone with aldehydes in aqueous medium under catalysis by zinc-proline (Zn(L-Pro)2) and secondary amines such as proline, (2S,4R)-4-hydroxyproline (Hyp) and (S)-(+)-1-(2-pyrrolidinomethyl)pyrrolidine (PMP) is shown to proceed by an enamine mechanism, as evidenced by reductive trapping of
Elizabeth F Redente et al.
American journal of respiratory cell and molecular biology, 50(4), 825-837 (2013-12-12)
Idiopathic pulmonary fibrosis (IPF) is a relentless, fibrotic parenchymal lung disease in which alternatively programmed macrophages produce profibrotic molecules that promote myofibroblast survival and collagen synthesis. Effective therapies to treat patients with IPF are lacking, and conventional therapy may be
V A Shkurupiy et al.
Bulletin of experimental biology and medicine, 154(3), 299-302 (2013-03-14)
In generalized BCG granulomatosis, fibrosis starts early (on day 3) and not only around the granulomas, but also in the organs. The severity of organ fibrosis is apparently determined by the concentration of granulomas, in particular their macrophages inducing proliferation
Ryota Tanaka et al.
The Journal of pharmacology and experimental therapeutics, 345(2), 271-283 (2013-02-28)
Idiopathic pulmonary fibrosis (IPF) is thought to involve inflammatory cells and reactive oxygen species (ROS), such as superoxide anion radical (O2(·-)). There is currently no effective treatment of IPF. We previously developed a human serum albumin (HSA)-thioredoxin 1 (Trx) fusion
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