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Zhen-Hai Zhang et al.
Journal of biomedical nanotechnology, 9(4), 601-609 (2013-04-30)
N-octyl-N-Arginine chitosan (OACS) was synthesized in an attempt to combine the permeation enhancing effects of arginine-rich peptides and the drug loading capacity of the amphipathic polymers for insulin oral delivery. OACS self-assembled micelles of insulin were prepared by the conventional
Stephanie Supper et al.
Expert opinion on drug delivery, 11(2), 249-267 (2013-12-07)
Thermogelling chitosan (CS)/glycerophosphate (GP) solutions have been reported as a new type of parenteral in situ forming depot system. These free-flowing solutions at ambient temperature turn into semi-solid hydrogels after parenteral administration. Formulation parameters such as CS physico-chemical characteristics, CS/gelling
Alyssa Reiffel Golas et al.
Plastic and reconstructive surgery, 132(6), 952e-963e (2013-11-28)
As vascularization represents the rate-limiting step in permanent incorporation of hydrogel-based tissue-regeneration templates, the authors sought to identify the material chemistry that would optimize endothelial cell adhesion and invasion into custom hydrogel constructs. The authors further investigated induction of endothelial
A Anitha et al.
Journal of biomedical nanotechnology, 9(3), 335-347 (2013-04-30)
In the current work, a sustained drug delivery system of flutamide (FLT) was developed using chitosan (CS) and dextran sulphate (DS) nanoparticles and were characterized using different techniques. The prepared nanoparticles showed a size of 80-120 nm with an entrapment
Pramila Chaubey et al.
Expert opinion on drug delivery, 11(8), 1163-1181 (2014-05-31)
The study aims at formulation and optimization of macrophage-targeted curcumin-loaded mannosylated chitosan nanoparticles (Cur-MCNPs) of curcumin (CUR) to improve its therapeutic potential in the treatment of visceral leishmaniasis (VL). Response surface methodology (RSM) using central composite design was employed to
Xiaowei Xu et al.
Acta biomaterialia, 86, 235-246 (2019-01-07)
Periodontitis is an inflammatory disease induced by complex interactions between host immune system and plaque microorganism. Alveolar bone resorption caused by periodontitis is considered to be one of the main reasons for tooth loss in adults. To terminate the alveolar
Fine tuning of reactive oxygen species homeostasis regulates primed immune responses in Arabidopsis.
Victoria Pastor et al.
Molecular plant-microbe interactions : MPMI, 26(11), 1334-1344 (2013-10-04)
Selected stimuli can prime the plant immune system for a faster and stronger defense reaction to pathogen attack. Pretreatment of Arabidopsis with the chemical agent β-aminobutyric acid (BABA) augmented H2O2 and callose production after induction with the pathogen-associated molecular pattern
Anna Ilnicka et al.
Materials science & engineering. C, Materials for biological applications, 52, 31-36 (2015-05-09)
Renewable raw materials chitin and chitosan (N-deacetylated derivative of chitin) were subjected to action of different copper modifiers that were carbonized in the atmosphere of the N2 inert gas. As a result of the novel manufacturing procedure, a series of
Hailing Liu et al.
Analytica chimica acta, 776, 24-30 (2013-04-23)
Based on the polyphosphonate-assisted coacervation of chitosan, a simple and versatile procedure for the encapsulation of proteins/enzymes in chitosan-carbon nanotubes (CNTs) composites matrix was developed. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), energy dispersive spectrum
Darren Svirskis et al.
Pharmaceutical development and technology, 19(5), 571-576 (2013-07-19)
This study aimed at improving the oral bioavailability of acyclovir (ACV) through incorporating it into gastroretentive dosage form based on floating hollow chitosan beads. Hollow chitosan beads were prepared using a solvent free, ionotropic gelation method. The effect of formulation
Tran Thi Nhung et al.
Journal of nanoscience and nanotechnology, 13(8), 5346-5350 (2013-07-26)
Flowerlike gold nanostructure was facilely prepared by the seed-mediated growth of gold nanoparticles in chitosan-TPP template films. Firstly, chitosan nanoparticles, spontaneously formed by inter and/or intra cross-linking with TPP, were transformed into gel-type of chitosan-TPP films under strong sonication process.
Shi Xu et al.
Journal of nanoscience and nanotechnology, 13(1), 129-138 (2013-05-08)
For the purpose of achieving targeted chemotherapy of pancreatic cancer, we prepared core-shell nanoparticles by coaxial electrospray technology, with folate-chitosan as the polymeric coating material and gemcitabine as the encapsulated drug. The effects of various solution properties and processing parameters
Huixin Zhang et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(12), 2768-2775 (2013-06-22)
A novel technique for a complete removal of both Cr(VI) and Cr(III) ions, namely cross-linked chitosan (CCTS) adsorption and base-precipitation combination, was studied in this work in great detail. The optimum conditions for Cr(VI) adsorption onto CCTS were determined as
Neelam Gogoi et al.
Journal of nanoscience and nanotechnology, 14(6), 4147-4155 (2014-04-18)
In this work storage of silver nanoparticles (Ag NPs) in chitosan gel and its subsequent release for catalytic reduction processes is investigated. The generation of small sized metal nanoparticles which acts as catalyst is prerequisite to progress of a catalytic
Alberto Busilacchi et al.
Carbohydrate polymers, 98(1), 665-676 (2013-08-31)
The idea of using chitosan as a functional delivery aid to support simultaneously PRP, stem cells and growth factors (GF) is associated with the intention to use morphogenic biomaterials to modulate the natural healing sequence in bone and other tissues.
Xiaojing Li et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(2), 304-304 (2014-01-21)
The purpose of the present study was to compare a newly developed chitosan-collagen membrane (CCM) with a standard collagen membrane (SCM) regarding their effects on guided bone regeneration. The right mandibular premolars and first molar were extracted from 12 beagle
Jumana Akhtar et al.
Plant and soil, 428(1), 57-65 (2018-01-01)
Understanding the structures and functions of carbon-based molecules in soils is an important goal in the context of soils as an ecosystem function of immense importance. Polysaccharides are implicated in maintaining soil aggregate status but have not been extensively dissected
Matthew B Dowling et al.
The Journal of surgical research, 193(1), 316-323 (2014-07-14)
Trauma represents a significant public health burden, and hemorrhage alone is responsible for 40% of deaths within the first 24 h after injury. Noncompressible hemorrhage accounts for the majority of hemorrhage-related deaths. Thus, materials which can arrest bleeding rapidly are
Hyejin Park et al.
Carbohydrate polymers, 97(2), 587-596 (2013-08-06)
Scaffolds derived from naturally occurring polysaccharides have attracted significant interest in bone tissue engineering due to their excellent biocompatibility and hydrophilic nature favorable for cell attachment. In this study, we developed composite chitosan (CH) scaffolds containing anionic carbohydrate, such as
A-B Liu et al.
Parasite immunology, 36(7), 292-302 (2014-04-08)
This study was designed to investigate the therapeutic efficacy of chitosan on Pneumocystis pneumonia (PCP) in immunosuppressed rats. The PCP rat model was established using intramuscular injections of dexamethasone sodium phosphate. To estimate treatment effects of chitosan on rat PCP
Wei-Hsuan Lo et al.
Molecules (Basel, Switzerland), 25(21) (2020-11-07)
(1) Background: Few antifungal drugs are currently available, and drug-resistant strains have rapidly emerged. Thus, the aim of this study is to evaluate the effectiveness of the antifungal activity from a combinational treatment of chitosan with a clinical antifungal drug
Ying Sun et al.
Journal of nanoscience and nanotechnology, 13(8), 5260-5266 (2013-07-26)
Calcium phosphate (CaP) has been widely used as the vector for gene transfection in the past three decades. However, clinical application is still not popular due to the poor-controlling of DNA/CaP complexes preparation, cytotoxicity and its low transfection efficiency. In
Milena Ignatova et al.
Macromolecular bioscience, 13(7), 860-872 (2013-06-12)
Chitosan is non-toxic, biocompatible, and biodegradable polysaccharide from renewable resources, known to have inherent antibacterial activity, which is mainly due to its polycationic nature. The combining of all assets of chitosan and its derivatives with the unique properties of electrospun
Lakshmi Narashimhan Ramana et al.
Biochimica et biophysica acta, 1840(1), 476-484 (2013-10-15)
Antiretroviral Therapy (ART) is currently the major therapeutic intervention in the treatment of AIDS. ART, however, is severely limited due to poor availability, high cytotoxicity, and enhanced metabolism and clearance of the drug molecules by the renal system. The use
Omar Abdelaziz Ouni et al.
Materials (Basel, Switzerland), 14(16) (2021-08-28)
The ability of bacteria to adhere to and form biofilms on implant surfaces is the primary cause of implant failure. Implant-associated infections are difficult to treat, as the biofilm mode of growth protects microorganisms from the host's immune response and
Martin Hsiu-Chu Lin et al.
International journal of molecular sciences, 22(16) (2021-08-28)
Gene transfection is a valuable tool for analyzing gene regulation and function, and providing an avenue for the genetic engineering of cells for therapeutic purposes. Though efficient, the potential concerns over viral vectors for gene transfection has led to research
Muhammad A Hassan et al.
Journal of biomedical nanotechnology, 9(3), 467-474 (2013-04-30)
Magnetically responsive engineered smart thin films of nanoferrites as contrast agent are employed to develop surface based magnetic resonance imaging to acquire simple yet fast molecular imaging. The work presented here can be of significant potential for future lab-on-chip point-of-care
Yong Ren et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(21), 3709-3712 (2014-02-06)
The concentrations of heavy metals in the extracting solutions of traditional Chinese medicine are usually very low. Furthermore, a vast number of organic components contained in the extracting solutions would be able to coordinate with heavy metals, which might lead
Xin-Yan Han et al.
The British journal of nutrition, 111(8), 1405-1411 (2014-01-07)
The present study was conducted to investigate the effects of chitosan (CS)-Zn on intestinal morphology, mucosal epithelial cell apoptosis and mucosal immune function in weanling pigs. A total of 150 weanling barrows with a body weight of 7.2 kg were
Ming-Yang Yeh et al.
Anticancer research, 33(11), 4867-4873 (2013-11-14)
According to the World Health Organization, Complementary and alternative medicine (CAM) is a comprehensive term referring to traditional medical treatments and various forms of indigenous medicines, also known as indigenous or folk medicine. Cancer patients often use CAM in the
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