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Nisha Patel et al.
American journal of human genetics, 94(5), 755-759 (2014-04-29)
We have previously described a syndrome characterized by facial dysmorphism, lens dislocation, anterior-segment abnormalities, and spontaneous filtering blebs (FDLAB, or Traboulsi syndrome). In view of the consanguineous nature of the affected families and the likely autosomal-recessive inheritance pattern of this
Yuki Kojima et al.
Drug development and industrial pharmacy, 39(9), 1484-1493 (2012-06-08)
The purpose of this study is to determine the process parameters of the laboratory-scale spray dryer affecting the solubility behavior and physical stability of solid dispersions. Solid dispersions of the model drug (nilvadipine or nifedipine) and hypromellose (HPMC) (w/w: 1/1)
Pravin S Shirude et al.
Journal of medicinal chemistry, 57(13), 5728-5737 (2014-05-31)
In a previous report, we described the discovery of 1,4-azaindoles, a chemical series with excellent in vitro and in vivo antimycobacterial potency through noncovalent inhibition of decaprenylphosphoryl-β-d-ribose-2'-epimerase (DprE1). Nevertheless, high mouse metabolic turnover and phosphodiesterase 6 (PDE6) off-target activity limited
Jeonghoon Han et al.
Aquatic toxicology (Amsterdam, Netherlands), 152, 308-317 (2014-05-13)
In this study, we investigated the effects of the water-accommodated fraction (WAF) of crude oil on the development and reproduction of the intertidal copepod Tigriopus japonicus through life-cycle experiments. Furthermore, we investigated the mechanisms underlying the toxic effects of WAF
Biosynthesis: A carbonate architect emerges.
Yuhui Sun
Nature chemical biology, 10(7), 486-487 (2014-05-20)
Faaiza Qazi et al.
Pakistan journal of pharmaceutical sciences, 26(4), 653-663 (2013-07-03)
The aim of this study was to develop a sustained release hydrophilic matrix tablet of Diltiazem HCl and evaluates the effect of formulation variables (e.g. lubricant, binder, polymer content and viscosity grades of HPMC) on drug release. Twelve different formulations
Muhammad Akram et al.
Pakistan journal of pharmaceutical sciences, 26(2), 323-332 (2013-03-05)
The objective of the present study was to formulate an insulin emulgel, selection of an optimize formulation through in vitro drug release kinetics and finally evaluate its hypoglycemic activity in animal model. Insulin emulgel was prepared using emu oil as
Dheeraj Baviskar et al.
Pakistan journal of pharmaceutical sciences, 26(1), 137-144 (2012-12-25)
The present study was undertaken to investigate the effect of hydrophilic, plastic and hydrophobic types of polymers and their content level on the release profile of drug from matrix systems. To improve therapeutic efficacy, systemic absorption and patient compliance a
Viviana Pensato et al.
Brain : a journal of neurology, 137(Pt 7), 1907-1920 (2014-05-17)
Hereditary spastic paraplegias are a heterogeneous group of neurodegenerative disorders, clinically classified in pure and complex forms. Genetically, more than 70 different forms of spastic paraplegias have been characterized. A subgroup of complicate recessive forms has been distinguished for the
True L Rogers et al.
Drug development and industrial pharmacy, 38(5), 521-539 (2011-10-04)
This three-part review has been developed following the evaluation of literature where ethylcellulose, methylcellulose, or hypromellose was used to make microcapsules. Parts 1 and 2 of the review are published in separate papers. Part 1 covers the various materials used
Hanna Helgeland et al.
Gene, 543(2), 268-274 (2014-03-04)
In mammals, two carotenoid cleaving oxygenases are known; beta-carotene 15,15'-monooxygenase (BCMO1) and beta-carotene 9',10'-oxygenase (BCO2). BCMO1 is a key enzyme in vitamin A synthesis by symmetrically cleaving beta-carotene into 2 molecules of all-trans-retinal, while BCO2 is responsible for asymmetric cleavage
Min-Soo Kim et al.
International journal of pharmaceutics, 445(1-2), 108-116 (2013-02-12)
The purpose of this study was to develop supersaturatable formulations for the enhanced solubility and oral absorption of sirolimus. Supersaturatable formulations of hydrophilic polymers and/or surfactants were screened by formulation screening, which is based on solvent casting. The solid dispersion
Aadi Moolam Ramesh et al.
Gene, 542(2), 113-121 (2014-04-01)
A new full length cDNA clone encoding stearoyl-ACP desaturase (SAD) was isolated from seeds of Pongamia pinnata, an oil yielding legume plant. The cDNA clone (PpSAD) contained a single open reading frame of 1182-bp coding for 393 amino acids with
Kofi Asare-Addo et al.
Colloids and surfaces. B, Biointerfaces, 104, 54-60 (2013-01-10)
Theophylline extended release (ER) matrices containing hypromellose (hydroxypropyl methylcellulose (HPMC) E4M and K4M were evaluated in media with a pH range of 1.2-7.5, using an automated USP type III, Bio-Dis dissolution apparatus. The objectives of this study were to evaluate
William McDonald et al.
Biochemistry, 53(27), 4467-4475 (2014-06-18)
Knowing how the protein environment modulates ligand pathways and redox centers in the respiratory heme-copper oxidases is fundamental for understanding the relationship between the structure and function of these enzymes. In this study, we investigated the reactions of O2 and
Salah El-Sousi et al.
The Journal of pharmacy and pharmacology, 65(2), 193-200 (2013-01-03)
The aim of this study was to prepare diclofenac/hydroxypropylmethylcellulose (HPMC) and diclofenac-loaded nanoparticles/HPMC films as potential systems for ocular delivery. Two different concentration of the polymer were used: 1.5 and 2.0% w/v. Chitosan-hyaluronic acid nanoparticles were prepared by the ionotropic
Michal Siller et al.
The Journal of biological chemistry, 289(15), 10476-10487 (2014-02-25)
Cytochrome P450 (P450) 2U1 has been shown to be expressed, at the mRNA level, in human thymus, brain, and several other tissues. Recombinant P450 2U1 was purified and used as a reagent in a metabolomic search for substrates in bovine
Stian A Clem et al.
Virology, 460-461, 207-216 (2014-07-11)
The Autographa californica multiple nucleopolyhedrovirus ac92 is a conserved baculovirus gene with homology to flavin adenine dinucleotide-linked sulfhydryl oxidases. Its product, Ac92, is a functional sulfhydryl oxidase. Deletion of ac92 results in almost negligible levels of budded virus (BV) production
Ellen W Moomaw et al.
Biochemical and biophysical research communications, 450(1), 750-754 (2014-06-24)
Membrane inlet mass spectrometry (MIMS) uses a semipermeable membrane as an inlet to a mass spectrometer for the measurement of the concentration of small uncharged molecules in solution. We report the use of MIMS to characterize the catalytic properties of
Somayeh Bahrami et al.
Veterinary parasitology, 203(1-2), 43-50 (2014-03-19)
Fasciola gigantica is a parasitic helminth that predominantly infects the liver and bile ducts of cattle and causes great losses of cattle production in the southwestern regions of Iran. The purpose of the present study was to find out the
Alexandre Kriznik et al.
Archives of biochemistry and biophysics, 548, 54-59 (2014-03-19)
The mouse methionine sulfoxide reductase A (MsrA) belongs to the subclass of MsrAs with one catalytic and two recycling Cys corresponding to Cys51, Cys198 and Cys206 in Escherichia coli MsrA, respectively. It was previously shown that in the absence of
Jane W Agger et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), 6287-6292 (2014-04-16)
The recently discovered lytic polysaccharide monooxygenases (LPMOs) are known to carry out oxidative cleavage of glycoside bonds in chitin and cellulose, thus boosting the activity of well-known hydrolytic depolymerizing enzymes. Because biomass-degrading microorganisms tend to produce a plethora of LPMOs
Xiaodong Zheng et al.
Cornea, 32(9), 1260-1264 (2013-07-19)
To compare 3 ocular lubricants containing sodium hyaluronate (SH), carboxymethylcellulose (CMC), and hydroxypropyl methylcellulose (HPMC) for their ability to enhance water retention and to protect human corneal epithelial cells (HCECs) from dehydration. Experiments were performed using 0.1% and 0.3% solutions
Ruijuan Qu et al.
Aquatic toxicology (Amsterdam, Netherlands), 150, 9-16 (2014-03-19)
In this study, laboratory experiments were conducted to investigate the combined effect of zinc and pH on metal accumulation and oxidative stress biomarkers in Carassius auratus. Fish were exposed to 0.1 and 1.0mg Zn/L at three pH values (5.0, 7.25
Chun-Woong Park et al.
Archives of pharmacal research, 35(11), 1935-1943 (2012-12-06)
The purposes of this study were to prepare a topical solution containing itraconazole (ITR)-phenol eutectic mixture and to evaluate its ex vivo skin permeation, in vivo deposition and in vivo irritation. The eutectic mixture was prepared by agitating ITR and
Katharine S Walter et al.
Journal of medical entomology, 51(3), 596-604 (2014-06-06)
Yellow fever virus is a reemerging infection responsible for widespread, sporadic outbreaks across Africa. Although Aedes aegypti (L.) is the most important vector globally, in East Africa, epidemics may be vectored by Aedes bromeliae (Theobald), a member of the Aedes
Fernando Andrés et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), E2760-E2769 (2014-07-01)
In Arabidopsis thaliana environmental and endogenous cues promote flowering by activating expression of a small number of integrator genes. The MADS box transcription factor SHORT VEGETATIVE PHASE (SVP) is a critical inhibitor of flowering that directly represses transcription of these
Jing Liu et al.
Archives of pharmacal research, 35(11), 1927-1934 (2012-12-06)
The purpose of this study was to develop and evaluate a colon-specific, pulsatile drug delivery system, which consists of an impermeable capsule body filled with a 5-aminosalicylic acid rapid-disintegrating tablet and a pectin-based erodible plug placed in the opening of
Jo Hoeser et al.
FEBS letters, 588(9), 1537-1541 (2014-04-01)
Cytochrome bd ubiquinol oxidase uses the electron transport from ubiquinol to oxygen to establish a proton gradient across the membrane. The enzyme complex consists of subunits CydA and B and contains two b- and one d-type hemes as cofactors. Recently
Qichen Jiang et al.
Ecotoxicology and environmental safety, 104, 423-428 (2014-04-01)
We evaluated the effect of acute exposure to nitrite on expression of antioxidant and metabolic enzyme genes in gill tissue of advanced juvenile Cherax quadricarinatus. A 48h nitrite exposure was conducted, using four test concentrations (NO2-N=0.5, 1, 1.5 and 2mg
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