43088

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关键词:'43088'

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Synthesis, 723-723 (1988)

[Effects of diphenyliodonium on the degree of conversion and the compressive strength of composite resin].

Yina Lin et al.

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 25(3), 593-596 (2008-08-13)

The degree of conversion (DC) and the compressive strength (CS) are important indexes of composite resin. This study is aimed to investigate the effects of diphenyliodonium on the DC and the CS of the light-curing composite resin. Different amount of

Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase.

Qingshan Wang et al.

Journal of neuroinflammation, 9, 32-32 (2012-02-22)

Both (-) and (+)-naloxone attenuate inflammation-mediated neurodegeneration by inhibition of microglial activation through superoxide reduction in an opioid receptor-independent manner. Multiple lines of evidence have documented a pivotal role of overactivated NADPH oxidase (NOX2) in inflammation-mediated neurodegeneration. We hypothesized that

Role of reactive oxygen species and proline cycle in anthraquinone accumulation in Rubia tinctorum cell suspension cultures subjected to methyl jasmonate elicitation.

María Perassolo et al.

Plant physiology and biochemistry : PPB, 49(7), 758-763 (2011-04-23)

Elicitors are compounds or factors capable of triggering a defense response in plants. This kind of response involves signal transduction pathways, second messengers and events such as Reactive Oxygen Species (ROS) generation, proline accumulation and secondary metabolite production. Anthraquinone (AQs)

Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5.

Jingli Wang et al.

Biochemical pharmacology, 91(4), 436-446 (2014-08-19)

SN30000 is a second-generation benzotriazine-N-oxide hypoxia-activated prodrug scheduled for clinical trial. Previously we showed that covalent binding of the hypoxia probe EF5 predicts metabolic activation of SN30000 in a panel of cancer cell lines under anoxia, suggesting that they are

NO-donating oximes relax corpora cavernosa through mechanisms other than those involved in arterial relaxation.

Bart Pauwels et al.

The journal of sexual medicine, 11(7), 1664-1674 (2014-05-21)

Erectile dysfunction (ED), as well as many cardiovascular diseases, is associated with impaired nitric oxide (NO) bioavailability. Recently, oxime derivatives have emerged as vasodilators due to their NO-donating capacities. However, whether these oximes offer therapeutic perspectives as an alternative NO

Unforeseen decreases in dissolved oxygen levels affect tube formation kinetics in collagen gels.

Hasan Erbil Abaci et al.

American journal of physiology. Cell physiology, 301(2), C431-C440 (2011-05-06)

The availability of oxygen (O(2)) is a critical parameter affecting vascular tube formation. In this study, we hypothesize that dissolved oxygen (DO) levels in collagen gels change during the three-dimensional (3D) culture of human umbilical vein endothelial cells (HUVECs) in

[Effects of diaryliodonium on the properties of light-curing composite resin].

Yi-Na Lin et al.

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 40(4), 700-703 (2009-09-22)

To test the effects of two kinds of diaryliodonium on the degree of conversion (DC), the compressive strength (CS) and the cure depth (CD) of the light-curing composite resin. BisS-GMA was used as reisin matrix, with TEGDMA as diluent and

Co-treatment with hepatocyte growth factor and TGF-beta1 enhances migration of HaCaT cells through NADPH oxidase-dependent ROS generation.

Hyun-Ja Nam et al.

Experimental & molecular medicine, 42(4), 270-279 (2010-02-24)

Wound healing requires re-epithelialization from the wound margin through keratinocyte proliferation and migration, and some growth factors are known to influence this process. In the present study, we found that the co-treatment with hepatocyte growth factor (HGF) and TGF-beta1 resulted

Effects of thymol and diphenyliodonium chloride against Campylobacter spp. during pure and mixed culture in vitro.

R C Anderson et al.

Journal of applied microbiology, 107(4), 1258-1268 (2009-06-03)

To determine if the purported deaminase inhibitors diphenyliodonium chloride (DIC) and thymol reduce the growth and survivability of Campylobacter. Growth rates of Campylobacter jejuni and Camp. coli were reduced compared to unsupplemented controls during culture in Muellar-Hinton broth supplemented with

Effect of thymol or diphenyliodonium chloride on performance, gut fermentation characteristics, and campylobacter colonization in growing swine.

Robin C Anderson et al.

Journal of food protection, 75(4), 758-761 (2012-04-11)

Food producing animals can be reservoirs of Campylobacter, a leading bacterial cause of human foodborne illness. Campylobacter spp. utilize amino acids as major carbon and energy substrates, a process that can be inhibited by thymol and diphenyliodonium chloride (DIC). To

Enantioselective α-arylation of N-acyloxazolidinones with copper(II)-bisoxazoline catalysts and diaryliodonium salts.

Aurélien Bigot et al.

Journal of the American Chemical Society, 133(35), 13778-13781 (2011-08-19)

A new strategy for the catalytic enantioselective α-arylation of N-acyloxazolidinones with chiral copper(II)-bisoxazoline complexes and diaryliodonium salts is described. The mild catalytic conditions are operationally simple, produce valuable synthetic building blocks in excellent yields and enantioselectivities, and can be applied

The Journal of Organic Chemistry, 4117-4117 (1987)

Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.

Carolyn K Dong et al.

Bioorganic & medicinal chemistry letters, 19(3), 972-975 (2008-12-23)

Plasmodium falciparum NDH2 (pfNDH2) is a non-proton pumping, rotenone-insensitive alternative enzyme to the multi-subunit NADH:ubiquinone oxidoreductases (Complex I) of many other eukaryotes. Recombinantly expressed pfNDH2 prefers coenzyme CoQ(0) as an acceptor substrate, and can also use the artificial electron acceptors

Synthesis of polybrominated diphenyl ethers via symmetrical tetra- and hexabrominated diphenyliodonium salts.

Daniel Teclechiel et al.

Chemosphere, 74(3), 421-427 (2008-11-11)

Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants (BFRs) which have become widespread environmental pollutants due to their persistence and bioaccumulativeness. Pure authentic PBDE congeners are required for chemical analysis, assessments of their chemical/physical properties and toxicological

Control of superoxide and nitric oxide formation during human sperm capacitation.

Eve de Lamirande et al.

Free radical biology & medicine, 46(10), 1420-1427 (2009-03-10)

We studied the modulation of superoxide anion (O(2).(-)) and nitric oxide (NO.) generation during human sperm capacitation (changes needed for the acquisition of fertility). The production of NO. (diaminofluorescein-2 fluorescence assay), but not that of O(2).(-) (luminescence assay), related to

Role of reactive oxygen species in transforming growth factor beta1-induced alpha smooth-muscle actin and collagen production in nasal polyp-derived fibroblasts.

Il-Ho Park et al.

International archives of allergy and immunology, 159(3), 278-286 (2012-06-23)

Myofibroblasts are detected in nasal polyps and are involved in nasal polyp formation by inducing extracellular matrix accumulation. Reactive oxygen species (ROS) are released during the differentiation of fibroblasts to myofibroblasts. The purpose of this study was to investigate ROS

The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca(2+) pump.

T Tazzeo et al.

British journal of pharmacology, 158(3), 790-796 (2009-10-01)

Diphenyleneiodonium (DPI) is often used as an NADPH oxidase inhibitor, but is increasingly being found to have unrelated side effects. We investigated its effects on smooth muscle contractions and the related mechanisms. We studied isometric contractions in smooth muscle strips

Effect of photoinitiators on the in vitro performance of a dentin adhesive exposed to simulated oral environment.

Qiang Ye et al.

Dental materials : official publication of the Academy of Dental Materials, 25(4), 452-458 (2008-11-26)

Our previous study showed poor mechanical durability and nano-sized heterogeneities in cross-linked dentin adhesives cured in the presence of water. To further explore the relationship between nano-scale heterogeneities and the long-term mechanical properties of dentin adhesives, the properties of model

Effect of initiator on photopolymerization of acidic, aqueous dental model adhesives.

Xinglin Guo et al.

Journal of biomedical materials research. Part A, 90(4), 1120-1127 (2008-08-02)

This study evaluated different initiator systems in self-etching model adhesives, in which camphorquinone (CQ) or [3-(3,4-dimethyl-9-oxo-9H-thioxanthen-2-yloxy)-2-hydroxylpropy] trimethylammonium chloride (QTX) was employed as a photoinitiator (dye). N-phenylglycine (NPG), ethyl 4-dimethylaminobenzoate (4E) or 2-(dimethylamino) ethyl methacrylate (DMAEMA) was used as the coinitiator

Myocardial autophagy after severe burn in rats.

Rong Xiao et al.

PloS one, 7(6), e39488-e39488 (2012-07-07)

Autophagy plays a major role in myocardial ischemia and hypoxia injury. The present study investigated the effects of autophagy on cardiac dysfunction in rats after severe burn. Protein expression of the autophagy markers LC3 and Beclin 1 were determined at

NADPH oxidase inhibitor DPI is neuroprotective at femtomolar concentrations through inhibition of microglia over-activation.

Li Qian et al.

Parkinsonism & related disorders, 13 Suppl 3, S316-S320 (2008-11-19)

In this paper we report that diphenyliodonium (DPI), a NADPH oxidase inhibitor, shows potent anti-inflammatory and neuroprotective effects at femtomolar concentrations (10(-13) to 10(-14) M) in primary midbrain cultures. Mechanistic studies revealed that DPI-elicited effects were mediated by the inhibition

Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes.

Sarah A Krawczyk et al.

PloS one, 7(4), e34904-e34904 (2012-04-12)

In obesity, there is an increase in reactive oxygen species (ROS) within adipose tissue caused by increases in inflammation and overnutrition. Hormone sensitive lipase (HSL) is part of the canonical lipolytic pathway and critical for complete lipolysis. This study hypothesizes

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome.

Franz Bauernfeind et al.

Journal of immunology (Baltimore, Md. : 1950), 187(2), 613-617 (2011-06-17)

A common denominator among the multiple damage-inducing agents that ultimately lead to activation of NLRP3 has not yet been identified. Recently, production of reactive oxygen species (ROS) has been suggested to act as a common event upstream of the NLRP3

NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration.

Liya Qin et al.

Journal of neuroinflammation, 9, 5-5 (2012-01-14)

Activation of microglia causes the production of proinflammatory factors and upregulation of NADPH oxidase (NOX) that form reactive oxygen species (ROS) that lead to neurodegeneration. Previously, we reported that 10 daily doses of ethanol treatment induced innate immune genes in

Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions.

Vladimir Mishin et al.

Toxicological sciences : an official journal of the Society of Toxicology, 141(2), 344-352 (2014-07-26)

Microsomal enzymes generate H2O2 in the presence of NADPH. In this reaction, referred to as "oxidase" activity, H2O2 is generated directly or indirectly via the formation of superoxide anion. In the presence of redox active transition metals, H2O2 can form

Z.-C. Chen et al.

The Journal of Organic Chemistry, 52, 4115-4115 (1987)

Amyloid β-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide.

Tao Ma et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(15), 5589-5595 (2011-04-15)

Generation of reactive oxygen species (ROS) causes cellular oxidative damage and has been implicated in the etiology of Alzheimer's disease (AD). In contrast, multiple lines of evidence indicate that ROS can normally modulate long-term potentiation (LTP), a cellular model for

Activation of equine neutrophils by phorbol myristate acetate or N-formyl-methionyl-leucyl-phenylalanine induces a different response in reactive oxygen species production and release of active myeloperoxidase.

T Franck et al.

Veterinary immunology and immunopathology, 130(3-4), 243-250 (2009-03-31)

Neutrophil (PMN) contribution to the acute inflammatory processes may lead to an excessive generation of reactive oxygen metabolites species (ROS) and secretion of granule enzymes. We compared the effects of either phorbol myristate acetate (PMA) or N-formyl-methionyl-leucyl-phenylalanine (fMLP) in combination

Serum amyloid A induces reactive oxygen species (ROS) production and proliferation of fibroblast.

E Hatanaka et al.

Clinical and experimental immunology, 163(3), 362-367 (2010-12-24)

Serum amyloid A (SAA) levels are elevated highly in acute phase response and elevated slightly and persistently in chronic diseases such as rheumatoid arthritis and diabetes. Given that fibroblasts exert profound effects on progression of inflammatory chronic diseases, the aim

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