Serafim Kiriakidis et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(7), 2814-2827 (2015-04-04)
Factor-inhibiting hypoxia-inducible factor (HIF)-1 (FIH-1) is an asparaginyl β-hydroxylase enzyme that was initially found to hydroxylate the HIF-α, preventing its transcriptional activity and leading to adaptive responses to hypoxia. More recently, other substrates, such as neurogenic locus notch homolog (Notch)