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Zoe M Smith et al.
Talanta, 130, 221-225 (2014-08-28)
Previous applications of manganese(IV) as a chemiluminescence reagent have required the use of formaldehyde to enhance the emission intensity to analytically useful levels. However, this known human carcinogen (by inhalation) is not ideal for routine application. A wide range of
Lauriane Goldwirt et al.
Journal of neuro-oncology, 122(2), 273-281 (2015-03-22)
Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Prognosis of GBM patients is poor with median overall survival around 15 months. Temozolomide is the chemotherapeutic agent used in the standard of care of newly diagnosed GBM
Leily Macedo Firoozmand et al.
Brazilian oral research, 27(2), 142-148 (2013-03-30)
The aim of this study was to evaluate the shear bond strength (SBS) of polycrystalline ceramic brackets (PCB) bonded after bleaching treatment using different composite resins and enamel etching times. A total of 144 bovine incisors were randomly divided into
Jung Yeon Kim et al.
Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01)
The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Carmen Vanessa Ortiz-Ruiz et al.
IUBMB life, 67(10), 757-767 (2015-09-25)
The development of effective tyrosinase inhibitors has become increasingly important in the cosmetic, medicinal, and agricultural industries for application as antibrowning and depigmenting agents. The kinetic mechanisms of action of tyrosinase on monophenols and o-diphenols are complex, particularly in the
Andreas Rathke et al.
The journal of adhesive dentistry, 15(2), 107-114 (2013-03-28)
To evaluate the composite-to-enamel bond following double etching of the enamel using phosphoric acid and different self-etching (SE) bonding systems with and without the application of their respective acidic primers. The enamel surfaces of 90 human molars were ground (600
Lina Zuluaga-Idárraga et al.
Journal of pharmaceutical and biomedical analysis, 95, 200-206 (2014-04-01)
One of the most important aspects regarding the therapeutic efficacy of antimalarials is its quantification in biologic fluids. The detection and measurement of antimalarial drug levels is important for demonstrating (1) adequate absorption of the drug being given, (2) compliance
Stephen R Groskreutz et al.
Journal of chromatography. A, 1354, 65-74 (2014-06-30)
Solvent-based on-column focusing is a powerful and well known approach for reducing the impact of pre-column dispersion in liquid chromatography. Here we describe an orthogonal temperature-based approach to focusing called temperature-assisted on-column solute focusing (TASF). TASF is founded on the
Yan Zhao et al.
Journal of pharmaceutical and biomedical analysis, 117, 73-78 (2015-09-08)
An effective and rapid method was developed for the simultaneous identification of aloe, catechu and gambir by high performance liquid chromatography-diode array detector (HPLC-DAD). Identification of three maker compounds presented in three medicinal materials was performed on high performance liquid
Best literature values for the pK of carbonic and phosphoric acid under physiological conditions.
Robert L Jungas
Analytical biochemistry, 349(1), 1-15 (2005-12-27)
Udesh Dhawan et al.
Journal of nanobiotechnology, 13, 79-79 (2015-11-11)
Nitric oxide (NO) plays a very important role in the cardiovascular system as a major secondary messenger in signaling pathway. Its concentration regulates most of the important physiological indexes including the systemic blood pressure, blood flow, regional vascular tone and
J Kanca
Quintessence international (Berlin, Germany : 1985), 21(2), 83-86 (1990-02-01)
This paper explores the possibility that the inflammatory response in pulpal tissues noted in some early studies when dentin was treated with phosphoric acid was not caused by the acid. It suggests that the inflammatory response was caused by the
Hao Wang et al.
The Journal of organic chemistry, 78(3), 1208-1215 (2013-01-10)
The chiral BINOL-phosphoric acid catalyzed allylboration and propargylation reactions are studied with density functional theory (B3LYP and B3LYP-D3). Two different models were recently proposed for these reactions by Goodman and our group, respectively. In Goodman's model for allylborations, the catalyst
Yijin Liu et al.
Journal of chromatography. A, 1420, 119-128 (2015-10-16)
To-date, there has been no effective chiral capillary electrophoresis-mass spectrometry (CE-MS) method reported for the simultaneous enantioseparation of the antidepressant drug, venlafaxine (VX) and its structurally-similar major metabolite, O-desmethylvenlafaxine (O-DVX). This is mainly due to the difficulty of identifying MS
Emil Meng-Lund et al.
Journal of pharmaceutical sciences, 103(7), 2053-2061 (2014-05-16)
The pH partition theory proposes a correlation between fraction of unionized drug substance and permeability. The aim of this study was to compare the permeability of metoprolol and mannitol in ex vivo human and porcine buccal mucosa models at varying
Arvind Thakkar et al.
International journal of oncology, 46(4), 1827-1834 (2015-02-06)
The objective of the present study was to establish the individual and combined chemopreventive potential of a widely used non-steroidal anti-inflammatory drug, ibuprofen (IBU), encapsulated in solid lipid nanoparticles (SLNs) for the chemoprevention of pancreatic cancer. The IBU SLNs were
C Escapa et al.
Bioresource technology, 185, 276-284 (2015-03-18)
This work aimed to study both the removal of nutrients and pharmaceuticals, namely salicylic acid or paracetamol, from water by the culture of Chlorella sorokiniana. The removal of nutrients was nearly complete at the end of the batch culture; above
Jigang Wang et al.
International journal of analytical chemistry, 2015, 763969-763969 (2015-04-16)
Majority of the proteomic studies on tissue samples involve the use of gel-based approach for profiling and digestion. The laborious gel-based approach is slowly being replaced by the advancing in-solution digestion approach. However, there are still several difficulties such as
D Sharmila et al.
Indian journal of pharmaceutical sciences, 77(5), 599-604 (2016-01-23)
The present study depicts the development of a validated reversed-phase high performance liquid chromatographic method for the determination of the everolimus in presence of degradation products or pharmaceutical excipients. Stress study was performed on everolimus and it was found that
Srinivasan Shanmugam et al.
Drug development and industrial pharmacy, 40(6), 803-812 (2013-06-21)
The main objective was to investigate the in vitro release profile/kinetics, and in vivo plasma pharmacokinetics (PK) and organ biodistribution (BD) of the prepared sildenafil vaginal suppositories (SVS). Suppositories containing 25 mg of sildenafil were prepared by the cream melting technique
Xuepei Zhang et al.
Journal of chromatography. A, 1359, 84-90 (2014-07-30)
A new approach for proteome-wide profiling drug binding proteins by using monolithic capillary affinity chromatography in combination with HPLC-MS/MS is reported. Two immunosuppresive drugs, namely FK506 and cyclosporin A, were utilized as the experimental models for proof-of-concept. The monolithic capillary
Emad F Al Maaitah et al.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 144(1), 43-49 (2013-07-03)
For most orthodontic patients, esthetic concerns are as important as functional demands. The purpose of this study was to assess the effect of self-etching primer and conventional acid etching on tooth color after orthodontic treatment. A total of 34 patients
Nieves Alonso-Blázquez et al.
Ecotoxicology (London, England), 24(2), 279-291 (2014-11-05)
In this study, we evaluated the antioxidant responses of wheat and maize growing in Zn-treated soils (200, 450 and 900 mg kg(-1)) at different exposure times (7, 14, 21 and 35 days). The Zn concentration in the plants increased with an increase in
Junichiro Marui et al.
International journal of food microbiology, 166(2), 238-243 (2013-08-27)
Miso (fermented soybean paste) is a traditional Japanese fermented food, and is now used worldwide. The solid-state culture of filamentous fungus, Aspergillus oryzae, grown on rice is known as rice-koji, and is important as a starter for miso fermentation because
Ibrahim El-Serafi et al.
PloS one, 10(11), e0141979-e0141979 (2015-11-07)
Cyclophosphamide is commonly used as an important component in conditioning prior to hematopoietic stem cell transplantation, a curative treatment for several hematological diseases. Cyclophosphamide is a prodrug activated mainly by cytochrome P450 2B6 (CYP2B6) in the liver. A high degree
Kai Bin Liew et al.
Pakistan journal of pharmaceutical sciences, 26(5), 961-966 (2013-09-17)
An easy, fast and validated RV-HPLC method was invented to quantify donepezil hydrochloride in drug solution and orally disintegrating tablet. The separation was carried out using reversed phase C-18 column (Agilent Eclipse Plus C-18) with UV detection at 268 nm.
Jun-Wei Zhang et al.
Chemical communications (Cambridge, England), 49(70), 7750-7752 (2013-07-26)
Chiral phosphoric acid and Hoveyda-Grubbs II were found to catalyze an olefin cross-metathesis-intramolecular oxo-Michael cascade reaction of the ortho-allylphenols and enones to provide a variety of benzofuran and benzoxazine derivatives in moderate to good yields and enantioselectivity.
R E Tirali et al.
The Journal of clinical pediatric dentistry, 37(3), 281-288 (2013-07-17)
The purpose of this study was to investigate the effects of different pretreatment protocols along with different bonding agents on the microleakage of a fissure sealant material. A total of 144 freshly extracted noncarious human third molars were used The
Jan Srbek et al.
Talanta, 130, 518-526 (2014-08-28)
In this study, direct analysis in real time-mass spectrometry (DART-MS) was assessed for the analysis of various pharmaceutical formulations with intention to summarize possible applications for the routine pharmaceutical development. As DART is an ambient ionization technique, it allows direct
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