Sander M J van Duijnhoven et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(9), 1422-1428 (2015-07-15)
Radioimmunotherapy and nuclear imaging (immuno-PET/SPECT) of cancer with radiometal-labeled antibody fragments or peptides is hampered by low tumor-to-kidney ratios because of high renal radiometal retention. Therefore, we developed and evaluated a pretargeting strategy using click chemistry in vivo to reduce