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Xiaolin Li et al.
NPJ breast cancer, 7(1), 132-132 (2021-10-09)
Chemotherapy-induced ovarian dysfunction is a serious adverse effect in premenopausal patients with cancer. Gonadotrophin-releasing hormone analogs (GnRHa) protect ovarian function, but its molecular mechanisms have not yet been determined. In this study, we attempted to determine the previously unknown molecular
Amy H Ponsford et al.
Autophagy, 17(6), 1500-1518 (2020-06-10)
Disorders of lysosomal physiology have increasingly been found to underlie the pathology of a rapidly growing cast of neurodevelopmental disorders and sporadic diseases of aging. One cardinal aspect of lysosomal (dys)function is lysosomal acidification in which defects trigger lysosomal stress
Bruno Pinto et al.
Neuron, 108(5), 887-904 (2020-10-08)
Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the
Investigation of the effects of semaphorin 3A on new bone formation in a rat calvarial defect model.
Sevinç Kenan et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 47(3), 473-483 (2019-01-09)
This study investigates the effects of semaphorin 3A on new bone formation in an experimental rat model. Cortical bone defects, 5 mm, were created in the calvaria of 40 Wistar rats, which were then separated into three groups: empty defect (control)
Z Sobańska et al.
Toxicology in vitro : an international journal published in association with BIBRA, 68, 104931-104931 (2020-07-09)
Significance of MoS2 nanoparticles as a lubricant or drug carriers indicates the need to assess their safety. In the study we analyzed the effects of MoS2 nano- and microparticles and their internalization in vitro, using 2D and 3D culture models
Mengdi Xu et al.
Poultry science, 99(8), 3823-3830 (2020-08-01)
The spleen is the largest peripheral lymphoid organ and an important site of immune response, in which the blood-spleen barrier (BSB) plays a significant role to resist various pathogens. The BSB structure of duck spleen is different from that of
P Sipilä et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6111-6128 (2020-03-20)
Hydroxysteroid (17β) dehydrogenase type 3 (HSD17B3) deficiency causes a disorder of sex development in humans, where affected males are born with female-appearing external genitalia, but are virilized during puberty. The hormonal disturbances observed in the Hsd17b3 knockout mice (HSD17B3KO), generated
Mika Pietilä et al.
Nature communications, 10(1), 2340-2340 (2019-05-30)
The human epidermal growth factor receptor 2 (HER2) is an oncogene targeted by several kinase inhibitors and therapeutic antibodies. While the endosomal trafficking of many other receptor tyrosine kinases is known to regulate their oncogenic signalling, the prevailing view on
Anthony Ravussin et al.
Journal of cell science, 134(3) (2021-01-21)
Late endosomes and lysosomes (endolysosomes) receive proteins and cargo from the secretory, endocytic and autophagic pathways. Although these pathways and the degradative processes of endolysosomes are well characterized, less is understood about protein traffic from these organelles. In this study
Eman Elagamey et al.
Proteomes, 4(3) (2017-03-02)
The extracellular matrix (ECM) has a molecular machinery composed of diverse proteins and proteoforms that combine properties of tensile strength with extensibility exhibiting growth-regulatory functions and self- and non-self-recognition. The identification of ECM proteoforms is the prerequisite towards a comprehensive
Si-Tu Xue et al.
Autophagy, 16(10), 1823-1837 (2020-01-29)
Although macroautophagy/autophagy is involved in hepatocellular carcinoma (HCC) initiation and development and has been identified as a mechanism of HCC therapy resistance, the role of ULK1 (unc-51 like autophagy activating kinase 1) in HCC remains unclear. Here, we report that
D Mitrecić et al.
Journal of microscopy, 232(3), 504-507 (2008-12-20)
Descriptive morphological studies are often combined with gene expression pattern analyses. Unembedded vibratome or cryotome sections are compatible with in situ RNA hybridization, but spatial resolution is rather low for precise microscopic studies necessary in embryology. Therefore, use of plastic
High resolution 3D microscopy study of cardiomyocytes on polymer scaffold nanofibers reveals formation of unusual sheathed structure
Balashov, et al.
Acta Biomaterialia (2018)
D E Nicolás-Álvarez et al.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 25(4), 989-997 (2019-07-06)
Here, different tissue surfaces of tomato root were characterized employing atomic force microscopy on day 7 and day 21 of growth through Young's modulus and plasticity index. These parameters provide quantitative information regarding the mechanical behavior of the tomato root
Tuğba Ekiz Yılmaz et al.
Acta histochemica, 122(2), 151470-151470 (2019-12-10)
Cyclophosphamide (CYP) is one of the alkylating chemotherapeutic agents and its adverse effects on folliculogenesis in the ovary are well-known due to the previous scientific research on this topic. Magnesium has various effects in organisms, including catalytic functions on the
Franziska Jehle et al.
ACS nano, 15(4), 6829-6838 (2021-04-02)
Protein-based biological materials are important role models for the design and fabrication of next generation advanced polymers. Marine mussels (Mytilus spp.) fabricate hierarchically structured collagenous fibers known as byssal threads via bottom-up supramolecular assembly of fluid protein precursors. The high
Cintia Monteiro de Barros et al.
Marine pollution bulletin, 124(1), 441-448 (2017-08-07)
Ascidians are good monitors for assessing water quality, since they filter large volumes of water; however, little is known about how xenobiotics, including metals, can affect ascidian hemocytes. Metals can be either toxic or beneficial to health, inducing many different
Role of NOD1/NOD2 receptors in Fusobacterium nucleatum mediated NETosis
Alyami, et al.
Microbial Pathogenesis (2019)
Victor Balashov et al.
Acta biomaterialia, 68, 214-222 (2017-12-31)
Building functional and robust scaffolds for engineered biological tissue requires a nanoscale mechanistic understanding of how cells use the scaffold for their growth and development. A vast majority of the scaffolds used for cardiac tissue engineering are based on polymer
Zehra Çınar et al.
Audiology & neuro-otology, 26(3), 195-205 (2021-03-08)
The aim of this study was to investigate the effects of systemic administration of decorin (DC) on facial nerve (FN) regeneration. A total of 32 female albino Wistar rats were divided into 4 groups: control (C) group: no bilateral FN
Pengwei Guo et al.
Translational andrology and urology, 10(8), 3486-3500 (2021-09-18)
Renal tubular epithelial cells play an important role in renal function and are a major site of injury from inflammation. Emerging evidence suggests that CYR61 is involved in the regulation of autophagy. However, there are few studies on CYR61 in
Elena Morelli et al.
Autophagy, 10(12), 2251-2268 (2015-01-01)
How autophagic degradation is linked to endosomal trafficking routes is little known. Here we screened a collection of uncharacterized Drosophila mutants affecting membrane transport to identify new genes that also have a role in autophagy. We isolated a loss of
B K Penney et al.
Canadian journal of zoology, 98(12), 777-786 (2020-12-01)
Molluscs often possess complex calcified elements in addition to the shell, but how these elements function and relate to other tissues is often poorly understood. Dorid nudibranchs typically possess innumerable calcareous spicules arranged in complex networks. To describe how these
Konstantin E Mochalov et al.
Ultramicroscopy, 182, 118-123 (2017-07-04)
In the past decade correlative microscopy, which combines the potentials of different types of high-resolution microscopies with a variety of optical microspectroscopy techniques, has been attracting increasing attention in material science and biological research. One of outstanding solutions in this
Antonia Mr Franco et al.
International journal of nanomedicine, 11, 6771-6780 (2016-12-23)
Coordination compounds of pentavalent antimony have been, and remain, the first-line drugs in leishmaniasis treatment for >70 years. Molecular forms of Sb (V) complexes are commercialized as sodium stibogluconate (Pentostam®) and meglumine antimoniate (MA) (Glucantime®). Ever-increasing drug resistance in the
Emma Cantisani et al.
The Analyst, 144(7), 2375-2386 (2019-02-26)
Red stains are a common discolouration on stone cultural heritage all over the world. These are very difficult to remove and little is known about the reddish pigmentation. Numerous red stains were mapped on the Baptistery of San Giovanni in
Reshma Kadam et al.
Nanoscale, 12(36), 18938-18949 (2020-09-12)
In this study, we present Janus nanoparticles that are designed for attaching to a eukaryotic cell surface with minimal cell uptake. This contrasts the rapid uptake via various endocytosis pathways that non-passivated isotropic particles usually encounter. Firmly attaching nanoparticles onto
Violaine Simon et al.
Endocrinology, 158(10), 3200-3211 (2017-10-05)
Secretion of 17-β-estradiol (E2) by human granulosa cells can be disrupted by various environmental toxicants. In the current study, we investigated whether carbon black nanoparticles (CB NPs) affect the steroidogenic activity of cultured human granulosa cells. The human granulosa cell
Arnold Lavaud et al.
Translational vision science & technology, 9(5), 13-13 (2020-08-22)
To evaluate visual streak (VS) identification on spectral-domain optical coherence tomography (SD-OCT) scans in awake rabbits. To report thickness measurements in the VS and adjacent retina on OCT B-scans and histologic sections and to assess inter-method bias, precision and repeatability
Charles C H Cohen et al.
Cell, 180(2), 311-322 (2019-12-31)
The propagation of electrical impulses along axons is highly accelerated by the myelin sheath and produces saltating or "jumping" action potentials across internodes, from one node of Ranvier to the next. The underlying electrical circuit, as well as the existence
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