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Role of NOD1/NOD2 receptors in Fusobacterium nucleatum mediated NETosis
Alyami, et al.
Microbial Pathogenesis (2019)
Victor Balashov et al.
Acta biomaterialia, 68, 214-222 (2017-12-31)
Building functional and robust scaffolds for engineered biological tissue requires a nanoscale mechanistic understanding of how cells use the scaffold for their growth and development. A vast majority of the scaffolds used for cardiac tissue engineering are based on polymer
Zehra Çınar et al.
Audiology & neuro-otology, 26(3), 195-205 (2021-03-08)
The aim of this study was to investigate the effects of systemic administration of decorin (DC) on facial nerve (FN) regeneration. A total of 32 female albino Wistar rats were divided into 4 groups: control (C) group: no bilateral FN
Pengwei Guo et al.
Translational andrology and urology, 10(8), 3486-3500 (2021-09-18)
Renal tubular epithelial cells play an important role in renal function and are a major site of injury from inflammation. Emerging evidence suggests that CYR61 is involved in the regulation of autophagy. However, there are few studies on CYR61 in
Tuğba Ekiz Yılmaz et al.
Acta histochemica, 122(2), 151470-151470 (2019-12-10)
Cyclophosphamide (CYP) is one of the alkylating chemotherapeutic agents and its adverse effects on folliculogenesis in the ovary are well-known due to the previous scientific research on this topic. Magnesium has various effects in organisms, including catalytic functions on the
Cintia Monteiro de Barros et al.
Marine pollution bulletin, 124(1), 441-448 (2017-08-07)
Ascidians are good monitors for assessing water quality, since they filter large volumes of water; however, little is known about how xenobiotics, including metals, can affect ascidian hemocytes. Metals can be either toxic or beneficial to health, inducing many different
D Mitrecić et al.
Journal of microscopy, 232(3), 504-507 (2008-12-20)
Descriptive morphological studies are often combined with gene expression pattern analyses. Unembedded vibratome or cryotome sections are compatible with in situ RNA hybridization, but spatial resolution is rather low for precise microscopic studies necessary in embryology. Therefore, use of plastic
Z Sobańska et al.
Toxicology in vitro : an international journal published in association with BIBRA, 68, 104931-104931 (2020-07-09)
Significance of MoS2 nanoparticles as a lubricant or drug carriers indicates the need to assess their safety. In the study we analyzed the effects of MoS2 nano- and microparticles and their internalization in vitro, using 2D and 3D culture models
Mengdi Xu et al.
Poultry science, 99(8), 3823-3830 (2020-08-01)
The spleen is the largest peripheral lymphoid organ and an important site of immune response, in which the blood-spleen barrier (BSB) plays a significant role to resist various pathogens. The BSB structure of duck spleen is different from that of
Si-Tu Xue et al.
Autophagy, 16(10), 1823-1837 (2020-01-29)
Although macroautophagy/autophagy is involved in hepatocellular carcinoma (HCC) initiation and development and has been identified as a mechanism of HCC therapy resistance, the role of ULK1 (unc-51 like autophagy activating kinase 1) in HCC remains unclear. Here, we report that
Franziska Jehle et al.
ACS nano, 15(4), 6829-6838 (2021-04-02)
Protein-based biological materials are important role models for the design and fabrication of next generation advanced polymers. Marine mussels (Mytilus spp.) fabricate hierarchically structured collagenous fibers known as byssal threads via bottom-up supramolecular assembly of fluid protein precursors. The high
High resolution 3D microscopy study of cardiomyocytes on polymer scaffold nanofibers reveals formation of unusual sheathed structure
Balashov, et al.
Acta Biomaterialia (2018)
D E Nicolás-Álvarez et al.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 25(4), 989-997 (2019-07-06)
Here, different tissue surfaces of tomato root were characterized employing atomic force microscopy on day 7 and day 21 of growth through Young's modulus and plasticity index. These parameters provide quantitative information regarding the mechanical behavior of the tomato root
P Sipilä et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6111-6128 (2020-03-20)
Hydroxysteroid (17β) dehydrogenase type 3 (HSD17B3) deficiency causes a disorder of sex development in humans, where affected males are born with female-appearing external genitalia, but are virilized during puberty. The hormonal disturbances observed in the Hsd17b3 knockout mice (HSD17B3KO), generated
Eman Elagamey et al.
Proteomes, 4(3) (2017-03-02)
The extracellular matrix (ECM) has a molecular machinery composed of diverse proteins and proteoforms that combine properties of tensile strength with extensibility exhibiting growth-regulatory functions and self- and non-self-recognition. The identification of ECM proteoforms is the prerequisite towards a comprehensive
Amy H Ponsford et al.
Autophagy, 17(6), 1500-1518 (2020-06-10)
Disorders of lysosomal physiology have increasingly been found to underlie the pathology of a rapidly growing cast of neurodevelopmental disorders and sporadic diseases of aging. One cardinal aspect of lysosomal (dys)function is lysosomal acidification in which defects trigger lysosomal stress
Elena Morelli et al.
Autophagy, 10(12), 2251-2268 (2015-01-01)
How autophagic degradation is linked to endosomal trafficking routes is little known. Here we screened a collection of uncharacterized Drosophila mutants affecting membrane transport to identify new genes that also have a role in autophagy. We isolated a loss of
B K Penney et al.
Canadian journal of zoology, 98(12), 777-786 (2020-12-01)
Molluscs often possess complex calcified elements in addition to the shell, but how these elements function and relate to other tissues is often poorly understood. Dorid nudibranchs typically possess innumerable calcareous spicules arranged in complex networks. To describe how these
Mika Pietilä et al.
Nature communications, 10(1), 2340-2340 (2019-05-30)
The human epidermal growth factor receptor 2 (HER2) is an oncogene targeted by several kinase inhibitors and therapeutic antibodies. While the endosomal trafficking of many other receptor tyrosine kinases is known to regulate their oncogenic signalling, the prevailing view on
Xiaolin Li et al.
NPJ breast cancer, 7(1), 132-132 (2021-10-09)
Chemotherapy-induced ovarian dysfunction is a serious adverse effect in premenopausal patients with cancer. Gonadotrophin-releasing hormone analogs (GnRHa) protect ovarian function, but its molecular mechanisms have not yet been determined. In this study, we attempted to determine the previously unknown molecular
Investigation of the effects of semaphorin 3A on new bone formation in a rat calvarial defect model.
Sevinç Kenan et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 47(3), 473-483 (2019-01-09)
This study investigates the effects of semaphorin 3A on new bone formation in an experimental rat model. Cortical bone defects, 5 mm, were created in the calvaria of 40 Wistar rats, which were then separated into three groups: empty defect (control)
Anthony Ravussin et al.
Journal of cell science, 134(3) (2021-01-21)
Late endosomes and lysosomes (endolysosomes) receive proteins and cargo from the secretory, endocytic and autophagic pathways. Although these pathways and the degradative processes of endolysosomes are well characterized, less is understood about protein traffic from these organelles. In this study
Bruno Pinto et al.
Neuron, 108(5), 887-904 (2020-10-08)
Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the
Mengying Wei et al.
EBioMedicine, 61, 103068-103068 (2020-10-26)
Paracellular barriers play an important role in the pathogenesis of Inflammatory bowel disease (IBD) and maintain gut homeostasis. N-myc downstream-regulated gene 2 (NDRG2) has been reported to be a tumour suppressor gene and to inhibit colorectal cancer metastasis. However, whether
Janne Hakkarainen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(6), 3229-3241 (2018-02-07)
The pituitary gonadotrophins and testosterone are the main hormonal regulators of spermatogenesis, but estradiol is also known to play a role in the process. The hormonal responses in the testis are partially mediated by somatic Sertoli cells that provide nutritional
Lisa Denny et al.
Clinical & translational immunology, 10(1), e1234-e1234 (2021-01-26)
Multiple sclerosis (MS) is a neurodegenerative disease characterised by inflammation and damage to the myelin sheath, resulting in physical and cognitive disability. There is currently no cure for MS, and finding effective treatments to prevent disease progression has been challenging.
G Lê-Bury et al.
Biology of the cell, 112(3), 92-101 (2020-01-11)
Non-typhoidal Salmonella (NTS) causes a severe invasive syndrome (iNTS disease) described in HIV-positive adults. The impact of HIV-1 on Salmonella pathogenesis and the molecular basis for the differences between these bacteria and classical diarrhoeal S. Typhimurium remains unclear. Here, we
C K E Bleck et al.
Journal of microscopy, 237(1), 23-38 (2010-01-09)
Bacteria are generally difficult specimens to prepare for conventional resin section electron microscopy and mycobacteria, with their thick and complex cell envelope layers being especially prone to artefacts. Here we made a systematic comparison of different methods for preparing Mycobacterium
Tuğba Kotil et al.
Zygote (Cambridge, England), 26(4), 319-325 (2018-10-04)
SummaryDigyny, the presence of a third pronucleus due to the failure of second polar body extrusion, is problematic after intracytoplasmic sperm injection (ICSI) practices. Mitochondria have critical roles such as production of adenosine triphosphate (ATP) and regulation of Ca2+ homeostasis
Viola L Boccasavia et al.
Cell reports, 34(11), 108861-108861 (2021-03-18)
T cells form immunological synapses with professional antigen-presenting cells (APCs) resulting in T cell activation and the acquisition of peptide antigen-MHC (pMHC) complexes from the plasma membrane of the APC. They thus become APCs themselves. We investigate the functional outcome of
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