CN
Search Within
45705
应用筛选条件
关键词:'45705'
显示 1-30 共 63 条结果 关于 "45705" 范围 论文
Jacques Auger et al.
Toxicological sciences : an official journal of the Society of Toxicology, 117(2), 475-484 (2010-07-10)
Little is known about the molecular impact of in vivo exposure to endocrine disruptors (EDs) on sperm structures and functions. We recently reported that the lifelong exposure of rats to the antiandrogenic compound vinclozolin results in low epididymal weight, changes
Carlos Guerrero-Bosagna et al.
PloS one, 5(9), doi:10-doi:10 (2010-10-12)
Previous observations have demonstrated that embryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination promotes transgenerational adult onset disease such as male infertility, kidney disease, prostate disease, immune abnormalities and tumor development. The current study investigates genome-wide promoter
Nadia Quignot et al.
Reproductive toxicology (Elmsford, N.Y.), 33(3), 339-352 (2012-01-31)
Reproductive functions are controlled by a finely tuned balance between estrogens and androgens. To further characterize the gonadal pathways leading to hormonal balance disruption by atrazine, vinclozolin, methoxychlor, and bisphenol A in rat, we investigated their effects in male and
Steffen Schneider et al.
Archives of toxicology, 91(12), 3961-3989 (2017-09-08)
The current investigation examines whether combined exposure to three anti-androgens (flutamide, prochloraz, vinclozolin) result in interference with endocrine homeostasis when applied at very low dose levels, and whether the results of combined exposure are more pronounced than to the individual
Michael K Skinner et al.
Critical reviews in oncogenesis, 13(1), 75-82 (2007-10-25)
Exposure to an environmental endocrine disruptor (e.g., vinclozolin) during embryonic gonadal sex determination appears to alter the male germ line epigenome and subsequently promotes transgenerational adult onset disease. The epigenetic mechanism involves the induction of new imprinted-like genes/DNA sequences in
Eun-Rim Kang et al.
Epigenetics, 6(7), 937-950 (2011-06-04)
Environmental endocrine disruptors (EDs) are synthetic chemicals that resemble natural hormones and are known to cause epigenetic perturbations. EDs have profound effects on development and fertility. Imprinted genes had been identified as susceptible loci to environmental insults by EDs because
Robert Kavlock et al.
Critical reviews in toxicology, 35(8-9), 721-726 (2006-01-19)
Vinclozolin is a fungicide that has been shown to cause Leydig cell tumors and atrophy of the accessory sex glands in adult rodents. In addition, exposure of rats during pregnancy causes a pattern of malformations in the male urogenital tract.
H El Sheikh Saad et al.
The Journal of endocrinology, 216(2), 245-263 (2012-11-20)
Exposure to low doses of environmental estrogens such as bisphenol A and genistein (G) alters mammary gland development. The effects of environmental anti-androgens, such as the fungicide vinclozolin (V), on mammary gland morphogenesis are unknown. We previously reported that perinatal
Khursheed Iqbal et al.
Genome biology, 16, 59-59 (2015-04-09)
Exposure to environmental endocrine-disrupting chemicals during pregnancy reportedly causes transgenerationally inherited reproductive defects. We hypothesized that to affect the grandchild, endocrine-disrupting chemicals must alter the epigenome of the germ cells of the in utero-exposed G1 male fetus. Additionally, to affect
Lei Yin et al.
Toxicological sciences : an official journal of the Society of Toxicology, 159(2), 307-326 (2017-10-01)
Primary testicular cell coculture model has been used to evaluate testicular abnormalities during development, and was able to identify the testicular toxicity of phthalates. However, the primary testicular cell coculture model has disadvantages in employing animals for the isolation of
Sergio Jarque et al.
International journal of molecular sciences, 20(7) (2019-04-11)
Small fish are an excellent experimental model to screen endocrine-disrupting compounds, but current fish-based assays to detect endocrine disruption have not been standardized yet, meaning that there is not consensus on endpoints and biomarkers to be measured. Moreover, exposure conditions
Shankar S Iyer et al.
Cell, 173(5), 1123-1134 (2018-05-19)
Genome-wide association studies have identified risk loci associated with the development of inflammatory bowel disease, while epidemiological studies have emphasized that pathogenesis likely involves host interactions with environmental elements whose source and structure need to be defined. Here, we identify
Bettina Seeger et al.
Toxicology letters, 241, 193-199 (2015-11-26)
Actual risk assessment only takes single pesticides into account, although about one third of the analyzed food samples in the European Union was contaminated with pesticide mixtures in 2013. A cumulative approach would group pesticides that share the same mechanism
Si Wang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(1), 78-89 (2014-06-15)
In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to different modes of action resulting in apparent estrogenicity, i.e., other
Fabien Vincent et al.
Bioorganic & medicinal chemistry letters, 19(23), 6793-6796 (2009-10-24)
The screening of known medicinal agents against new biological targets has been shown to be a valuable approach for revealing new pharmacology of marketed compounds. Recently, carbamate, urea and ketone inhibitors of fatty acid amide hydrolase (FAAH) have been described
Christina N Robitaille et al.
Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 126-135 (2014-10-18)
Several pesticides suspected or known to have endocrine disrupting effects were screened for pro- or antiandrogenic properties by determining their effects on proliferation, prostatic-specific antigen (PSA) secretion and androgen receptor (AR) expression, and AR phosphorylation in androgen-dependent LNCaP human prostate
Eric Nilsson et al.
Epigenetics, 13(8), 875-895 (2018-09-13)
Two of the most prevalent ovarian diseases affecting women's fertility and health are Primary Ovarian Insufficiency (POI) and Polycystic Ovarian Syndrome (PCOS). Previous studies have shown that exposure to a number of environmental toxicants can promote the epigenetic transgenerational inheritance
David Crews et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(23), 9143-9148 (2012-05-23)
Ancestral environmental exposures have previously been shown to promote epigenetic transgenerational inheritance and influence all aspects of an individual's life history. In addition, proximate life events such as chronic stress have documented effects on the development of physiological, neural, and
Frauke Hoffmann et al.
Hormones and behavior, 58(4), 653-659 (2010-07-06)
Vinclozolin (VIN) is an antiandrogenic model substance as well as a common fungicide that can affect the endocrine system of vertebrates. The objective of this study was to investigate how VIN affects mate calling behavior of South African clawed frogs
Rebecca A Alyea et al.
Environmental and molecular mutagenesis, 55(3), 292-298 (2013-11-22)
Recently, there has been a growing concern that chemically or nutritionally mediated epigenetic changes might lead to adverse health outcomes. The natural question is whether the existing chemical safety assessment paradigm is or is not protective of epigenetic-mediated effects, and
Michael A Wheeler et al.
Cell, 176(3), 581-596 (2019-01-22)
Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, but no methods are available for their comprehensive investigation. We developed an approach that combines genomic data, screens in a novel zebrafish model, computational
Nadia Quignot et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(1), 107-118 (2011-11-29)
Environmental toxicants are a serious health concern, and numerous studies have been devoted to studying the effects of environmental Endocrine Disrupting Chemicals (EDCs). The balance between androgens and estrogens controls the function of many EDC-sensitive organs, and the aromatase enzyme
Aljoscha Kreß et al.
Journal of insect physiology, 99, 113-121 (2017-04-12)
Phenotypic plasticity is considered as one of the key traits responsible for the establishment of populations of the invasive mosquito Aedes albopictus, an important vector of viral and parasitic pathogens. The successful spread of this species to higher altitudes and
I Fegert et al.
Reproductive toxicology (Elmsford, N.Y.), 34(3), 331-339 (2012-06-09)
The extended one-generation reproduction toxicity study (OECD 443, adopted 28-July-2011) produces more information with fewer animals than the two-generation study (OECD 416), by including F1 neurotoxicity and immunotoxicity assessments, and omitting an F2 generation if there are no relevant F1
Estelle Rathahao-Paris et al.
Rapid communications in mass spectrometry : RCM, 28(24), 2713-2722 (2014-11-08)
Concern for public health entails the need to evaluate the degree of exposure of population to toxicants. To do this, robust high-throughput approaches are required to be able to perform a large number of analyses in cohort studies. In this
Wided Kouidhi et al.
Toxicologic pathology, 40(4), 593-604 (2012-02-10)
It has been suggested that hormonally controlled submandibular salivary gland (SSG) development and secretions may be affected by endocrine disruptor compounds. We investigated the effects of oral gestation-lactation exposure to 1 mg/kg body weight daily dose of the estrogenic soy-isoflavone
Jinchao Wei et al.
Mikrochimica acta, 186(2), 66-66 (2019-01-11)
Nanoceria with a remarkable phosphatase mimicking activity was synthesized and used to catalyze the hydrolysis of phosphate esters in pH 10 solution. The catalytic effect of nanoceria was firstly investigated by selecting p-nitrophenyl phosphate as a model substrate. The pH value
Bennard van Ravenzwaay et al.
Toxicology letters, 223(3), 271-279 (2013-04-06)
In the late 1980s vinclozolin was tested for prenatal developmental toxicity in rats for registration purposes in USA. At 1000mg/kgbw, 95% of all fetuses were female upon visual inspection (ano-genital distance determination). Anti-androgenic effects (AA) were also noted in a
Steffen Schneider et al.
Reproductive toxicology (Elmsford, N.Y.), 37, 6-14 (2013-01-15)
The goal of this study was to examine the potential transgenerational inheritance of anti-androgenic effects induced by Vinclozolin administered intraperitoneally to pregnant Wistar rats (Crl:WI[Han]). Dams were dosed with Vinclozolin at 0, 4 or 100mg/kg bw/d on gestation days 6-15.
Derik E Haggard et al.
Reproductive toxicology (Elmsford, N.Y.), 77, 80-93 (2018-02-20)
There continues to be a need to develop in vivo high-throughput screening (HTS) and computational methods to screen chemicals for interaction with the estrogen, androgen, and thyroid pathways and as complements to in vitro HTS assays. This study explored the
1/3