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Subhankar Tripathi et al.
Bioorganic & medicinal chemistry letters, 22(1), 216-221 (2011-12-07)
An efficient synthesis of honokiol with Suzuki-Miyaura cross coupling obtained an overall yield of 45%. The proposed approach successfully synthesized several structurally similar alkyl, alkenyl and alkynyl analogues, seven of which showed potential neuropreventive activity against MPP(+)-induced and CHP/TBHP oxidative
Chung-Oui Hong et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 53, 214-220 (2012-12-06)
Lindera obtusiloba Blume, a native plant of East Asia, has traditionally been used as a folk medicine for liver disease. We studied the in vitro antioxidant and in vivo hepatoprotective activities of a 70% ethanolic extract of L. obtusiloba (LOE)
Sarangerel Oidovsambuu et al.
Planta medica, 79(2), 116-122 (2013-01-26)
The fruit and root parts of Paeonia anomala L. are used for the treatment of many kinds of disorders in Mongolian traditional medicine. The protective effect of a fruit extract from P. anomala against tert-butylhydroperoxide-induced cell damage was evaluated in
Chung-Oui Hong et al.
Bioscience, biotechnology, and biochemistry, 77(1), 58-64 (2013-01-08)
Considering the growing evidence of the presence of antioxidant compounds in plant extracts, the objectives of this study were to identify antioxidant compounds in Lindera obtusiloba Blume (Lauraceae) and to evaluate their antimelanogenic activities on B16F10 melanoma cells. Organic solvent
Sung-Yong Yang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 55, 92-99 (2013-01-12)
Perilla frutescens leaves are often used in East Asian gourmet food. In this study, we investigated the hepatoprotective effects of caffeic acid (CA), rosmarinic acid (RA), and their combination. P. frutescens contains 1.32μg CA/mg dry material (DM) and 26.84μg RA/mg
A M O'Sullivan et al.
Food chemistry, 134(2), 1137-1140 (2012-10-31)
The ability of brown seaweed extracts, Ascophyllum nodosum, Laminaria hyperborea, Pelvetia canaliculata, Fucus vesiculosus and Fucus serratus to protect against tert-butyl hydroperoxide (tert-BOOH) induced stress in Caco-2 cells was investigated. Oxidative stress was determined by measuring alteration in the enzymatic
Darko Bosnakovski et al.
Skeletal muscle, 4(1), 4-4 (2014-02-04)
Facioscapulohumeral muscular dystrophy (FSHD) is caused by epigenetic alterations at the D4Z4 macrosatellite repeat locus on chromosome 4, resulting in inappropriate expression of the DUX4 protein. The DUX4 protein is therefore the primary molecular target for therapeutic intervention. We have
Martin Jabůrek et al.
The international journal of biochemistry & cell biology, 45(4), 816-825 (2013-01-29)
Mitochondrial uncoupling protein-2 (UCP2) has been suggested to participate in the attenuation of the reactive oxygen species production, but the mechanism of action and the physiological significance of UCP2 activity remain controversial. Here we tested the hypothesis that UCP2 provides
L Deferme et al.
Toxicology, 306, 24-34 (2013-02-16)
Oxidative stress plays an important role in chemically induced liver injury, however, our insight into molecular responses to different oxygen radicals is fragmentary. Since these cellular responses will differ over time, examining time-dependent changes in gene expression, and correlating these
Yilei Zhang et al.
Nature cell biology, 20(10), 1181-1192 (2018-09-12)
The roles and regulatory mechanisms of ferroptosis (a non-apoptotic form of cell death) in cancer remain unclear. The tumour suppressor BRCA1-associated protein 1 (BAP1) encodes a nuclear deubiquitinating enzyme to reduce histone 2A ubiquitination (H2Aub) on chromatin. Here, integrated transcriptomic
Zhouguang Wang et al.
Journal of cellular and molecular medicine, 19(3), 595-607 (2014-12-24)
Extensive research focused on finding effective strategies to prevent or improve recovery from myocardial ischaemia/reperfusion (I/R) injury. Basic fibroblast growth factor (bFGF) has been shown to have therapeutic potential in some heart disorders, including ischaemic injury. In this study, we
Pedro Gonçalves et al.
European journal of pharmacology, 699(1-3), 88-100 (2012-12-04)
Our aim was to investigate the effect of oxidative stress upon butyrate uptake at the intestinal epithelial level. For this, IEC-6 cells were treated with tert-butylhydroperoxide 3000μM (tBOOH), which increased levels of oxidative stress biomarkers, while maintaining cellular viability. The
Richard M Monaghan et al.
Nature cell biology, 17(6), 782-792 (2015-05-12)
The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing. Mitochondria communicate with nuclei through retrograde signalling pathways that modulate nuclear gene expression to maintain mitochondrial
Arunodoy Sur et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(47), 16754-16759 (2014-11-12)
The retinal pigmented epithelial (RPE) layer is one of the major ocular tissues affected by oxidative stress and is known to play an important role in the etiology of age-related macular degeneration (AMD), the major cause of blinding in the
Ying-Chieh Wong et al.
Organic letters, 14(23), 6024-6027 (2012-11-30)
The radical cascade protocol of the α-cyano α-TMS/aryl-capped alkynyl aryl ketones promoted by tert-butyl hydroperoxide under catalysis with tetrabutylammonium iodide in refluxing benzene has been developed, leading to the construction of a variety of highly functionalized [6,6,5] tricyclic frameworks in
Sangram Singh et al.
Journal of environmental biology, 33(5), 867-870 (2013-06-06)
Calcium ions play an importantrole in various physiological processes such as nerve impulse transmission, muscle contraction, hormone action, blood clotting. They ions act as an intracellular second messenger, relaying information within cells to regulate their activity. To understand the mechanism
Sanhita Roy et al.
Cornea, 34(6), 668-674 (2015-03-27)
To investigate the effect of mutations in SLC4A11 on cellular localization of the protein, mitochondrial function, and apoptosis due to oxidative stress. Mutations in SLC4A11 have been associated with 2 different forms of corneal endothelial dystrophy that lead to degeneration
Yan Wang et al.
Pharmaceutical research, 31(11), 3106-3119 (2014-05-23)
Although Cu complexes have been investigated as anticancer agents, there has been no description of Cu itself as a cancer killing agent. A stealth liposomal Cu formulation (LpCu) was studied in vitro and in vivo. LpCu was evaluated in prostate
Shin Koike et al.
FEBS letters, 587(21), 3548-3555 (2013-09-24)
Polysulfide is a bound sulfur species derived from endogenous H2S. When mouse neuroblastoma, Neuro2A cells were exposed to tert-butyl hydroperoxide after treatment with polysulfide, a significant decline in cell toxicity was observed. Rapid uptake of polysulfides induced translocation of Nrf2
Yan He et al.
Glia, 63(9), 1568-1580 (2015-04-17)
Astrocytes produce and export the antioxidant glutathione (GSH). Previously, we found that interleukin-1β (IL-1β) enhanced the expression of astrocyte system xc (-) , the transporter that delivers the rate-limiting substrate for GSH synthesis-cyst(e)ine. Herein, we demonstrate directly that IL-1β mediates
Ludovic Peyre et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1916-1931 (2015-08-05)
Testing hepatotoxicity is a crucial step in the development and toxicological assessment of drugs and chemicals. Bio-activation can lead to the formation of metabolites which may present toxicity for the organism. Classical cytotoxic tests are not always appropriate and are
Maxim O Ratnikov et al.
Journal of the American Chemical Society, 135(4), 1549-1557 (2013-01-10)
A general mechanism is proposed for transition metal-catalyzed oxidative Mannich reactions of N,N-dialkylanilines with tert-butyl hydroperoxide (TBHP) as the oxidant. The mechanism consists of a rate-determining single electron transfer (SET) that is uniform from 4-methoxy- to 4-cyano-N,N-dimethylanilines. The tert-butylperoxy radical
Bavneet Benipal et al.
Biochemical pharmacology, 85(9), 1379-1388 (2013-02-20)
Compensatory renal hypertrophy following reduction in renal mass leads to a hypermetabolic state and increases in basal mitochondrial oxidative stress and susceptibility to several nephrotoxicants. Previous studies provide conflicting data on whether renal mitochondria after reduction in renal mass undergo
A Dăneasă et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 122(3), 154-162 (2014-03-20)
Because polycystic ovarian syndrome (PCOS) is a risk factor for type 2 diabetes, the affected women can present frequently prediabetic states such as impaired fasting glycaemia and/or impaired glucose tolerance. The purpose of our study is to explore the effect
Minyu Xie et al.
Biology of reproduction, 103(5), 1121-1131 (2020-08-04)
Mammalian spermatozoa are highly polarized cells characterized by compartmentalized cellular structures and energy metabolism. Adenylate kinase (AK), which interconverts two ADP molecules into stoichiometric amounts of ATP and AMP, plays a critical role in buffering adenine nucleotides throughout the tail
Ciric To et al.
Carcinogenesis, 36(7), 769-781 (2015-05-06)
Lung cancer accounts for the highest number of cancer-related deaths in the USA, highlighting the need for better prevention and therapy. Activation of the Nrf2 pathway detoxifies harmful insults and reduces oxidative stress, thus preventing carcinogenesis in various preclinical models.
He Ren et al.
The journal of physical chemistry. A, 116(44), 10647-10655 (2012-10-19)
A dual-level direct dynamic method is employed to study the reaction mechanism of hydroxyl radical with (CH(3))(3)COOH and (CH(3))(2)CHOOH. Eight hydrogen abstraction channels are found for title reactions. The energy paths are optimized at the BH&H-HLYP/6-311G(d,p) level, and the energy
Junho Kim et al.
Journal of cellular biochemistry, 114(3), 716-727 (2012-10-13)
Human mesenchymal stromal or stem cells (hMSCs) are being investigated for cell therapy in a wide range of diseases. MSCs are a potent source of trophic factors and actively remodel their immediate microenvironment through the secretion of bioactive factors in
Didier Betbeder et al.
International journal of nanomedicine, 10, 5355-5366 (2015-09-09)
Curcumin exhibits antioxidant properties potentially beneficial for human health; however, its use in clinical applications is limited by its poor solubility and relative instability. Nanoparticles exhibit interesting features for the efficient distribution and delivery of curcumin into cells, and could
Yang Bian et al.
Experimental eye research, 135, 26-36 (2015-04-25)
Inflammation is a pathological hallmark of ischemia reperfusion (I/R) injury. The present study was conducted to explore the ability of a new anti-inflammatory compound, X22, to attenuate retinal I/R injury via cytokine-inhibitory mechanism. For the in vitro experiment, ARPE-19 cells
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