459-32-5

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关键词:'459-32-5'

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Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses.

J R Backstrom et al.

The Journal of biological chemistry, 275(31), 23620-23626 (2000-05-19)

Phosphorylation-deficient serotonin 5-HT(2C) receptors were generated to determine whether phosphorylation promotes desensitization of receptor responses. Phosphorylation of mutant 5-HT(2C) receptors that lack the carboxyl-terminal PDZ recognition motif (Ser(458)-Ser-Val-COOH; DeltaPDZ) was not detectable based on a band-shift phosphorylation assay and incorporation

Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity.

N B Chrapkiewicz et al.

Nucleic acids research, 17(16), 6651-6667 (1989-08-25)

Several overlapping cDNA and genomic DNA clones corresponding to mRNA g33 and gene 33, respectively, were isolated and characterized. The mRNA g33 molecule is 2971 nt in length, exclusive of a poly(A+) tail, and encodes a putative 459 amino acid

KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome.

C Donger et al.

Circulation, 96(9), 2778-2781 (1997-12-31)

KVLQT1, the gene encoding the alpha-subunit of a cardiac potassium channel, is the most common cause of the dominant form of long-QT syndrome (LQT1-type), the Romano-Ward syndrome (RWS). The overall phenotype of RWS is characterized by a prolonged QT interval

Rising HIV-1 viral load set point at a population level coincides with a fading impact of host genetic factors on HIV-1 control.

Daniëlle van Manen et al.

AIDS (London, England), 25(18), 2217-2226 (2011-08-24)

Heterozygosity for a 32 base pair deletion in the CCR5 gene (CCR5wt/Δ32) and the minor alleles of a single-nucleotide polymorphism in the HCP5 gene (rs2395029) and in the HLA-C gene region (-35HLA-C; rs9264942) has been associated with a lower viral

Changes of placental syndecan-1 expression in preeclampsia and HELLP syndrome.

Szilvia Szabo et al.

Virchows Archiv : an international journal of pathology, 463(3), 445-458 (2013-06-29)

Preeclampsia is characterized by maternal systemic anti-angiogenic and pro-inflammatory states. Syndecan-1 is a cell surface proteoglycan expressed by the syncytiotrophoblast, which plays an important role in angiogenesis and resolution of inflammation. Our aim was to examine placental syndecan-1 expression in

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.

Asmaa S Abdelhamid et al.

The Cochrane database of systematic reviews, 3, CD003177-CD003177 (2020-03-03)

Omega-3 polyunsaturated fatty acids from oily fish (long-chain omega-3 (LCn3)), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), as well as from plants (alpha-linolenic acid (ALA)) may benefit cardiovascular health. Guidelines recommend increasing omega-3-rich foods, and sometimes supplementation, but recent

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