463-18-3

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A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients.

Roberto Pecoits-Filho et al.

Kidney international. Supplement, (84), S172-S176 (2003-04-16)

Cardiovascular disease (CVD) is the leading cause of mortality in end-stage renal disease (ESRD) patients and there is emerging evidence that genetic factors may contribute to the development of atherosclerosis. Myeloperoxidase (MPO) is an abundant enzyme involved in the production

Shiga Toxin-Producing Escherichia coli Contamination of Raw Beef and Beef-Based Ready-to-Eat Products at Retail Outlets in Pretoria, South Africa.

Libby O Onyeka et al.

Journal of food protection, 83(3), 476-484 (2020-02-18)

A cross-sectional study was conducted to determine the prevalence of and factors associated with Shiga toxin-producing Escherichia coli (STEC) in raw beef and ready-to-eat (RTE) beef products sold in 31 retail outlets in Pretoria, South Africa, and nearby areas. A

The human collagen X gene. Complete primary translated sequence and chromosomal localization.

J T Thomas et al.

The Biochemical journal, 280 ( Pt 3), 617-623 (1991-12-15)

We report on the complete primary translated sequence of human alpha 1(X) collagen, deduced from a genomic clone, and the chromosomal localization of the human collagen X gene. The primary translated product of human collagen X is encoded by two

Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients.

J D Barros-Silva et al.

British journal of cancer, 100(3), 487-493 (2009-01-22)

The clinical significance of ERBB2 amplification/overexpression in gastric cancer remains unclear. In this study, we evaluated the ERBB2 status in 463 gastric carcinomas using immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH), and compared the findings with histopathological characteristics and

Efficacy, safety, and tolerability of a monophasic oral contraceptive containing nomegestrol acetate and 17β-estradiol: a randomized controlled trial.

Carolyn Westhoff et al.

Obstetrics and gynecology, 119(5), 989-999 (2012-04-25)

To estimate the efficacy, cycle control, tolerability, and safety of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-estradiol (E2) in comparison with drospirenone and ethinyl E2. In a randomized, open-label, comparative multicenter trial, healthy women (n=2,281; age 18-50

Genetic variant of AMD1 is associated with obesity in urban Indian children.

Rubina Tabassum et al.

PloS one, 7(4), e33162-e33162 (2012-04-13)

Hyperhomocysteinemia is regarded as a risk factor for cardiovascular diseases, diabetes and obesity. Manifestation of these chronic metabolic disorders starts in early life marked by increase in body mass index (BMI). We hypothesized that perturbations in homocysteine metabolism in early

The founder mutation MSH2*1906G-->C is an important cause of hereditary nonpolyposis colorectal cancer in the Ashkenazi Jewish population.

W D Foulkes et al.

American journal of human genetics, 71(6), 1395-1412 (2002-11-28)

Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by mutations in the mismatch-repair genes. We report here the identification and characterization of a founder mutation in MSH2 in the Ashkenazi Jewish population. We identified a nucleotide substitution, MSH2*1906G-->C, which results in

Shorter leukocyte telomere length is independently associated with poor survival in patients with bladder cancer.

Alessia Russo et al.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 23(11), 2439-2446 (2014-09-23)

Shorter telomere length (TL) has been reported to be associated with increased risk of early death in elder individuals. Telomere shortening has been also related to chromosomal instability, which may possibly contribute to the development of several types of digestive

A sequence repeat in the insulin-like growth factor-1 gene and risk of breast cancer.

Stacey A Missmer et al.

International journal of cancer, 100(3), 332-336 (2002-07-13)

Insulin-like growth factor-1 (IGF-I), a potent mitogen, is hypothesized to influence breast cancer risk. In 3 previous studies, a polymorphism in the IGF-1 gene (sequence repeat length) was associated with plasma IGF-I level. We evaluated prospectively the relationships among a

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.

Daniel I Swerdlow et al.

Lancet (London, England), 385(9965), 351-361 (2014-09-30)

Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. We used single nucleotide polymorphisms in the HMGCR

Distributions of five common point mutants in the human tracheal-bronchial epithelium.

Hiroko Sudo et al.

Mutation research, 596(1-2), 113-127 (2006-02-07)

The mutations C742T, G746T, G747T in the TP53 gene and G35T in the KRAS gene have been repeatedly found in sectors of human tumors by direct DNA sequencing. The mutation G508A in the HPRT1 gene has been repeatedly found among

Ruthenium complexes containing 2-(2-nitrosoaryl)pyridine: structural, spectroscopic, and theoretical studies.

Siu-Chung Chan et al.

Inorganic chemistry, 50(22), 11636-11643 (2011-10-26)

Ruthenium complexes containing 2-(2-nitrosoaryl)pyridine (ON(^)N) and tetradentate thioether 1,4,8,11-tetrathiacyclotetradecane ([14]aneS4), [Ru(ON(^)N)([14]aneS4)](2+) [ON(^)N = 2-(2-nitrosophenyl)pyridine (2a), 10-nitrosobenzo[h]quinoline (2b), 2-(2-nitroso-4-methylphenyl)pyridine, (2c), 2-(2-nitrosophenyl)-5-(trifluoromethyl)pyridine (2d)] and analogues with the 1,4,7-trithiacyclononane ([9]aneS3)/tert-butylisocyanide ligand set, [Ru(ON(^)N)([9]aneS3)(C≡N(t)Bu)](2+) (4a and 4b), have been prepared by insertion of a

Selenium supplementation for Hashimoto's thyroiditis.

Esther J van Zuuren et al.

The Cochrane database of systematic reviews, 6(6), CD010223-CD010223 (2013-06-08)

Hashimoto's thyroiditis is a common auto-immune disorder. The most common presenting symptoms may include anxiety, negative mood, depression, dry skin, cold intolerance, puffy eyes, muscle cramps and fatigue, deep voice, constipation, slow thinking and poor memory. Clinical manifestations of the

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