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Vicente Ferreira et al.
Journal of chromatography. A, 1407, 30-41 (2015-07-15)
SPME is extremely sensitive to experimental parameters affecting liquid-gas and gas-solid distribution coefficients. Our aims were to measure the weights of these factors and to design a multivariate strategy based on the addition of a pool of internal standards, to
Edward W Tekwa et al.
Lab on a chip, 15(18), 3723-3729 (2015-08-01)
Localized interactions are predicted to favour the evolution of cooperation amongst individuals within a population. One important factor that can localize interactions is habitat patchiness. We hypothesize that habitats with greater patchiness (greater edge-to-area ratio) can facilitate the maintenance of
Peng Xue et al.
Biomedical microdevices, 17(2), 39-39 (2015-03-10)
Circulating tumor cells (CTCs), which are derived from primary tumor site and transported to distant organs, are considered as the major cause of metastasis. So far, various techniques have been applied for CTC isolation and enumeration. However, there exists great
Anna Turetsky et al.
Theranostics, 5(8), 796-804 (2015-05-23)
Molecular profiling of central nervous system lymphomas in cerebrospinal fluid (CSF) samples can be challenging due to the paucicellular and limited nature of the samples. Presented herein is a microfluidic platform for complete CSF lymphoid cell analysis, including single cell
Adam C Mirando et al.
Scientific reports, 5, 13160-13160 (2015-08-15)
Aminoacyl-tRNA synthetases (AARSs) catalyze an early step in protein synthesis, but also regulate diverse physiological processes in animal cells. These include angiogenesis, and human threonyl-tRNA synthetase (TARS) represents a potent pro-angiogenic AARS. Angiogenesis stimulation can be blocked by the macrolide
Dannielle S Figueroa et al.
Journal of biomechanical engineering, 136(10), 101010-101010 (2014-07-18)
Hyperglycemia is a defining characteristic of diabetes, and uncontrolled blood glucose in diabetes is associated with accelerated cardiovascular disease. Chronic hyperglycemia glycates extracellular matrix (ECM) collagen, which can lead to endothelial cell dysfunction. In healthy conditions, endothelial cells respond to
Nisarga Naik et al.
Biomedical microdevices, 17(4), 83-83 (2015-08-01)
Microvascularization of an engineered tissue construct is necessary to ensure the nourishment and viability of the hosted cells. Microvascular constructs can be created by seeding the luminal surfaces of microfluidic channel arrays with endothelial cells. However, in a conventional flow-based
Elishai Ezra et al.
Biomedical microdevices, 17(4), 82-82 (2015-08-01)
Microfluidic applications range from combinatorial synthesis to high throughput screening, with platforms integrating analog perfusion components, digitally controlled micro-valves and a range of sensors that demand a variety of communication protocols. Currently, discrete control units are used to regulate and
David A Alvarez et al.
Marine pollution bulletin, 81(2), 347-354 (2013-05-21)
Three passive sampling devices (PSDs), polar organic chemical integrative samplers (POCIS), polyethylene devices (PEDs), and solid-phase microextraction (SPME) samplers were used to sample a diverse set of chemicals in the coastal waters of San Francisco Bay and the Southern California
Samaneh Mashaghi et al.
Scientific reports, 5, 11837-11837 (2015-07-03)
Scale reduction of chemical reactions enables novel screening and synthesis approaches that facilitate a highly parallelized and combinatorial exploration of chemical space. Droplet-based microfluidics have evolved as a powerful platform to allow many chemical reactions within small volumes that each
Patrick Vanraes et al.
Water research, 72, 361-371 (2014-12-09)
In recent decades, several types of persistent substances are detected in the aquatic environment at very low concentrations. Unfortunately, conventional water treatment processes are not able to remove these micropollutants. As such, advanced treatment methods are required to meet both
Xin Li et al.
Journal of environmental sciences (China), 32, 15-25 (2015-06-05)
Powdered activated carbon (PAC) adsorption of two fishy odorants, trans,trans-2,4-heptadienal (HDE) and trans,trans-2,4-decadienal (DDE), was investigated. Both the pseudo first-order and the pseudo second-order kinetic models well described the kinetics curves, and DDE was more readily removed by PAC. In
Martin Bauch et al.
Optics express, 22(26), 32026-32038 (2015-01-22)
Corrugated metallic surfaces offer means for efficient amplification of fluorescence bioassay signal based on the near field coupling between surface plasmons and fluorophore emitters that are used as labels. This paper discusses the design of such plasmonic structure to enhance
Ian Y Wong et al.
Nature materials, 13(11), 1063-1071 (2014-08-19)
During cancer progression, malignant cells in the tumour invade surrounding tissues. This transformation of adherent cells to a motile phenotype has been associated with the epithelial-mesenchymal transition (EMT). Here, we show that EMT-activated cells migrate through micropillar arrays as a
Andrzej L Dawidowicz et al.
Talanta, 146, 195-202 (2015-12-24)
The main limitation in the standard application of head space analysis employing solid phase microextraction (HS-SPME) for the evaluation of plants as sources of essential oils (EOs) are different quantitative relations of EO components from those obtained by direct analysis
Narjes Allahrabbi et al.
Biomicrofluidics, 9(3), 034110-034110 (2015-07-17)
Assessment of the microbial safety of water resources is among the most critical issues in global water safety. As the current detection methods have limitations such as high cost and long process time, new detection techniques have transpired among which
Scalable single-step microfluidic production of single-core double emulsions with ultra-thin shells.
L R Arriaga et al.
Lab on a chip, 15(16), 3335-3340 (2015-07-15)
We report a versatile and robust device for the continuous production of double emulsion drops with very thin shell thicknesses, of about 5% of the radius: for emulsions 50 μm in radius the shells can be as thin as a
Nicole Favreau-Farhadi et al.
Journal of food science, 80(10), C2140-C2146 (2015-09-27)
Rosmarinic acid and Epigallocatechin gallate concentrations were studied as natural inhibitors of Maillard browning in glucose/glycine model systems, and in bakery rolls and applesauce. The concentrations of the inhibitors were varied to determine the highest level of inhibition without a
Dario Sirabella et al.
Experimental biology and medicine (Maywood, N.J.), 240(8), 1008-1018 (2015-06-13)
The pressing need for effective cell therapy for the heart has led to the investigation of suitable cell sources for tissue replacement. In recent years, human pluripotent stem cell research expanded tremendously, in particular since the derivation of human-induced pluripotent
Christian A Di Buduo et al.
Blood, 125(14), 2254-2264 (2015-01-13)
We present a programmable bioengineered 3-dimensional silk-based bone marrow niche tissue system that successfully mimics the physiology of human bone marrow environment allowing us to manufacture functional human platelets ex vivo. Using stem/progenitor cells, megakaryocyte function and platelet generation were
Kai-Jie Kao et al.
Biosensors & bioelectronics, 69, 272-279 (2015-03-17)
Over-expression/amplification of human epidermal growth factor receptors 2 (HER2) is a verified therapeutic biomarker for breast and gastric cancers. HER2 is also served as prognostic biomarker for gastric cancer because HER2 over-expression is associated with a 5-10% increase in cancer
Simone Allazetta et al.
Small (Weinheim an der Bergstrasse, Germany), 11(42), 5647-5656 (2015-09-10)
A microfluidic in vitro cell encapsulation platform to systematically test the effects of microenvironmental parameters on cell fate in 3D is developed. Multiple cell types including fibroblasts, embryonic stem cells, and cancer cells are incorporated in enzymatically cross-linked poly(ethylene glycol)-based
Cheng Wang et al.
Biosensors & bioelectronics, 71, 222-229 (2015-04-29)
This paper presents an aptameric graphene nanosensor for detection of small-molecule biomarkers. To address difficulties in direct detection of small molecules associated with their low molecular weight and electrical charge, we incorporate an aptamer-based competitive affinity assay in a graphene
Don't be so BOLD: potential limitations in the use of BOLD MRI for studies of renal oxygenation.
R G Evans et al.
Kidney international, 71(12), 1327-1328 (2007-06-08)
Suzue Arii et al.
Applied and environmental microbiology, 81(8), 2667-2675 (2015-02-11)
Cyanobacteria produce numerous volatile organic compounds (VOCs), such as β-cyclocitral, geosmin, and 2-methylisoborneol, which show lytic activity against cyanobacteria. Among these compounds, only β-cyclocitral causes a characteristic color change from green to blue (blue color formation) in the culture broth
Vincenzo Abbate et al.
Journal of inorganic biochemistry, 105(2), 268-275 (2011-01-05)
Biotransformations make use of biological systems to catalyze or promote specific chemical reactions. Transformations that utilize enzymes as "greener" and milder catalysts compared to traditional reaction conditions are of particular interest. Recently, organosilicon compounds have begun to be explored as
D E Liu et al.
Acta biomaterialia, 18, 112-117 (2015-03-01)
Equilibrium water content of and solute partitioning in silicone hydrogels (SiHys) are investigated using gravimetric analysis, fluorescence confocal laser-scanning microscopy (FCLSM), and back extraction with UV/Vis-absorption spectrophotometry. Synthesized silicone hydrogels consist of silicone monomer, hydrophilic monomer, cross-linking agent, and triblock-copolymer
Cheng Guo Li et al.
Lab on a chip, 15(16), 3286-3292 (2015-07-21)
The development of real-time innocuous blood diagnosis has been a long-standing goal in healthcare; an improved, miniature, all-in-one point-of-care testing (POCT) system with low cost and simplified operation is highly desired. Here, we present a one-touch-activated blood multidiagnostic system (OBMS)
Alexandra J Dickinson et al.
Analytical and bioanalytical chemistry, 406(27), 7027-7036 (2014-07-02)
Sphingosine kinase (SK) is a promising therapeutic target in a number of cancers, including leukemia. Traditionally, SK has been measured in bulk cell lysates, but this technique obscures the cellular heterogeneity present in this pathway. For this reason, SK activity
Shidong Lv et al.
PloS one, 9(12), e116428-e116428 (2015-01-01)
The quality of tea is presently evaluated by the sensory assessment of professional tea tasters, however, this approach is both inconsistent and inaccurate. A more standardized and efficient method is urgently needed to objectively evaluate tea quality. In this study
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