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E Zachary Oblak et al.
Organic & biomolecular chemistry, 10(43), 8597-8604 (2012-10-04)
A direct route to analogs of the naturally occurring tropolone β-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated. Several of these compounds demonstrated very high levels of
Shicheng Liu et al.
Cancer letters, 286(2), 240-249 (2009-07-28)
Increasing evidence has confirmed that hinokitiol (beta-thujaplicin), a tropolone-related compound, exhibits anticancer activity in a variety of cancers through inhibition of cell proliferation. The present study indicates that hinokitiol selectively inhibits cell growth and DNA synthesis in FEM human melanoma
Yu-Tzu Tsao et al.
International journal of molecular sciences, 17(2), 248-248 (2016-02-24)
H inokitiol purified from the heartwood of cupressaceous plants has had various biological functions of cell differentiation and growth. Hinokitiol has been demonstrated as having an important role in anti-inflammation and anti-bacteria effect, suggesting that it is potentially useful in
Ryuichi Fujisaki et al.
The Southeast Asian journal of tropical medicine and public health, 43(2), 270-279 (2012-10-23)
Abstract. The anti-plasmodial activity of 47 essential oils and 10 of their constituents were screened for in vitro activity against Plasmodium falciparum. Five of these essential oils (sandalwood, caraway, monarda, nutmeg, and Thujopsis dolabrata var. hondai) and 2 constituents (thymoquinone
A novel synthetic pathway for tropolone ring formation via the olefin monoterpene intermediate terpinolene in cultured Cupressus lusitanica cells
Fujita, Koki and Bunyu, et al.
Journal of Plant Physiology, 171, 610-614 (2014)
Maria Koufaki et al.
European journal of medicinal chemistry, 45(3), 1107-1112 (2010-01-05)
beta-Thujaplicin (hinokitiol or 2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one), a natural tropolone, shows numerous activities while its synthetic analogues were found to exhibit anticancer and anti-ischemic activity. However, the ability of tropolone derivatives to protect neuronal cells from oxidative stress-induced cell damage has not been
Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections.
B M Krenn et al.
Journal of virology, 83(1), 58-64 (2008-10-17)
We have discovered two metal ion binding compounds, pyrithione (PT) and hinokitiol (HK), that efficiently inhibit human rhinovirus, coxsackievirus, and mengovirus multiplication. Early stages of virus infection are unaffected by these compounds. However, the cleavage of the cellular eukaryotic translation
Jong Yuh Cherng et al.
The American journal of Chinese medicine, 40(2), 387-398 (2012-03-16)
Solar UV radiation damages human skin by affecting skin tone and resiliency and leads to premature aging (photoaging). The skin damage is caused by the activation of the AP-1 transcription factor, which increases matrix metalloproteinase (MMP) expression and collagen degradation.
Yasuhiko Higashi et al.
Journal of cosmetic science, 64(5), 381-389 (2013-10-22)
Hinokitiol, a potent, broad-spectrum antibacterial agent, is a component of various personal care products. In this study, the concentration of hinokitiol in skin lotion was analyzed by means of high-performance liquid chromatography-ultraviolet detection (380 nm) after precolumn derivatization with 4-fluoro-7-nitro-2,1
Photophysical Spectral Features of fluorescent complexes on the basis of the novel ligand $\beta$-thujaplicin
Liu, Yang and Liu, et al.
Journal of Luminescence, 218, 116852-116852 (2020)
Ransika De Alwis et al.
Journal of plant physiology, 166(7), 720-728 (2008-11-26)
Elicitor treatment initiates defense responses in cultured Cupressus lusitanica cells. In order to investigate the defense mechanism with a yeast extract elicitor, we carried out solid-phase microextraction coupled with gas chromatography for monoterpene analysis. Ten hydrocarbon monoterpenes, including high amounts
Toyotaka Murakami et al.
Neuroreport, 23(18), 1071-1076 (2012-11-07)
Predator odors, such as 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), induce a stress-like behavior in some rodents, and there is activation of a complex mix of brain regions including the anterior piriform cortex (APC) and the bed nucleus of stria terminalis (BST). In contrast
Yasuhiko Higashi et al.
Journal of cosmetic science, 60(5), 519-525 (2009-10-14)
Hinokitiol is found in the heartwood of several cupressaceous plants and is frequently added to cosmetic products such as hair restorers, skin lotions, and body soaps because of its potent and broad-spectrum antibacterial activity. In this study, we established a
Antibacterial activity of beta-thujaplicin.
T J Trust et al.
Canadian journal of microbiology, 19(11), 1341-1346 (1973-11-01)
Junichiro Ishii et al.
Animal science journal = Nihon chikusan Gakkaiho, 83(1), 36-42 (2012-01-19)
This study evaluated the effects of hinokitiol (a natural antibacterial compound extracted from Thujopsis dolabrata var. hondai) and an organic acid mixture (citrate content 50%) on ruminal fermentation. Antibacterial properties were examined by measuring minimal inhibitory concentration. Hinokitiol at 1.56µg/mL
Yu-Jing Zhu et al.
Journal of enzyme inhibition and medicinal chemistry, 25(6), 798-803 (2010-06-29)
The inhibitory effects of hinokitiol, a constituent of the woody oils isolated from Cupressaceae heartwood, on mushroom tyrosinase and melanin formation in B16 melanoma cells as well as its antimicrobial activity were investigated. Our results showed that hinokitiol could strongly
Yaeno Arima et al.
The Journal of antimicrobial chemotherapy, 51(1), 113-122 (2002-12-21)
Beta-thujaplicin (hinokitiol) is a tropolone-related compound purified from the wood of Chamaecyparis obtusa, SIEB: et Zucc. and Thuja plicata D. Don. All Staphylococcus aureus isolates were inhibited by beta-thujaplicin with MICs of 1.56-3.13 mg/L. However, a paradoxical zone phenomenon occurred
Tsair-Bor Yen et al.
Bioresource technology, 99(11), 4871-4877 (2007-11-06)
The ethanolic extract of Calocedrus macrolepis var. formosana heartwood was screened for antifungal compounds by agar dilution assay and liquid chromatography. Two compounds, beta-thujaplicin and gamma-thujaplicin, responsible for the antifungal property of C. macrolepis var. formosana heartwood were isolated by
S L Hwang et al.
Journal of microencapsulation, 25(5), 351-356 (2008-05-10)
Nanocapsules containing hinokitiol (HKL) were prepared by an emulsion-diffusion method. In an emulsification step in preparing nanocapsules, cetyltrimethylamonium chloride (CTAC) was employed as a cationic emulsifier, Poly(epsilon-caprolactone) (PCL) was use as a wall material and HKL dissolved in octylsalicylate (OS)
Satoshi Takahashi et al.
Bioorganic & medicinal chemistry, 18(22), 8112-8118 (2010-10-16)
Tyrosinase inhibitors are important agents for cosmetic products. We examined here the inhibitory effects of three isomers of thujaplicins (α, β and γ) on mushroom tyrosinase and analyzed their binding modes using a homology model from the crystal structure of
Synthesis of naturally occurring tropones and tropolones
Liu, Na and Song, et al.
Tetrahedron, 70, 9281-9305 (2014)
Amy R Cameron et al.
Metallomics : integrated biometal science, 2(3), 195-203 (2010-11-12)
Metal-binding compounds have recently been reported to have anti-hyperglycaemic properties in vivo. In the current study, we have investigated the ability of these compounds and related structures to induce insulin-like signal transduction to downstream effectors such as the transcription factor
Xia Yang et al.
Drug development and industrial pharmacy, 36(5), 556-562 (2010-02-10)
Behenyltrimethylammonium chloride (BTAC) and stearic acid (SA) could be associated with each other through salt bridges, and the associated BTAC/SA could build bilayer vesicles with the aid of hinokitiol (HKL). The vesicles were prepared by a precipitation method and used
J Ye et al.
Eye (London, England), 29(7), 964-971 (2015-05-09)
This study assessed the anti-inflammatory effect and mechanism of action of hinokitiol in human corneal epithelial (HCE) cells. HCE cells were incubated with different concentrations of hinokitiol or dimethylsulfoxide (DMSO), which served as a vehicle control. Cell viability was evaluated
Myong Jin Lee et al.
Biochemical and biophysical research communications, 396(2), 370-375 (2010-04-27)
Hypoxia-inducible factor (HIF)-1 has been established as a master regulator of vascular responses to hypoxia and ischemia by driving transcriptional activation of angiogenic factors. Oxygen- and 2-oxoglutarate (2-OG)-dependent, iron(II) containing HIF-specific prolyl-4-hydroxylases (PHDs) and factor inhibiting HIF-1alpha (FIH-1) catalyze the
Jeffrey P Gilbard et al.
Cornea, 29(5), 559-563 (2010-03-24)
Time-kill testing was performed for a linalool-hinokitiol-based eyelid cleanser against Pseudomonas aeruginosa, Moraxella catarrhalis, Escherichia coli, Serratia marcescens, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Staphylococcus epidermidis, and Pityrosporum ovale to evaluate its efficacy. An inoculum of 1 mL of each
Hyang Hee Joo et al.
Drug delivery, 15(1), 19-22 (2008-01-17)
In vitro permeation of hinokitiol (HKL) through hairless mouse skin was investigated using a diffusion cell. Either propylene glycol (PG) or ethanol (EtOH) was used as a vehicle for HKL. After applying the HKL solutions of 0.5%. 1%, 2%, and
M-F Shih et al.
International journal of immunopathology and pharmacology, 25(1), 39-48 (2012-04-18)
β-thujaplicin, an active constituent from Chamaecyparis obtusa, has been shown to have acaricidal and antimicrobial effects. Very few studies have focused on the potential of the anti-inflammatory effect of β-thujaplicin. Moreover, its capability of inhibiting inflammatory mediators e.g. TNF-a gene
Yun Chen et al.
Virus research, 204, 58-67 (2015-04-23)
In our previous study, Bush Sophora Root polysaccharide (BSRPS) and its sulfate (sBSRPS) exhibited anti-duck virus hepatitis (DVH) abilities as well as anti-oxidative and immuno-enhancement effects. The aim of this paper was to ulteriorly investigate the exact anti-DVH mechanisms of
J Zhao et al.
Applied microbiology and biotechnology, 55(3), 301-305 (2001-05-09)
Production of a novel antimicrobial tropolone, beta-thujaplicin, in Cupressus lusitanica suspension cultures was studied by using a variety of chemicals and fungal elicitors. Sodium alginate, chitin, and methyl jasmonate resulted in 2-, 2.5-, and 3-fold higher beta-thujaplicin production, respectively, than
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