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显示 1-30 共 1689 条结果 关于 "46955" 范围 论文
Koji Takayama et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(10), 1326-1332 (2014-06-27)
DNA damage is a cause of age related pathologies, including osteoarthritis (OA). Excision repair cross complementation group 1 (ERCC1) is an endonuclease required for DNA damage repair. In this study we investigated the function of ERCC1 in chondrocytes and its
Xingxing He et al.
Oncotarget, 6(4), 2034-2045 (2015-01-13)
Mutation in the p53 gene is arguably the most frequent type of gene-specific alterations in human cancers. Current p53-based gene therapy contains the administration of wt-p53 or the suppression of mutant p53 expression in p53-defective cancer cells. . We hypothesized
Fatima Kyari et al.
Ophthalmic epidemiology, 22(2), 98-108 (2015-03-18)
To determine normative values for defining glaucoma in cross-sectional surveys in Nigerian adults. Multistage stratified cluster random sampling with probability-proportional-to-size procedures to select a nationally representative sample of 15,027 persons aged ≥ 40 years in 305 clusters across Nigeria. Systematic
Jeremy A Goettel et al.
Blood, 125(25), 3886-3895 (2015-04-03)
Mice reconstituted with a human immune system provide a tractable in vivo model to assess human immune cell function. To date, reconstitution of murine strains with human hematopoietic stem cells (HSCs) from patients with monogenic immune disorders have not been
Neha Dixit et al.
Arthritis research & therapy, 16(6), 496-496 (2014-12-03)
Bone erosion in inflammatory arthritis depends on the recruitment and activation of bone resorbing cells, the osteoclasts. Interleukin-23 (IL-23) has been primarily implicated in mediating inflammatory bone loss via the differentiation of Th17 receptor activator of nuclear factor κB ligand
Hitoshi Matsui et al.
Biological & pharmaceutical bulletin, 37(12), 1907-1912 (2014-12-03)
TRPV2, a member of the transient receptor potential family, has been isolated as a capsaicin-receptor homolog and is thought to respond to noxious heat. Here we show that TRPV2 mRNA is predominantly expressed in the subpopulation of olfactory sensory neurons
Jingyu Yao et al.
Autophagy, 11(6), 939-953 (2015-06-16)
Autophagy regulates cellular homeostasis and response to environmental stress. Within the retinal pigment epithelium (RPE) of the eye, the level of autophagy can change with both age and disease. The purpose of this study is to determine the relationship between
K A Walker et al.
American journal of physiology. Renal physiology, 308(8), F888-F898 (2015-02-07)
While urothelial signals, including sonic hedgehog (Shh), drive bladder mesenchyme differentiation, it is unclear which pathways within the mesenchyme are critical for its development. Studies have shown that fibroblast growth factor receptor (Fgfr)2 is necessary for kidney and ureter mesenchymal
Shanshan Cheng et al.
The international journal of biochemistry & cell biology, 57, 186-196 (2014-12-03)
Impairment in the microRNA (miRNA) network causes a number of neurodegenerative diseases. Endoribonuclease Dicer is a key RNase to produce mature miRNAs. It has been shown that Dicer is important for the maintenance of excitatory neuron survival during early postnatal
Carolina Schinke et al.
Blood, 125(20), 3144-3152 (2015-03-27)
Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that are not eliminated by conventional therapies. Novel therapeutic targets against preleukemic stem cells need to be identified for potentially curative strategies. We conducted parallel transcriptional
R Sumagin et al.
Mucosal immunology, 7(4), 905-915 (2013-12-19)
Neutrophil (PMN) transepithelial migration (TEM) and accumulation in luminal spaces is a hallmark of mucosal inflammation. TEM has been extensively modeled; however, the functional consequences and molecular basis of PMN interactions with luminal epithelial ligands are not clear. Here we
Akiko Motoyoshi-Yamashiro et al.
The Journal of veterinary medical science, 76(10), 1353-1358 (2014-10-07)
Amphotericin B (AmB) is a polyene antifungal drug and is reported to be one of a few reagents having therapeutic effects on prion diseases, that is, a delay in the appearance of clinical signs and prolongation of the survival time
Melanie Di Benedetto et al.
British journal of cancer, 113(5), 773-785 (2015-07-22)
Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that has important roles in angiogenesis. Our knowledge of the significance of VEGF isoforms in human cancer remains incomplete. Bioluminescence imaging and transcriptomic analysis were used to study the colonisation capacity
Tsukasa Kitahashi et al.
Pancreas, 44(1), 76-86 (2014-07-19)
The aim of the present study was to characterize molecular targets for the prevention/diagnosis of pancreatic cancer using a chemically induced hamster pancreatic carcinogenesis model, in which background injuries to the parenchyma, for example, chronic pancreatitis or acinar atrophy, are
Denise Compera et al.
Journal of ophthalmology, 2015, 450212-450212 (2015-10-02)
Purpose. To describe morphology of lamellar hole-associated epiretinal proliferation (LHEP) removed from eyes with lamellar macular holes (LMH). Methods. Based on optical coherence tomography data, 10 specimens of LHEP were removed from 10 eyes with LMH during standard vitrectomy. Specimens
Wan-Jie Chia et al.
Neurochemistry international, 87, 43-59 (2015-05-26)
The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known
Hun Lee et al.
Biomicrofluidics, 8(4), 044113-044113 (2014-11-08)
In this paper, we propose a continuous flow droplet-based microfluidic platform for magnetic particle-based assays by employing in-droplet washing. The droplet-based washing was implemented by traversing functionalized magnetic particles across a laterally merged droplet from one side (containing sample and
Patricia Tagliaferro et al.
Neurobiology of disease, 82, 359-371 (2015-07-21)
Mutations in the gene for LRRK2 are the most common cause of familial Parkinson's disease (PD) and patients with these mutations manifest clinical features that are indistinguishable from those of the more common sporadic form. Thus, investigations of disease mechanisms
Shin-ichi Kondo et al.
Chemical & pharmaceutical bulletin, 63(7), 489-494 (2015-07-03)
We fabricated polymeric micelles containing 5-fluorouracil (5-FU) or fluorescein using the amphiphilic block copolymer, poly-4-vinylpyridine-b-6-O-methacryloyl galactopyranose. Although the polymeric micelles were stable at pH 7.4, they readily decomposed at pH 5, resulting in near complete release of 5-FU. Uptake of
Yichao Jin et al.
Journal of neurotrauma, 32(14), 1090-1100 (2015-05-06)
Here, we evaluated changes in autophagy after post-traumatic brain injury (TBI) followed by moderate hypothermia in rats. Adult male Sprague-Dawley rats were randomly divided into four groups: sham injury with normothermia group (37 °C); sham injury with hypothermia group (32
Yuka Okura et al.
Journal of clinical immunology, 35(2), 158-167 (2015-02-11)
Chronic granulomatous disease (CGD) is a primary immunodeficiency disease that is characterized by susceptibility to bacterial and fungal infections. Various mutations in CYBB encoding the gp91(phox) subunit of the phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase impair the respiratory burst
M Kovalska et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(6), 767-776 (2015-01-03)
Global brain ischemia-reperfusion causes delayed cell death in hippocampal CA1 (cornus ammonis 1) pyramidal neurons after reperfusion. Ischemic tolerance evoked by preconditioning (IPC) represents a phenomenon of CNS adaptation to any subsequent ischemia. This paper was designed to describe changes
Jong-Hang Chen et al.
Cell transplantation, 24(5), 779-796 (2014-01-02)
Previous studies showed that transplantation of cultured neural stem/progenitor cells (NSPCs) could improve functional recovery for various neurological diseases. This study aims to develop a stem cell-based model for predictive toxicology of development in the neurological system after acrylamide exposure.
Zhongliang Ma et al.
Oncology reports, 32(5), 2111-2117 (2014-09-02)
Isatin is an endogenous indole in mammalian tissues and fluids that is expected to have antitumor effects in human breast cancer cells. Human breast cancer cells (MCF-7) were exposed to isatin at various concentrations (0, 50, 100, 200 µmol/l) for 48 h.
K M Fernandes et al.
Medical and veterinary entomology, 29(3), 245-254 (2015-05-15)
The mosquito Stegomyia aegypti (=Aedes aegypti) (Diptera: Culicidae) is a vector for the dengue and yellow fever viruses. As blood digestion occurs in the midgut, this organ constitutes the route of entry of many pathogens. The effects of the insecticide
William Stevenson et al.
Cornea, 33(12), 1336-1341 (2014-09-26)
The aim of this study was to establish and characterize extraorbital lacrimal gland excision (LGE) as a model of aqueous tear-deficient dry eye disease in mice. Female C57BL/6 mice at 6 to 8 weeks of age were randomized to extraorbital
Ranran Ding et al.
Stem cell research & therapy, 6, 91-91 (2015-05-10)
Transplantation of bone marrow mesenchymal stem cells (BMSCs) can repair injured hearts. However, whether BMSC populations contain cells with cardiac stem cell characteristics is ill-defined. We report here that Notch signalling can promote differentiation of c-Kit(POS)/NKX2.5(POS) BMSCs into cardiomyocyte-like cells.
Kamal El Bissati et al.
Vaccine, 32(26), 3243-3248 (2014-04-17)
We created and produced a novel self-assembling nanoparticle platform for delivery of peptide epitopes that induces CD8(+) and CD4(+)T cells that are protective against Toxoplasma gondii infection. These self-assembling polypeptide nanoparticles (SAPNs) are composed of linear peptide (LP) monomers which
Thunjiradasiree Kojarunchitt et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 74-81 (2014-12-08)
Thermoresponsive, particle-loaded, Poloxamer 407 (P407)-Pluronic-R® (25R4) or chitosan-methyl cellulose (MC) formulations were developed as single-dose, sustained release vaccines. The sol-gels, loaded either with a particulate vaccine (cubosomes) or soluble antigen (ovalbumin) and adjuvants (Quil A and monophosphoryl lipid A), were
Amber Khan et al.
Research in microbiology, 165(6), 411-419 (2014-05-27)
Manipulation of endogenous responses during programmed cell death (PCD) in fungi can lead to development of effective therapeutic strategies. In the present study, we evaluated the physiology of cell death in Candida albicans in response to Ocimum sanctum essential oil
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