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Ulrike Harre et al.
Nature communications, 6, 6651-6651 (2015-04-01)
Immunglobulin G (IgG) sialylation represents a key checkpoint that determines the engagement of pro- or anti-inflammatory Fcγ receptors (FcγR) and the direction of the immune response. Whether IgG sialylation influences osteoclast differentiation and subsequently bone architecture has not been determined
Marc R Mansour et al.
British journal of haematology, 168(2), 230-238 (2014-09-27)
Activating mutations of the interleukin-7 receptor (IL7R) occur in approximately 10% of patients with T cell acute lymphoblastic leukaemia (T-ALL). Most mutations generate a cysteine at the transmembrane domain leading to receptor homodimerization through disulfide bond formation and ligand-independent activation
Ozlem Akman et al.
Epilepsia, 56(11), 1793-1802 (2015-10-17)
Genetic Absence Epilepsy Rats from Strasbourg (GAERS) show a resistance to secondary generalization of focal limbic seizures evoked by kindling. The substantia nigra pars reticulata (SNR) is involved in the propagation and modulation of seizures in kindling. We first examined
Sophie Gilibert et al.
Journal of immunology (Baltimore, Md. : 1950), 193(2), 817-826 (2014-06-18)
Scavenger receptor class B type I (SR-BI)-deficient mice display reduced survival to endotoxic shock and sepsis. The understanding of the mechanisms underlying SR-BI protection has been hampered by the large spectrum of SR-BI functions and ligands. It notably plays an
Takaaki Inaba et al.
PloS one, 9(6), e99205-e99205 (2014-06-06)
Tear secretion is important as it supplies water to the ocular surface and keeps eyes moist. Both the parasympathetic and sympathetic pathways contribute to tear secretion. Although intracellular Ca2+ elevation in the acinar cells of lacrimal glands is a crucial
Hirokazu Wakuda et al.
Biological & pharmaceutical bulletin, 37(12), 1866-1871 (2014-12-03)
Although hyperlipidemia, high blood pressure, and diabetes increase the risk of arteriosclerosis, it is not clear whether hyperuricemia increases the risk of arteriosclerosis or not. We examined the effects of uric acid and curative drugs for hyperuricemia on atherosclerosis-susceptible C57BL/6J
Esther Roselló-Lletí et al.
PloS one, 9(11), e112971-e112971 (2014-11-15)
Dilated cardiomyopathy (DCM) is a public health problem with no available curative treatment, and mitochondrial dysfunction plays a critical role in its development. The present study is the first to analyze the mitochondrial proteome in cardiac tissue of patients with
Hsiang-Hua D Chang et al.
PloS one, 10(3), e0120489-e0120489 (2015-03-19)
The type 2 transmembrane serine protease matriptase is under tight control primarily by the actions of the integral membrane Kunitz-type serine protease inhibitor HAI-1. Growing evidence indicates that HAI-2 might also be involved in matriptase inhibition in some contexts. Here
Thapasimuthu V Anilkumar et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 102(7), 1506-1516 (2014-03-07)
Isolation procedures for the recovery of extracellular matrices (ECMs) from animal organs/tissues that are useful in regenerative medicine involve multiple sequential steps/stages including collection of the source organ at slaughter, their transportation to laboratory, decellularization, decontamination, stabilization, and sterilization. Most
Fotis Ioakeimidis et al.
PloS one, 9(8), e104237-e104237 (2014-08-12)
Mitochondrial structure and function is emerging as a major contributor to neuromuscular disease, highlighting the need for the complete elucidation of the underlying molecular and pathophysiological mechanisms. Following a forward genetics approach with N-ethyl-N-nitrosourea (ENU)-mediated random mutagenesis, we identified a
Athina Bakopoulou et al.
Stem cells and development, 24(21), 2496-2512 (2015-07-24)
Stem cells from the apical papilla (SCAP) of human adult teeth are considered an accessible source of cells with angiogenic properties. The aims of this study were to investigate the endothelial transdifferentiation of SCAP, the secretion of pro- and antiangiogenic
Panyu Zhou et al.
Cell biochemistry and biophysics, 70(2), 1265-1275 (2014-06-08)
Sepsis is a common and critical complication in surgical patients that often leads to multiple organ failure syndrome (MOFS), including acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Despite intensive supportive care and treatment modalities, the mortality of
Roseanne Rosario et al.
Gynecologic oncology, 131(2), 325-329 (2013-09-07)
The aim of this research was to use nucleic acids isolated from formalin-fixed paraffin-embedded (FFPE) tissue to investigate the diagnostic potential and prognostic significance of FOXL2 in adult-type GCTs, particularly as a marker of identifying early stage patients that are
Xiaohong Du et al.
PloS one, 9(7), e103016-e103016 (2014-07-23)
Methoxychlor (MXC), an organochlorine pesticide, has adverse effects on male reproduction at toxicological doses. Humans and wild animals are exposed to MXC mostly through contaminated dietary intake. Higher concentrations of MXC have been found in human milk, raising the demand
Juhani Metsola et al.
Pediatric research, 76(6), 515-521 (2014-09-05)
Adenosine levels are regulated by ecto-5'-nucleotidase/CD73 and adenosine deaminase (ADA). Adenosine regulates endothelial permeability and anti-inflammatory responses via adenosine receptors. Here, the adenosine receptors and purine-converting enzymes were studied during postnatal development and inflammation. Newborn, 1-, 10-, 14-d-old and adult
Sebastian A Mikolajczak et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(9), 1707-1715 (2014-05-16)
Immunization with live-attenuated Plasmodium sporozoites completely protects against malaria infection. Genetic engineering offers a versatile platform to create live-attenuated sporozoite vaccine candidates. We previously generated a genetically attenuated parasite (GAP) by deleting the P52 and P36 genes in the NF54
Dan-Dan Wei et al.
Journal of pharmaceutical and biomedical analysis, 98, 334-338 (2014-07-06)
Thioacetamide (TAA) is a well-known toxicant and its long term exposure could induce liver fibrosis and cirrhosis. A liver fibrosis rat model was established by consecutive injection of TAA solution for 7 weeks. Serum and urine samples were collected weekly
Kevin L Schully et al.
PloS one, 9(12), e115066-e115066 (2014-12-17)
Burkholderia mallei and Burkholderia pseudomallei are potentially lethal pathogens categorized as biothreat agents due, in part, to their ability to be disseminated via aerosol. There are no protective vaccines against these pathogens and treatment options are limited and cumbersome. Since
Yi Chen et al.
Cytokine, 69(2), 255-262 (2014-07-24)
Activin A, a member of the transforming growth factor-β superfamily, is stimulated early in inflammation via the Toll-like receptor (TLR) 4 signalling pathway, which is also activated in myocardial ischaemia-reperfusion. Neutralising activin A by treatment with the activin-binding protein, follistatin
K Plessl et al.
Placenta, 36(4), 365-371 (2015-02-11)
Notch signalling has been shown to control cytotrophoblast (CTB) proliferation, differentiation and motility suggesting that the conserved signalling pathway could be critical for human placental development. Since individual Notch receptors have not been elucidated, we herein investigated expression pattern and
Choline supplementation restores substrate balance and alleviates complications of Pcyt2 deficiency.
Laila C Schenkel et al.
The Journal of nutritional biochemistry, 26(11), 1221-1234 (2015-08-06)
Choline plays a critical role in systemic lipid metabolism and hepatic function. Here we conducted a series of experiments to investigate the effect of choline supplementation on metabolically altered Pcyt2(+/-) mice. In Pcyt2(+/-) mice, the membrane phosphatidylethanolamine (PE) turnover is
James A Carroll et al.
Journal of virology, 89(4), 2388-2404 (2014-12-17)
Gliosis is often a preclinical pathological finding in neurodegenerative diseases, including prion diseases, but the mechanisms facilitating gliosis and neuronal damage in these diseases are not understood. To expand our knowledge of the neuroinflammatory response in prion diseases, we assessed
Marc Hirschfeld et al.
Molecular carcinogenesis, 53(11), 883-892 (2013-06-15)
The ubiquitously expressed splicing factor YT521 (YTHDC1) is characterized by alternatively spliced isoforms with regulatory impact on cancer-associated gene expression. Our recent findings account for the prognostic significance of YT521 in endometrial cancer. In this study, we investigated the hypoxia-dependency
Miljana Tanic et al.
International journal of cancer, 136(3), 593-602 (2014-06-12)
Screening for germline mutations in breast cancer-associated genes BRCA1 and BRCA2 is indicated for patients with breast cancer from high-risk breast cancer families and influences both treatment options and clinical management. However, only 25% of selected patients test positive for
Maria Cekanova et al.
Experimental cell research, 331(1), 1-10 (2014-12-17)
We have previously demonstrated that the anti-apoptotic protein BAD is expressed in normal human breast tissue and shown that BAD inhibits expression of cyclin D1 to delay cell-cycle progression in breast cancer cells. Herein, expression of proteins in breast tissues
Antonietta Rosella Farina et al.
Oncotarget, 6(34), 35636-35651 (2015-09-29)
In human SH-SY5Y neuroblastoma (NB) cells, nascent immature N-glycosylated 110kDa TrkA moves rapidly from the endoplasmic reticulum (ER) to the Golgi Network (GN), where it matures into the 140kDa receptor prior to being transported to the cell surface, creating GN
Qian Liu et al.
Infection and immunity, 83(5), 2168-2174 (2015-03-18)
SasX is a recently described surface protein of Staphylococcus aureus that is linked to the epidemic success of hospital-associated methicillin-resistant clones, in particular in Asia. It enhances nasal colonization and virulence in skin and lung infection models. Here, we evaluated
Dalal Alhashmialameer et al.
Dalton transactions (Cambridge, England : 2003), 44(46), 20216-20231 (2015-11-06)
Lithium and sodium compounds supported by tetradentate amino-bis(phenolato) ligands, [Li2(N2O2(BuBuPip))] (1), [Na2(N2O2(BuBuPip))] (2) (where [N2O2(BuBuPip)] = 2,2'-N,N'-homopiperazinyl-bis(2-methylene-4,6-tert-butylphenol), and [Li2(N2O2(BuMePip))] (3), [Na2(N2O2(BuMePip))] (4) (where [N2O2(BuMePip)] = 2,2'-N,N'-homopiperazinyl-bis(2-methylene-4-methyl-6-tert-butylphenol) were synthesized and characterized by NMR spectroscopy and MALDI-TOF mass spectrometry. Variable temperature NMR
Pratima Chaurasia et al.
The Journal of clinical investigation, 124(6), 2378-2395 (2014-04-26)
Cord blood (CB) cells that express CD34 have extensive hematopoietic capacity and rapidly divide ex vivo in the presence of cytokine combinations; however, many of these CB CD34+ cells lose their marrow-repopulating potential. To overcome this decline in function, we
Caterina Fotia et al.
Cytotechnology, 67(6), 1073-1084 (2014-05-07)
The aim of the study was to obtain the highest number of multipotent adipose-derived mesenchymal stem cells (ADMSCs) by using culture conditions which favour cell expansion without loss of mesenchymal stem cells (MSC)-like properties. Based on the assumption that stem
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