CN
Search Within
47608
应用筛选条件
关键词:'47608'
显示 1-30 共 3075 条结果 关于 "47608" 范围 论文
Maria B Lebron et al.
Cancer biology & therapy, 15(9), 1208-1218 (2014-06-13)
Stem cell factor receptor (c-Kit) exerts multiple biological effects on target cells upon binding its ligand stem cell factor (SCF). Aberrant activation of c-Kit results in dysregulated signaling and is implicated in the pathogenesis of numerous cancers. The development of
Pierre-Yves Collart-Dutilleul et al.
Nanoscale research letters, 9(1), 564-564 (2014-11-12)
The way cells explore their surrounding extracellular matrix (ECM) during development and migration is mediated by lamellipodia at their leading edge, acting as an actual motor pulling the cell forward. Lamellipodia are the primary area within the cell of actin
Lusine Danielyan et al.
Cell transplantation, 23 Suppl 1, S123-S139 (2014-10-11)
In view of the rapid preclinical development of cell-based therapies for neurodegenerative disorders, traumatic brain injury, and tumors, the safe and efficient delivery and targeting of therapeutic cells to the central nervous system is critical for maintaining therapeutic efficacy and
Meng Na et al.
Seizure, 25, 141-146 (2014-12-03)
Surgery is regarded as a common treatment option for patients with mesial temporal lobe epilepsy (MTLE) as a result of hippocampal sclerosis (HS). However, approximately one-third of patients with intractable epilepsy did not become seizure-free after tailored resection strategies. It
Grace Hill et al.
PloS one, 9(11), e112840-e112840 (2014-11-20)
Radiotherapy of head and neck cancers often results in collateral damage to adjacent salivary glands associated with clinically significant hyposalivation and xerostomia. Due to the reduced capacity of salivary glands to regenerate, hyposalivation is treated by substitution with artificial saliva
Jae Ho Jo et al.
Biomedical materials (Bristol, England), 10(4), 045007-045007 (2015-07-15)
This study was undertaken to evaluate the effects of different rhBMP-2 release profiles in defect areas around dental implants on osseointegration and bone regeneration. Four beagle dogs (13-15 kg) were used. The defect was 3 mm deep and there was a 1 mm
Marcin Grąz et al.
Canadian journal of microbiology, 61(8), 545-554 (2015-06-27)
Heavy metals are difficult to remediate and traditional remedial processes are expensive, so bioremediation technology using bacteria, fungi, or plants is of interest. Many studies have demonstrated that basidiomycetes fungi are able to growth under heavy metals stress. In this
Uğur Havlucu et al.
The Journal of oral implantology, 41(4), e110-e117 (2014-04-29)
The present study assesses histopathologically and histomorphometrically the effects of light-emitting diode (LED) photobiomodulation therapy (LPT) on bone healing in BioOss-filled femoral defects of rats. It has been reported that LPT modulates cellular metabolic processes, leading to an enhanced regenerative
Narcy Arizmendi et al.
Respiratory research, 15, 71-71 (2014-06-28)
Pulmonary fibrotic diseases induce significant morbidity and mortality, for which there are limited therapeutic options available. Rac2, a ras-related guanosine triphosphatase expressed mainly in hematopoietic cells, is a crucial molecule regulating a diversity of mast cell, macrophage, and neutrophil functions.
Yan-Min Liu et al.
Oncology reports, 34(6), 2977-2986 (2015-09-16)
Hepatocellular carcinoma (HCC) is an aggressive disease with a poor outcome due to the high incidence of metastasis. Cancer stem cells (CSCs) have been identified to be responsible for tumor progression and may be generated by epithelial-mesenchymal transition (EMT) characteristics.
Li-Yan Zhao et al.
Marine drugs, 13(4), 2306-2326 (2015-04-16)
Our previous studies demonstrated that xyloketal B, a novel marine compound with a unique chemical structure, has strong antioxidant actions and can protect against endothelial injury in different cell types cultured in vitro and model organisms in vivo. The oxidative
C D Katsetos et al.
Archives of pathology & laboratory medicine, 118(6), 633-639 (1994-06-01)
Calbindin-D28k is a highly conserved 28,000 (dalton) molecular-weight (Mr) calcium binding protein with broad tissue distribution, yet cell-type-specific expression predominantly in subpopulations of central and peripheral nervous system neurons, distal tubular cells of the kidney, and enteric neuroendocrine cells. A
Gimano D Amatngalim et al.
Journal of immunology (Baltimore, Md. : 1950), 194(7), 3340-3350 (2015-02-26)
Basal cells play a critical role in the response of the airway epithelium to injury and are recently recognized to also contribute to epithelial immunity. Antimicrobial proteins and peptides are essential effector molecules in this airway epithelial innate immunity. However
Jeff Gobel et al.
Journal of biomolecular screening, 20(6), 729-738 (2015-04-12)
Respiratory syncytial virus (RSV) is a commonly occurring pathogen that can cause severe disease in children, the elderly, and immunocompromised individuals with a large, unmet clinical need. We developed a high-throughput, primary cell-based antiviral RSV assay to enable identification of
Piotr Rytlewski et al.
Materials (Basel, Switzerland), 13(10) (2020-05-16)
Selective metallization of polymeric materials using the technique known as laser direct structuring (LDS) is intensively developed. In this technique, metallized products can be manufactured by injection molding or by 3D printing process if rapid prototyping is need. Special additives
Sang Mi Cho et al.
BioTechniques, 59(1), 34-41 (2015-07-15)
The use of secondary or reprogrammable cells in the production of induced pluripotent stem cells (iPSCs) circumvents random infection by various viral particles and random, uncontrollable integrations of the viral genomes into different genomic loci. We have developed a convenient
Tiha M Long et al.
Infection and immunity, 82(7), 2802-2814 (2014-04-16)
Enteropathogenic Escherichia coli (EPEC) primarily infects children in developing countries and causes diarrhea that can be deadly. EPEC pathogenesis occurs through type III secretion system (T3SS)-mediated injection of effectors into intestinal epithelial cells (IECs); these effectors alter actin dynamics, modulate
Joshua M Barnett et al.
Investigative ophthalmology & visual science, 55(10), 6490-6498 (2014-08-28)
We investigated endoglin expression in hypoxic microvascular endothelial cells and retinal endoglin expression in rats that develop experimental oxygen-induced retinopathy (OIR). We also tested neutralizing antibodies (Abs) against endoglin (anti-CD105 Ab) and VEGF (anti-VEGF Ab) either alone or in combination
Laura A Díaz-Martínez et al.
The EMBO journal, 33(17), 1960-1976 (2014-07-16)
The antimitotic anti-cancer drugs, including taxol, perturb spindle dynamics, and induce prolonged, spindle checkpoint-dependent mitotic arrest in cancer cells. These cells then either undergo apoptosis triggered by the intrinsic mitochondrial pathway or exit mitosis without proper cell division in an
O Chudomel et al.
Neurochemical research, 40(4), 747-757 (2015-02-04)
Previous studies have shown that the pharmacologic effects of GABAergic drugs and the postsynaptic phasic GABAAergic inhibitory responses in the anterior part of the rat substantia nigra pars reticulata (SNRA) are age- and sex-specific. Here, we investigate whether there are
Edyta Bajak et al.
Toxicology letters, 233(2), 187-199 (2014-12-20)
Higher efficacy and safety of nano gold therapeutics require examination of cellular responses to gold nanoparticles (AuNPs). In this work we compared cellular uptake, cytotoxicity and RNA expression patterns induced in Caco-2 cells exposed to AuNP (5 and 30nm). Cellular
David P W Rastall et al.
International immunology, 26(12), 685-695 (2014-08-05)
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a critical component of the adaptive immune system that has been shown to increase or decrease the presentation of specific peptides on MHC class I molecules. Here, we have demonstrated that ERAP1 functions are
Jeffrey P Murry et al.
Virology, 471-473, 1-12 (2014-10-14)
Long-lived pools of latently infected cells are a significant barrier to the development of a cure for HIV-1 infection. A better understanding of the mechanisms of reactivation from latency is needed to facilitate the development of novel therapies that address
Alberto Nilo et al.
ACS chemical biology, 10(7), 1737-1746 (2015-04-24)
Gram-positive Streptococcus agalactiae or group B Streptococcus (GBS) is a leading cause of invasive infections in pregnant women, newborns, and elderly people. Vaccination of pregnant women represents the best strategy for prevention of neonatal disease, and GBS polysaccharide-based conjugate vaccines
Chenghe Wang et al.
FEBS letters, 588(24), 4654-4664 (2014-12-03)
We have previously reported that synthetic dsRNA can activate p21 expression by targeting the p21 promoter, thereby suppressing the proliferation of human bladder cancer cells. As complementarity between dsRNA and its target sequences is necessary for RNA activation, miRNAs may
Akito Takeuchi et al.
Bulletin of environmental contamination and toxicology, 79(1), 1-4 (2007-07-10)
Formaldehyde is a carcinogen to which humans are exposed daily, but few methods are available to quantify formaldehyde in biological samples. We developed a simple, sensitive and rapid technique for the quantification of formaldehyde in urine by derivatization with O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine
Somiraa S Said et al.
Pharmaceutical research, 31(12), 3335-3347 (2014-05-24)
For building functional vasculature, controlled delivery of fibroblast growth factor-9 (FGF9) from electrospun fibers is an appealing strategy to overcome challenges associated with its short half-life. FGF9 sustained delivery could potentially drive muscularization of angiogenic sprouts and help regenerate stable
Andy C-M Chang et al.
Clinical & experimental metastasis, 32(1), 15-27 (2014-11-14)
Stanniocalcin-1 (STC1) is a secreted glycoprotein implicated in several pathologies including retinal degeneration, cerebral ischemia, angiogenesis and inflammation. Aberrant STC1 expression has been reported in breast cancer but the significance of this is not clear. High levels of STC1 expression
Shuxun Ren et al.
PloS one, 9(11), e111606-e111606 (2014-11-05)
We recently reported that the PPM1l gene encodes an endoplasmic reticulum (ER) membrane targeted protein phosphatase (named PP2Ce) with highly specific activity towards Inositol-requiring protein-1 (IRE1) and regulates the functional outcome of ER stress. In the present report, we found
K R Kampen et al.
Molecular cancer research : MCR, 13(6), 982-992 (2015-05-07)
Loss of ephrin receptor (EphB1) expression may associate with aggressive cancer phenotypes; however, the mechanism of action remains unclear. To gain detailed insight into EphB1 function in acute myelogenous leukemia (AML), comprehensive analysis of EphB1 transcriptional regulation was conducted. In
1/103