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Maria B Lebron et al.
Cancer biology & therapy, 15(9), 1208-1218 (2014-06-13)
Stem cell factor receptor (c-Kit) exerts multiple biological effects on target cells upon binding its ligand stem cell factor (SCF). Aberrant activation of c-Kit results in dysregulated signaling and is implicated in the pathogenesis of numerous cancers. The development of
Jae Ho Jo et al.
Biomedical materials (Bristol, England), 10(4), 045007-045007 (2015-07-15)
This study was undertaken to evaluate the effects of different rhBMP-2 release profiles in defect areas around dental implants on osseointegration and bone regeneration. Four beagle dogs (13-15 kg) were used. The defect was 3 mm deep and there was a 1 mm
Somayeh Jamali et al.
Scientific reports, 5, 13605-13605 (2015-09-05)
The most aggressive tumour cells, which often reside in hypoxic environments, rely on glycolysis for energy production. Thereby they release vast amounts of lactate and protons via monocarboxylate transporters (MCTs), which exacerbates extracellular acidification and supports the formation of a
Young-Jun Kim et al.
PLoS genetics, 11(2), e1004988-e1004988 (2015-02-28)
Stabilization of neurotransmitter receptors at postsynaptic specializations is a key step in the assembly of functional synapses. Drosophila Neto (Neuropillin and Tolloid-like protein) is an essential auxiliary subunit of ionotropic glutamate receptor (iGluR) complexes required for the iGluRs clustering at
Silvia Pellegrini et al.
Acta diabetologica, 52(6), 1025-1035 (2015-03-04)
New sources of insulin-secreting cells are strongly required for the cure of diabetes. Recent successes in differentiating embryonic stem cells, in combination with the discovery that it is possible to derive human induced pluripotent stem cells (iPSCs) from somatic cells
Meng Na et al.
Seizure, 25, 141-146 (2014-12-03)
Surgery is regarded as a common treatment option for patients with mesial temporal lobe epilepsy (MTLE) as a result of hippocampal sclerosis (HS). However, approximately one-third of patients with intractable epilepsy did not become seizure-free after tailored resection strategies. It
Grace Hill et al.
PloS one, 9(11), e112840-e112840 (2014-11-20)
Radiotherapy of head and neck cancers often results in collateral damage to adjacent salivary glands associated with clinically significant hyposalivation and xerostomia. Due to the reduced capacity of salivary glands to regenerate, hyposalivation is treated by substitution with artificial saliva
Narcy Arizmendi et al.
Respiratory research, 15, 71-71 (2014-06-28)
Pulmonary fibrotic diseases induce significant morbidity and mortality, for which there are limited therapeutic options available. Rac2, a ras-related guanosine triphosphatase expressed mainly in hematopoietic cells, is a crucial molecule regulating a diversity of mast cell, macrophage, and neutrophil functions.
Yan-Min Liu et al.
Oncology reports, 34(6), 2977-2986 (2015-09-16)
Hepatocellular carcinoma (HCC) is an aggressive disease with a poor outcome due to the high incidence of metastasis. Cancer stem cells (CSCs) have been identified to be responsible for tumor progression and may be generated by epithelial-mesenchymal transition (EMT) characteristics.
Pierre-Yves Collart-Dutilleul et al.
Nanoscale research letters, 9(1), 564-564 (2014-11-12)
The way cells explore their surrounding extracellular matrix (ECM) during development and migration is mediated by lamellipodia at their leading edge, acting as an actual motor pulling the cell forward. Lamellipodia are the primary area within the cell of actin
Lusine Danielyan et al.
Cell transplantation, 23 Suppl 1, S123-S139 (2014-10-11)
In view of the rapid preclinical development of cell-based therapies for neurodegenerative disorders, traumatic brain injury, and tumors, the safe and efficient delivery and targeting of therapeutic cells to the central nervous system is critical for maintaining therapeutic efficacy and
Joshua M Barnett et al.
Investigative ophthalmology & visual science, 55(10), 6490-6498 (2014-08-28)
We investigated endoglin expression in hypoxic microvascular endothelial cells and retinal endoglin expression in rats that develop experimental oxygen-induced retinopathy (OIR). We also tested neutralizing antibodies (Abs) against endoglin (anti-CD105 Ab) and VEGF (anti-VEGF Ab) either alone or in combination
Li-Yan Zhao et al.
Marine drugs, 13(4), 2306-2326 (2015-04-16)
Our previous studies demonstrated that xyloketal B, a novel marine compound with a unique chemical structure, has strong antioxidant actions and can protect against endothelial injury in different cell types cultured in vitro and model organisms in vivo. The oxidative
Carole J Kuehl et al.
PloS one, 9(11), e112738-e112738 (2014-11-19)
Shigella flexneri is a human pathogen that triggers its own entry into intestinal cells and escapes primary vacuoles to gain access to the cytosolic compartment. As cytosolic and motile bacteria encounter the cell cortex, they spread from cell to cell
Rina Ulmansky et al.
Journal of immunology (Baltimore, Md. : 1950), 194(11), 5103-5109 (2015-04-24)
We have previously shown that naturally occurring as well as acquired Abs against the Mycobacterium tuberculosis heat shock protein (HSP)65 protect against the induction of murine autoimmune inflammatory arthritis. In the present work, we have studied the anti-inflammatory effect of
Edgar Holznagel et al.
The Journal of infectious diseases, 212(9), 1459-1468 (2015-04-22)
Protease-resistant prion protein (PrP(res)) accumulation in lymphoreticular tissues indicates prion infection. To date, tonsillectomy and appendectomy samples have been used in population prevalence surveys to detect clinically silent carriers of variant Creutzfeldt-Jakob disease (vCJD). However, the temporal sequence of prion
An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells.
A Tito et al.
International journal of cosmetic science, 37(6), 588-594 (2015-05-06)
Raspberry plants, belonging to the species of Rubus idaeus, are known for their excellent therapeutic properties as they are particularly rich in compounds with strong antioxidant activity, which promote health and well-being of human cells. Besides their high content of
Francesco Napoletano et al.
Cell reports, 36(11), 109694-109694 (2021-09-16)
Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer's disease (AD) and cancer. However, the mechanisms governing heterochromatin
Chrissy M Leopold Wager et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 4060-4071 (2014-09-10)
Nonprotective immune responses to highly virulent Cryptococcus neoformans strains, such as H99, are associated with Th2-type cytokine production, alternatively activated macrophages, and inability of the host to clear the fungus. In contrast, experimental studies show that protective immune responses against
Matthias Preusser et al.
European journal of cancer (Oxford, England : 1990), 51(13), 1803-1811 (2015-07-15)
Brain metastases (BM) are a life-threatening complication. We aimed to analyse gene mutations in lung adenocarcinoma BM. We performed next generation sequencing (NGS) of a pre-defined set of 48 cancer-related genes in a cohort of 76 neurosurgical lung adenocarcinoma BM
H Lee et al.
Mucosal immunology, 8(5), 1083-1098 (2015-02-12)
Intranasal (i.n.) vaccination generates immunity across local, regional, and distant sites. However, nasal dendritic cells (DCs), pivotal for the induction of i.n. vaccine-induced immune responses, have not been studied in detail. Here, by using a variety of parameters, we define
Danil I Peregud et al.
Neurochemical research, 40(1), 130-138 (2014-11-14)
Brain-derived neurotrophic factor (BDNF) is believed to play a crucial role in the mechanisms underlying opiate dependence; however, little is known about specific features and mechanisms regulating its expression in the brain under these conditions. The aim of this study
Cinzia Cordazzo et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(7), 539-547 (2014-03-07)
Microparticles are membrane vesicles shed by cells upon activation and apoptosis. Agonists capable of inducing microparticle generation include cytokines, bacterial products, P-selectin, histamine. Cigarette smoke extract has also been recognized as an agonist involved in microparticle generation with an apoptosis-dependent
Hyung Joon Kim et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(44), 14872-14884 (2015-11-06)
RE-1 silencing transcription factor (REST), a master negative regulator of neuronal differentiation, controls neurogenesis by preventing the differentiation of neural stem cells. Here we focused on the role of REST in the early steps of differentiation and maturation of adult
Patrick W Howorth et al.
The Journal of comparative neurology, 512(2), 141-157 (2008-11-13)
The spinal dorsal horn receives a dense innervation of noradrenaline-containing fibers that originate from pontine neurons in the A5, locus coeruleus (LC), and A7 cell groups. These pontospinal neurons are believed to constitute a component of the endogenous analgesic system.
Aline Pic-Taylor et al.
Behavioural processes, 118, 102-110 (2015-06-07)
Ayahuasca, a psychoactive beverage used by indigenous and religious groups, is generally prepared by the coction of Psychotria viridis and Banisteriopsis caapi plants containing N,N-dimethyltryptamine (DMT) and β-carboline alkaloids, respectively. To investigate the acute toxicity of ayahuasca, the infusion was
Zhihao Ding et al.
PLoS genetics, 10(11), e1004798-e1004798 (2014-11-21)
Associating genetic variation with quantitative measures of gene regulation offers a way to bridge the gap between genotype and complex phenotypes. In order to identify quantitative trait loci (QTLs) that influence the binding of a transcription factor in humans, we
Panfeng Fu et al.
American journal of physiology. Lung cellular and molecular physiology, 308(10), L1025-L1038 (2015-03-22)
Paxillin is phosphorylated at multiple residues; however, the role of tyrosine phosphorylation of paxillin in endothelial barrier dysfunction and acute lung injury (ALI) remains unclear. We used siRNA and site-specific nonphosphorylable mutants of paxillin to abrogate the function of paxillin
Edward T Richardson et al.
Infection and immunity, 83(6), 2242-2254 (2015-03-18)
Mycobacterium tuberculosis survives within macrophages and employs immune evasion mechanisms to persist in the host. Protective T helper type 1 (Th1) responses are induced, and the immune response in most individuals is sufficient to restrict M. tuberculosis to latent infection
Nagham Asp et al.
Biochimica et biophysica acta, 1843(9), 1987-1996 (2014-04-22)
The ErbB3 receptor is an important regulator of cell growth and carcinogenesis. Among breast cancer patients, up to 50-70% have ErbB3 overexpression and 20-30% show overexpressed or amplified ErbB2. ErbB3 has also been implicated in the development of resistance to
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