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Jun Iwamoto et al.
Expert opinion on pharmacotherapy, 14(4), 449-458 (2013-01-26)
The effect of the anti-osteoporosis medicine, menatetrenone (vitamin K(2); menaquinone-4) on the skeleton remains a matter of controversy. The objective of the present review study was to evaluate the effect of menatetrenone on the skeleton of postmenopausal women, men and
Norio Iinuma
Clinical calcium, 15(6), 1034-1039 (2005-06-03)
Vitamin K2 (menatetrenone) treatment was reported to significantly prevent new clinical fracture (chi2 = 10.935;p = 0.0273) in a 2-year group comparison study of patients with osteoporosis, although it only maintained the baseline bone mineral density. This result strongly suggested
Takayuki Hosoi
Clinical calcium, 17(11), 1727-1730 (2007-11-06)
Menatetrenone (MK-4) is a form of vitamin K(2) (VK(2)) which is utilized for the treatment of osteoporosis. MK4 has a grade B as a total recommendation rate in the Japanese guideline for the prevention and treatment of osteoporosis in 2006
Sherry M Farley et al.
Molecular nutrition & food research, 56(6), 912-922 (2012-06-19)
The mechanism for increased bleeding and decreased vitamin K status accompanying vitamin E supplementation is unknown. We hypothesized that elevated hepatic α-tocopherol (α-T) concentrations may stimulate vitamin K metabolism and excretion. Furthermore, α-T may interfere with the side chain removal
Mariko Ochiai et al.
Nephron. Clinical practice, 117(1), c15-c19 (2010-08-07)
A low level of intact parathyroid hormone (PTH) is an indicator of adynamic bone disease in hemodialysis patients, and is associated with a significant increase of all-cause mortality. Thus, effective treatment for adynamic bone disease is required. We previously investigated
Makoto Otsuka et al.
Colloids and surfaces. B, Biointerfaces, 85(2), 338-342 (2011-04-05)
A biodegradable drug delivery system with perforated macro pores was established using an apatite/collagen composite cement containing menatetrenone (VK2). The drug-release capabilities of the device were investigated in vitro under osteoblast and osteoclast-like conditions (SOB and SOC). A bulk powder
Ala Al Rajabi et al.
The Journal of nutrition, 142(5), 841-845 (2012-03-23)
Phylloquinone (PK) is converted into menaquinone-4 (MK-4) via side chain removal-addition. Stable isotope use is an effective approach to identify the tissue location of this conversion, which is currently unknown. Following a 14-d PK-deficient diet, male Fischer 344 rats (8
Akihiko Tsuchida et al.
Hepato-gastroenterology, 58(106), 290-297 (2011-06-15)
Pancreaticobiliary maljunction (PBM) is a high risk factor of biliary tract cancer. The chemopreventive effects of Vitamin K2 (menaquinone-4: MK4) in a hamster PBM model were investigated. The extrahepatic bile duct at the distal end of the common duct was
Fumiaki Hanzawa et al.
The Journal of nutrition, 143(7), 1067-1073 (2013-05-24)
We have shown that intake of sesame seed and its lignan increases vitamin E concentrations and decreases urinary excretion levels of vitamin E metabolites in male Wistar rats, suggesting inhibition of vitamin E catabolism by sesame lignan. The aim of
T Terachi et al.
Journal of animal science, 89(4), 1056-1061 (2010-12-21)
The effect of several vitamin K homologs on plasma vitamin K concentration was determined to assess their potential as a vitamin K supplement for adult horses. Sixteen Thoroughbred horses consisting of 8 mares and 8 geldings, aged 8.4 ± 3.6
Mitsuru Ishizuka et al.
Anticancer research, 32(12), 5415-5420 (2012-12-12)
The aim of this study was to investigate whether menatetrenone (MNT) suppresses hepatocellular carcinoma (HCC) recurrence in patients undergoing hepatectomy. Between January 2005 and September 2009, 101 patients who underwent curative hepatectomy for primary HCC were enrolled in the study.
Effects of menatetrenone on bone loss induced by ovariectomy in rats.
Akiyama Y, et al.
Japanese Journal of Pharmacology, 62(2), 145-153 (1993)
Jun Iwamoto et al.
Calcified tissue international, 87(3), 254-262 (2010-06-18)
The purpose of the present study was to examine the effects of vitamin K2 on cortical and cancellous bone mass, cortical osteocyte and lacunar system, and porosity in sciatic neurectomized rats. Thirty-four female Sprague-Dawley retired breeder rats were randomized into
Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma.
Kang W, et al.
Journal of Pharmaceutical and Biomedical Analysis, 44(5), 1178-1182 (2007)
Cathrine Arnason Bøe et al.
Frontiers in bioengineering and biotechnology, 8, 191-191 (2020-04-08)
Cheese produced with Lactococcus lactis is the main source of vitamin K2 in the Western diet. Subclinical vitamin K2 deficiency is common, calling for foods with enhanced vitamin K2 content. In this study we describe analyses of vitamin K2 (menaquinone)
Gilbert R Kaats et al.
International journal of medical sciences, 8(3), 180-191 (2011-03-31)
The US Surgeon General's Report on Bone Health suggests America's bone-health is in jeopardy and issued a "call to action" to develop bone-health plans incorporating components of (1) improved nutrition, (2) increased health literacy, and (3) increased physical activity. To
Michael L Nickerson et al.
Human mutation, 34(2), 317-329 (2012-11-22)
Schnyder corneal dystrophy (SCD) is an autosomal dominant disease characterized by germline variants in UBIAD1 introducing missense alterations leading to deposition of cholesterol in the cornea, progressive opacification, and loss of visual acuity. UBIAD1 was recently shown to synthesize menaquinone-4
Kazuo Kojima et al.
Hepato-gastroenterology, 57(102-103), 1264-1267 (2011-03-18)
Hepatocellular carcinoma occurs frequently in cirrhosis related to hepatitis C virus (type C cirrhosis), and preventative treatment with interferon is costly and likely to cause adverse reactions. Menatetrenone, a vitamin K2 preparation, has recently been reported to inhibit the posttreatment
Jun Iwamoto et al.
Clinical drug investigation, 29(7), 471-479 (2009-06-09)
Patients with neurological diseases such as Alzheimer's disease, stroke and Parkinson's disease have been reported to have vitamin K deficiency secondary to malnutrition, which increases the risk of non-vertebral and hip fractures. The purpose of the present study was to
Peter F Schnatz et al.
Journal of women's health (2002), 21(8), 858-864 (2012-06-14)
This study analyzed associations between plasma vitamin D(3) (25OHD(3)) and bone mineral density (BMD) and whether the effects of conjugated equine estrogens (CEE) on BMD are modulated by 25OHD(3). Fifty cynomolgus monkeys were fed a diet containing 25OHD(3) (providing a
Pornpimol Rianthavorn et al.
Journal of pediatric endocrinology & metabolism : JPEM, 25(3-4), 307-312 (2012-07-10)
Long-term treatment with glucocorticoids can induce bone loss and increase fracture risks. To compare the efficacy of a 12-month treatment between alfacalcidol and menatetrenone in preventing bone loss in children treated with long-term glucocorticoids. Twenty children on a stable dosage
Vitamin K2 (menatetrenone) inhibits bone loss induced by prednisolone partly through enhancement of bone formation in rats.
Hara K, et al.
Bone, 31(5), 575-581 (2002)
Natsuko Sogabe et al.
Bone, 48(5), 1036-1042 (2011-02-08)
Vitamin K is a cofactor for γ-glutamyl carboxylase, which is an essential enzyme for the γ-carboxylation of vitamin K-dependent proteins such as osteocalcin and matrix Gla protein. Although it has been suggested that vitamin K plays an important role in
I H Baek et al.
Journal of clinical pharmacy and therapeutics, 36(3), 390-398 (2011-05-07)
This study aimed to model the atypical absorption of menatetrenone and its epoxide metabolite and to examine the influence of the single nucleotide polymorphism (SNP) of vitamin K2 epoxide reductase complex subunit 1 (VKORC1) on the pharmacokinetics. After the administration
Yoshitomo Suhara et al.
Journal of medicinal chemistry, 55(4), 1553-1558 (2012-01-19)
We synthesized new vitamin K analogues with demethylation or reduction of the double bonds of the side chain of menaquinone-4 (MK-4) and evaluated their SXR-mediated transcriptional activity as well as the extent of their conversion to MK-4. The results indicated
Fengsen Duan et al.
Scientific reports, 10(1), 7714-7714 (2020-05-10)
Vitamin K2 has been shown to exert remarkable anticancer activity. However, the detailed mechanism remains unclear. Here, our study was the first to show that Vitamin K2 significantly promoted the glycolysis in bladder cancer cells by upregulating glucose consumption and
Wei-Jie Wu et al.
Journal of medicinal food, 17(12), 1298-1305 (2014-09-27)
The effect of dietary vitamin K2 (menaquinone-7, MK-7) and cheonggukjang (CGJ) on the prevention of ovariectomy (OVX)-induced bone loss was studied in rats. Female Sprague-Dawley rats were divided into eight groups: sham-operated; OVX control; OVX treated with MK-7 at doses
Erin D Lew et al.
eLife, 3 (2014-09-30)
The TAM receptor tyrosine kinases Tyro3, Axl, and Mer regulate key features of cellular physiology, yet the differential activities of the TAM ligands Gas6 and Protein S are poorly understood. We have used biochemical and genetic analyses to delineate the
Pinkesh G Sutariya et al.
Talanta, 147, 590-597 (2015-11-26)
A new, simple, ultra-sensitive and selective approach has been reported for the "on spot" colorimetric detection of creatinine based on calix[4]arene functionalized gold nanoparticles (AuNPs) with excellent discrimination in the presence of other biomolecules. The lower detection limit of the
Katheryne Z Edson et al.
Biochemistry, 52(46), 8276-8285 (2013-10-22)
Vitamin K plays an essential role in many biological processes including blood clotting, maintenance of bone health, and inhibition of arterial calcification. A menaquinone form of vitamin K, MK4, is increasingly recognized for its key roles in mitochondrial electron transport
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