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Peter F Infante et al.
International journal of occupational and environmental health, 15(1), 36-42 (2009-03-10)
Two cases of angiosarcoma of the liver (ASL) are, to the best of our knowledge, the first literature reports of such cases identified among hairdressers and barbers who used hair sprays containing vinyl chloride (VC) as a propellant. The cases
J Kielhorn et al.
Environmental health perspectives, 108(7), 579-588 (2000-07-25)
Vinyl chloride (VC) is both a known carcinogen and a regulated chemical, and its production capacity has almost doubled over the last 20 years, currently 27 million tons/year worldwide. According to recent reports it is still a cause for concern.
Qi Wang et al.
International journal of hygiene and environmental health, 216(1), 76-81 (2012-03-20)
In this study, we estimated the possibility of using benchmark dose (BMD) to assess the dose-response relationship between vinyl chloride monomer (VCM) exposure and chromosome damage. A group of 317 workers occupationally exposed to vinyl chloride monomer and 166 normal
Vinyl chloride monomer and hepatocarcinoma.
N Bourgeois
Acta gastro-enterologica Belgica, 64(1), 25-34 (2001-04-27)
J Phillip Kaiser et al.
International journal of toxicology, 31(6), 551-563 (2012-12-01)
Liver disease is a major health issue characterized by several pathological changes, with steatosis (fatty liver) representing a common initial step in its pathogenesis. Steatosis is of critical importance because prevention of fatty liver can obviate downstream pathologies of liver
Fang Ji et al.
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 29(8), 583-588 (2012-02-18)
To explore the association between chromosomal damage induced by vinyl chloride monomer (VCM) and polymorphisms of xenobiotic metabolism genes and DNA repair genes. Cytokinesis-block micronucleus (CBMN) test was performed to detect chromosomal damage in peripheral lymphocytes of 402 VCM-exposed workers.
R Lewis
Occupational medicine (Philadelphia, Pa.), 14(4), 719-742 (1999-09-25)
Polyvinyl chloride (PVC) is an important plastic resin for construction, pipe and tubing, siding, and other uses. Exposures to vinyl chloride monomer during the early years of production resulted in an important sentinel health event: the recognition of an excess
H J Clewell et al.
Chemosphere, 31(1), 2561-2578 (1995-07-01)
Risk assessments for vinyl chloride (VC) and trichloroethylene (TCE) are presented as examples of approaches for incorporating chemical-specific pharmacokinetic and mechanistic information into a more scientifically plausible cancer risk assessment. For VC, the evidence regarding mode of action includes direct
Elisa Frullanti et al.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 44(9), 775-779 (2012-03-24)
It has been proposed that vinyl chloride exposure is associated with increased risk of death from cirrhosis, although epidemiologic evidence is limited. We analyzed the risk of death from cirrhosis by occupational vinyl chloride exposure by conducting a meta-analysis on
Replication of N2,3-ethenoguanine by DNA polymerases.
Linlin Zhao et al.
Angewandte Chemie (International ed. in English), 51(22), 5466-5469 (2012-04-11)
Kimberly Brinker et al.
MMWR. Morbidity and mortality weekly report, 63(53), 1233-1237 (2015-01-13)
On November 30, 2012, at approximately 7:00 am, a freight train derailed near a small town in New Jersey. Four tank cars, including a breached tank car carrying vinyl chloride, landed in a tidal creek. Vinyl chloride, a colorless gas
G M Bodienkova et al.
Meditsina truda i promyshlennaia ekologiia, (3)(3), 21-27 (2013-06-22)
This paper considers the features of disorders of immunity in chronic exposure to vinyl chloride at work and in experimental animals. It is shown that one of the earliest and most sensitive indicators of the formation of the resistance of
Young-Soo Han et al.
Water research, 46(19), 6339-6350 (2012-10-09)
Abiotic degradation of cis-dichloroethylene (cis-DCE) and vinyl chloride (VC) was investigated using Fe hydroxides obtained by hydrolyzing Fe(II) salts over a pH range of 7.7-8.0. Within this narrow pH range, a green rust (GR) precipitated. The dechlorination reactivity of the
J A Swenberg et al.
IARC scientific publications, (150)(150), 29-43 (2000-01-08)
Vinyl chloride is a known human and animal carcinogen that induces angiosarcomas of the liver. We review here studies on the formation and repair of DNA adducts associated with vinyl chloride and vinyl fluoride in exposed and control rodents and
Marek Tobiszewski et al.
Environmental science and pollution research international, 19(6), 1994-2006 (2012-02-02)
Chlorinated ethanes and ethenes are among the most frequently detected organic pollutants of water. Their physicochemical properties are such that they can contaminate aquifers for decades. In favourable conditions, they can undergo degradation. In anaerobic conditions, chlorinated solvents can undergo
Intratec Solutions
Vinyl Chloride Production from Ethylene Dichloride - Cost Analysis - VCM E11A (2016)
Kelly E Fletcher et al.
Water research, 45(20), 6625-6636 (2011-11-04)
Thermal treatment is capable of removing significant free-phase chlorinated solvent mass while potentially enhancing bioremediation effectiveness by establishing temperature gradients in the perimeter of the source zone and by increasing electron donor availability. The objectives of this study were to
Qi Wang et al.
Mutation research, 754(1-2), 7-14 (2013-04-09)
In this study, a group of 317 workers occupationally exposed to vinyl chloride monomer and 166 normal, unexposed referents in Shandong province (Northern China) were examined for chromosomal damage in peripheral lymphocytes using the cytokinesis-blocked micronucleus (CB-MN) assay. The exposure
J Whysner et al.
Pharmacology & therapeutics, 71(1-2), 7-28 (1996-01-01)
Vinyl chloride produced several tumor types among species. Angiosarcoma of the liver is found in all tested species, including humans with occupational exposures. Vinyl chloride is biotransformed by CYP2E1 to DNA-reactive chloroethylene oxide producing cyclic etheno adducts, which are mutagenic.
Ashish Thakur et al.
Chemical communications (Cambridge, England), 48(2), 203-205 (2011-11-16)
A protocol for the Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides that minimizes protodeboronation is described. A combination of catalytic amounts of Pd(OAc)(2) and SPhos in conjunction with CsF in isopropanol effectively affords a variety of coupled products.
Underestimating risk for three important human carcinogens: vinyl chloride, benzene, and butadiene.
M S Legator
Annals of the New York Academy of Sciences, 837, 170-175 (1998-02-24)
V J Cogliano et al.
Toxicology, 111(1-3), 21-28 (1996-07-17)
Complementary sources of information are analyzed to characterize the early-life cancer risk from inhaling vinyl chloride. A study of partial-lifetime exposures suggests that the lifetime cancer risk depends on age at exposure, with higher lifetime risks attributable to exposures at
Eugenia Dogliotti
Annali dell'Istituto superiore di sanita, 42(2), 163-169 (2006-10-13)
In 1974 vinyl chloride (VC), a gas used in the plastics industry, was shown to be a human carcinogen, inducing a very rare type of tumor, angiosarcoma of the liver. The same type of tumor was induced in rodents exposed
Morris Sherman
Journal of hepatology, 51(6), 1074-1081 (2009-10-20)
Vinyl chloride monomer is a known cause of angiosarcoma of the liver. It also has other toxic effects on the liver, and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. However, the data on
Yu-lan Qiu et al.
Journal of occupational and environmental medicine, 53(12), 1442-1446 (2011-11-15)
To evaluate the expressions of p53, p21, and CCND1 in the peripheral blood lymphocytes of vinyl chloride monomer (VCM)-exposed workers and potential relationships with their exposures, polymorphisms, and chromosomal aberrations. The study was performed on 77 occupationally VCM-exposed workers and
Catalysis: The accelerator.
Mark Peplow
Nature, 495(7440), S10-S11 (2013-03-15)
Esra Mutlu et al.
Chemical research in toxicology, 25(2), 391-399 (2012-01-04)
Vinyl chloride (VC) is an industrial chemical that is known to be carcinogenic to animals and humans. VC primarily induces hepatic angiosarcomas following high exposures (≥50 ppm). VC is also found in Superfund sites at ppb concentrations as a result
Christ De Rooij et al.
Environmental monitoring and assessment, 97(1-3), 57-67 (2004-09-21)
This risk assessment on vinyl chloride was carried out specifically for the marine environment, according to the methodology laid down in the European Union (EU) risk assessment Regulation (1488/94) and the Technical Guidance Documents for New and Existing Substances (TGD
Richard Albertini et al.
Regulatory toxicology and pharmacology : RTP, 37(1), 105-132 (2003-03-29)
The estimation and characterization of a cancer risk is grounded in the observation of tumors in humans and/or experimental animals. Increasingly, however, other kinds of data (non-tumor data) are finding application in cancer risk assessment. Metabolism and kinetics, adduct formation
Iridium-catalyzed chemoselective and enantioselective hydrogenation of (1-chloro-1-alkenyl) boronic esters.
Ivana Gazić Smilović et al.
Angewandte Chemie (International ed. in English), 51(4), 1014-1018 (2011-12-20)
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