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Yanzhong Yang et al.
Nature communications, 6, 6428-6428 (2015-03-05)
The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two spliceosome-associated proteins-SAP145 and SAP49-as PRMT9-binding partners, linking PRMT9 to U2 snRNP maturation.
Zhuo Zhang et al.
Oncotarget, 5(23), 12383-12397 (2014-12-05)
The potential utility of circulating tumor cells (CTCs) to guide clinical care in oncology patients has gained momentum with emerging micro- and nanotechnologies. Establishing the role of CTCs in tumor progression and metastasis depends both on enumeration and on obtaining
Ling Rao et al.
Dalton transactions (Cambridge, England : 2003), 43(35), 13343-13348 (2014-07-30)
Polyethylene glycol (PEG) modified BaLuF5:Gd/Yb/Er upconversion nanoparticles (UCNPs) were synthesized by a facile one-pot hydrothermal method for simultaneous synthesis and surface functionalization. The novel, excellently biocompatible and water-soluble bioprobes were used for simultaneous upconversion (UC) luminescence and X-ray bioimaging for
Olatz Arteaga et al.
PloS one, 10(11), e0142424-e0142424 (2015-11-07)
Despite advances in neonatal care, hypoxic-ischemic brain injury is still a serious clinical problem, which is responsible for many cases of perinatal mortality, cerebral palsy, motor impairment and cognitive deficits. Resveratrol, a natural polyphenol with important anti-oxidant and anti-inflammatory properties
Plant science. Best practices for biofuels.
Heather Youngs et al.
Science (New York, N.Y.), 344(6188), 1095-1096 (2014-06-07)
Riza-Arief Putranto et al.
PloS one, 10(4), e0123618-e0123618 (2015-04-24)
Tolerance of recurrent mechanical wounding and exogenous ethylene is a feature of the rubber tree. Latex harvesting involves tapping of the tree bark and ethephon is applied to increase latex flow. Ethylene is an essential element in controlling latex production.
Akira Kotani et al.
Journal of pharmaceutical and biomedical analysis, 97, 47-53 (2014-05-13)
The effects of hyperglycemia on the pharmacokinetics of valproic acid (VPA) were examined by time-concentration profiles of plasma VPA accompanied with blood glucose (BG) changing. In addition, time-concentration profiles of plasma free fatty acids (FFAs) were also obtained to examine
Ning Ding et al.
International journal of oncology, 44(6), 2139-2145 (2014-03-22)
Because K-Ras mutation and cyclooxygenase-2 (COX-2) overexpression are hallmarks of majority of pancreatic cancer patients, an approach to inhibit the progression and growth of pancreatic cancer using the simultaneous administration of agents that inhibit the function of both targets, should
Yunfei Zhan et al.
Experimental and therapeutic medicine, 9(1), 11-16 (2014-12-03)
Pulmonary tuberculosis (PTB) is a high burden infectious disease in China. The immune function is damaged in patients with diabetes mellitus (DM) who are easy to infect with
Taomin Huang et al.
Talanta, 147, 501-509 (2015-11-26)
To the best of our knowledge, this study is the first to successfully apply a novel, highly selective enrichment technique based on boronic acid-functionalized core-shell magnetic microspheres (BA-Fe3O4@SiO2-Au@mSiO2) with a large surface area and uniform pore size, to determine the
Luisa Del Río-Ospina et al.
BMC cancer, 15, 100-100 (2015-04-18)
Analysing human papillomavirus (HPV) viral load is important in determining the risk of developing cervical cancer (CC); most knowledge to date regarding HPV viral load and cervical lesions has been related to HPV-16. This study evaluated the association between the
Wesam Salem et al.
International journal of medical microbiology : IJMM, 305(1), 85-95 (2014-12-04)
Vibrio cholerae and enterotoxic Escherichia coli (ETEC) remain two dominant bacterial causes of severe secretory diarrhea and still a significant cause of death, especially in developing countries. In order to investigate new effective and inexpensive therapeutic approaches, we analyzed nanoparticles
Christof Kaltenmeier et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3768-3777 (2015-03-18)
IL-21 can induce both plasma cells and regulatory B cells. In this article, we demonstrate that untreated HIV patients display CD4(+) T cells with enhanced IL-21 expression and high in vivo frequencies of regulatory B cells overexpressing the serine protease
S Li et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(7), 962-970 (2014-04-25)
Although without evidence of organic structural abnormalities, pain or discomfort is a prominent symptom of functional dyspepsia and considered to reflect visceral hypersensitivity whose underlying mechanism is poorly understood. Here, we studied electrophysiological properties and expression of voltage-gated potassium channels
A B Knudsen et al.
Scandinavian journal of medicine & science in sports, 25(1), e116-e123 (2014-04-11)
The myotendinous junction (MTJ) is a specialized structure in the musculotendinous system, where force is transmitted from muscle to tendon. Animal models have shown that the MTJ takes form of tendon finger-like processes merging with muscle tissue. The human MTJ
Sarah E Latchney et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 5059-5071 (2015-08-20)
Myocyte enhancer factor (Mef)-2 transcription factors are implicated in activity-dependent neuronal processes during development, but the role of MEF2 in neural stem/progenitor cells (NSPCs) in the adult brain is unknown. We used a transgenic mouse in which Mef2a, -c, and
Yao Yu et al.
Drug design, development and therapy, 9, 6363-6377 (2015-12-18)
In a previous study, we confirmed that netrin-1 acts as an antiangiogenic factor by inhibiting alkali burn-induced corneal neovascularization in rats. Here, we continue working on the role of netrin-1 in retinal neovascularization. Using an in vitro angiogenesis assay, we
Dannielle S Figueroa et al.
Journal of biomechanical engineering, 136(10), 101010-101010 (2014-07-18)
Hyperglycemia is a defining characteristic of diabetes, and uncontrolled blood glucose in diabetes is associated with accelerated cardiovascular disease. Chronic hyperglycemia glycates extracellular matrix (ECM) collagen, which can lead to endothelial cell dysfunction. In healthy conditions, endothelial cells respond to
Supradip Saha et al.
Food chemistry, 177, 369-375 (2015-02-11)
Accelerated solvent extraction (ASE) is applied for the extraction of carotenoids from orange carrot and the extraction parameters were optimized. Two carotenoids, lutein and β-carotene, are selected as the validation process. Hildebrand solubility parameters and dielectric constant of solvents were
Sargo Aalto et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(3), 424-431 (2014-12-11)
Ethanol increases the interstitial dopamine (DA) concentration in the nucleus accumbens (NAcc) of experimental animals, but positron emission tomography (PET) studies using the single-bolus protocol of the [(11)C]-raclopride competition paradigm have yielded conflicting results in humans. To resolve disparate previous
Nitish Nagpal et al.
Biotechnology and applied biochemistry, 62(2), 154-163 (2014-05-28)
Succinylcholine apnea happens in cases of null butyrylcholinesterase activity after administration of preintubation succinylcholine. So far, there is no such popular test that can rapidly screen null butyrylcholinesterase activity from plasma. Development of a novel method for rapid screening of
Hannah K Wayment-Steele et al.
ACS applied materials & interfaces, 6(12), 9093-9099 (2014-05-23)
Understanding the kinetics of dye adsorption and desorption on semiconductors is crucial for optimizing the performance of dye-sensitized solar cells (DSSCs). Quartz crystal microbalance with dissipation monitoring (QCM-D) measures adsorbed mass in real time, allowing determination of binding kinetics. In
Francesco Fiorentino et al.
Human reproduction (Oxford, England), 29(12), 2802-2813 (2014-10-23)
Can next-generation sequencing (NGS) techniques be used reliably for comprehensive aneuploidy screening of human embryos from patients undergoing IVF treatments, with the purpose of identifying and selecting chromosomally normal embryos for transfer? Extensive application of NGS in clinical preimplantation genetic
Faruk Karaca et al.
Acta orthopaedica et traumatologica turcica, 48(3), 326-332 (2014-06-06)
The aim of this study was to examine the influence of bone drilling on local bone temperature and bone regeneration and determine optimal drilling speed and pressure in an animal model. The study included 12 skeletally mature New Zealand white
Mahdi Shahmiri et al.
Scientific reports, 5, 16378-16378 (2015-11-18)
Aurein 1.2 is a 13 residue antimicrobial peptide secreted by the Australian tree frog Litoria Aurea. It is a surface-acting membrane disrupting peptide that permeabilizes bacterial membranes via the carpet mechanism; the molecular details of this process are mostly unknown.
Wolfram Gronwald et al.
Kidney international, 79(11), 1244-1253 (2011-03-11)
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (NMR) spectroscopy with support vector machine-based
Shengxian Jia et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 22(6), 730-739 (2014-09-19)
Curcumin, a spice found in turmeric, is widely used in alternative medicine for its purported anti-inflammatory and antioxidant activities. The goal of this study was to test the curcumin efficacy on rabbit ear wounds under nonischemic, ischemic, and ischemia-reperfusion conditions.
Luca Rolle et al.
Food chemistry, 173, 105-113 (2014-12-04)
The aim of this work was to determine the impact of using independently berry density and diameter as sorting methodologies on important physicochemical parameters affecting the grape quality, such as mechanical properties, phenolic composition and aromatic profile. Muscat Hamburg berries
Shaobo Ke et al.
International journal of oncology, 46(3), 1051-1058 (2014-12-17)
The functions of the high mobility group box 1 (HMGB1) in tumor cells include replenishing telomeric DNA and maintaining cell immortality. There is a negative correlation between human telomerase reverse transcriptase (hTERT) and radiosensitivity in tumor cells. Our aim was
Valentina Di Felice et al.
Journal of tissue engineering and regenerative medicine, 9(11), E51-E64 (2013-04-18)
The use of three-dimensional (3D) cultures may induce cardiac progenitor cells to synthesize their own extracellular matrix (ECM) and sarcomeric proteins to initiate cardiac differentiation. 3D cultures grown on synthetic scaffolds may favour the implantation and survival of stem cells
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