494410

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X-ray structure analysis reveals β-turn mimicry by N-amino-imidazolidin-2-ones.

Ngoc-Duc Doan et al.

Biopolymers, 104(5), 629-635 (2015-03-20)

The conformation of the N-amino-imidazolidin-2-one (Aid) peptidomimetic was investigated using NMR spectroscopy and X-ray crystallography. In solution, the tetrapeptide model p-bromobenzoyl-Aid-l-Phe-N'-iso-propylamide (1) exhibited shielded and solvent exposed amide protons indicative of a turn conformation. In the crystal lattice of 1

Is comprehensive analysis of potentially relevant migrants from recycled paperboard into foods feasible?

Maurus Biedermann et al.

Journal of chromatography. A, 1272, 106-115 (2012-12-25)

Legislation on food contact materials, mainly focusing on food safety, requires the absence of potentially harmful substances in the migrate from packaging materials. For recycled paperboard with essentially unknown input this presupposes comprehensive analysis of all substances potentially migrating above

Tobacco guard cells fix CO2 by both Rubisco and PEPcase while sucrose acts as a substrate during light-induced stomatal opening.

Danilo M Daloso et al.

Plant, cell & environment, 38(11), 2353-2371 (2015-04-15)

Transcriptomic and proteomic studies have improved our knowledge of guard cell function; however, metabolic changes in guard cells remain relatively poorly understood. Here we analysed metabolic changes in guard cell-enriched epidermal fragments from tobacco during light-induced stomatal opening. Increases in

A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma.

JeenJoo S Kang et al.

Quarterly reviews of biophysics, 48(4), 453-464 (2015-11-06)

Means to cause an immunogenic cell death could lead to significant insight into how cancer escapes immune control. In this study, we screened a library of five pyrrole-imidazole polyamides coding for different DNA sequences in a model of B-cell lymphoma

Toward prediction of alkane/water partition coefficients.

Anita Toulmin et al.

Journal of medicinal chemistry, 51(13), 3720-3730 (2008-06-19)

Partition coefficients were measured for 47 compounds in the hexadecane/water ( P hxd) and 1-octanol/water ( P oct) systems. Some types of hydrogen bond acceptor presented by these compounds to the partitioning systems are not well represented in the literature

Sulphation pattern analysis of chemically sulphated polysaccharide LbGp1 from Lycium barbarum by GC-MS.

Yujiao Sun et al.

Food chemistry, 170, 22-29 (2014-10-13)

The polysaccharide LbGp1 from Lycium barbarum L. was sulphated with sulphur trioxide-pyridine complex in DMF, yielding two sulphated polysaccharides, which were LbGp1-OL-SL with 13.7% sulphate content, and LbGp1-OL-SH with 27.4% sulphate content. The sulphation patterns were analysed using a GC-MS

The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates.

Isabella M Guimaraes et al.

Molecular brain, 8, 24-24 (2015-04-18)

The metabotropic glutamate receptor 5 (mGluR5) is involved in various brain functions, including memory, cognition and motor behavior. Regarding locomotor activity, we and others have demonstrated that pharmacological antagonism of mGluR5 promotes hyperkinesia in mice. Moreover, increased locomotor activity can

Rapid identification of ligand-binding sites by using an assignment-free NMR approach.

Yuya Kodama et al.

Journal of medicinal chemistry, 56(22), 9342-9350 (2013-11-01)

In this study, we developed an assignment-free approach for rapid identification of ligand-binding sites in target proteins by using NMR. With a sophisticated cell-free stable isotope-labeling procedure that introduces (15)N- or (13)C-labels to specific atoms of target proteins, this approach

In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.

Giorgio Ottaviani et al.

Journal of medicinal chemistry, 50(4), 742-748 (2007-02-16)

The development of in silico and in vitro tools to estimate or predict the passive human skin permeation and distribution of new chemical entities, useful in dermal drug delivery, in absorption studies of toxic compounds, and in the cosmetics industry

De novo RNA sequencing and transcriptome analysis of Colletotrichum gloeosporioides ES026 reveal genes related to biosynthesis of huperzine A.

Guowei Zhang et al.

PloS one, 10(3), e0120809-e0120809 (2015-03-24)

Huperzine A is important in the treatment of Alzheimer's disease. There are major challenges for the mass production of huperzine A from plants due to the limited number of huperzine-A-producing plants, as well as the low content of huperzine A

Multivariate analysis of mainstream tobacco smoke particulate phase by headspace solid-phase micro extraction coupled with comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry.

Michał Brokl et al.

Journal of chromatography. A, 1370, 216-229 (2014-12-03)

A method involving headspace solid-phase microextraction (HS-SPME) and comprehensive two-dimensional gas chromatography (GC×GC) coupled to time-of-flight mass spectrometry (TOFMS) was developed and applied to evaluate profiles of volatile compounds present in mainstream tobacco smoke particulate matter trapped on glass fiber

A mitochondria-specific visible-light sensitized europium β-diketonate complex with red emission.

V Divya et al.

Dalton transactions (Cambridge, England : 2003), 42(34), 12317-12323 (2013-07-16)

Our recently developed Eu(3+) coordination compound, Eu(pfppd)3(tpy) [where Hpfppd = 4,4,5,5,5-pentafluoro-3-hydroxy-1-(phenanthren-3-yl)pentanedione and tpy = 2,2':6,6''-terpyridine] exhibits significant quantum yield (Φoverall = 41%) and long (5)D0 lifetime (880 μs) values under biologically relevant pH conditions (pH = 7.4) when excited with

Catalytic wet peroxidation of pyridine bearing wastewater by cerium supported SBA-15.

V Subbaramaiah et al.

Journal of hazardous materials, 248-249, 355-363 (2013-02-19)

Cerium supported SBA-15 (Ce/SBA-15) was synthesized by two-step synthesis method in acidic medium. It was further characterized by various characterization techniques such as X-ray diffraction, field-emission scanning electron microscopy, Fourier transform infrared spectroscopy and N2 adsorption-desorption pore size distribution analysis.

Synergistic photocatalytic degradation of pyridine using precious metal supported TiO2 with KBrO3.

Fei Tian et al.

Journal of environmental sciences (China), 25(11), 2299-2305 (2014-02-21)

A series of precious metals catalysts (M/TiO2, M = Ru, Rh, Pd, Ag, Ir, Pt or Au) were prepared by a light deposition method and the synergistic photocatalytic degradations of pyridine (20 mg/L) under UV irradiation (365 nm) using M/TiO2

Nano-colloid printing of functionalized PLA-b-PEO copolymers: tailoring the surface pattern of adhesive motif and its effect on cell attachment.

E Mázl Chánová et al.

Physiological research, 64 Suppl 1, S61-S73 (2015-10-09)

In this study, we investigate the preparation of surface pattern of functional groups on poly(lactide) (PLA) surfaces through the controlled deposition of core-shell self-assemblies based on functionalized PLA-b-PEO amphiphilic block copolymers from selective solvents. Through grafting RGDS peptide onto the

Identification of organic acids as potential biomarkers in the urine of autistic children using gas chromatography/mass spectrometry.

Joanna Kałużna-Czaplińska et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 966, 70-76 (2014-02-26)

There is a need to identify metabolic phenotypes in autism as they might each require unique approaches to prevention. Biological markers can help define autism subtypes and reveal potential therapeutic targets. The aim of the study was to identify alterations

Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs.

Shigeo Hayashi et al.

Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)

Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage

Bioassay-guided isolation of Poliovirus-inhibiting constituents from Zephyranthes candida.

Ogbole Omonike Oluyemisi et al.

Pharmaceutical biology, 53(6), 882-887 (2014-11-29)

Plants of the Zephyranthes genus are globally used in folk medicine. In a previous study, Zephyranthes candida Linn. (Amaryllidaceae) was identified as having antiviral properties; this led to anti-poliovirus assay-guided isolation of compounds from crude methanol extract of the plant.

Cyclophosphamide plasma and cerebrospinal fluid kinetics with and without dimethyl sulfoxide.

M J Egorin et al.

Clinical pharmacology and therapeutics, 32(1), 122-128 (1982-07-01)

Ten patients with brain tumors and indwelling ventricular reservoirs were pretreated with 5% to 10% dimethyl sulfoxide (DMSO) (intravenous, oral, or both) and were then treated with 1.0 to 1.25 gm/m2 cyclophosphamide (CYC). All patients were also on anticonvulsants and

Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese.

Flavia Badoud et al.

Journal of proteome research, 13(7), 3455-3466 (2014-06-17)

A subgroup of obese individuals, referred to as metabolically healthy obese (MHO), have preserved insulin sensitivity and a normal lipid profile despite being obese. The molecular basis for this improved cardiometabolic profile remains unclear. Our objective was to integrate metabolite

Development of an analytical method for the determination of the misuse in sports of boldenone through the analysis of urine by on-line coupling liquid chromatography-gas chromatography-combustion-isotope ratio mass spectrometry.

R M Toledano et al.

Journal of chromatography. A, 1370, 171-178 (2014-12-03)

Boldenone (Bo), androsta-1,4-dien-17β-ol-3-one, is an anabolic androgenic steroid not clinically approved for human application. Despite this, many cases are reported every year of athletes testing positive for Bo or its main metabolite 5β-androst-1-en-17β-ol-3-one (BoM). Recently the capability of different human

Immobilization of Candida rugosa lipase onto an eco-friendly support in the presence of ionic liquid.

Rebeca Y Cabrera-Padilla et al.

Bioprocess and biosystems engineering, 38(5), 805-814 (2014-11-14)

Candida rugosa lipase (CRL) was immobilized on an eco-friendly support poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV), by physical adsorption, using different ionic liquids (ILs) as immobilization additives. This was to investigate the influence of cationic core ([C4mpy]Cl, [C4min]Cl), of anions ([C4min]Cl, [C4min]N(CN)2, [C4min]Tf2N), and

A study of lipid- and water-soluble arsenic species in liver of Northeast Arctic cod (Gadus morhua) containing high levels of total arsenic.

Veronika Sele et al.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 30, 171-179 (2015-01-27)

In the present study liver samples (n=26) of Northeast Arctic cod (Gadus morhua), ranging in total arsenic concentrations from 2.1 to 240mg/kg liver wet weight (ww), were analysed for their content of total arsenic and arsenic species in the lipid-soluble

Copper-catalyzed aerobic oxidative C-H and C-C functionalization of 1-[2-(arylamino)aryl]ethanones leading to acridone derivatives.

Jipan Yu et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 19(13), 4271-4277 (2013-02-13)

Efficient copper-catalyzed aerobic oxidative C-H and C-C functionalization of 1-[2-(arylamino)aryl]ethanones leading to acridones has been developed. The procedure involves cleavage of aromatic C-H and acetyl C-C bonds with intramolecular formation of a diarylketone bond. The protocol uses inexpensive Cu(O2CCF3)2 as

The vibrational spectrum of pyridine and the thermodynamic properties of pyridine vapors.

Kline Jr CH and Turkevich J.

J. Chem. Phys. , 12(7), 300-309 (1944)

Biotreatment of waste gas containing pyridine in a biofilter.

R A Pandey et al.

Bioresource technology, 98(12), 2258-2267 (2006-07-04)

Industrial waste gas emissions containing pyridine are generated from pyridine manufacturing industries, and in industrial operations where pyridine is used as a solvent, as an intermediate for synthesis and as a catalyst for a variety of applications. Pyridine has unpleasant

Bioluminescent liquid light guide pad biosensor for indoor air toxicity monitoring.

Evgeni Eltzov et al.

Analytical chemistry, 87(7), 3655-3661 (2015-03-17)

Indoor air pollution became a recent concern found to be oftentimes worse than outdoor air quality. We developed a tool that is cheap and simple and enables continuous monitoring of air toxicity. It is a biosensor with both a nondisposable

A new bis-tetraamine ligand with a chromophoric 4-(9-anthracenyl)-2,6-dimethylpyridinyl linker for glyphosate and ATP sensing.

Jacky Pouessel et al.

Dalton transactions (Cambridge, England : 2003), 42(14), 4859-4872 (2013-02-02)

The synthesis of a new linear bis-tetraamine ligand L1, based on two 1,4,8,11-tetraazaundecane units grafted at the 2 and 6 positions of a pyridinyl linker substituted by an anthracenyl fluorophore in the para position, is described and anion complexation studies

Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.

T Shimada et al.

Cancer research, 51(19), 5284-5291 (1991-10-01)

The ability of cigarette smoke condensate to induce a genotoxic response has been measured in liver microsomal and reconstituted monooxygenase systems containing rat and human cytochrome P-450 (P-450) enzymes, as determined by umu gene expression in Salmonella typhimurium TA1535/pSK1002. The

Liver Transplantation for Acute Intermittent Porphyria: Biochemical and Pathologic Studies of the Explanted Liver.

Makiko Yasuda et al.

Molecular medicine (Cambridge, Mass.), 21, 487-495 (2015-06-11)

Acute intermittent porphyria (AIP) is an autosomal-dominant hepatic disorder caused by the half-normal activity of hydroxymethylbilane (HMB) synthase. Symptomatic individuals experience life-threatening acute neurovisceral attacks that are precipitated by factors that induce the hepatic expression of 5-aminolevulinic acid synthase 1

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