49549

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Expression of the lantibiotic mersacidin in Bacillus amyloliquefaciens FZB42.

Anna Maria Herzner et al.

PloS one, 6(7), e22389-e22389 (2011-08-04)

Lantibiotics are small peptide antibiotics that contain the characteristic thioether amino acids lanthionine and methyllanthionine. As ribosomally synthesized peptides, lantibiotics possess biosynthetic gene clusters which contain the structural gene (lanA) as well as the other genes which are involved in

4-Hydroxyisoleucine: a plant-derived treatment for metabolic syndrome.

Lucie Jetté et al.

Current opinion in investigational drugs (London, England : 2000), 10(4), 353-358 (2009-04-02)

The plant fenugreek has been used for centuries as a treatment for diabetes. This article presents evidence that the major isomer of 4-hydroxyisoleucine, an atypical branched-chain amino acid derived from fenugreek, is responsible for the effects of this plant on

Characterisation of liver pathogenesis, human immune responses and drug testing in a humanised mouse model of HCV infection.

Choong Tat Keng et al.

Gut, 65(10), 1744-1753 (2015-07-08)

HCV infection affects millions of people worldwide, and many patients develop chronic infection leading to liver cancers. For decades, the lack of a small animal model that can recapitulate HCV infection, its immunopathogenesis and disease progression has impeded the development

4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion.

C Broca et al.

European journal of pharmacology, 390(3), 339-345 (2000-03-10)

4-Hydroxyisoleucine, a peculiar amino acid extracted from fenugreek seeds and never found in mammalian tissues, exhibits interesting insulinotropic activity. To investigate the structural requirements for this stimulating effect, the insulinotropic activity of the major isomer (2S,3R,4S) of 4-hydroxyisoleucine, in the

Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13.

Jasmin Dischinger et al.

PloS one, 4(8), e6788-e6788 (2009-08-27)

Lantibiotics are small microbial peptide antibiotics that are characterized by the presence of the thioether amino acids lanthionine and methyllanthionine. Lantibiotics possess structural genes which encode inactive prepeptides. During maturation, the prepeptide undergoes posttranslational modifications including the introduction of rare

Complex genetic architecture of cardiac disease in a wild type inbred strain of Drosophila melanogaster.

Zhi Zhang et al.

PloS one, 8(4), e62909-e62909 (2013-05-03)

Natural populations of the fruit fly, Drosophila melanogaster, segregate genetic variation that leads to cardiac disease phenotypes. One nearly isogenic line from a North Carolina peach orchard, WE70, is shown to harbor two genetically distinct heart phenotypes: elevated incidence of

Development of an integrated reporting system for verifying hemolysis, icterus, and lipemia in clinical chemistry results.

Dong Hoon Shin et al.

Annals of laboratory medicine, 34(4), 307-312 (2014-07-02)

Hemolysis, icterus, and lipemia (HIL) cause preanalytical interference and vary unpredictably with different analytical equipments and measurement methods. We developed an integrated reporting system for verifying HIL status in order to identify the extent of interference by HIL on clinical

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