49767

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Dilong prevents the high-KCl cardioplegic solution administration-induced apoptosis in H9c2 cardiomyoblast cells mediated by MEK.

Chien-Kuo Han et al.

The American journal of Chinese medicine, 42(6), 1507-1519 (2014-12-09)

Infusion of high-KCl cardioplegic solution (High-KCS) is the most common method used to induce asystole before cardiac surgery. However, our previous study showed the High-KCS can cause the apoptosis of cardiomyocytes in patients who were administered High-KCS prior to undergoing

The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing.

Filipe V Jacinto et al.

Genes & development, 29(12), 1224-1238 (2015-06-18)

Nucleoporins (Nups) are a family of proteins best known as the constituent building blocks of nuclear pore complexes (NPCs), membrane-embedded channels that mediate nuclear transport across the nuclear envelope. Recent evidence suggests that several Nups have additional roles in controlling

Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice.

Jessica Nicks et al.

Neurobiology of disease, 70, 224-236 (2014-07-12)

Charcot--Marie-Tooth disease type 1A (CMT1A) is a hereditary peripheral neuropathy characterized by progressive demyelination and distal muscle weakness. Abnormal expression of peripheral myelin protein 22 (PMP22) has been linked to CMT1A and is modeled by Trembler J (TrJ) mice, which

Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors.

Zhenghui Li et al.

Bioorganic & medicinal chemistry, 22(24), 6735-6745 (2014-12-04)

A small molecule library of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives has been synthesized and evaluated as inhibitors of caspase-3 and -7, in which some of them showed nanomolar potency against caspase-3 and -7 in vitro. Meanwhile, in 10 lM concentration, both compounds

The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1.

Tariq A Tahir et al.

Cellular signalling, 26(7), 1379-1384 (2014-03-20)

Angiopoietin-1 (Ang1) is a ligand for the receptor tyrosine kinase Tie2 and has key roles in the development of the vascular system and vascular protection. In a screen to define signalling pathways regulated by Ang1 in endothelial cells we found

Microbial food safety: Potential of DNA extraction methods for use in diagnostic metagenomics.

Mathilde H Josefsen et al.

Journal of microbiological methods, 114, 30-34 (2015-05-06)

The efficiency of ten widely applied DNA extraction protocols was evaluated for suitability for diagnostic metagenomics. The protocols were selected based on a thorough literature study. Chicken fecal samples inoculated with about 1×10(3) and 1×10(6) CFU/g Campylobacter jejuni were used

Prevalence, seasonality, and growth of enterococci in raw and pasteurized milk in Victoria, Australia.

Catherine M McAuley et al.

Journal of dairy science, 98(12), 8348-8358 (2015-10-20)

This study investigated the prevalence, seasonality, and species variety of enterococci present in raw milk factory silos and pasteurized milk in 3 dairying regions in Victoria, Australia, over a 1-yr period. Additionally, the growth ability of thermoduric enterococci isolated in

Effects of age increase on hepatic expression and activity of cytochrome P450 in male C57BL/6 mice.

Hui Chan Kwak et al.

Archives of pharmacal research, 38(5), 857-864 (2014-07-26)

Effects of aging on hepatic expression and activity of cytochrome P450 (CYP) isoforms were investigated in male mice aged 2, 6, 18, and 30 months. Microsomal protein, total CYP, cytochrome b5 and NADPH-dependent cytochrome P450 reductase contents in liver were fully

Crystals of Na(+)/K(+)-ATPase with bound cisplatin.

Miroslav Huliciak et al.

Biochemical pharmacology, 92(3), 494-498 (2014-09-10)

Cisplatin is the most widely used chemotherapeutics for cancer treatment, however, its administration is connected to inevitable adverse effects. Previous studies suggested that cisplatin is able to inhibit Na(+)/K(+)-ATPase (NKA), the enzyme responsible for maintaining electrochemical potential and sodium gradient

Class-IIa Histone Deacetylase Inhibition Promotes the Growth of Neural Processes and Protects Them Against Neurotoxic Insult.

Louise M Collins et al.

Molecular neurobiology, 51(3), 1432-1442 (2014-07-30)

Small molecule histone deacetylase inhibitors (HDIs) hold much promise as pharmacological modifiers of the epigenetic status of the central nervous system (CNS), given their ability to cross the blood-brain barrier. This is particularly relevant given the lack of disease-modifying therapies

HupB, a nucleoid-associated protein of Mycobacterium tuberculosis, is modified by serine/threonine protein kinases in vivo.

Meetu Gupta et al.

Journal of bacteriology, 196(14), 2646-2657 (2014-05-13)

HU, a widely conserved bacterial histone-like protein, regulates many genes, including those involved in stress response and virulence. Whereas ample data are available on HU-DNA communication, the knowledge on how HU perceives a signal and transmit it to DNA remains

Diorcinol D Exerts Fungicidal Action against Candida albicans through Cytoplasm Membrane Destruction and ROS Accumulation.

Ying Li et al.

PloS one, 10(6), e0128693-e0128693 (2015-06-06)

Candida albicans, which is the most common human fungal pathogen, causes high mortality among immunocompromised patients. Antifungal drug resistance becomes a major challenge for the management of Candida infection. Diorcinol D (DD), a diphenyl ether derivative isolated from an endolichenic

Bioconversion of crude glycerol by fungi.

R W Nicol et al.

Applied microbiology and biotechnology, 93(5), 1865-1875 (2012-02-11)

The production of synthetic glycerol from petrochemical feedstocks has been decreasing in recent years. This is largely due to increasing supplies of crude glycerol derived as a co-product from the oleochemical industry, especially biodiesel production. The price of glycerol is

Ret is critical for podocyte survival following glomerular injury in vivo.

Guoqing Hou et al.

American journal of physiology. Renal physiology, 308(7), F774-F783 (2015-01-15)

Podocyte injury and loss directly cause proteinuria and the progression to glomerulosclerosis. Elucidation of the mechanisms of podocyte survival and recovery from injury is critical for designing strategies to prevent the progression of glomerular diseases. Glial cell line-derived neurotrophic factor

Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders.

Jenna M Puccini et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), 5271-5283 (2015-04-04)

Leucine-rich repeat kinase 2 (LRRK2) is the single most common genetic cause of both familial and sporadic Parkinson's disease (PD), both of which share pathogenetic and neurologic similarities with human immunodeficiency virus 1 (HIV-1)-associated neurocognitive disorders (HAND). Pathologic LRRK2 activity

Crystal structures and functional characterization of wild-type CYP101D1 and its active site mutants.

Dipanwita Batabyal et al.

Biochemistry, 52(49), 8898-8906 (2013-11-23)

Although CYP101D1 and P450cam catalyze the same reaction at similar rates and share strikingly similar active site architectures, there are significant functional differences. CYP101D1 thus provides an opportunity to probe what structural and functional features must be shared and what

Insights from reconstitution reactions of COPII vesicle formation using pure components and low mechanical perturbation.

Sebastian Daum et al.

Biological chemistry, 395(7-8), 801-812 (2014-07-09)

As shape transformations of membranes are vital for intracellular trafficking, it is crucial to understand both the mechanics and the biochemistry of these processes. The interplay of these two factors constitutes an experimental challenge, however, because biochemical experiments are not

Peroxide-based oxygen generating topical wound dressing for enhancing healing of dermal wounds.

Prafulla K Chandra et al.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(6), 830-841 (2015-06-09)

Oxygen generating biomaterials represent a new trend in regenerative medicine that aims to generate and supply oxygen at the site of requirement, to support tissue healing and regeneration. To enhance the healing of dermal wounds, we have developed a highly

Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme.

Choong-Soo Yun et al.

Nature communications, 6, 8758-8758 (2015-10-28)

Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing

Starch/silver nanocomposite: Effect of thermal treatment temperature on the morphology, oxygen and water transport properties.

Perrine Cheviron et al.

Carbohydrate polymers, 134, 635-645 (2015-10-03)

The present work reports a strategy involving the preparation of nanostructured starch based film containing silver nanoparticles (AgNPs) using a completely green chemistry process. The nanocomposite films were prepared by solution cast process. The AgNPs were in situ generated inside

Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival.

Kazushi Aoto et al.

Human molecular genetics, 24(3), 698-713 (2014-10-09)

Congenital brain and craniofacial defects often occur together as a consequence of their developmental dependency on common progenitor tissue interactions and signaling pathways during embryogenesis. A classic example of this is perturbation of midline embryo development, and disruption of Hedgehog

Structural evidence for Scc4-dependent localization of cohesin loading.

Stephen M Hinshaw et al.

eLife, 4, e06057-e06057 (2015-06-04)

The cohesin ring holds newly replicated sister chromatids together until their separation at anaphase. Initiation of sister chromatid cohesion depends on a separate complex, Scc2(NIPBL)/Scc4(Mau2) (Scc2/4), which loads cohesin onto DNA and determines its localization across the genome. Proper cohesin

Proteomics unravels extracellular vesicles as carriers of classical cytoplasmic proteins in Candida albicans.

Ana Gil-Bona et al.

Journal of proteome research, 14(1), 142-153 (2014-11-05)

The commensal fungus Candida albicans secretes a considerable number of proteins and, as in different fungal pathogens, extracellular vesicles (EVs) have also been observed. Our report contains the first proteomic analysis of EVs in C. albicans and a comparative proteomic

Determination of 3-methylhistidine and 1-methylhistidine in untreated urine samples by capillary electrophoresis.

Petr Tůma et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821(1), 53-59 (2005-05-19)

Capillary electrophoretic (CE) method was developed for the determination of urinary 3-methylhistidine (3MH) and 1-methylhistidine (1MH) indicating the extent of degradation of skeletal muscle proteins and thereby the state of human health. 3MH, 1MH and histidine can be separated in

Efficient production of Tymovirus like particles displaying immunodominant epitopes of Japanese Encephalitis Virus envelope protein.

Pallichera Vijayan Shahana et al.

Protein expression and purification, 113, 35-43 (2015-05-12)

Japanese Encephalitis (JE) is a mosquito borne arboviral infection caused by Japanese Encephalitis Virus (JEV). It is a major cause of viral encephalitis in Asian countries including India. In the present study, we have used a Tymovirus [i.e. Physalis Mottle

A new member of the DMATS superfamily from Aspergillus niger catalyzes prenylations of both tyrosine and tryptophan derivatives.

Aili Fan et al.

Applied microbiology and biotechnology, 98(24), 10119-10129 (2014-06-28)

A putative prenyltransferase gene of the dimethylallyltryptophan synthase (DMATS) family, An13g01840, was identified in the genome sequence of Aspergillus niger. The deduced polypeptide CAK41583 consists of 465 amino acids with a calculated molecular mass of 52.7 kDa. To evaluate gene

Arjunolic acid ameliorates reactive oxygen species via inhibition of p47(phox)-serine phosphorylation and mitochondrial dysfunction.

Sumitra Miriyala et al.

The international journal of biochemistry & cell biology, 68, 70-77 (2015-09-01)

Impaired cardiovascular function during acute myocardial infarction (MI) is partly associated with recruitment of activated polymorphonuclear neutrophils. The protective role of arjunolic acid (AA; 2,3,23-trihydroxy olean-12-en-28-oic acid) is studied in the modulation of neutrophil functions in vitro by measuring the

Lipid Metabolites from the Mushroom Meripilus giganteus.

Francesca Catenia et al.

Natural product communications, 10(11), 1833-1838 (2016-01-12)

The phytochemical investigation of the methanolic extract of the white rot fungus Meripilus giganteus resulted in the isolation and identification of complex mixtures of free fatty acids (1), monoacylglycerols (2), cerebrosides (3), ergosterol (4) and ergosterol peroxide (5). The structures

Identification and characterization of starvation induced msdgc-1 promoter involved in the c-di-GMP turnover.

Binod K Bharati et al.

Gene, 528(2), 99-108 (2013-08-13)

C-di-GMP [Bis-(3'-5')-cyclic-dimeric-guanosine monophosphate], a second messenger is involved in intracellular communication in the bacterial species. As a result several multi-cellular behaviors in both Gram-positive and Gram-negative bacteria are directly linked to the intracellular level of c-di-GMP. The cellular concentration of

Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.

Béatrice Dirat et al.

Molecular cancer therapeutics, 14(2), 586-596 (2014-12-21)

Cell migration is a critical step in the progression of prostate cancer to the metastatic state, the lethal form of the disease. The antidiabetic drug metformin has been shown to display antitumoral properties in prostate cancer cell and animal models;

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