搜索范围
49770
应用筛选条件
关键词:'49770'
显示 1-30 #N/A 1985 条结果 关于 "49770" 范围 论文
Masayuki Tanaka et al.
The Journal of surgical research, 194(2), 571-580 (2014-12-17)
High-mobility group box 1 (HMGB1) has recently been identified as an important mediator of various kinds of acute and chronic inflammation. The protein encoded by the box-A domain of the HMGB1 gene is known to act as a competitive inhibitor
Ana Gil-Bona et al.
Journal of proteome research, 14(1), 142-153 (2014-11-05)
The commensal fungus Candida albicans secretes a considerable number of proteins and, as in different fungal pathogens, extracellular vesicles (EVs) have also been observed. Our report contains the first proteomic analysis of EVs in C. albicans and a comparative proteomic
Petr Tůma et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821(1), 53-59 (2005-05-19)
Capillary electrophoretic (CE) method was developed for the determination of urinary 3-methylhistidine (3MH) and 1-methylhistidine (1MH) indicating the extent of degradation of skeletal muscle proteins and thereby the state of human health. 3MH, 1MH and histidine can be separated in
Francesca Catenia et al.
Natural product communications, 10(11), 1833-1838 (2016-01-12)
The phytochemical investigation of the methanolic extract of the white rot fungus Meripilus giganteus resulted in the isolation and identification of complex mixtures of free fatty acids (1), monoacylglycerols (2), cerebrosides (3), ergosterol (4) and ergosterol peroxide (5). The structures
Chien-Kuo Han et al.
The American journal of Chinese medicine, 42(6), 1507-1519 (2014-12-09)
Infusion of high-KCl cardioplegic solution (High-KCS) is the most common method used to induce asystole before cardiac surgery. However, our previous study showed the High-KCS can cause the apoptosis of cardiomyocytes in patients who were administered High-KCS prior to undergoing
Aili Fan et al.
Applied microbiology and biotechnology, 98(24), 10119-10129 (2014-06-28)
A putative prenyltransferase gene of the dimethylallyltryptophan synthase (DMATS) family, An13g01840, was identified in the genome sequence of Aspergillus niger. The deduced polypeptide CAK41583 consists of 465 amino acids with a calculated molecular mass of 52.7 kDa. To evaluate gene
Sumitra Miriyala et al.
The international journal of biochemistry & cell biology, 68, 70-77 (2015-09-01)
Impaired cardiovascular function during acute myocardial infarction (MI) is partly associated with recruitment of activated polymorphonuclear neutrophils. The protective role of arjunolic acid (AA; 2,3,23-trihydroxy olean-12-en-28-oic acid) is studied in the modulation of neutrophil functions in vitro by measuring the
Binod K Bharati et al.
Gene, 528(2), 99-108 (2013-08-13)
C-di-GMP [Bis-(3'-5')-cyclic-dimeric-guanosine monophosphate], a second messenger is involved in intracellular communication in the bacterial species. As a result several multi-cellular behaviors in both Gram-positive and Gram-negative bacteria are directly linked to the intracellular level of c-di-GMP. The cellular concentration of
Béatrice Dirat et al.
Molecular cancer therapeutics, 14(2), 586-596 (2014-12-21)
Cell migration is a critical step in the progression of prostate cancer to the metastatic state, the lethal form of the disease. The antidiabetic drug metformin has been shown to display antitumoral properties in prostate cancer cell and animal models;
Matthias Hillenbrand et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(11), E1181-E1190 (2015-03-04)
Agonist binding to G-protein-coupled receptors (GPCRs) triggers signal transduction cascades involving heterotrimeric G proteins as key players. A major obstacle for drug design is the limited knowledge of conformational changes upon agonist binding, the details of interaction with the different
An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells.
A Tito et al.
International journal of cosmetic science, 37(6), 588-594 (2015-05-06)
Raspberry plants, belonging to the species of Rubus idaeus, are known for their excellent therapeutic properties as they are particularly rich in compounds with strong antioxidant activity, which promote health and well-being of human cells. Besides their high content of
M Y Khuhawar et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 873(1), 15-19 (2008-09-02)
Capillary gas chromatographic (GC) determination of methylglyoxal (MGo) was developed on the basis of precolumn derivatization with 1,2-diaminopropane (DAP) at pH 3. The elution was carried out on an HP-5 (30 m x 0.32 mm i.d.) connected with FID. The
Yoshihiko Miyata et al.
The Journal of biological chemistry, 289(48), 33320-33332 (2014-10-25)
Trp-Asp (WD) repeat protein 68 (WDR68) is an evolutionarily conserved WD40 repeat protein that binds to several proteins, including dual specificity tyrosine phosphorylation-regulated protein kinase (DYRK1A), MAPK/ERK kinase kinase 1 (MEKK1), and Cullin4-damage-specific DNA-binding protein 1 (CUL4-DDB1). WDR68 affects multiple
Xi Xia et al.
Scientific reports, 5, 17077-17077 (2015-11-21)
Mycoplasma gallisepticum is a significant pathogenic bacterium that infects poultry, causing chronic respiratory disease and sinusitis in chickens and turkeys, respectively. M. gallisepticum infection poses a substantial economic threat to the poultry industry, and this threat is made worse by
Sharmistha Sinha et al.
Journal of molecular biology, 426(12), 2328-2345 (2014-04-22)
Bacterial microcompartments (MCPs) are the simplest organelles known. They function to enhance metabolic pathways by confining several related enzymes inside an all-protein envelope called the shell. In this study, we investigated the factors that govern MCP assembly by performing scanning
Jessica A Chadwick et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4544-4554 (2015-07-17)
Early treatment with heart failure drugs lisinopril and spironolactone improves skeletal muscle pathology in Duchenne muscular dystrophy (DMD) mouse models. The angiotensin converting enzyme inhibitor lisinopril and mineralocorticoid receptor (MR) antagonist spironolactone indirectly and directly target MR. The presence and
Evelyne Lima-Fernandes et al.
Nature communications, 5, 4431-4431 (2014-07-17)
Tumour suppressor PTEN is a phosphatase that negatively regulates the PI3K/AKT pathway. The ability to directly monitor PTEN conformation and function in a rapid, sensitive manner is a key step towards developing anti-cancer drugs aimed at enhancing or restoring PTEN-dependent
Hui Xia et al.
Experimental physiology, 99(7), 974-984 (2014-05-08)
Non-small cell lung cancer (NSCLC) is one of the most common diseases encountered in medical oncology practice. The aim of the present study was to test the antitumour effects of short-hairpin RNA targeting aquaporin 3 (AQP3) in experimental NSCLC. Expression of
Mi-Kyung Shin et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(7), 765-776 (2014-08-12)
Obstructive sleep apnea causes chronic intermittent hypoxia (IH) and is associated with impaired glucose metabolism, but mechanisms are unknown. Carotid bodies orchestrate physiological responses to hypoxemia by activating the sympathetic nervous system. Therefore, we hypothesized that carotid body denervation would
Choong-Soo Yun et al.
Nature communications, 6, 8758-8758 (2015-10-28)
Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing
Tadahiro Suzuki et al.
Toxins, 7(1), 187-200 (2015-01-23)
Host plants excrete a glucosylation enzyme onto the plant surface that changes mycotoxins derived from fungal secondary metabolites to glucosylated products. Deoxynivalenol-3-glucoside (DON3G) is synthesized by grain uridine diphosphate-glucosyltransferase, and is found worldwide, although information on its toxicity is lacking.
Jeannette G Lumaban et al.
Human molecular genetics, 24(8), 2175-2184 (2015-01-02)
Fragile X syndrome results from loss of FMR1 expression. Individuals with the disorder exhibit not only intellectual disability, but also an array of physical and behavioral abnormalities, including sleep difficulties. Studies in mice demonstrated that Fmr1, along with its paralog
Son Hoang Minh et al.
Microbiology and immunology, 59(3), 114-122 (2015-02-04)
Shiga toxin producing Escherichia coli (STEC) are dangerous foodborne pathogens. Foods are considered as important sources for STEC infection in human. In this study, STEC contamination of raw meats was investigated and the virulence factors of 120 clinical STEC strains
Dipanwita Batabyal et al.
Biochemistry, 52(49), 8898-8906 (2013-11-23)
Although CYP101D1 and P450cam catalyze the same reaction at similar rates and share strikingly similar active site architectures, there are significant functional differences. CYP101D1 thus provides an opportunity to probe what structural and functional features must be shared and what
Jessica Nicks et al.
Neurobiology of disease, 70, 224-236 (2014-07-12)
Charcot--Marie-Tooth disease type 1A (CMT1A) is a hereditary peripheral neuropathy characterized by progressive demyelination and distal muscle weakness. Abnormal expression of peripheral myelin protein 22 (PMP22) has been linked to CMT1A and is modeled by Trembler J (TrJ) mice, which
Catherine M McAuley et al.
Journal of dairy science, 98(12), 8348-8358 (2015-10-20)
This study investigated the prevalence, seasonality, and species variety of enterococci present in raw milk factory silos and pasteurized milk in 3 dairying regions in Victoria, Australia, over a 1-yr period. Additionally, the growth ability of thermoduric enterococci isolated in
Zhenghui Li et al.
Bioorganic & medicinal chemistry, 22(24), 6735-6745 (2014-12-04)
A small molecule library of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives has been synthesized and evaluated as inhibitors of caspase-3 and -7, in which some of them showed nanomolar potency against caspase-3 and -7 in vitro. Meanwhile, in 10 lM concentration, both compounds
Rafael de Cabo et al.
Aging, 7(3), 152-166 (2015-04-10)
The cumulative effects of cellular senescence and cell loss over time in various tissues and organs are considered major contributing factors to the ageing process. In various organisms, caloric restriction (CR) slows ageing and increases lifespan, at least in part
Nima Motamedi et al.
Journal of medical microbiology, 63(Pt 7), 923-930 (2014-05-20)
Antimicrobial peptides are an important component of the innate immune defence. Mycobacterium avium subsp. hominissuis (M. avium) is an organism that establishes contact with the respiratory and gastrointestinal mucosa as a necessary step for infection. M. avium is resistant to
Zhu Wang et al.
PLoS genetics, 11(3), e1005027-e1005027 (2015-03-17)
Appropriate nutrient response is essential for growth and reproduction. Under favorable nutrient conditions, the C. elegans nuclear receptor DAF-12 is activated by dafachronic acids, hormones that commit larvae to reproductive growth. Here, we report that in addition to its well-studied
1/67