500-99-2

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Highly efficient asymmetric reduction of 2-octanone in biphasic system by immobilized Acetobacter sp. CCTCC M209061 cells.

Xiao-Yang Ou et al.

Journal of biotechnology, 299, 37-43 (2019-05-03)

Highly efficient asymmetric reduction of 2-octanone to (R)-2-octanol catalyzed by immobilized Acetobacter sp. CCTCC M209061 cells was achieved in a biphasic system. Bioreduction conducted in aqueous single phase buffer was limited due to poor solubility and toxicity towards cells cause

Continuous production of chiral 1,3-butanediol using immobilized biocatalysts in a packed bed reactor: promising biocatalysis method with an asymmetric hydrogen-transfer bioreduction.

Nobuya Itoh et al.

Applied microbiology and biotechnology, 75(6), 1249-1256 (2007-04-20)

An asymmetric hydrogen-transfer biocatalyst consisting of mutated Rhodococcus phenylacetaldehyde reductase (PAR) or Leifsonia alcohol dehydrogenase (LSADH) was applied for some water-soluble ketone substrates. Among them, 4-hydroxy-2-butanone was reduced to (S)/(R)-1,3-butanediol, a useful intermediate for pharmaceuticals, with a high yield and

Precipitation recovery of boron from wastewater by hydrothermal mineralization.

Takeshi Itakura et al.

Water research, 39(12), 2543-2548 (2005-06-28)

It is well known that boric acid exhibits various toxic effects on plant, animal and human beings even at very low concentrations. Thus, the development of boron-removal technique from wastewater has been intensively investigated. In this study, a new hydrothermal

CD4-derived peptide and sulfated polysaccharides have similar mechanisms of anti-HIV activity based on electrostatic interactions with positively charged gp120 fragments.

D Meshcheryakova et al.

Molecular immunology, 30(11), 993-1001 (1993-08-01)

The mechanism of antiviral activity of the CD4-derived peptide 75-99 was compared with that of sulfated polysaccharides. A set of peptides representing all the high positive charge density regions of gp120 and gp41 was used to determine whether electrostatic interactions

ADC

Lifang Wu et al.

Journal of magnetic resonance imaging : JMRI, 46(3), 820-830 (2017-03-10)

To explore the threshold of intravoxel incoherent motion (IVIM) parameters, apparent diffusion coefficient [ADC Institutional Review Board approval and informed consent were obtained for this prospective study. There were 30 patients undergoing 1.5T magnetic resonance imaging (MRI) with IVIM-DWI of

Daily consumption of banana marginally improves blood glucose and lipid profile in hypercholesterolemic subjects and increases serum adiponectin in type 2 diabetic patients.

Ratchada Cressey et al.

Indian journal of experimental biology, 52(12), 1173-1181 (2015-02-06)

In this study, we explored the effects of consumption of banana in thirty hypercholesterolemic and fifteen type 2 diabetic subjects. They were given a daily dose of 250 or 500 grams of banana for breakfast for 12 weeks. Fasting serum

Hydrothermal synthesis and photocatalytic activity of CdO2 nanocrystals.

Yan Liu et al.

Journal of hazardous materials, 163(2-3), 1310-1314 (2008-09-06)

CdO(2) nanocrystals with different sizes were synthesized via the hydrothermal reaction of 3CdSO(4).8H(2)O and H(2)O(2) in 1.25-6.25 vol.% ammonia solutions at 100-140 degrees C for 12h. The resultant products were characterized by powder X-ray diffraction, transmission electron microscope, thermal gravimetric

Determination of picogram levels of midazolam, and 1- and 4-hydroxymidazolam in human plasma by gas chromatography-negative chemical ionization-mass spectrometry.

C B Eap et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 802(2), 339-345 (2004-03-17)

Midazolam is a widely accepted probe for phenotyping cytochrome P4503A. A gas chromatography-mass spectrometry (GC-MS)-negative chemical ionization method is presented which allows measuring very low levels of midazolam (MID), 1-OH midazolam (1OHMID) and 4-OH midazolam (4OHMID), in plasma, after derivatization

Bactericidal group IIA phospholipase A2 in serum of patients with bacterial infections.

Juha O Grönroos et al.

The Journal of infectious diseases, 185(12), 1767-1772 (2002-06-27)

Group IIA phospholipase A2 (PLA2-IIA) is a newly recognized antibacterial acute phase protein. The concentration of PLA2-IIA increases up to 500-fold in the blood plasma of patients with severe acute diseases, compared with healthy persons. Despite numerous studies, the exact

Efficacy of an injectable combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle.

G W Hutchinson et al.

Veterinary parasitology, 162(3-4), 278-284 (2009-04-21)

The objective was to compare the efficacy against artificially induced 2- and 4-week old early immature triclabendazole-susceptible liver flukes (Fasciola hepatica) of an injectable combination of nitroxynil, clorsulon and ivermectin with oral and pour-on combination formulations containing triclabendazole. Groups of

First-line eradication rates comparing two shortened non-bismuth quadruple regimens against Helicobacter pylori: an open-label, randomized, multicentre clinical trial.

Antonio Cuadrado-Lavín et al.

The Journal of antimicrobial chemotherapy, 70(8), 2376-2381 (2015-04-10)

Helicobacter pylori eradication remains a challenge. Non-bismuth-based quadruple regimens (NBQR) have shown high eradication rates (ER) elsewhere that need to be locally confirmed. The objective of this study was to compare the first-line ER of a hybrid therapy (20 mg

Efficacy of selected coccidiostats in sandhill cranes (Grus canadensis) following challenge.

James W Carpenter et al.

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 36(3), 391-400 (2007-02-23)

The anticoccidial efficacy of amprolium, clazuril, and monensin were studied in sandhill cranes (Grus canadensis) infected with a mixture of Eimeria spp. oocysts. Five groups of four 1-day-old sandhill crane chicks were maintained on a crumbled ration containing no coccidiostat

Determination of formetanate hydrochloride in selected fruits by coupled-column cation exchange liquid chromatography.

R A Niemann

Journal of AOAC International, 76(6), 1362-1368 (1993-11-01)

A strong cation exchange (SCX) liquid chromatographic (LC) method is described for determination of formetanate hydrochloride residue in pome, citrus, and stone fruits. A test portion of fruit, homogenized with the peel left on, was blended with acidified acetonitrile and

5-Hexyl-2'-deoxyuridine blocks the cytotoxic effects of 5-fluorodeoxyuridine or deoxyadenosine in leukemia L1210 cells in culture.

J G Cory et al.

Cancer research, 50(15), 4552-4556 (1990-08-01)

Antitumor agents which block the de novo synthesis of nucleotides can be circumvented by the presence of salvage pathways for the reutilization of nucleobases and nucleosides. Studies have been carried out which show that 5-hexyl-2'-deoxyuridine (HdUrd) effectively blocks the cytotoxic

HPLC-FLD methods to quantify chloroaluminum phthalocyanine in nanoparticles, plasma and tissue: application in pharmacokinetic and biodistribution studies.

Líliam Teixeira Oliveira et al.

Journal of pharmaceutical and biomedical analysis, 56(1), 70-77 (2011-05-21)

Analytical and bioanalytical methods of high-performance liquid chromatography with fluorescence detection (HPLC-FLD) were developed and validated for the determination of chloroaluminum phthalocyanine in different formulations of polymeric nanocapsules, plasma and livers of mice. Plasma and homogenized liver samples were extracted

Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers.

Simon C Roberts et al.

Chemical research in toxicology, 28(6), 1265-1274 (2015-05-26)

Polybrominated diphenyl ether (PBDE) flame retardants are endocrine disruptors and suspected neurodevelopmental toxicants. While the direct mechanisms of neurodevelopmental toxicity have not been fully elucidated, it is conceivable that alterations in thyroid hormone levels in the developing brain may contribute

High response rate and improved exercise capacity and quality of life with a new regimen of darbepoetin alfa with or without filgrastim in lower-risk myelodysplastic syndromes: a phase II study by the GFM.

C Kelaidi et al.

Annals of hematology, 92(5), 621-631 (2013-01-30)

Darbepoetin (DAR), with or without granulocyte colony-stimulating factor (G-CSF), has proved effective in treating anemia in patients with lower-risk myelodysplastic syndrome (MDS), but its effects on quality of life (QoL) and exercise functioning are less well established. In this phase

Evaluation of denitrification performance and bacterial community of a sequencing batch reactor under intermittent aeration.

Ji Hyeon Kwon et al.

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 55(2), 179-192 (2019-10-28)

Effects of operational parameters (initial nitrite concentration, initial nitrate concentration, carbon source, and COD/N ratio) on denitrification performance was evaluated using a sequencing batch reactor (SBR) under intermittent aeration. Complete denitrification was observed without N2O accumulation when the initial nitrite

Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial.

Benjamin Speich et al.

The Lancet. Infectious diseases, 15(3), 277-284 (2015-01-16)

Existing anthelmintic drugs (eg, albendazole and mebendazole) have low efficacy against the intestinal nematode species Trichuris trichiura and the drug pipeline is exhausted. We aimed to investigate the strategy of combination chemotherapy with existing drugs to establish whether their efficacy

Complete degradation of Orange G by electrolysis in sub-critical water.

Asli Yuksel et al.

Journal of hazardous materials, 190(1-3), 1058-1062 (2011-03-29)

Complete degradation of azo dye Orange G was studied using a 500 mL continuous flow reactor made of SUS 316 stainless steel. In this system, a titanium reactor wall acted as a cathode and a titanium plate-type electrode was used

Successful rechallenge for oxaliplatin hypersensitivity reactions in patients with metastatic colorectal cancer.

Takako Yanai et al.

Anticancer research, 32(12), 5521-5526 (2012-12-12)

Discontinuation of oxaliplatin-containing regimens is sometimes necessary due to hypersensitivity reactions for which effective countermeasures have not yet been identified. We retrospectively reviewed cases in which hypersensitivity reactions developed in 623 patients treated with oxaliplatin for colorectal cancer. Clinical outcomes

Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.

Kei Kitahara et al.

Disease markers, 25(3), 175-180 (2008-12-20)

Alcohol abuse is one of the most common risk factor for chronic pancreatitis, but the underlying pathophysiological mechanisms remain unclear. The aim of this study was to identify genes that contribute to susceptibility or resistance for alcoholic chronic pancreatitis by

[Study on 3-nitrophenol wastewater treatment in UASB].

Wei-Gang Liu et al.

Huan jing ke xue= Huanjing kexue, 27(11), 2206-2211 (2007-03-01)

Characteristics of anaerobic granules before and after acclimation, removal efficiencies of 3-nitrophenol (3-NP) and performance of 3-NP wastewater treatment were investigated in a lab-scale upflow anaerobic sludge bed (UASB). The results showed that granular sludge acclimatized to 3-NP rapidly during

A reduced-toxicity regimen is associated with durable engraftment and clinical cure of nonmalignant genetic diseases among children undergoing blood and marrow transplantation with an HLA-matched related donor.

Kris Michael Mahadeo et al.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 21(3), 440-444 (2014-12-03)

Blood and marrow transplantation (BMT) is a standard curative therapy for patients with nonmalignant genetic diseases. Myeloablative conditioning has been associated with significant regimen-related toxicity (RRT), whereas reduced-intensity conditioning regimens have been associated with graft failure. In this prospective pilot

Subgingival bacteria in Ghanaian adolescents with or without progression of attachment loss.

Gunnar Dahlén et al.

Journal of oral microbiology, 6 (2014-05-17)

This study describes subgingival bacterial profiles associated with clinical periodontal status in Ghanaian adolescents with or without progression of attachment loss. Among 500 adolescents included in a cohort study, 397 returned 2 years later for a periodontal re-examination, including full-mouth

Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos: a randomised, single-blind trial.

Wendelin Moser et al.

The Lancet. Infectious diseases, 18(7), 729-737 (2018-04-21)

Albendazole and mebendazole are commonly used to control hookworm, but have shortcomings in their efficacy profiles. We assessed whether triple drug therapy (TDT) with albendazole, pyrantel pamoate, and oxantel pamoate was more effective than the co-administration of two drugs for

omega-Amino acid:pyruvate transaminase from Alcaligenes denitrificans Y2k-2: a new catalyst for kinetic resolution of beta-amino acids and amines.

Hyungdon Yun et al.

Applied and environmental microbiology, 70(4), 2529-2534 (2004-04-07)

Alcaligenes denitrificans Y2k-2 was obtained by selective enrichment followed by screening from soil samples, which showed omega-amino acid:pyruvate transaminase activity, to kinetically resolve aliphatic beta-amino acid, and the corresponding structural gene (aptA) was cloned. The gene was functionally expressed in

Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy subjects.

Marta L Capone et al.

Journal of the American College of Cardiology, 45(8), 1295-1301 (2005-04-20)

We investigated the occurrence of pharmacodynamic interaction between low-dose aspirin and naproxen. The uncertainty of cardioprotection by naproxen has encouraged its combination with aspirin in patients with arthritis and cardiovascular disease. The incubation of washed platelets with naproxen for 5

Gene conversion and evolution of Xq28 duplicons involved in recurring inversions causing severe hemophilia A.

Richard D Bagnall et al.

Genome research, 15(2), 214-223 (2005-02-03)

Inversions breaking the 1041 bp int1h-1 or the 9.5-kb int22h-1 sequence of the F8 gene cause hemophilia A in 1/30,000 males. These inversions are due to homologous recombination between the above sequences and their inverted copies on the same DNA

Isolation and characterization of a highly efficient chlorpyrifos degrading strain of Cupriavidus taiwanensis from sludge.

Daosheng Wang et al.

Journal of basic microbiology, 55(2), 229-235 (2014-12-04)

In this study, a highly effective chlorpyrifos (CP)-degrading bacterium (termed strain X1) was isolated from the sludge of drain outlet of a chlorpyrifos manufacturer. Strain X1 was identified as Cupriavidus taiwanensis based upon the analysis of the 16S rDNA gene

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