504-30-3

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PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers.

Filip Janku et al.

PloS one, 6(7), e22769-e22769 (2011-08-11)

Oncogenic mutations of PIK3CA, RAS (KRAS, NRAS), and BRAF have been identified in various malignancies, and activate the PI3K/AKT/mTOR and RAS/RAF/MEK pathways, respectively. Both pathways are critical drivers of tumorigenesis. Tumor tissues from 504 patients with diverse cancers referred to

Efficacy and tolerability of cyclobenzaprine extended release for acute muscle spasm: a pooled analysis.

Arnold J Weil et al.

Postgraduate medicine, 122(4), 158-169 (2010-08-03)

To assess the efficacy and tolerability of once-daily cyclobenzaprine extended release (CER) 15 and 30 mg in relieving acute muscle spasm. This is a pooled analysis of 2 randomized, double-blind, placebo-controlled, parallel-group studies of identical design. Adults with local muscle

Investigation of the mechanism of clearance of AMG 386, a selective angiopoietin-1/2 neutralizing peptibody, in splenectomized, nephrectomized, and FcRn knockout rodent models.

Benjamin Wu et al.

Pharmaceutical research, 29(4), 1057-1065 (2011-12-23)

To investigate the mechanisms of clearance of AMG 386, an investigational recombinant peptide-Fc fusion protein (peptibody) that blocks tumor angiogenesis by neutralizing the interaction between angiopoietin-1 and -2 and the Tie2 receptor. The role of the neonatal Fc receptor (FcRn)

Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects.

S Engelborghs et al.

Journal of neurology, neurosurgery, and psychiatry, 74(8), 1148-1151 (2003-07-24)

The authors conducted a prospective study of neurodegenerative and vascular dementia in Belgium. Strict diagnostic inclusion criteria were used to include well defined patients and controls. The results of apolipoprotein E (APOE) genotype effect on risk and clinical characteristics are

Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial.

Mohammad Reza Safarinejad et al.

The British journal of nutrition, 110(1), 164-171 (2012-12-04)

The main objective of the present study was to determine the potential of n-3 and n-6 fatty acids or coenzyme Q10 (CoQ10) to alter serum prostate-specific antigen (PSA) levels in normal healthy men. A total of 504 healthy men with

Effect of diet containing phytate and phytase on the activity and messenger ribonucleic acid expression of carbohydrase and transporter in chickens.

N Liu et al.

Journal of animal science, 86(12), 3432-3439 (2008-08-19)

The effect of dietary phytate and phytase on carbohydrase activity and hexose transport was investigated in broiler chickens. Diets containing phytate P (2.2 or 4.4 g/kg) with different phytase dose rates (0, 500, or 1,000 phytase units/kg) were fed to

Potent Therapy and Transcriptional Profile of Combined Erythropoietin-Derived Peptide Cyclic Helix B Surface Peptide and Caspase-3 siRNA against Kidney Ischemia/Reperfusion Injury in Mice.

Yuanyuan Wu et al.

The Journal of pharmacology and experimental therapeutics, 375(1), 92-103 (2020-08-08)

Cause-specific treatment and timely diagnosis are still not available for acute kidney injury (AKI) apart from supportive therapy and serum creatinine measurement. A novel erythropoietin-derived cyclic helix B surface peptide (CHBP) protects kidneys against AKI with different causes, but the

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