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Ewelina Dziubakiewicz et al.
Colloids and surfaces. B, Biointerfaces, 104, 122-127 (2013-01-10)
Potentiometric titration and zeta potential measurements are crucial techniques for the characterization of the surface properties of bacterial cells. In this study, we investigated the effects of two commonly used electrolytes, NaNO(3) and NaClO(4), on the viability and acid-base properties
Marianna Sikorska et al.
Neurobiology of aging, 35(10), 2329-2346 (2014-04-30)
Although the support for the use of antioxidants, such as coenzyme Q(10) (CoQ(10)), to treat Parkinson's disease (PD) comes from the extensive scientific evidence, the results of conducted thus far clinical trials are inconclusive. It is assumed that the efficacy
Hanyong Jin et al.
International journal of molecular sciences, 16(3), 6217-6234 (2015-03-21)
Acylpeptide hydrolases (APHs) catalyze the removal of N-acylated amino acids from blocked peptides. Like other prolyloligopeptidase (POP) family members, APHs are believed to be important targets for drug design. To date, the binding pose of organophosphorus (OP) compounds of APH
Li Nan et al.
Materials science & engineering. C, Materials for biological applications, 48, 228-234 (2015-01-13)
Cu-bearing antibacterial stainless steels have been gaining popularity in recent years due to their strong antibacterial performances. However, only a few studies were reported for their actual performances against microbiologically influenced corrosion (MIC). In this study, electrochemical methods and surface
Michał Brokl et al.
Journal of chromatography. A, 1370, 216-229 (2014-12-03)
A method involving headspace solid-phase microextraction (HS-SPME) and comprehensive two-dimensional gas chromatography (GC×GC) coupled to time-of-flight mass spectrometry (TOFMS) was developed and applied to evaluate profiles of volatile compounds present in mainstream tobacco smoke particulate matter trapped on glass fiber
Lama Talje et al.
FEBS letters, 588(14), 2315-2320 (2014-05-27)
The kinesin-13 family of microtubule depolymerases is a major regulator of microtubule dynamics. RNA interference-induced knockdown studies have highlighted their importance in many cell division processes including spindle assembly and chromosome segregation. Since microtubule turnovers and most mitotic events are
He-Ping Zhao et al.
Environmental science & technology, 47(3), 1565-1572 (2013-01-10)
We evaluated a strategy for achieving complete reduction of perchlorate (ClO(4)(-)) in the presence of much higher concentrations of sulfate (SO(4)(2-)) and nitrate (NO(3)(-)) in a hydrogen-based membrane biofilm reactor (MBfR). Full ClO(4)(-) reduction was achieved by using a two-stage
Minal Çalışkan et al.
PloS one, 9(9), e107166-e107166 (2014-09-06)
Epstein-Barr virus (EBV) transformed lymphoblastoid cell lines (LCLs) are a widely used renewable resource for functional genomic studies in humans. The ability to accumulate multidimensional data pertaining to the same individual cell lines, from complete genomic sequences to detailed gene
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 15(3), 567-571 (2005-01-25)
The inhibition of five human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes; the cytosolic hCA I and II, the membrane-bound hCA IV, the mitochondrial hCA V, and the tumor-associated, transmembrane hCA IX, with anions isosteric and isoelectronic with sulfate, nitrate, and
Ann-Charlotte Almstrand et al.
Analytical biochemistry, 474, 50-58 (2015-01-13)
Chemical reactions with unsaturated phospholipids in the respiratory tract lining fluid have been identified as one of the first important steps in the mechanisms mediating environmental ozone toxicity. As a consequence of these reactions, complex mixtures of oxidized lipids are
J C Huang et al.
Journal of animal science, 92(12), 5749-5756 (2014-11-05)
The objective of this study was to determine the effects of physical restraint and electrical stunning on plasma corticosterone, postmortem metabolism, and quality of broiler breast muscle. Before slaughter, a total of 160 Arbor Acres broilers were randomly categorized into
Zheng Xiang et al.
Molecular bioSystems, 11(4), 1067-1078 (2015-01-30)
The cooperative material basis of the multi-component and multi-target mechanism of action of Traditional Chinese Medicine (TCM) is difficult to elucidate because of the current lack of appropriate techniques and strategies. In this paper, we focus on rhubarb treatment of
Yuka Sumi et al.
Shock (Augusta, Ga.), 42(2), 142-147 (2014-03-29)
Our previous work has shown that polymorphonuclear neutrophils (PMNs) require cellular adenosine triphosphate (ATP) release and autocrine purinergic signaling for their activation. Here we studied in a mouse model of cecal ligation and puncture (CLP) whether sepsis affects this purinergic
A Yu et al.
Acta anaesthesiologica Scandinavica, 59(1), 115-122 (2014-10-29)
This retrospective study investigated the effect of nicotine dependence on required postoperative opioid administration in patients undergoing thoracic surgery. The subjects consisted of 215 male patients (112 nonsmokers, 103 smokers) who underwent thoracic surgery and received postoperative patient-controlled intravenous analgesia.
Xilin Du et al.
Applied microbiology and biotechnology, 99(2), 813-825 (2014-10-12)
Phenazine-1-carboxylic acid (PCA), an environmentally compatible redox-active metabolite produced by Pseudomonas sp., has been found to effectively protect against various phytopathogens. The objective of this study was to discover whether PCA can also act as a signaling molecule that regulates
Dwight R Stoll et al.
Analytical and bioanalytical chemistry, 407(1), 265-277 (2014-07-30)
In this paper, we describe the findings of a study aimed at assessing the detection sensitivity of comprehensive two-dimensional high-performance liquid chromatography (LCxLC) separation of a degraded active pharmaceutical ingredient (API) with UV absorption as the detection technique. Specifically, we
Y Z Chiang et al.
The British journal of dermatology, 172(1), 130-137 (2014-07-22)
While alopecia has been shown to have substantial psychological consequences, previous studies have not explicitly explored the key beliefs of patients with primary cicatricial alopecia (PCA) and the relationship between clinical and psychological measures. To identify the key psychological factors
Pedro A Pereira et al.
Neurotoxicology and teratology, 44, 53-61 (2014-06-04)
Neuropeptide Y (NPY)- and acetylcholine-containing interneurons of the nucleus accumbens (NAc) seem to play a major role in the rewarding effects of alcohol. This study investigated the relationship between chronic alcohol consumption and subsequent withdrawal and the expression of NPY
Gary A Attard et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(10), 2044-2051 (2014-07-06)
PtM overlayers (where M=Fe, Co or Ni) supported on Pt{111} are prepared via thermal annealing in either a nitrogen/water or hydrogen ambient of dilute aqueous droplets containing M(Z+) cations directly attached to the electrode. Two different PtM phases are detected
José Luís Dores-Sousa et al.
Toxicology, 329, 106-119 (2015-01-15)
Age is a known susceptibility factor for the cardiotoxicity of several anticancer drugs, including mitoxantrone (MTX). The impact of anticancer drugs in young patients is underestimated, thus we aimed to evaluate the cardiotoxicity of MTX in juvenile and adult animals.
Matthew Eady et al.
Journal of food protection, 78(4), 668-674 (2015-04-04)
This study was designed to evaluate hyperspectral microscope images for early and rapid detection of Salmonella serotypes Enteritidis, Heidelberg, Infantis, Kentucky, and Typhimurium at incubation times of 6, 8, 10, 12, and 24 h. Images were collected by an acousto-optical
YuXia Zhou et al.
Journal of separation science, 37(11), 1248-1255 (2014-03-13)
The characterization of process-related impurities and forced degradants of alogliptin benzoate (Alb) in bulk drugs and a stability-indicating HPLC method for the separation and quantification of all the impurities were investigated. Alb was found to be unstable under acid and
Aneta Piesiewicz et al.
Chronobiology international, 32(1), 59-70 (2014-09-16)
Previously, we have demonstrated the postembryonic development of chicken (Gallus gallus domesticus L.) pineal gland functions expressed as changes in melatonin (MEL) biosynthesis. Pineal concentrations of MEL and its precursor serotonin (5-HT) were shown to increase between the 2nd and
Anne R Tinning et al.
American journal of physiology. Renal physiology, 307(11), F1215-F1226 (2014-10-24)
Both the processing and release of secretory granules involve water movement across granule membranes. It was hypothesized that the water channel aquaporin (AQP)1 directly contributes to the recruitment of renin-positive cells in the afferent arteriole. AQP1(-/-) and AQP1(+/+) mice were
Keir X X Yong et al.
Brain : a journal of neurology, 137(Pt 12), 3284-3299 (2014-10-30)
Crowding is a breakdown in the ability to identify objects in clutter, and is a major constraint on object recognition. Crowding particularly impairs object perception in peripheral, amblyopic and possibly developing vision. Here we argue that crowding is also a
Kenji Maeda et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 589-604 (2014-06-21)
Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel drug candidate in clinical development for psychiatric disorders with high affinity for serotonin, dopamine, and noradrenaline receptors. In particular, it bound with high affinity (Ki < 1 nM) to human serotonin 1A (h5-HT1A)-, h5-HT2A-
Flávia de Souza Lins Borba et al.
Forensic science international, 249, 73-82 (2015-02-14)
The objective of this work is assessing whether the combination of Raman spectroscopy and chemometric tools is appropriate to differentiate blue ballpoint pen inks. Fourteen commercial blue ballpoint pen inks from different brands and models were studied and Raman spectra
Role of glutamate and advantages of combining memantine with a 5HT6 ligand in a model of depression.
Renny Abraham et al.
Pharmacological reports : PR, 66(3), 394-398 (2014-06-07)
It is a well-known fact that 5HT6 ligands increase glutamate levels. In the current study we investigated whether a 5HT6 antagonist, SB399885 would show antidepressant like property at a dose which would significantly increase the glutamate levels. Further we studied
María Amparo Asensi-Fabado et al.
Journal of experimental botany, 66(3), 957-971 (2014-11-28)
Tocopherol cyclase, encoded by the gene SUCROSE EXPORT DEFECTIVE1, catalyses the second step in the synthesis of the antioxidant tocopherol. Depletion of SXD1 activity in maize and potato leaves leads to tocopherol deficiency and a 'sugar export block' phenotype that
Xu Gao et al.
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 20(1), 83-90 (2014-02-22)
Onyx has been widely adopted for the treatment of arteriovenous malformations (AVMs). However, its control demands operators accumulate a considerable learning curve. We describe our initial experience using a novel injection method for the embolization of AVMs. We retrospectively reviewed
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