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Julieta Gradinaru et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 35-45 (2015-02-17)
A rapid method for the simultaneous determination of the in vitro activity of the 10 major human liver UDP-glucuronosyltransferase (UGT) enzymes was developed based on the cocktail approach. Specific substrates were first selected for each UGT: etoposide for UGT1A1, chenodeoxycholic
Muhammad Badruzzaman et al.
Fish physiology and biochemistry, 41(1), 61-71 (2014-11-05)
In the neuroendocrine system controlling fish reproduction, dopamine (DA) acts as a gonadotropin inhibitory factor and plays a role in regulating gonadal development of certain species. The present study examined the effects of chemical destruction of dopaminergic neurons in the
Michael B McDonald et al.
ChemSusChem, 7(11), 3021-3027 (2014-09-25)
A bipolar membrane can maintain a steady-state pH difference between the sites of oxidation and reduction in membrane-supported, solar-driven water-splitting systems without changing the overall thermodynamics required to split water. A commercially available bipolar membrane that can serve this purpose
Martin G Liebensteiner et al.
Science (New York, N.Y.), 340(6128), 85-87 (2013-04-06)
Perchlorate and chlorate anions [(per)chlorate] exist in the environment from natural and anthropogenic sources, where they can serve as electron acceptors for bacteria. We performed growth experiments combined with genomic and proteomic analyses of the hyperthermophile Archaeoglobus fulgidus that show
Fulai Yu et al.
Biological & pharmaceutical bulletin, 38(1), 75-81 (2015-03-07)
Methods to improve the bioactive component content of cultivated licorice have become the bottleneck of industrial licorice extraction for pharmaceutical use. To evaluate the effects of genotype, environment and their interaction on major bioactive components, we analyzed the five bioactive
Aline Donato-Trancoso et al.
Acta histochemica, 116(7), 1169-1177 (2014-07-24)
Joannesia princeps (Cotieira) is a well known medicinal plant in Brazil, however, the therapeutic effects of oil obtained from its seeds have still not been demonstrated. The beneficial effects of J. princeps seed oil on cutaneous wound healing on the
B De Witte et al.
Marine pollution bulletin, 85(1), 146-155 (2014-06-28)
This study compared species identity, microplastics, chemical and microbial contamination between consumption mussels and wild type mussels, collected at Belgian department stores and Belgian groynes and quaysides, respectively. Species identification based on genetic analysis showed a high number of Mytilus
Mohamed E El-Boshy et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 29, 104-110 (2014-06-24)
Cadmium is a non-essential toxic metal used in industrial process, causes severe risk to human health. Selenium (Se) is an essential trace mineral of fundamental importance for human health. Selenium has antioxidant enzymes roles and is needed for the proper
Changtao Jiang et al.
The Journal of clinical investigation, 125(1), 386-402 (2014-12-17)
Nonalcoholic fatty liver disease (NAFLD) is a major worldwide health problem. Recent studies suggest that the gut microbiota influences NAFLD pathogenesis. Here, a murine model of high-fat diet-induced (HFD-induced) NAFLD was used, and the effects of alterations in the gut
Narelle K Hansell et al.
PloS one, 10(4), e0123886-e0123886 (2015-04-11)
Relational complexity (RC) is a metric reflecting capacity limitation in relational processing. It plays a crucial role in higher cognitive processes and is an endophenotype for several disorders. However, the genetic underpinnings of complex relational processing have not been investigated.
Mona Dergham et al.
Environmental research, 137, 256-267 (2015-01-21)
While the evidence for the health adverse effects of air pollution Particulate Matter (PM) has been growing, there is still uncertainty as to which constituents within PM are most harmful. Hence, to contribute to fulfill this gap of knowledge, some
Ethan den Boer et al.
Therapeutic drug monitoring, 36(6), 819-823 (2014-04-18)
The folate antagonist methotrexate (MTX) is the anchor drug in the treatment of rheumatoid arthritis. The therapeutic effects of MTX are attributed to the intracellular levels of MTX, present in the cell as polyglutamates (MTX-PGs). We aimed to validate an
Barbara Peil et al.
Genetic epidemiology, 39(2), 114-121 (2014-12-30)
The addition of sequence data from own-study individuals to genotypes from external data repositories, for example, the HapMap, has been shown to improve the accuracy of imputed genotypes. Early approaches for reference panel selection favored individuals who best reflect recombination
Nurullah Şanlı et al.
Journal of pharmaceutical and biomedical analysis, 107, 217-222 (2015-01-18)
A RP-LC-FL detection method has been developed to identify and quantitate four amino acid neurotransmitters including glutamic acid, glycine, taurine and γ-aminobutyric acid in rat and mouse spinal cord tissue. 3-(4-carboxybenzoyl)-2-quinolinecarboxaldehyde (CBQCA) was employed for the derivatization of these neurotransmitters
Sara Batelli et al.
Neuro-degenerative diseases, 15(1), 13-23 (2014-12-17)
Dopaminergic degeneration is a major finding in brains of patients with Parkinson's disease (PD), together with Lewy bodies, intraneuronal inclusions mainly composed of the fibrillogenic protein α-synuclein (α-syn). The familial-PD-related protein DJ-1 was reported to reduce dopaminergic degeneration triggered by
Amit K Jha et al.
PloS one, 9(6), e98640-e98640 (2014-06-18)
Osteogenic differentiation of human mesenchymal stem cells (hMSCs) is guided by various physical and biochemical factors. Among these factors, modulus (i.e., rigidiy) of the ECM has gained significant attention as a physical osteoinductive signal that can contribute to endochondral ossification
Timothy D Harrington et al.
Biotechnology and bioengineering, 112(5), 858-866 (2014-11-26)
We investigated ion transport limitations on 3D graphite felt electrodes by growing Geobacter sulfurreducens biofilms with advection to eliminate external mass transfer limitations. We characterized ion transport limitations by: (i) showing that serially increasing NaCl concentration up to 200 mM
Zhao Huang et al.
Materials science & engineering. C, Materials for biological applications, 50, 160-172 (2015-03-10)
To overcome the limited intrinsic cartilage repair, autologous chondrocyte or bone-marrow-derived mesenchymal stromal cell (BM-MSC) was implanted into cartilage defects. For this purpose suitable biocompatible scaffolds are needed to provide cell retention, chondrogenesis and initial mechanical stability. The present study
Yongxing Liu et al.
PloS one, 9(7), e100885-e100885 (2014-07-24)
Human induced pluripotent stem cells (hiPSCs) can differentiate into notochordal cell (NC)-like cells when cultured in the presence of natural porcine nucleus pulposus (NP) tissue matrix. The method promises massive production of high-quality, functional cells to treat degenerative intervertebral discs
Luciana Romina Frick et al.
Behavioural brain research, 277, 193-203 (2014-06-21)
Serotonin (5-HT) has been proposed as a possible encoder of reward. Nevertheless, the role of this neurotransmitter in reward-based tasks is not well understood. Given that the major serotonergic circuit in the rat brain comprises the dorsal raphe nuclei and
Kurian A Kuttiyiel et al.
Nature communications, 5, 5185-5185 (2014-11-07)
Considerable efforts to make palladium and palladium alloys active catalysts and a possible replacement for platinum have had a marginal success. Here we report on a structurally ordered Au10Pd₄₀Co₅₀ catalyst that exhibits comparable activity to conventional platinum catalysts in both
Michael P Waalkes et al.
Archives of toxicology, 88(8), 1619-1629 (2014-07-10)
In mice, inorganic arsenic in the drinking water in the parts per million range via the dam during in utero life or with whole-life exposure is a multi-site carcinogen in the offspring. However, human arsenic exposure is typically in the
E Malmström et al.
Thrombosis and haemostasis, 112(6), 1230-1243 (2014-08-12)
Early diagnosis of severe infectious diseases is essential for timely implementation of lifesaving therapies. In a search for novel biomarkers in sepsis diagnosis we focused on polymorphonuclear neutrophils (PMNs). Notably, PMNs have their protein cargo readily stored in granules and
Karen L Foster et al.
The Science of the total environment, 506-507, 430-443 (2014-12-02)
With declining sea ice conditions in Arctic regions owing to changing climate, the large prospective reservoirs of oil and gas in Baffin Bay and Davis Strait are increasingly accessible, and the interest in offshore exploration and shipping through these regions
Ashok K Tiwari et al.
Pharmacognosy magazine, 10(Suppl 2), S383-S391 (2014-07-06)
Hyperglycemia induced generation of free radicals and consequent development of oxidative stress by polyol pathway is one of the crucial mechanisms stirring up development of diabetic complications. We evaluated influence of ten vegetables' juice on polyol pathway along with their
C Preston Pugh et al.
Archives of biochemistry and biophysics, 564, 244-253 (2014-12-03)
The widely used anticoagulant Coumadin (R/S-warfarin) undergoes oxidation by cytochromes P450 into hydroxywarfarins that subsequently become conjugated for excretion in urine. Hydroxywarfarins may modulate warfarin metabolism transcriptionally or through direct inhibition of cytochromes P450 and thus, UGT action toward hydroxywarfarin
Sheppard A Martin et al.
Inhalation toxicology, 26(10), 598-619 (2014-08-22)
Ethanol (EtOH) exposure induces a variety of concentration-dependent neurological and developmental effects in the rat. Physiologically-based pharmacokinetic (PBPK) models have been used to predict the inhalation exposure concentrations necessary to produce blood EtOH concentrations (BEC) in the range associated with
Running on poison.
David Biello
Scientific American, 308(6), 30-30 (2013-06-05)
Minyoung Jung et al.
Journal of dermatological science, 76(3), 231-239 (2014-10-16)
Dry skin in atopic dermatitis (AD) mainly results from barrier impairment due to deficiency of ceramide and natural moisturizing factors including pyrrolidone carboxylic acid (PCA) in stratum corneum (SC). Caspase-14 cleaves filaggrin monomers to free amino acids and their derivatives
Lingjian Yang et al.
BMC bioinformatics, 15, 390-390 (2014-12-06)
Applying machine learning methods on microarray gene expression profiles for disease classification problems is a popular method to derive biomarkers, i.e. sets of genes that can predict disease state or outcome. Traditional approaches where expression of genes were treated independently
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