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Fabrice Gritti et al.
Journal of chromatography. A, 1095(1-2), 27-39 (2005-11-09)
The adsorption isotherms of an ionizable compound, nortriptyline, were accurately measured by frontal analysis (FA) on a C(18)-Discovery column, first without buffer (in an aqueous solution of acetonitrile at 15%, v/v of ACN), then with a buffer (in 28%, v/v
Wenkui Li et al.
Journal of pharmaceutical and biomedical analysis, 30(1), 67-75 (2002-08-02)
A gradient high performance liquid chromatographic method with evaporative light scattering detection (ELSD) for the simultaneous determination of ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J, bilobalide, quercetin, kaempferol and isorhamnetin in Ginkgo biloba is described. Samples are analyzed by
Erik Haghedooren et al.
Talanta, 78(3), 665-671 (2009-03-10)
The rise of monolithic stationary phases offers to routine and research laboratories several advantages. In spite of their recent discovery, they have rapidly become highly popular separation media for liquid chromatography. Time reduction and economic reasons like e.g. a diminished
Michael S Roberts et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 151-157 (2014-05-09)
An LC-ESI-MS/MS method using high-throughput solid-phase extraction (SPE) was developed and validated to measure crizotinib in human and mouse plasma to support ongoing clinical and preclinical pharmacokinetic studies. Chromatographic separation of mouse or human plasma extracts was performed on a
Kodali Sucharita et al.
The Journal of general and applied microbiology, 56(2), 93-99 (2010-06-02)
A phototrophic gammaproteobacterium designated strain JA395(T) was isolated from a sediment sample collected from the coast of Birds' Island in the southern sector of Chilika Lagoon, India. The bacterium is a Gram-negative, motile coccus with a single polar flagellum. Bacteriochlorophyll
Jianxing Zhang et al.
Acta crystallographica. Section C, Crystal structure communications, 59(Pt 7), o381-o382 (2003-07-12)
In the crystal structure of the title compound, C(18)H(20)O(5), all geometric parameters fall within experimental error of the expected values. Analysis of the molecular-packing plots reveals an infinite one-dimensional linear array running parallel to the c axis, formed by an
Abbas Khan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(24), 2423-2429 (2011-07-26)
A novel isocratic reversed-phase high performance liquid-chromatography/ultraviolet detection method for simultaneous determination of cefdinir and cefixime in human plasma was developed and validated after optimization of various chromatographic conditions and other experimental parameters. Sample preparation based on a simple extraction
Mayca Onega et al.
Future medicinal chemistry, 1(5), 865-873 (2009-08-01)
There is an increasing interest in the preparation of (18)F-labeled radiopharmaceuticals with potential applications in PET for medicinal imaging. Appropriate synthetic methods require a quick and efficient route in which to incorporate the (18)F into a ligand, due to the
Agata Zygler et al.
Talanta, 82(5), 1742-1748 (2010-09-30)
The objective of this paper is to provide information about application of solid-phase extraction (SPE) for isolation of nine high-intensity sweeteners (acesulfame-K, alitame, aspartame, cyclamate, dulcin, neotame, saccharin, sucralose and neohesperidin dihydrochalcone) from aqueous solutions. The influence of several types
Michael T Baynham et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 772(1), 155-161 (2002-05-23)
The alpha3beta4 subtype of the neuronal nicotinic acetylcholine receptor (nAChR) subtype was immobilized on a liquid chromatographic support and the resulting column used for the rapid and direct on-line screening for nAChR ligands. A multidimensional chromatographic system was developed consisting
Ramisetti Nageswara Rao et al.
Journal of separation science, 32(9), 1312-1322 (2009-04-29)
Modafinil, adrafinil and their related substances were synthesized and analyzed by RP-LC with ESI-MS/MS. The ionization mode, polarity, cone voltage, and chromatographic conditions were evaluated. The optimum LC-MS conditions to obtain fragment ions indispensable for identification of the structures were
Wenyan Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 863(1), 163-166 (2008-02-05)
A quick, precise and reliable HPLC method has been developed to determine tripterin in rat plasma. After liquid-liquid extraction, the analytes was analyzed on a Discovery ODS C(18) column (5microm, 4.6mmx250mm) with an isocratic elution consisting of methanol-water-phosphoric acid (87:13:0.2
Shivva Vittal et al.
Biomedical chromatography : BMC, 20(11), 1252-1259 (2006-07-14)
A simple, sensitive and specific high-performance liquid chromatography method is described for simultaneous determination of rosuvastatin (RST) and gemfibrozil (GFZ) in human plasma using celecoxib as an internal standard (IS). The assay procedure involved extraction of RST, GFZ and IS
Ramakrishna Nirogi et al.
Biomedical chromatography : BMC, 21(12), 1240-1244 (2007-06-26)
A simple, reliable HPLC method with UV detection (295 nm) in rat plasma was developed and validated for quantification of tenatoprazole, a novel proton pump inhibitor, which is in clinical trials. Following a single-step liquid-liquid extraction, the analyte and internal
H Z Bu et al.
Rapid communications in mass spectrometry : RCM, 15(10), 741-748 (2001-05-10)
The inhibition potential of drugs towards five major human hepatic cytochrome P450 (CYP) isozymes (CYP2A6, 3A4, 2C9, 2D6, and 2E1) was investigated via cassette dosing of the five probe substrates (coumarin, midazolam, tolbutamide, dextromethorphan, and chlorzoxazone) in human liver microsomes
Wen-zhi Yang et al.
Analytica chimica acta, 739, 56-66 (2012-07-24)
To discover new natural compounds from herbal medicines tends to be more and more difficult. In this paper, a strategy integrating orthogonal column chromatography and liquid chromatography/mass spectrometry (LC/MS) analysis was proposed, and was applied for rapid discovery of new
Ravi Shankar Prasad Singh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(28), 2796-2802 (2010-09-25)
Curcumin and its derivatives generally display favorable cytotoxic activities against a number of cancer cell types. We focus our rational antineoplastic drug design program on curcumin analogues containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore. Favorable outcomes from pharmacological screens of this series demanded
Himal Paudel Chhetri et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 22(5), 483-487 (2014-12-05)
This study presents the optimization of a simple HPLC-UV method for the determination of metformin in human plasma. Ion pair separation followed by UV detection was performed on deproteinized human plasma samples. The separation was carried out on a Discovery
Macarena Ramos et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 789(2), 373-381 (2003-05-14)
A simple and sensitive high-performance liquid chromatographic (HPLC) method has been developed for the determination of five different quinolones: enrofloxacin, ciprofloxacin, sarafloxacin, oxolinic acid and flumequine in pork and salmon muscle. The method includes one extraction and clean-up step for
H Z Bu et al.
Rapid communications in mass spectrometry : RCM, 14(20), 1943-1948 (2000-10-03)
A highly efficient direct injection on-line guard cartridge extraction/tandem mass spectrometry (DI-GCE/MS/MS) method has been validated for high-throughput evaluation of cytochrome P450 (CYP) 3A4, 2D6 and 2E1 inhibition potential via cassette dosing of midazolam, dextromethorphan and chlorzoxazone using human hepatic
Ganyu Gu et al.
Applied and environmental microbiology, 77(17), 6189-6198 (2011-07-12)
A striking feature of Burkholderia contaminans strain MS14 is the production of a glycolipopeptide named occidiofungin. Occidiofungin has a broad range of antifungal activities against plant and animal pathogens. In this study, a complete covalent structure characterization and identification of
Lucie Nováková et al.
Analytical and bioanalytical chemistry, 379(5-6), 781-787 (2004-03-05)
This paper deals with the development of a novel method for simultaneous determination of estradiol, its degradation product estrone, and two preservatives, methylparaben and propylparaben, in the topical preparation Estradiol HBF. After optimization of the analytical conditions the method was
A Srinivas et al.
International journal of systematic and evolutionary microbiology, 62(Pt 10), 2528-2532 (2011-12-20)
An oval to rod-shaped, Gram-stain-negative, phototrophic bacterium, strain JA738(T), was isolated from a sediment sample collected from a pink pond. Strain JA738(T) was non-motile and had vesicular-type intracellular photosynthetic membranes. Bacteriochlorophyll a and carotenoids of the spheroidene series were present
Mugunthu R Dhananjeyan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 867(2), 247-252 (2008-05-03)
A sensitive and rapid high-performance liquid chromatography method has been developed for simultaneous determination of procaine and its metabolite p-aminobenzoic acid (PABA) from human and rat liver tissue extracts. The method has been validated according to ICH guidelines in terms
Jiaoyuan Li et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 27(9), 1029-1035 (2018-06-13)
Background: Telomere dysfunction triggers cellular senescence and constitutes a driving force for cancer initiation. Genetic variants in genes involved in telomere maintenance may contribute to colorectal cancer susceptibility.Methods: In this study, we firstly captured germline mutations in 192 patients with
Curtis O Green et al.
Biomedical chromatography : BMC, 21(1), 48-54 (2006-11-03)
The concentrations of the polymethoxylated flavones (PMFs) in peels of selected citrus cultivars grown in Jamaica and Mexico were determined. The PMFs were extracted from sun-dried citrus peels with reagent-grade methanol. Analyses were carried out by reverse-phase HPLC and UV
Sheelendra Pratap Singh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(27), 2845-2851 (2011-09-06)
Tamoxifen is the agent of choice for the treatment of estrogen receptor-positive breast cancer. Tamoxifen is a substrate of P-glycoprotein (P-gp) and microsomal cytochrome P450 (CYP) 3A, and biochanin A (BCA) is an inhibitor of P-gp and CYP3A. Hence, it
Robert A Parise et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 791(1-2), 39-44 (2003-06-12)
Imatinib mesylate (Gleevec, Glivec, STI571) is a targeted, small molecule inhibitor of the oncogenes, BCR/ABL and c-KIT, and has striking antitumor activity in patients with chronic myelogenous leukemia or gastrointestinal stromal tumors. We have developed a liquid chromatographic-electrospray ionization mass
Antal Péter et al.
Journal of chromatography. A, 1031(1-2), 171-178 (2004-04-03)
Direct and indirect reversed-phase (RP) high-performance liquid chromatographic methods were developed for the separation of enantiomers of 18 unnatural beta-amino acids, including several beta-3-homo amino acids. The direct separations of the underivatized analytes were performed on chiral stationary phases (CSPs)
G F van Rooyen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 768(2), 223-229 (2002-03-14)
A sensitive method for the determination of clarithromycin in plasma is described, using high-performance liquid chromatographic separation with tandem mass spectrometric detection. Samples were prepared using liquid-liquid extraction and separated on a Supelco Discovery C18 column with a mobile phase
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