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F A Norris et al.
The Journal of biological chemistry, 272(17), 10987-10989 (1997-04-25)
Inositol polyphosphate 4-phosphatase (4-phosphatase), an enzyme that catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, was shown to be a substrate for the calcium-dependent protease calpain in vitro and in stimulated human platelets. Stimulation of platelets with the
Daniela Fenoglio et al.
Cancer immunology, immunotherapy : CII, 62(6), 1041-1052 (2013-04-18)
Anti-tumor vaccination is a new frontier in cancer treatment applicable to immunogenic neoplasms such as prostate and renal cancers. GX301 is a vaccine constituted by four telomerase peptides and two adjuvants, Montanide ISA-51 and Imiquimod. The aim of this study
Hua Yang et al.
Journal of cancer research and clinical oncology, 136(2), 275-281 (2009-08-20)
Lysosomal protein transmembrane 4 beta-35 (LAPTM4B-35) is a tetra-transmembrane glycoprotein that is abundantly localized on membrane-bound organelles including endosomes and lysosomes, and promotes cell proliferation and tumorigenesis through regulation of cell cycle and signaling pathways. The aim of the present
Maria Kabbaj et al.
Annales de biologie clinique, 69(3), 295-301 (2011-06-11)
We have studied the distribution of HLA-A, -B and DRB1 alleles and haplotypes by sequence specific oligonucleotide amplification in a sample of 125 unrelated healthy Moroccan individuals from Casablanca in Morocco. The city of Casablanca is known of its big
Naofumi Kamimura et al.
Journal of bacteriology, 192(13), 3394-3405 (2010-05-04)
Sphingobium sp. strain SYK-6 converts various lignin-derived biaryls with guaiacyl (4-hydroxy-3-methoxyphenyl) and syringyl (4-hydroxy-3,5-dimethoxyphenyl) moieties to vanillate and syringate. These compounds are further catabolized through the protocatechuate (PCA) 4,5-cleavage (PCA45) pathway. In this article, the regulatory system of the PCA45
Zhi Sun et al.
Journal of computational chemistry, 35(13), 998-1009 (2014-03-14)
Transition metal complexes with terminal oxo and dioxygen ligands exist in metal oxidation reactions, and many are key intermediates in various catalytic and biological processes. The prototypical oxo-metal [(OC)5Cr-O, (OC)4Fe-O, and (OC)3 Ni-O] and dioxygen-metal carbonyls [(OC)5Cr-OO, (OC)4Fe-OO, and (OC)3Ni-OO]
Shigang Ding et al.
Oncology reports, 17(2), 369-375 (2007-01-05)
The expression of VEGF-A and -C was investigated immunohistochemically in 51 specimens of gastric carcinoma. The expression intensity was evaluated by means of a semi-quantitative scoring system and a quantitative analysis. The results showed that VEGF-A and -C were located
R Reves et al.
Journal of clinical gastroenterology, 5(3), 223-227 (1983-06-01)
Seventy adults in the United States with acute diarrhea who were attending classes in Guadalajara, Mexico, enrolled in a double-blind placebo-controlled treatment study of an anticholinergic drug, mepenzolate bromide (MZB). Thirty-five patients received MZB (50 mg) and 35 received placebo
M Salković-Petrisić et al.
Journal of neural transmission (Vienna, Austria : 1996), 110(1), 15-29 (2003-01-24)
Intracerebroventricular (icv) administration of betacytotoxics alters brain monoamine neurotransmission, without producing hyperglycemia. By means of in situ hybridization, we have investigated the expression of dopamine, noradrenaline and serotonin transporter (DAT, NAT, 5-HTT, respectively) mRNAs, in the brain of alloxan- and
Nachwa Jarkas et al.
Journal of medicinal chemistry, 48(13), 4254-4265 (2005-06-25)
A series of N,N-dimethylated and N-monomethylated analogues of N,N-dimethyl-2-(2'-amino-4'-iodophenylthio)benzylamine substituted at the 4'-phenyl position have been prepared and evaluated in vitro for serotonin transporter (SERT) selectivity. Several derivatives were prepared where the 4'-position was either unsubstituted 13 and 33a or
Peter Tsenovoy et al.
Cardiology, 112(3), 202-204 (2008-08-07)
To investigate the association of increased cardiac troponin I levels with in-hospital mortality and valve replacement in patients with infective endocarditis (IE). The 62 patients included 36 men and 26 women, with a mean age of 60 +/- 9 years
B Górski et al.
American journal of human genetics, 66(6), 1963-1968 (2000-05-02)
We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian
Ksenia A Zaripova et al.
International journal of molecular sciences, 22(19) (2021-10-14)
Skeletal muscle unloading results in atrophy. We hypothesized that pannexin 1 ATP-permeable channel (PANX1) is involved in the response of muscle to unloading. We tested this hypothesis by blocking PANX1, which regulates efflux of ATP from the cytoplasm. Rats were
E Koczy-Baron et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 61(12), 1405-1409 (2012-08-24)
Overproduction of vascular endothelial growth factor (VEGF) in atopic dermatitis (AD) lesions has previously been observed. It is also known that platelet is an important source of VEGF and platelet factor 4 (PF-4), a potential marker of AD severity. To
S G King et al.
The Veterinary record, 173(18), 450-450 (2013-10-17)
Plasma progesterone concentrations were estimated for 381 nulliparous dairy heifers from eight farms on days 4-6 after insemination. Heifers were synchronised using two treatments of prostaglandin F2α (PGF2α) 11 days apart. Alternate heifers were treated with 1500 IU human chorionic
Spectrum and frequency of jagged1 (JAG1) mutations in Alagille syndrome patients and their families.
I D Krantz et al.
American journal of human genetics, 62(6), 1361-1369 (1998-06-19)
Alagille syndrome (AGS) is a dominantly inherited disorder characterized by liver disease in combination with heart, skeletal, ocular, facial, renal, and pancreatic abnormalities. We have recently demonstrated that Jagged1 (JAG1) is the AGS gene. JAG1 encodes a ligand in the
O Brugière et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 9(6), 1427-1438 (2009-08-07)
Human leukocyte antigen-G (HLA-G), a nonclassical HLA class I protein, promotes immune tolerance of solid-organ allografts, yet its role in lung transplantation (LTx) is unknown. We examined the expression of HLA-G in lung allografts through immunohistochemistry by a cross-sectional study
P Brown et al.
Neurology, 42(2), 422-427 (1992-02-11)
An American family of English origin with an unusually early onset and long-duration form of Creutzfeldt-Jakob disease (CJD) had a heterozygous insert mutation in the region of repeating octapeptide coding sequences between codons 51 and 91 of the PRNP gene
Kun Qian et al.
Public health nutrition, 23(14), 2485-2493 (2020-06-11)
To determine which set of BMI cut-offs is the most appropriate to define child and adolescent obesity in urban China. A cross-sectional study was carried out between 1 November and 31 December in 2017. Community Healthcare Center in Minhang District
Anna Tamburrino et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(13), 3532-3540 (2012-07-04)
Understanding the molecular pathogenesis of medullary thyroid carcinoma (MTC) is prerequisite to the design of targeted therapies for patients with advanced disease. We studied by immunohistochemistry the phosphorylation status of proteins of the RAS/MEK/ERK and PI3K/AKT/mTOR pathways in 53 MTC
Lei Pan et al.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 33(4), 265-267 (2010-07-22)
To explore the role of CD(47) and P-selectin in patients with COPD. The blood plasma levels of CD(47) and P-selectin in 20 healthy volunteers (control group) and 35 patients with COPD in acute exacerbation and at stable stage were measured
Amy Berrington de Gonzalez et al.
Journal of the National Cancer Institute, 101(3), 205-209 (2009-01-30)
BRCA mutation carriers are recommended to start mammographic screening for breast cancer as early as age 25-30 years. We used an excess relative risk model (based on a pooled analysis of three cohorts with 7600 subjects who received radiation exposure)
P Sabbatini et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 17(3), 589-594 (2007-02-16)
The objective of this study was to analyze retrospective populations with recurrent ovarian cancer to assess differences in CA-125 patterns during chemotherapy. The populations included all patients treated between January 1994 and January 2004, who received liposomal doxorubicin and topotecan
S Hashimoto et al.
Blood, 88(2), 561-573 (1996-07-15)
Deficiencies of Bruton's tyrosine kinase (Btk) have been implicated in the pathogenesis of human X-linked agammaglobulinemia (XLA). The distinctive phenotype observed in B-cell deficiency indicates the crucial role of Btk in B-cell development. This report describes a nationwide study of
Qiong Jiang et al.
BMC cancer, 9, 194-194 (2009-06-23)
MicroRNAs are the endogenous small non-coding RNA molecules capable of silencing protein coding genes at the posttranscriptional level. Based on computer-aided predictions, a single microRNA could have over a hundred of targets. On the other hand, a single protein-coding gene
Katarina Vrede et al.
Applied and environmental microbiology, 68(6), 2965-2971 (2002-06-01)
Marine bacterioplankton were isolated and grown in batch cultures until their growth became limited by organic carbon (C), nitrogen (N), or phosphorus (P). Samples were taken from the cultures at both the exponential and stationary phases. The elemental composition of
A D Darnel et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 16(3), 262-266 (2009-05-15)
Infection by high-risk human papillomaviruses (HPVs) is considered to be the central cause of invasive cervical cancer. Previously reported studies have shown that Id genes regulate cell invasion and metastasis in several human carcinomas including cervical cancer. In order to
Xiao-Yan Liu et al.
Journal of separation science, 43(23), 4247-4262 (2020-09-26)
A method of ultra-fast liquid chromatography in series with tandem mass spectrometry for the rapid and sensitive detection of 57 compounds in Spatholobi Caulis (the vine stem of Spatholobus suberectus Dunn) within 35 min was established. This assay can simultaneously determine
A Höhne et al.
Domestic animal endocrinology, 61, 77-83 (2017-07-25)
The peptide hormone ghrelin is suggested to be involved in food intake regulation in young growing chicken. Whether ghrelin is involved in the regulation of energetic balance associated with laying performance in adult laying hens was studied by use of
A D Darnel et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 16(3), 262-266 (2009-05-15)
Infection by high-risk human papillomaviruses (HPVs) is considered to be the central cause of invasive cervical cancer. Previously reported studies have shown that Id genes regulate cell invasion and metastasis in several human carcinomas including cervical cancer. In order to
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