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Carmen Puig et al.
Applied and environmental microbiology, 80(22), 7088-7095 (2014-09-07)
Biofilm formation by nontypeable (NT) Haemophilus influenzae remains a controversial topic. Nevertheless, biofilm-like structures have been observed in the middle-ear mucosa of experimental chinchilla models of otitis media (OM). To date, there have been no studies of biofilm formation in
Michelle Grace Acoba et al.
Cell reports, 34(11), 108869-108869 (2021-03-18)
Mitochondrial carriers (MCs) mediate the passage of small molecules across the inner mitochondrial membrane (IMM), enabling regulated crosstalk between compartmentalized reactions. Despite MCs representing the largest family of solute carriers in mammals, most have not been subjected to a comprehensive
Siva Wu et al.
PloS one, 9(7), e99204-e99204 (2014-07-10)
Non-typeable Haemophilus influenzae (NTHi) is a common acute otitis media pathogen, with an incidence that is increased by previous antibiotic treatment. NTHi is also an emerging causative agent of other chronic infections in humans, some linked to morbidity, and all
Gitte Loozen et al.
Anaerobe, 35(Pt A), 45-53 (2014-09-25)
The predation of Bdellovibrio bacteriovorus on different periodontal pathogens has already been described. However, it is necessary to consider the polymicrobial nature of periodontal disease. The current study explores the predation of Bdellovibrio on oral pathogens organized in multispecies communities.
Andy J Chen et al.
Journal of biomedical optics, 25(1), 1-11 (2019-12-19)
Hemozoin, the heme detoxification end product in malaria parasites during their growth in the red blood cells (RBCs), serves as an important marker for diagnosis and treatment target of malaria disease. However, the current method for hemozoin-targeted drug screening mainly
Natalya Kraeva et al.
PLoS pathogens, 11(8), e1005127-e1005127 (2015-09-01)
The co-infection cases involving dixenous Leishmania spp. (mostly of the L. donovani complex) and presumably monoxenous trypanosomatids in immunocompromised mammalian hosts including humans are well documented. The main opportunistic parasite has been identified as Leptomonas seymouri of the sub-family Leishmaniinae.
Ibone Anza et al.
Applied and environmental microbiology, 80(14), 4251-4259 (2014-05-06)
Due to the scarcity of water resources in the "Mancha Húmeda" Biosphere Reserve, the use of treated wastewater has been proposed as a solution for the conservation of natural threatened floodplain wetlands. In addition, wastewater treatment plants of many villages
Sumanta Dey et al.
Infection and immunity, 82(8), 3113-3126 (2014-05-14)
The liver efficiently restores function after damage induced during malarial infection once the parasites are cleared from the blood. However, the molecular events leading to the restoration of liver function after malaria are still obscure. To study this, we developed
Yang-Sui Liu et al.
World journal of gastroenterology, 20(26), 8572-8582 (2014-07-16)
To investigate the effect of zinc protoporphyrin IX on the response of hepatoma cells to cisplatin and the possible mechanism involved. Cytotoxicity was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Apoptosis was determined by a flow cytometric assay. Western blotting was
Mohd Ahmad et al.
Biosensors & bioelectronics, 187, 113280-113280 (2021-05-22)
In order to define public health policies, simple, inexpensive and robust detection methods for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are vital for mass-testing in resource limited settings. The current choice of molecular methods for identification of SARS-CoV-2 infection
María I Tracanna et al.
Phytotherapy research : PTR, 29(3), 393-397 (2014-11-25)
A new phenolic derivative, 2,8-dihydroxy-7H-furo[2,3-f]chromen-7-one (1), together with isoquercitrin (2), was isolated from the aerial parts of Tibouchina paratropica. Compound structures were elucidated by spectroscopic methods. Both compounds show antimicrobial activity towards a panel of bacterial and fungal pathogens, and
The role of hemin in the regulation of protein synthesis in erythroid cells.
I M London et al.
Federation proceedings, 35(11), 2218-2222 (1976-09-01)
Estefanía Calvo-Álvarez et al.
PLoS neglected tropical diseases, 9(3), e0003666-e0003666 (2015-04-01)
Visceral leishmaniasis (VL) is hypoendemic in the Mediterranean region, where it is caused by the protozoan Leishmania infantum. An effective vaccine for humans is not yet available and the severe side-effects of the drugs in clinical use, linked to the
Guangyu Wang et al.
Oncology letters, 10(5), 2835-2841 (2016-01-02)
MicroRNA-181 (miR-181) has been recently demonstrated to participate in the differentiation and development of immune cells, including natural killer cells and B and T lymphocytes, and myeloid linages, including erythroid and megakaryocytic cells. The aberrant expression of miR-181, particularly low
Xian Tang et al.
Journal of pharmaceutical and biomedical analysis, 107, 258-264 (2015-01-28)
A novel strategy for dual-channel detection of metallothioneins (MTs) and Hg(2+) has been proposed. In the absence of Hg(2+), the functional chimera aptamer (FCA) designed can form an intact G-quadruplex with flexibility, which was demonstrated to have peroxidase-like activities upon
Nancy Carolina Andrés et al.
Experimental and molecular pathology, 97(3), 321-331 (2014-09-23)
The expression of heme oxygenase-1 (HO-1) has been shown to be up-regulated in colorectal cancer (CRC), but the role it plays in this cancer type has not yet been addressed. The aims of this study have been to analyze HO-1
[Hemin control of globin synthesis].
H Suzuki
Seikagaku. The Journal of Japanese Biochemical Society, 54(10), 1167-1178 (1982-01-01)
Samit Ghosh et al.
PloS one, 6(3), e18399-e18399 (2011-04-13)
Sickle cell disease (SCD) is characterized by hemolysis, vaso-occlusion and ischemia reperfusion injury. These events cause endothelial dysfunction and vasculopathies in multiple systems. However, the lack of atherosclerotic lesions has led to the idea that there are adaptive mechanisms that
Mark T Duncan et al.
Biotechnology and bioengineering, 111(10), 2082-2094 (2014-05-24)
The directed differentiation toward erythroid (E) or megakaryocytic (MK) lineages by the MK-E progenitor (MEP) could enhance the ex vivo generation of red blood cells and platelets for therapeutic transfusions. The lineage choice at the MEP bifurcation is controlled in
Kerstin A Heyl et al.
mBio, 5(5), e01492-e01414 (2014-08-28)
The C-type lectin receptor Dectin-1 is expressed mainly on myeloid cells mediating the immune response targeting respiratory pathogens such as Aspergillus fumigatus and Mycobacterium tuberculosis. The pulmonary epithelium serves as an important interface for interactions between these pathogens and the
Beren Karaosmanoglu et al.
Frontiers in physiology, 12, 679919-679919 (2021-06-29)
Diamond Blackfan Anemia (DBA) is an inherited bone marrow (BM) failure syndrome, characterized by a paucity of erythroid differentiation. DBA is mainly caused by the mutations in ribosomal protein genes, hence classified as ribosomopathy. However, in approximately 30% of patients
Kwi-Hoon Jang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(8), 9030-9043 (2019-06-15)
Keratin 8 (K8) and keratin 18 (K18) are the intermediate filament proteins whose phosphorylation/transamidation associate with their aggregation in Mallory-Denk bodies found in patients with various liver diseases. However, the functions of other post-translational modifications in keratins related to liver
Kazuko Ishiguro et al.
Journal of microbiological methods, 115, 22-26 (2015-05-20)
Bacterial metabolic activity is associated with the onset and progression mechanisms of oral biofilm-mediated disease; however, at present no method to monitor bacterial metabolism exists, especially for periodontopathic bacteria. Therefore, we aimed to establish a novel method for monitoring the
Daphna Nachmani et al.
Nature genetics, 51(10), 1518-1529 (2019-10-02)
RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are lacking. Here, we link ribosomal RNA 2'-O-methylation (2'-O-Me) to the etiology of dyskeratosis congenita. We identify nucleophosmin (NPM1) as
Tao Liu et al.
The Analyst, 139(17), 4315-4321 (2014-07-06)
The rapid and sensitive detection of Alicyclobacillus acidoterrestris (AA) has become very important due to the frequent occurrence of fruit juice spoilage by AA. In the present study, using guaiacol, both as the metabolic product of AA related to its
C A Genco
Advances in dental research, 9(1), 41-47 (1995-02-01)
As with other pathogens, a requirement for the in vivo growth of Porphyromonas gingivalis is that the organism must be capable of obtaining iron from the host. The ability to utilize hemin and hemin-containing compounds for nutritional iron has been
Samit Ghosh et al.
The Journal of clinical investigation, 123(11), 4809-4820 (2013-10-03)
The prevention and treatment of acute chest syndrome (ACS) is a major clinical concern in sickle cell disease (SCD). However, the mechanism underlying the pathogenesis of ACS remains elusive. We tested the hypothesis that the hemolysis byproduct hemin elicits events
Shuo Gu et al.
RNA (New York, N.Y.), 11(1), 38-44 (2004-12-03)
Small inhibitory RNAs (siRNAs) are produced from longer RNA duplexes by the RNAse III family member Dicer. The siRNAs function as sequence-specific guides for RNA cleavage or translational inhibition. The precise mechanism by which siRNAs direct the RNA-induced silencing complex
L Alcalá et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 34(8), 1515-1525 (2015-04-24)
A multicenter study of Clostridium difficile infection (CDI) performed during 2008 in Spain revealed that two of every three episodes went undiagnosed or were misdiagnosed owing to nonsensitive diagnostic tests or lack of clinical suspicion and request. Since then, efforts
Maria G Detsika et al.
Biochemical and biophysical research communications, 460(3), 786-792 (2015-04-01)
The differential localization of HO-1 in renal cells under conditions of injury, and the demonstration that exaggerated HO-1 expression can have detrimental rather than beneficial effects, raises the question of whether HO-1 expression in these cells is subject to control.
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