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Nisreen Shumayrikh et al.
Nucleic acids research, 43(8), 4191-4201 (2015-04-01)
Guanine-rich, single-stranded, DNAs and RNAs are able to fold to form G-quadruplexes that are held together by guanine base quartets. G-quadruplexes are known to bind ferric heme [Fe(III)-protoporphyrin IX] and to strongly activate such bound hemes toward peroxidase (1-electron oxidation)
Prakash Dharmalingam et al.
ACS nano, 14(3), 2827-2846 (2020-02-13)
Therapy for intracerebral hemorrhage (ICH) remains elusive, in part dependent on the severity of the hemorrhage itself as well as multiple deleterious effects of blood and its breakdown products such as hemin and free iron. While oxidative injury and genomic
Wenhan Zhu et al.
Cell host & microbe, 27(3), 376-388 (2020-02-23)
During short-lived perturbations, such as inflammation, the gut microbiota exhibits resilience and reverts to its original configuration. Although microbial access to the micronutrient iron is decreased during colitis, pathogens can scavenge iron by using siderophores. How commensal bacteria acquire iron
Rocio Crespo et al.
Avian diseases, 59(3), 388-393 (2015-10-20)
Between 2012 and 2014, 141 chickens from 10 organic layer flocks with a history of severe drop in egg production (up to 40%) and slight increased mortality (up to 1% per week) were submitted to the Avian Health and Food
Ji Hoon Yu et al.
The international journal of biochemistry & cell biology, 60, 147-156 (2015-01-17)
Ataxia telangiectasia (AT) is caused by mutational inactivation of the ataxia telangiectasia mutated (Atm) gene, which is involved in DNA repair. Increased oxidative stress has been shown in human AT cells and neuronal tissues of Atm-deficient mice. Heme oxygenase-1 (HO-1)
Alex Steimle et al.
STAR protocols, 2(2), 100607-100607 (2021-06-29)
Reproducible in vivo models are necessary to address functional aspects of the gut microbiome in various diseases. Here, we present a gnotobiotic mouse model that allows for the investigation of specific microbial functions within the microbiome. We describe how to
Justus Reunanen et al.
Applied and environmental microbiology, 81(11), 3655-3662 (2015-03-22)
Akkermansia muciniphila is a Gram-negative mucin-degrading bacterium that resides in the gastrointestinal tracts of humans and animals. A. muciniphila has been linked with intestinal health and improved metabolic status in obese and type 2 diabetic subjects. Specifically, A. muciniphila has
A Curti et al.
Journal of immunology (Baltimore, Md. : 1950), 166(2), 848-854 (2001-01-06)
We studied cytokine-driven differentiation of primitive human CD34(+)HLA-DR(-) cells to myeloid dendritic cells (DC). Hemopoietic cells were grown in long-term cultures in the presence of various combinations of early acting cytokines such as FLT3-ligand (FLT3-L) and stem cell factor (SCF)
Jean Winter et al.
Molecular nutrition & food research, 58(3), 550-558 (2013-10-12)
Red meat is considered a risk factor for colorectal cancer (CRC). Heme is considered to promote colonic hyperproliferation and cell damage. Resistant starch (RS) is a food that ferments in the colon with studies demonstrating protective effects against CRC. By
J Correa-Betanzo et al.
Food chemistry, 165, 522-531 (2014-07-21)
Wild blueberries are rich in polyphenols and have several potential health benefits. Understanding the factors that affect the bioaccessibility and bioavailability of polyphenols is important for evaluating their biological significance and efficacy as functional food ingredients. Since the bioavailability of
Anabel Soldano et al.
Biochimica et biophysica acta, 1840(11), 3208-3217 (2014-08-06)
Heme oxygenase catalyzes the conversion of heme to iron, carbon monoxide and biliverdin employing oxygen and reducing equivalents. This enzyme is essential for heme-iron utilization and contributes to virulence in Leptospira interrogans. A phylogenetic analysis was performed using heme oxygenases
Wei Zheng et al.
The Journal of pharmacology and experimental therapeutics, 353(2), 288-298 (2015-02-24)
Small vessel vasculitis is a life-threatening condition and patients typically present with renal and pulmonary injury. Disease pathogenesis is associated with neutrophil accumulation, activation, and oxidative damage, the latter being driven in large part by myeloperoxidase (MPO), which generates hypochlorous
Younglan Lim et al.
International journal of molecular sciences, 22(17) (2021-09-11)
Keratin 8 and keratin 18 (K8/K18) are intermediate filament proteins that form the obligate heteropolymers in hepatocytes and protect the liver against toxins. The mechanisms of protection include the regulation of signaling pathway associated with cell survival. Previous studies show
John A McIntyre et al.
Autoimmunity, 48(5), 344-351 (2015-02-13)
A robust blood biomarker is urgently needed to facilitate early prognosis for those at risk for Alzheimer's disease (AD). Redox reactive autoantibodies (R-RAAs) represent a novel family of antibodies detectable only after exposure of cerebrospinal fluid (CSF), serum, plasma or
Fan Zeng et al.
Journal of neurochemistry, 158(3), 724-736 (2020-05-23)
Cerebrovascular-related amyloidogenesis is found in over 80% of Alzheimer's disease (AD) cases, and amyloid β (Aβ) generation is increased in the peripheral macrophages during infection of Porphyromonas gingivalis (P. gingivalis), a causal bacterium for periodontitis. In this study, we focused
Manabu Nakano et al.
Journal of medical microbiology, 64(10), 1244-1252 (2015-08-06)
The main components of oral malodour have been identified as volatile sulfur compounds (VSCs), including hydrogen sulfide (H(2)S) and methyl mercaptan (CH(3)SH). The lactoperoxidase (LPO) system (consisting of LPO, glucose oxidase, glucose and thiocyanate) was previously shown to exhibit antimicrobial
Gunjan Arora et al.
PLoS neglected tropical diseases, 8(11), e3315-e3315 (2014-11-21)
Mycobacterium ulcerans, the causative agent of Buruli ulcer in humans, is unique among the members of Mycobacterium genus due to the presence of the virulence determinant megaplasmid pMUM001. This plasmid encodes multiple virulence-associated genes, including mup011, which is an uncharacterized
W Wei et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 106, 163-169 (2013-02-05)
A colorimetric method for detection of DNA damage was developed by using hemin-graphene nanosheets (H-GNs). H-GNs were skillfully synthesized by adsorping of hemin on graphene through π-π interactions. The as-prepared H-GNs possessed both the ability of graphene to differentiate the
Diogo R M Moreira et al.
Journal of enzyme inhibition and medicinal chemistry, 30(4), 615-621 (2014-11-29)
This study reports on the design, synthesis and antiparasitic activity of three new semi-synthetic naphthoquinones structurally related to the naturally-occurring lapachol and lapachone. Of the compounds tested, 3-(3-methylbut-1-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl acetate (1) was the most active against Plasmodium falciparum among both natural
Chul-Hyun Park et al.
Life sciences, 92(12), 740-746 (2013-02-27)
The present study examined the effect of the heme oxygenase (HO)-1 inducer hemin on skeletal muscle atrophy induced by single limb immobilization in mice. Immobilization was conducted in the left hindlimb of C57BL/6 mice for 1 week and the right
G S Zijlstra et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 67(3), 667-675 (2007-06-01)
The purpose of this study was to formulate hemin as a powder for inhalation and to show proof of concept of heme oxygenase 1 (HO-1) expression in the lungs of mice by inhalation of hemin. Hemin was spray dried from
José Luis Olloqui-Sariego et al.
Analytical chemistry, 87(21), 10807-10814 (2015-10-07)
Covalent immobilization of enzymes at electrodes via amide bond formation is usually carried out by a two-step protocol, in which surface carboxylic groups are first activated with the corresponding cross-coupling reagents and then reacted with protein amine groups. Herein, it
Denise Gay et al.
Science advances, 6(12), eaay3704-eaay3704 (2020-03-29)
Human and murine skin wounding commonly results in fibrotic scarring, but the murine wounding model wound-induced hair neogenesis (WIHN) can frequently result in a regenerative repair response. Here, we show in single-cell RNA sequencing comparisons of semi-regenerative and fibrotic WIHN
Lianet Monzote et al.
Parasitology, 142(9), 1239-1248 (2015-06-02)
Nemorosone (Nem) and guttiferone A (GutA) are acyl phloroglucinol derivatives (APD) that are present in different natural products. For both compounds anti-cancer and anti-microbial properties have been reported. In particular, an anti-leishmanial activity of both compounds was demonstrated. The aim
Nguyen Thi Hoang Yen et al.
Journal of inorganic biochemistry, 126, 7-16 (2013-05-28)
Indolone-N-oxides (INODs) are bioreducible and possess remarkable anti-malarial activities in the low nanomolar range in vitro against different Plasmodium falciparum (P. falciparum) strains and in vivo. INODs have an original mechanism of action: they damage the host cell membrane without
Kim Y Fong et al.
International journal for parasitology. Drugs and drug resistance, 5(3), 84-91 (2015-07-08)
The Malaria Box, assembled by the Medicines for Malaria Venture, is a set of 400 structurally diverse, commercially available compounds with demonstrated activity against blood-stage Plasmodium falciparum. The compounds are a representative subset of the 20,000 in vitro antimalarials identified from
Zhen Zhang et al.
The Journal of biological chemistry, 291(30), 15628-15640 (2016-05-28)
One mode of γ-globin gene silencing involves a GATA-1·FOG-1·Mi2β repressor complex that binds to the -566 GATA site relative to the (A)γ-globin gene cap site. However, the mechanism of how this repressor complex is assembled at the -566 GATA site
Ricardo M Santos et al.
Biosensors & bioelectronics, 44, 152-159 (2013-02-20)
A novel biomimetic microsensor for measuring nitric oxide (NO) in the brain in vivo was developed. The sensor consists of hemin and functionalized multi-wall carbon nanotubes covalently attached to chitosan via the carbodiimide crosslinker EDC followed by chitosan electrodeposition on
Soumya Mukherjee et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 19(8), 1355-1365 (2014-09-25)
Serotonin (5-HT) is an essential neurotransmitter for cognitive functions and formation of new memories. A deficit in 5-HT dependent neuronal activity is somewhat specific for Alzheimer's disease. Metal-mediated oxidative degradation of neurotransmitters by Aβ bound to metals has been investigated.
Chunmao He et al.
Journal of inorganic biochemistry, 122, 38-48 (2013-03-12)
Nitrophorins are proteins occurring in the saliva of the blood-sucking insect Rhodnius prolixus to carry NO as a vasodilator and blood-coagulation inhibitor into the victim's tissue. It was suggested that the rate of NO release can be enhanced by the
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