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Béatrice Dendelé et al.
Chemico-biological interactions, 207, 41-51 (2013-11-20)
Plasma membrane is an early target of polycyclic aromatic hydrocarbons (PAH). We previously showed that the PAH prototype, benzo[a]pyrene (B[a]P), triggers apoptosis via DNA damage-induced p53 activation (genotoxic pathway) and via remodeling of the membrane cholesterol-rich microdomains called lipid rafts
Ankur Gupta et al.
Journal of chromatography. A, 1278, 16-21 (2013-01-23)
A novel supermacroporous cryogel matrix, poly(4-vinyl pyridine-co-divinyl benzene) has been synthesized by free radical polymerization using 4-vinyl pyridine and divinyl benzene as monomers and poly(ethylene glycol) diacrylate as crosslinker. Hydrophobic property of such synthesized matrix allows capture of polyaromatic hydrocarbons
Long Zhao et al.
Ecotoxicology and environmental safety, 108, 120-128 (2014-07-23)
A comprehensive investigation of the levels, distribution patterns, and sources of polycyclic aromatic hydrocarbons (PAHs) in agricultural soils of the coal production area surrounding Xinzhou, China, was conducted, and the potential human health risks associated with the levels observed were
C Paul Nathanail et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 48(6), 594-603 (2013-02-28)
A former coking works in England is being remediated to enable its redevelopment. We have developed site specific human health risk assessment criteria (SSAC) for benzo[a]pyrene (BaP) based on detailed characterisation of red shale proposed for reuse in an area
Juan Zhang et al.
Journal of chromatography. A, 1388, 9-16 (2015-03-03)
Zeolitic imidazolate frameworks (ZIFs), a subfamily of metal-organic frameworks (MOFs), have received considerable attention as a novel porous material for sample preparation due to their fascinating structures and unique properties. Here, we developed a novel bio-inspired polydopamine (PDA) method to
Shu-qun Cheng et al.
Environmental toxicology and pharmacology, 36(2), 648-658 (2013-07-31)
Benzo(a)pyrene (B[a]P) is an environmental carcinogen that induces tumors in many animal species, but the neurotoxic effects of B[a]P have not been well studied. In the present study, we investigated the effects of subacute exposure to B[a]P in Sprague-Dawley (SD)
Paul L Severson et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 775-776, 48-54 (2014-12-02)
Genetic mutations are known to drive cancer progression and certain tumors have mutation signatures that reflect exposures to environmental carcinogens. Benzo[a]pyrene (BaP) has a known mutation signature and has proven capable of inducing changes to DNA sequence that drives normal
María I Cuartero et al.
Circulation, 130(23), 2040-2051 (2014-11-02)
Aryl hydrocarbon receptor (AhR) is a transcription factor that belongs to the basic helix-loop-helix PAS (Per-Arnt-Sim homology domain) family known to mediate the toxic and carcinogenic effects of xenobiotics. Interestingly, AhR is widely expressed in the central nervous system, but
Xin Xu et al.
Molecular carcinogenesis, 54(2), 134-147 (2013-09-07)
Rat mammary carcinoma susceptibility 5a1 (Mcs5a1), which is concordant to human MCS5A1 breast cancer risk locus, mediates susceptibility by a non-mammary cell-autonomous mechanism associated with T cell differential expression of F-box protein 10 (Fbxo10). Human FBXO10, an evolutionarily conserved ubiquitin
Jun Bo et al.
Environmental toxicology, 29(5), 517-525 (2012-05-23)
The effects of polycyclic aromatic hydrocarbons (PAHs) have been reported to modulate the immune response in aquatic animals, but the collected information of their effects on fish immunity is so far ambiguous. This study demonstrated that Benzo[a]pyrene (BaP) exposure altered
Bo-Mi Kim et al.
Aquatic toxicology (Amsterdam, Netherlands), 152, 232-243 (2014-05-06)
Despite being a strong toxicant for aquatic ecosystems, the effect of benzo[a]pyrene (B[a]P) on whole cytochrome P450 (CYP) biotransformation mechanisms has not been deeply investigated in aquatic organisms. To understand the mode of action of B[a]P on CYP molecular responses
Kroum Alexandrov et al.
Carcinogenesis, 23(12), 1969-1977 (2003-01-01)
Benzo[a]pyrene diol epoxide (BPDE)-DNA adducts are involved in the induction of p53 mutations and probably in the causation of human lung cancer associated with cigarette smoking. The ratio between CYP1A1 and GST enzyme activities is a critical determinant of the
Ohgew Kweon et al.
Journal of bacteriology, 196(19), 3503-3515 (2014-07-30)
Despite the considerable knowledge of bacterial high-molecular-weight (HMW) polycyclic aromatic hydrocarbon (PAH) metabolism, the key enzyme(s) and its pleiotropic and epistatic behavior(s) responsible for low-molecular-weight (LMW) PAHs in HMW PAH-metabolic networks remain poorly understood. In this study, a phenotype-based strategy
M E Boerrigter et al.
Mechanisms of ageing and development, 82(1), 31-50 (1995-07-28)
In this study, we employed the sensitive 32P-postlabeling assay to assess the influence of age on the formation and disappearance of benzo[a]pyrene (B[a]P) DNA adducts in six organs of two different mouse strains with different life spans, C57BL/6ByJ (C57BL/6) and
Daniel W Nebert et al.
Molecular pharmacology, 84(3), 304-313 (2013-06-14)
Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH); this ubiquitous environmental carcinogenic agent is found in tobacco smoke, charcoal-grilled foods, and PAH-contaminated surfaces of roofs, playgrounds, and highways. Cytochrome P450 1 wild-type, Cyp1a2(-/-), Cyp1b1(-/-), or Cyp1a2/1b1(-/-) knockouts, and mice
Heiko U Käfferlein et al.
Critical reviews in toxicology, 40(2), 126-150 (2010-01-21)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in our environment and can cause cancer. Exposure to PAHs can be assessed by protein adduct dosimetry using benzo[a]pyrene (B[a]P) as a model compound. We present an overview of analytical methods to detect B[a]P-
A P Wolterbeek et al.
Cancer letters, 89(1), 107-116 (1995-02-10)
Several experimental models have been developed to study respiratory tract carcinogenesis. The most widely applied in vivo model uses Syrian golden hamsters which receive intratracheal instillations of a suspension of benzo[a]pyrene (B[a]P) particles attached to ferric-oxide (Fe2O3) particles in saline;
Jae-Suk Choi et al.
Biological & pharmaceutical bulletin, 37(12), 1963-1970 (2014-12-03)
Rice bran oil extracted by supercritical CO2 extraction (RB-SCE) reportedly exhibits pharmacological activities such as antioxidant and in vivo hair growth-inducing effects. Such activities raise the possibility of the development of novel hair growth-inducing agents using RB-SCE. The aim of
Anne Graupner et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 772, 34-41 (2014-10-14)
The OECD has developed test guidelines (TG) to identify agents with genotoxic effects. The in vivo alkaline single cell gel electrophoresis (SCGE) assay is currently being prepared to become such a TG. The performance of a combined SCGE/Pig-a gene mutation
I W H Jarvis et al.
Toxicology letters, 229(1), 25-32 (2014-06-10)
Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants that occur naturally in complex mixtures. Many of the adverse health effects of PAHs including cancer are linked to the activation of intracellular stress response signaling. This study has investigated intracellular MAPK
Vasilis P Androutsopoulos et al.
Toxicology letters, 230(2), 304-313 (2013-09-03)
Eupatorin-5-methyl ether (E5M) is a flavone containing 4 methoxy groups that is present in plants with medicinal activity, whereas luteolin (L) is a polyhydroxylated flavone commonly encountered in dietary products. In the present study we investigated the interaction of the
J F Collins et al.
Regulatory toxicology and pharmacology : RTP, 13(2), 170-184 (1991-04-01)
Benzo[a]pyrene is the most studied carcinogenic polycyclic aromatic hydrocarbon and one of the most potent, and it is often used as a toxicological prototype or surrogate for all carcinogenic polycyclic aromatic hydrocarbons. Quantitative risk assessment of benzo[a]pyrene has been hampered
Sonja Kaisarevic et al.
Environmental toxicology and pharmacology, 39(1), 358-368 (2015-01-03)
Rat hepatoma cells H4IIE were treated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons (PAHs) (dibenz(a,h)anthracene, benzo(a)pyrene, benz(a)anthracene, chrysene), low-concentration mixtures of PAHs and TCDD, and environmental mixtures contaminated by PAHs and their derivatives. Expression of the gene battery comprising cytochrome
Olga Mavrofrydi et al.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 31(4), 335-347 (2013-02-12)
Hypoxia inducible factor-1α (HIF-lα) is a central regulator of tumor survival and metastasis, responsible for metabolic adaptation to hypoxic conditions and promotion of angiogenesis. It has been also shown to respond to non-hypoxic stimuli, such as growth factors and moderate
Yu Bon Man et al.
Mutation research, 752(1-2), 47-56 (2013-02-09)
The aim of this study was to evaluate mutagenicity and genotoxicity of soils from 12 different land use types such as electronic waste dismantling workshop, open burning site and car dismantling workshop (CDW), based on soil concentrations of polycyclic aromatic
Yizhi Song et al.
Environmental pollution (Barking, Essex : 1987), 195, 178-184 (2014-09-23)
A whole-cell bacterial bioreporter Acinetobacter baylyi strain ADP1_recA_lux that responds to genotoxins was employed to directly assess the adverse effects of the bioavailable fraction of mitomycin C (MMC), benzo[a]pyrene (BaP), chromium (VI) and lead (II) in amended soils and soil
H Fromme et al.
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)), 55(4), 195-205 (1993-04-01)
Polycyclic aromatic hydrocarbons (PAH) have become an ubiquitous upper soil component in consequence of industrialisation involving a multitude of combustion processes. Meaningful contaminations can be found on child playgrounds, for example. These may enter into the organism of small children
Liyun Gao et al.
Toxicology letters, 223(2), 205-210 (2013-10-03)
It has recently been found that the new class of transcripts, long non-coding RNAs (lncRNAs), are pervasively transcribed in the genome. LncRNAs are a large family of non-coding RNAs and regulate many protein-coding genes. Growing evidence indicates that lncRNAs may
Lenka Smerdová et al.
Toxicology, 314(1), 30-38 (2013-09-13)
Long-term deregulated inflammation represents one of the key factors contributing to lung cancer etiology. Previously, we have observed that tumor necrosis factor-α (TNF-α), a major pro-inflammatory cytokine, enhances genotoxicity of benzo[a]pyrene (B[a]P), a highly carcinogenic polycyclic aromatic hydrocarbon, in rat
Heloísa H P Oliveira et al.
Ecotoxicology and environmental safety, 96, 67-74 (2013-07-23)
In an attempt to explore complex metabolic interactions between toxicants present in polluted freshwater, hepatic metabolism of benzo(a)pyrene (BaP) and tributyltin (TBT) in fish was investigated when these compounds were administrated alone, mixed together and along with dichlorodiphenyltrichloroethane (DDT). Ten
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