521-10-8

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Physical health and incident late-life depression: modification by cytokine genes.

Jae-Min Kim et al.

Neurobiology of aging, 34(1), 356-356 (2012-08-28)

Inflammatory cytokines have been implicated in the pathophysiology of depression, potentially underlying its association with worse physical health. Cytokine production is influenced by the transcriptional activity of several polymorphisms. We hypothesized that alleles related to higher proinflammatory and/or lower anti-inflammatory

Genome-wide association study identifies PERLD1 as asthma candidate gene.

Ramani Anantharaman et al.

BMC medical genetics, 12, 170-170 (2011-12-23)

Recent genome-wide association studies (GWAS) for asthma have been successful in identifying novel associations which have been well replicated. The aim of this study is to identify the genetic variants that influence predisposition towards asthma in an ethnic Chinese population

Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.

Dan E Arking et al.

PloS one, 5(3), e9879-e9879 (2010-04-03)

Existing studies indicate a significant genetic component for sudden cardiac arrest (SCA) and genome-wide association studies (GWAS) provide an unbiased approach for identification of novel genes. We performed a GWAS to identify genetic determinants of SCA. We used a case-control

TMPRSS2-ERG gene fusion is associated with low Gleason scores and not with high-grade morphological features.

Samson W Fine et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 23(10), 1325-1333 (2010-06-22)

TMPRSS2-ERG gene rearrangement is seen in about half of clinically localized prostate cancers, yet controversy exists with regard to its prognostic implications. Similarly, the relationship of TMPRSS2-ERG fusion to Gleason score and morphology remains uncertain. We assigned Gleason scores and

Once-weekly dalbavancin versus daily conventional therapy for skin infection.

Helen W Boucher et al.

The New England journal of medicine, 370(23), 2169-2179 (2014-06-05)

Dalbavancin, a lipoglycopeptide antibiotic agent that is active against gram-positive pathogens, has a long plasma half-life, allowing for once-weekly dosing. DISCOVER 1 and DISCOVER 2 were identically designed noninferiority trials of dalbavancin for the treatment of acute bacterial skin and

Screening for genomic rearrangements in BRCA1 and BRCA2 genes in Czech high-risk breast/ovarian cancer patients: high proportion of population specific alterations in BRCA1 gene.

Ivana Ticha et al.

Breast cancer research and treatment, 124(2), 337-347 (2010-02-06)

Large genomic rearrangements (LGR) represent substantial proportion of pathogenic mutations in the BRCA1 gene, whereas the frequency of rearrangements in the BRCA2 gene is low in many populations. We screened for LGRs in BRCA1 and BRCA2 genes by multiplex ligation-dependent

Determination of eight nitrosamines in water at the ng L(-1) levels by liquid chromatography coupled to atmospheric pressure chemical ionization tandem mass spectrometry.

Cristina Ripollés et al.

Analytica chimica acta, 702(1), 62-71 (2011-08-09)

In this work, we have developed a sensitive method for detection and quantification of eight N-nitrosamines, N-nitrosodimethylamine (NDMA), N-nitrosomorpholine (NMor), N-nitrosomethylethylamine (NMEA), N-nitrosopirrolidine (NPyr), N-nitrosodiethylamine (NDEA), N-nitrosopiperidine (NPip), N-nitroso-n-dipropylamine (NDPA) and N-nitrosodi-n-butylamine (NDBA) in drinking water. The method is based

Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.

Hannu Laaksovirta et al.

The Lancet. Neurology, 9(10), 978-985 (2010-08-31)

The genetic cause of amyotrophic lateral sclerosis (ALS) is not well understood. Finland is a well suited location for a genome-wide association study of ALS because the incidence of the disease is one of the highest in the world, and

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