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Siddharth Jambhrunkar et al.
Molecular pharmaceutics, 11(10), 3642-3655 (2014-08-29)
Mesoporous silica nanoparticles (MCM-41) with different surface chemistry were used as carrier system to study its influence on drug delivery and anticancer activity of curcumin (CUR). CUR was encapsulated in pristine MCM-41 (hydrophilic and negatively charged), amino functionalized MCM-41 (MCM-41-NH2
Francisco J Prado-Prado et al.
Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27)
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability with which a drug is active against
Shih-Chen Hsu et al.
Small (Weinheim an der Bergstrasse, Germany), 11(2), 195-201 (2014-08-15)
Au-Cu2 O core-shell nanocubes, octahedra, and rhombic dodecahedra display facet-dependent optical properties. Furthermore, different-sized Au-Cu2 O octahedra with 58, 65, 68, and 73 nm octahedral gold cores clearly show a transition from the shell thickness-independent gold surface plasmon resonance band
Kun Zhang et al.
Scientific reports, 5, 8766-8766 (2015-03-06)
Ultrasound contrast agents (UCAs) designed by the conventional composition-based strategy, often suffer from relatively low ultrasound utilization efficiency. In this report, a structure-based design concept of double-scattering/reflection in a single nanoparticle for enhancing ultrasound imaging has been proposed. To exemplify
Jyothi C Abbar et al.
Colloids and surfaces. B, Biointerfaces, 106, 158-164 (2013-02-26)
An electrochemical method has been described for the voltammetric oxidation and determination of an antihyperlipoproteinemic drug, atorvastatin (ATOR), at a carbon paste electrode (CPE) in the presence of an enhancing agent, cetyltrimethyl ammonium bromide (CTAB) using cyclic and differential pulse
Jihye Choi et al.
Journal of biomedical optics, 19(5), 051203-051203 (2013-12-04)
Biomarker-specific photothermal nanoparticles that can efficiently sense markers that are overexpressed in distinguished adenocarcinomas have attracted much interest in an aspect of efficacy increase of cancer treatment. We demonstrated a promising prospect of a smart photothermal therapy agent employing anti-epidermal
Yi Min et al.
Journal of chromatography. A, 1356, 148-156 (2014-07-08)
In this work, 1.9 μm reversed-phase packing materials with superficially porous structure were prepared to achieve the rapid and high efficient separation of peptides and proteins. The silica particles were synthesized via three steps, nonporous silica particle preparation by a
Kvar C L Black et al.
ACS nano, 8(5), 4385-4394 (2014-04-29)
With Au nanocages as an example, we recently demonstrated that radioactive (198)Au could be incorporated into the crystal lattice of Au nanostructures for simple and reliable quantification of their in vivo biodistribution by measuring the γ radiation from (198)Au decay
Imène Chaïr-Yousfi et al.
International immunopharmacology, 25(1), 19-29 (2015-01-21)
Lung injury and respiratory distress syndrome are frequent symptoms observed in the most severe cases of scorpion envenomation. The uncontrolled transmigration of leukocyte cells into the lung interstitium and alveolar space and pulmonary edema may be the cause of death.
Amit Kumar Mandal et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 14(4), 788-796 (2012-11-13)
Femtosecond upconversion, single-molecule fluorescence resonance energy transfer (sm-FRET) and fluorescence correlation spectroscopy (FCS) are applied to study the competition between excited-state proton transfer (ESPT) and FRET [to rhodamine 6G (R6G)] of 8-hydroxypyranine-1,3,6-trisulfonate (HPTS) in cetyltrimethylammonium chloride (CTAC) micelles. Pyranine exhibits
Vitaly A Khanadeev et al.
Nanotechnology, 25(40), 405602-405602 (2014-09-13)
High-quality colloidal crystals (CCs) are important for use in photonic research and as templates for large-scale plasmonic SERS substrates. We investigated how variations in temperature, colloid concentration, and dip-drawing parameters (rate, incubation time, etc) affect the structure of 2D CCs
Haiyu Tian et al.
Analytica chimica acta, 768, 136-142 (2013-03-12)
In this paper, two colorimetric and turn-on fluorescent probes N-[2-(2-hydroxy)-ethoxy] ethyl-4-azido-1,8-naphthalimide (SS1) and N-butyl-4-azido-1,8-naphthalimide (SS2) for selective recognition of H2S were designed and synthesized. The probes were constructed by incorporating an azido group into the naphthalimide fluorophore as a specifical
Yingshuai Liu et al.
Journal of colloid and interface science, 439, 7-11 (2014-12-03)
Polyamine-capped gold nanorods (AuNRs) were developed as nanoprobes for localized surface Plasmon resonance (LSPR)-based simple, selective, and sensitive detection of Cu(2+) ions. Poly(sodium-4-styrenesulfonate) (PSS) and polyethylenimine (PEI) was successively adsorbed on the positively charged AuNRs via electrostatic adsorption, resulting in
Amir H Salehi et al.
Journal of liposome research, 25(1), 38-45 (2014-06-25)
Ag:Au alloy nanoparticles were successfully synthesized through the new route using co-reduction method with silver nitrate, chloroauric acid, cetyl trimethyl ammonium bromide (CTAB) and sodium borohydride at room temperature. The Ag:Au alloy nanoparticles were then loaded within the phosphatidylcholine (97%)
R C Beier et al.
Journal of applied microbiology, 118(2), 326-342 (2014-11-29)
To evaluate susceptibility of Pseudomonas aeruginosa veterinary isolates to antibiotics and disinfectants. Pseudomonas aeruginosa isolates collected from dogs (n = 155) and other animals (n = 20) from sixteen states during 1994-2003 were tested for susceptibility. Most isolates were resistant
Lan Ge et al.
American journal of physiology. Heart and circulatory physiology, 308(5), H500-H509 (2014-12-21)
Emerging evidence suggests a potential role of neutrophil extracellular traps (NETs) in linking sterile inflammation and thrombosis. We hypothesized that NETs would be induced during myocardial ischemia-reperfusion (I/R), and NET-mediated microthrombosis may contribute to myocardial "no-reflow". Male Wistar rats were
Hong-Min Meng et al.
Analytical chemistry, 86(24), 12321-12326 (2014-11-18)
Glutathione (GSH) serves vital cellular biological functions, and its abnormal levels are associated with many diseases. To better understand its physiological and pathological functions, efficient methods for monitoring of GSH in living systems are desired. Although quite a few small
Laila Abdel-Fattah et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 136 Pt B, 178-184 (2014-10-16)
In this study, a simple and sensitive spectrophotometric method was developed for determination of Losartan potassium (LST K), an angiotensin-II receptor (type AT1) antagonist, in presence of cationic surfactant cetyltrimethylammonium bromide (CTAB). The physicochemical interaction of LST K with CTAB
Anne Fischbeck et al.
Inflammatory bowel diseases, 20(11), 1933-1941 (2014-09-05)
The heat shock protein gp96 is an endoplasmic reticulum chaperone involved in endoplasmic reticulum stress reactions. gp96 binds antigens and is secreted into extracellular space on cell stress. After reinternalization by antigen presenting cells, antigens can be transferred to major
Teresa J Hughes et al.
Mycologia, 106(4), 686-697 (2014-06-04)
Fusarium tucumaniae is the only known sexually reproducing species among the seven closely related fusaria that cause soybean sudden death syndrome (SDS) or bean root rot (BRR). In a previous study, laboratory mating of F. tucumaniae yielded recombinant ascospore progeny
Lei Wu et al.
Biosensors & bioelectronics, 62, 13-18 (2014-06-29)
As thiocyanate (SCN(-)) acts as an important biomarker in human health assessment, there remains an urgent need to realize rapid and reproducible analysis of SCN(-) in body fluids. Here, a droplet microfluidic device has been designed and fabricated for SCN(-)
S R Kim et al.
Cell death & disease, 5, e1498-e1498 (2014-10-31)
Abnormality in mitochondria has been suggested to be associated with development of allergic airway disorders. In this study, to evaluate the relationship between mitochondrial reactive oxygen species (ROS) and NLRP3 inflammasome activation in allergic asthma, we used a newly developed
Nabanita Chatterjee et al.
Journal of leukocyte biology, 96(2), 325-336 (2014-04-04)
The use of live, attenuated, or genetically modified microbes or their cellular component(s) or metabolites has begun to emerge as a potential new approach in medicinal research to deliver biologically active entities. Thus, advancing our knowledge of such microbe-mediated therapy
Verónica Ramírez-Alcántara et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(11), G1002-G1010 (2014-04-20)
Pharmacotherapy based on 5-aminosalicylic acid (5-ASA) is a preferred treatment for ulcerative colitis, but variable patient response to this therapy is observed. Inflammation can affect therapeutic outcomes by regulating the expression and activity of drug-metabolizing enzymes; its effect on 5-ASA
Xiao Xiao et al.
Food chemistry, 167, 438-446 (2014-08-26)
With the prevalence of inflammatory bowel disease (IBD) and its associated risk for development of colorectal cancer, it is of great importance to prevent and treat IBD. However, due to the complexity of etiology and potentially serious adverse effects, treatment
Karina Lopes Dornelas et al.
Analytica chimica acta, 858, 82-90 (2015-01-20)
This paper presents a simple and low-cost method for patterning poly(dimethylsiloxane) (PDMS) barriers in porous support such as paper for the construction of flexible microfluidic paper-based analytical devices (μPADs). The fabrication method consisted of contact-printing a solution of PDMS and
Rangel R Bonfim et al.
Basic & clinical pharmacology & toxicology, 115(3), 237-243 (2014-10-03)
Monoterpenes, compounds mainly presented in essential oils, have important pharmacological actions. Isopropoxy-carvacrol (IPC) is a derivative of the monoterpene carvacrol, and its pharmacological properties have not yet been investigated. The aim of this study was to analyse the acute anti-inflammatory
Zhong Luo et al.
Journal of biomedical materials research. Part A, 102(11), 3781-3794 (2013-11-30)
Mesoporous silica nanoparticles (MSNs) present themselves as one of the most promising nano-carriers for drug delivery. To reduce their immunotoxicities, in this study, natural proteins of gelatin (Gel), bovine serum albumin (BSA), and lysozyme (Lys) were employed as end-caps of
Peng Yan et al.
Acta biomaterialia, 10(8), 3786-3794 (2014-05-13)
The fabrication of highly efficient nonviral gene carriers with low cytotoxicity remains a challenge in gene therapy. This paper reports a facile strategy to combine the advantages of gold nanorods (Au NRs) and polycations through surface functionalization. Different Au NR
Kamil Wojciechowski et al.
Biochimica et biophysica acta, 1838(7), 1931-1940 (2014-04-22)
The interactions between a model phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and a biosurfactant Quillaja Bark Saponin (QBS) obtained from the bark of Quillaja saponaria Molina were studied using simple models of biological membranes. QBS is known to interact strongly with the latter
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