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R C Beier et al.
Journal of applied microbiology, 118(2), 326-342 (2014-11-29)
To evaluate susceptibility of Pseudomonas aeruginosa veterinary isolates to antibiotics and disinfectants. Pseudomonas aeruginosa isolates collected from dogs (n = 155) and other animals (n = 20) from sixteen states during 1994-2003 were tested for susceptibility. Most isolates were resistant
Teresa J Hughes et al.
Mycologia, 106(4), 686-697 (2014-06-04)
Fusarium tucumaniae is the only known sexually reproducing species among the seven closely related fusaria that cause soybean sudden death syndrome (SDS) or bean root rot (BRR). In a previous study, laboratory mating of F. tucumaniae yielded recombinant ascospore progeny
Katelyn T Gause et al.
ACS nano, 9(3), 2433-2444 (2015-02-26)
The development of subunit antigen delivery formulations has become an important research endeavor, especially in cases where a whole cell vaccine approach has significant biosafety issues. Particle-based systems have shown particular efficacy due to their inherent immunogenicity. In some cases
Mohammad Yahya Hanafi-Bojd et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 248-258 (2014-12-17)
Recent studies with inorganic nanoparticles modified with functional groups have demonstrated improvement in drug delivery into cancer cells. In the present study, we prepared, characterized, and evaluated mesoporous silica nanoparticles (MSNs) as carriers for epirubicin hydrochloride (EPI) in order to
Jiabei Liang et al.
Scientific reports, 5, 7985-7985 (2015-01-24)
Ginseng, which is the root of Panax ginseng (Araliaceae), has been used in Oriental medicine as a stimulant and dietary supplement for more than 7,000 years. Older ginseng plants are substantially more medically potent, but ginseng age can be simulated
Cui Li et al.
Investigative ophthalmology & visual science, 55(10), 6886-6900 (2014-10-10)
To determine if IL-17 regulates Mer tyrosine kinase-positive (MerTK+) cells in Pseudomonas aeruginosa keratitis. Interleukin 17 was tested in normal and infected cornea of susceptible C57BL/6 and resistant BALB/c mice. The latter were treated with recombinant mouse (rm) IL-17; both
Anne Fischbeck et al.
Inflammatory bowel diseases, 20(11), 1933-1941 (2014-09-05)
The heat shock protein gp96 is an endoplasmic reticulum chaperone involved in endoplasmic reticulum stress reactions. gp96 binds antigens and is secreted into extracellular space on cell stress. After reinternalization by antigen presenting cells, antigens can be transferred to major
Laila Abdel-Fattah et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 136 Pt B, 178-184 (2014-10-16)
In this study, a simple and sensitive spectrophotometric method was developed for determination of Losartan potassium (LST K), an angiotensin-II receptor (type AT1) antagonist, in presence of cationic surfactant cetyltrimethylammonium bromide (CTAB). The physicochemical interaction of LST K with CTAB
Lan Ge et al.
American journal of physiology. Heart and circulatory physiology, 308(5), H500-H509 (2014-12-21)
Emerging evidence suggests a potential role of neutrophil extracellular traps (NETs) in linking sterile inflammation and thrombosis. We hypothesized that NETs would be induced during myocardial ischemia-reperfusion (I/R), and NET-mediated microthrombosis may contribute to myocardial "no-reflow". Male Wistar rats were
Hong-Min Meng et al.
Analytical chemistry, 86(24), 12321-12326 (2014-11-18)
Glutathione (GSH) serves vital cellular biological functions, and its abnormal levels are associated with many diseases. To better understand its physiological and pathological functions, efficient methods for monitoring of GSH in living systems are desired. Although quite a few small
Jianjun Zhang et al.
Bioorganic & medicinal chemistry, 19(1), 498-503 (2010-11-30)
Reported previously by our group, one-pot cycloaddition using naphthoquinone, sodium azide and alkyl halides can lead to the formation of both 1-alkyl-1H- and 2-alkyl-2H-naphtho[2,3-d]triazole-4,9-diones. Herein, the effect of leaving group and additive in dictating the selectivity between the formation of
Kun Zhang et al.
Scientific reports, 5, 8766-8766 (2015-03-06)
Ultrasound contrast agents (UCAs) designed by the conventional composition-based strategy, often suffer from relatively low ultrasound utilization efficiency. In this report, a structure-based design concept of double-scattering/reflection in a single nanoparticle for enhancing ultrasound imaging has been proposed. To exemplify
Francisco J Prado-Prado et al.
Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27)
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability with which a drug is active against
Siddharth Jambhrunkar et al.
Molecular pharmaceutics, 11(10), 3642-3655 (2014-08-29)
Mesoporous silica nanoparticles (MCM-41) with different surface chemistry were used as carrier system to study its influence on drug delivery and anticancer activity of curcumin (CUR). CUR was encapsulated in pristine MCM-41 (hydrophilic and negatively charged), amino functionalized MCM-41 (MCM-41-NH2
Jyothi C Abbar et al.
Colloids and surfaces. B, Biointerfaces, 106, 158-164 (2013-02-26)
An electrochemical method has been described for the voltammetric oxidation and determination of an antihyperlipoproteinemic drug, atorvastatin (ATOR), at a carbon paste electrode (CPE) in the presence of an enhancing agent, cetyltrimethyl ammonium bromide (CTAB) using cyclic and differential pulse
Jihye Choi et al.
Journal of biomedical optics, 19(5), 051203-051203 (2013-12-04)
Biomarker-specific photothermal nanoparticles that can efficiently sense markers that are overexpressed in distinguished adenocarcinomas have attracted much interest in an aspect of efficacy increase of cancer treatment. We demonstrated a promising prospect of a smart photothermal therapy agent employing anti-epidermal
Yi Min et al.
Journal of chromatography. A, 1356, 148-156 (2014-07-08)
In this work, 1.9 μm reversed-phase packing materials with superficially porous structure were prepared to achieve the rapid and high efficient separation of peptides and proteins. The silica particles were synthesized via three steps, nonporous silica particle preparation by a
Brandy J Johnson et al.
PloS one, 7(11), e50356-e50356 (2012-12-12)
The potential for encapsulating RNA within tunable, semi-permeable structures for storage and transportation purposes offers an interesting approach to the reduction of stringent storage requirements that often hamper the field application of genetic analysis methods. In this study, we assessed
Amit Kumar Mandal et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 14(4), 788-796 (2012-11-13)
Femtosecond upconversion, single-molecule fluorescence resonance energy transfer (sm-FRET) and fluorescence correlation spectroscopy (FCS) are applied to study the competition between excited-state proton transfer (ESPT) and FRET [to rhodamine 6G (R6G)] of 8-hydroxypyranine-1,3,6-trisulfonate (HPTS) in cetyltrimethylammonium chloride (CTAC) micelles. Pyranine exhibits
S R Kim et al.
Cell death & disease, 5, e1498-e1498 (2014-10-31)
Abnormality in mitochondria has been suggested to be associated with development of allergic airway disorders. In this study, to evaluate the relationship between mitochondrial reactive oxygen species (ROS) and NLRP3 inflammasome activation in allergic asthma, we used a newly developed
Kamil Wojciechowski et al.
Biochimica et biophysica acta, 1838(7), 1931-1940 (2014-04-22)
The interactions between a model phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and a biosurfactant Quillaja Bark Saponin (QBS) obtained from the bark of Quillaja saponaria Molina were studied using simple models of biological membranes. QBS is known to interact strongly with the latter
Paul J Ackerman et al.
Nature communications, 6, 6012-6012 (2015-01-22)
Some of the most exotic condensed matter phases, such as twist grain boundary and blue phases in liquid crystals and Abrikosov phases in superconductors, contain arrays of topological defects in their ground state. Comprised of a triangular lattice of double-twist
The effect of progesterone on systemic inflammation and oxidative stress in the rat model of sepsis.
Ayse Nur Aksoy et al.
Indian journal of pharmacology, 46(6), 622-626 (2014-12-30)
To explore the protective effect of progesterone on inflammation and oxidative stress in a rat model of sepsis created by cecal ligation and puncture (CLP). Rats were randomly divided into 4 groups: Overiectomy group (OVX), sham operated (control), sepsis (CLP)
Limei Tian et al.
Biosensors & bioelectronics, 59, 208-215 (2014-04-15)
Printable multi-marker biochips that enable simultaneous quantitative detection of multiple target biomarkers in point-of-care and resource-limited settings are a holy grail in the field of biodiagnostics. However, preserving the functionality of biomolecules, which are routinely employed as recognition elements, during
Nabanita Chatterjee et al.
Journal of leukocyte biology, 96(2), 325-336 (2014-04-04)
The use of live, attenuated, or genetically modified microbes or their cellular component(s) or metabolites has begun to emerge as a potential new approach in medicinal research to deliver biologically active entities. Thus, advancing our knowledge of such microbe-mediated therapy
Mateus Fortes Rossato et al.
Inflammation, 38(2), 606-615 (2014-08-15)
Vitamin E (vit-E) is a lipophilic antioxidant, and its anti-inflammatory activity is still not full characterized. Thus, our goal was to investigate the anti-inflammatory effect of repeated vit-E treatment in the arthritis induced by the intraplantar injection of complete Freund's
Yiye Li et al.
ACS nano, 8(11), 11529-11542 (2014-11-07)
Near-infrared plasmonic nanoparticles demonstrate great potential in disease theranostic applications. Herein a nanoplatform, composed of mesoporous silica-coated gold nanorods (AuNRs), is tailor-designed to optimize the photodynamic therapy (PDT) for tumor based on the plasmonic effect. The surface plasmon resonance of
Lei Wu et al.
Biosensors & bioelectronics, 62, 13-18 (2014-06-29)
As thiocyanate (SCN(-)) acts as an important biomarker in human health assessment, there remains an urgent need to realize rapid and reproducible analysis of SCN(-) in body fluids. Here, a droplet microfluidic device has been designed and fabricated for SCN(-)
Trinidad Montero-Melendez et al.
The American journal of pathology, 184(8), 2333-2341 (2014-07-01)
Because there is clinical evidence for an association between periodontal disease and rheumatoid arthritis, it is important to develop suitable experimental models to explore pathogenic mechanisms and therapeutic opportunities. The K/BxN serum model of inflammatory arthritis was applied using distinct
Imène Chaïr-Yousfi et al.
International immunopharmacology, 25(1), 19-29 (2015-01-21)
Lung injury and respiratory distress syndrome are frequent symptoms observed in the most severe cases of scorpion envenomation. The uncontrolled transmigration of leukocyte cells into the lung interstitium and alveolar space and pulmonary edema may be the cause of death.
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