539112

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Investigation of a Privileged Polymorphic Motif: a Dimeric ROY Derivative.

Katie M Lutker et al.

Crystal growth & design, 8(1), 136-139 (2008-01-01)

Bis(5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrilyl)acetylene, a derivative of the highly polymorphic compound 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY) that possesses two chromophores electronically coupled through a triple bond, was found to be trimorphic. Structural data for two of these forms indicates that symmetry is maintained in one structure

Efficient nucleophilic aromatic substitution between aryl nitrofluorides and alkynes.

Patrick L DeRoy et al.

Organic letters, 9(14), 2741-2743 (2007-06-08)

The nucleophilic aromatic substitution reaction between electron-deficient aryl fluorides and terminal alkynes is shown to be efficiently promoted by sodium bis(trimethylsilyl)amide as a base. Moderate to excellent yields of 2-ethynylnitrobenzene products can be obtained under mild conditions.

1,5-Disubstituted benzimidazoles that direct cardiomyocyte differentiation from mouse embryonic stem cells.

Karl J Okolotowicz et al.

Bioorganic & medicinal chemistry, 23(17), 5282-5292 (2015-08-19)

Cardiomyopathy is the leading cause of death worldwide. Despite progress in medical treatments, heart transplantation is one of the only current options for those with infarcted heart muscle. Stem cell differentiation technology may afford cell-based therapeutics that may lead to

Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity.

Erik Rytter Ottosen et al.

Journal of medicinal chemistry, 46(26), 5651-5662 (2003-12-12)

We wish to report the synthesis and structure-activity relationship (SAR) of a series of 4-aminobenzophenones, as a novel compound class with high antiinflammatory activity. Our initial lead, (4-[(2-aminophenyl)amino]phenyl)(phenyl)methanone (3), was systematically optimized and resulted in compounds that potently inhibited the

Dibenzazepines and dibenzoxazepines as sodium channel blockers.

Stephen M Lynch et al.

Bioorganic & medicinal chemistry letters, 25(1), 43-47 (2014-12-04)

We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.

Mild and General Access to Diverse 1

Venkateshwarlu Gurram et al.

Advanced synthesis & catalysis, 357(2-3), 451-462 (2015-03-03)

Benzotriazoles are a highly important class of compounds with broad-ranging applications in such diverse areas as medicinal chemistry, as auxiliaries in organic synthesis, in metallurgical applications, in aircraft deicing and brake fluids, and as antifog agents in photography. Although there

Synthesis and evaluation of 11C-labeled naphthalene derivative as a novel non-peptidergic probe for the β-secretase (BACE1) imaging in Alzheimer's disease brain.

Tomoki Kawai et al.

Nuclear medicine and biology, 40(5), 705-709 (2013-05-28)

As a first trial for in vivo imaging of β-secretase (BACE1) in Alzheimer's disease brain, we applied a novel non-peptidergic small molecule which has high affinity to the enzyme, naphthalene-1-carboxylic acid (3'-chloro-4'-fluoro-4-piperazin-1-yl-biphenyl-3-yl)amide (NCFB) into positron emission tomography (PET) probe. In

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