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关键词:'54-11-5'
显示 1-30 共 300 条结果 关于 "54-11-5" 范围 论文
Marcel S F Lie Ken Jie et al.
Lipids, 38(12), 1293-1297 (2004-02-12)
A methylene-interrupted C18 keto-acetylenic fatty ester (methyl 12-oxo-9-octadecynoate) was obtained from methyl ricinoleate by bromination-dehydrobromination followed by oxidation. Reaction of methyl 12-oxo-9-octadecynoate with bis(benzonitrile) palladium(II) chloride, allyl bromide, or methyl-allyl bromide furnished methyl 8-[5-hexyl-3-allyl-furan-2-yl]-octanoate (1, 56%) or methyl 8-15-hexyl-3-(2-methyl-allyl)-furan-2-yl]-octanoate (2
Ajit Dhananjay Jagtap et al.
European journal of medicinal chemistry, 85, 268-288 (2014-08-05)
A series of 6-acylureido derivatives containing a 3-(pyrrol-2-ylmethylidene)indolin-2-one scaffold were synthesized as potential dual Aurora B/FLT3 inhibitors by replacing the 6-arylureido moiety in 6-arylureidoindolin-2-one-based multi-kinase inhibitors. (Z)-N-(2-(pyrrolidin-1-yl)ethyl)-5-((6-(3-(2-fluoro-4-methoxybenzoyl)ureido)-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (54) was identified as a dual Aurora B/FLT3 inhibitor (IC50 = 0.4 nM and 0.5 nM, respectively).
R G Ridley et al.
Bioscience reports, 6(1), 87-94 (1986-01-01)
Poly(A)+RNA was isolated from brown adipose tissue of cold acclimated rats and a fraction enriched for uncoupling protein mRNA was used to generate a cDNA library in pBR 322. Immunological screening of 1,500 colonies with an affinity-purified antiserum against the
Linni Fan et al.
BMC cancer, 11, 320-320 (2011-07-30)
CD133 is known to be a cancer stem cell (CSC) marker. However, recent studies have revealed that CD133 is not restricted to CSC but to be expressed not only in human normal tissues but also in some cancers and could
Brittany Z Dashevsky et al.
The breast journal, 25(1), 69-74 (2018-12-07)
Evaluate the clinical presentation and imaging findings of breast implant-associated anaplastic large cell lymphoma (BIA ALCL) at a large US cancer center. HIPAA-compliant IRB approved retrospective study, for which informed consent was waived. The Hospital Information System was screened for
Ashish Bains et al.
American journal of clinical pathology, 137(3), 387-394 (2012-02-18)
Acute myeloid leukemia (AML) with isolated trisomy 4 is rare. Associations with KIT mutations on chromosome 4q12 have been documented. The clinicopathologic features and mutational status of KIT, FLT3, NPM1, CEBPA, and RAS were assessed in 13 AML cases with
Carolien Doorenbos et al.
Genetics, 179(1), 693-699 (2008-05-22)
We investigated the effect of apolipoprotein E (Apoe) on albuminuria in the males of two independent F2 intercrosses between C57BL/6J and A/J mice, using wild-type inbred strains in the first cross and B6-Apoe(-/-) animals in the second cross. In the
Young Hwa Soung et al.
Human pathology, 39(6), 895-900 (2008-04-24)
Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Mutations of genes encoding caspases, the executioners of apoptosis, have been detected in human cancers, indicating inactivation of apoptosis by the mutations of caspase is
Riyad Peeraully et al.
International urology and nephrology, 51(8), 1321-1327 (2019-06-12)
We evaluated the efficacy and safety outcomes of endoscopic intradetrusor botulinum toxin A (BTA) injections for the treatment of children with neuropathic bladder (NB) and non-neuropathic bladder (NNB) with or without detrusor overactivity in a single centre with a retrospective
A Kobiella et al.
Translational psychiatry, 1, e37-e37 (2011-01-01)
The serotonin transporter-linked promoter region (5-HTTLPR) polymorphism of the serotonin transporter gene is associated with amygdala response during negative emotion. The aim of this study was to investigate whether this genotype effect on amygdala function is mediated by current serotonin
Jeffrey P North et al.
Journal of cutaneous pathology, 46(10), 736-741 (2019-05-31)
Sebaceous carcinoma (SeC) is an uncommon malignancy arising from sebaceous glands of the conjunctiva and skin. Recurrent mutations in the ZNF750 were recently identified in ocular SeC. We assessed whether ZNF750 loss is a specific feature of ocular SeC or
M Grieff et al.
Genomics, 44(2), 227-231 (1997-09-23)
Human Xp22.1 contains genes involved in mineral balance that are implicated in X-linked hypophosphatemia (XLH) in humans, its murine homologue (Hyp), and another distinct murine hypophosphatemic disorder (Gy). In XLH, a gene, PEX, has been found to be mutated in
Lluis Catasús et al.
Human pathology, 35(11), 1360-1368 (2005-01-26)
Endometrioid carcinomas of the ovary closely resemble their uterine counterparts. It has been suggested that the former tumors have the same molecular alterations (microsatellite instability [MSI], PTEN, and beta-catenin) described in endometrioid carcinomas of the uterus. We analyzed 55 ovarian
Guang W Wong et al.
The Journal of biological chemistry, 279(4), 2438-2452 (2003-10-30)
Probing of the mouse EST data base at GenBank trade mark with known tryptase cDNAs resulted in the identification of undiscovered serine protease transcripts whose genes reside at a 1.5-Mb complex on mouse chromosome 17A3.3. Mouse tryptase-5 (mT5), tryptase-6 (mT6)
Rachel E Farquhar et al.
Frontiers in physiology, 13, 905834-905834 (2022-07-15)
Targeting proteins to a specific membrane is crucial for proper epithelial cell function. KCa3.1, a calcium-activated, intermediate-conductance potassium channel, is targeted to the basolateral membrane (BLM) in epithelial cells. Surprisingly, the mechanism of KCa3.1 membrane targeting is poorly understood. We
I V Pronina et al.
Molekuliarnaia biologiia, 43(3), 439-445 (2009-06-25)
Gene expression decreasing in tumors permits to suggest tumor-suppressor activities for these genes. Thus, mRNA quantity decrease was found for SEMA3B gene in many cell lines of small cell (SCLC) and non-small cell lung carcinoma (NSCLC) and it is well-known
Li-Jie Han et al.
British journal of haematology, 179(1), 120-130 (2017-07-25)
We retrospectively investigated outcomes of haploidentical donor (HID) transplant for adults with standard-risk acute lymphoblastic leukaemia (ALL) in first complete remission (CR1) compared with human leucocyte antigen (HLA)-matched sibling donor (MSD) and HLA-matched unrelated donor (MUD) transplants. A total of
S Giraud et al.
American journal of human genetics, 63(2), 455-467 (1998-07-31)
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant syndrome predisposing to tumors of the parathyroid, endocrine pancreas, anterior pituitary, adrenal glands, and diffuse neuroendocrine tissues. The MEN1 gene has been assigned, by linkage analysis and loss of heterozygosity
Chang-Woo Yeo et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(4), 711-716 (2011-01-20)
The objectives of this study were to identify the genetic variants of CYP2C8, analyze CYP2C8 single nucleotide polymorphisms (SNPs), and characterize their functional consequences in the CYP2C8 substrate drug rosiglitazone in humans. The direct full sequencing of CYP2C8 genomic DNA
Chia-Yun Chen et al.
Journal of environmental management, 102, 125-133 (2012-04-26)
Mesoporous TiO2 microparticles (TiO2-11) were prepared through the micelle hydrothermal method using a 1:1 M ratio of 1-tetradecylamine:Ti(OiPr)4. TiO2-11 microparticles exhibited significantly higher decolorization percentage of Remazol Black 5 (RB5) and Remazol Brilliant Orange (3R) dyes than other TiO2 microparticles
Bharat Rekhi et al.
Pathology, 44(1), 11-17 (2011-12-17)
Alveolar soft part sarcoma accounts for 0.5-1.0% of soft tissue sarcomas in the United States. At our Hospital, it constitutes 1.8% of the newly diagnosed soft tissue sarcomas. Lately, TFE3 has been found to be a useful immunohistochemical marker for
Naveen Sharma et al.
Neurological research, 35(4), 424-428 (2013-04-02)
Nitric oxide (NO) is well known to be a vasodilator, and NO donor compounds are currently used for treating vasospasm following subarachnoid hemorrhage. However, the action mechanism of cerebral vascular relaxation is not yet clear. L-type calcium channels have been
Shao-hui Shi et al.
Zhonghua wai ke za zhi [Chinese journal of surgery], 48(17), 1305-1308 (2010-11-26)
To analyze retrospectively the formation and histological changes of sclerosis rim in patients with osteonecrosis of the femoral head (ONFH), and to study the relationship between bone morphogenetic proteins (BMP4) and sclerosis rim, so as to acquire experimental and theoretical
Andrew C Singer et al.
Environmental toxicology and chemistry, 22(9), 1998-2004 (2003-09-10)
This study investigated the interactive effects of bioaugmentation, biostimulation, and the rhizosphere during remediation of Aroclor 1242-contaminated soil. Treatments were repeatedly augmented with polychlorinated bipheny (PCB)-degrading bacteria, inducers (carvone and salicylic acid), surfactant (sorbitan trioleate), minimal salts medium in a
Meng Yuan et al.
Cell reports, 41(7), 111650-111650 (2022-11-07)
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concerns (VOCs) continue to emerge, cross-neutralizing antibody responses become key toward next-generation design of a more universal COVID-19 vaccine. By analyzing published data from the literature, we report here that
D Fraser Davidson et al.
Annals of clinical biochemistry, 48(Pt 4), 358-366 (2011-06-15)
Neuroblastoma is the most common extracranial solid tumour in childhood (8% of all childhood cancers), the most frequently diagnosed in infancy, and has one of the highest death rates, while chromaffin tumours rarely present in childhood. Both tumour types produce
Paulo Castro-Chaves et al.
European journal of pharmacology, 544(1-3), 91-96 (2006-07-18)
We analyzed the influence of endothelin-1 and endocardial endothelium on the myocardial effects of angiotensin-II. Angiotensin-II (10(-9)-10(-5) M) was tested in rabbit right papillary muscles in absence (Protocol-A) or presence of PD-145065 (10(-7) M; Protocol-B), BQ-123 (10(-7) M; Protocol-C) or
Nuno Cerveira et al.
International journal of cancer, 108(4), 592-595 (2003-12-30)
We describe a new one-step RT-PCR assay for the detection of the mammaglobin (MGB1) gene transcript in the peripheral blood of breast cancer patients. With this approach, the MGB1 transcript could be detected in the peripheral blood of 22 of
Xiong Zhang et al.
Neuroscience letters, 514(1), 16-21 (2012-03-06)
Expanded alleles of the fragile X mental retardation 1 (FMR1) gene are generally divided into four classes based on the abundance of unstable CGG repeat expansions (CGGs) in its 5'-untranslated region. It has recently been reported that two of the
John O Prior et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 57(3), 416-419 (2015-12-05)
Respiratory motion negatively affects PET/CT image quality and quantitation. A novel Pulsatile-Flow Ventilation (PFV) system reducing respiratory motion was applied in spontaneously breathing patients to induce sustained apnea during PET/CT. Four patients (aged 65 ± 14 y) underwent PET/CT for
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