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Saduman Balaban Adim et al.
World journal of surgical oncology, 8, 22-22 (2010-03-30)
To investigate the role of maspin expression in the progression of gastrointestinal stromal tumors, and its value as a prognostic indicator. In the study 54 patients with GIST diagnosis were included in Uludag University of Faculty of Medicine, Department of
A Georgopoulos et al.
The Journal of clinical endocrinology and metabolism, 85(9), 3155-3160 (2000-09-22)
Patients with type 2 diabetes are frequently dyslipidemic or hypertriglyceridemic. To assess whether increased intestinal triglyceride input leads to elevated fasting and postprandial triglycerides in type 2 diabetes, we used the codon 54 polymorphism of the fatty acid-binding protein 2
Yujiro Hayashi et al.
Molecular oncology, 14(10), 2375-2383 (2020-06-14)
Telomerase reverse transcriptase (TERT) promoter mutations are frequently found in tumors or urine from patients with urothelial carcinoma (UC). TERT promoter mutations are also detected in urine from patients with no evidence of cancer but are associated with subsequent UC
S Murayama-Hosokawa et al.
Oncogene, 29(13), 1897-1908 (2010-01-12)
Endometrial cancer is one of the tumor types in which either chromosomal instability (CIN) or microsatellite instability (MSI) may occur. It is known to possess mutations frequently in the Ras-PI3K (phosphatidylinositol 3'-kinase) pathway. We performed a comprehensive genomic survey in
Meltem Isikgoz Tasbakan et al.
International journal of antimicrobial agents, 40(6), 554-556 (2012-10-16)
The aim of this study was to evaluate the effect of nitrofurantoin (NFT) in the treatment of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli-related lower urinary tract infection (LUTI). The hospital records of all patients aged >18 years with dysuria or problems
Jamie Koo et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 25(6), 893-901 (2012-03-06)
Neuroendocrine tumors can present as liver metastases before discovery of the primary tumor. Islet 1 and PAX8 have recently been proposed as markers for neuroendocrine tumors of pancreatic origin. In this study, we compared the utility of Islet 1 and
Barbara Mroczko et al.
Folia histochemica et cytobiologica, 49(1), 125-131 (2011-04-29)
Matrix metalloproteinase 2 (MMP-2) is able to degrade type IV collagen, and thus plays a key role in the migration of tumor cells. MMP-2 activity is inhibited by its tissue inhibitor (TIMP-2). The imbalance between MMPs and TIMPs may facilitate
Georgia Gatidou et al.
Environmental science and pollution research international, 18(6), 949-957 (2011-02-03)
Photodegradation and hydrolysis of two substituted urea herbicides, monolinuron [3-(4-chlorophenyl)-1-methoxy-1-methylurea] and linuron [3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea], and one organophosphorous insecticide, phoxim [2-(diethoxyphosphinothioyloxyimino)-2-phenylacetonitrile], were studied using buffered sterilized distilled water (pH 4, 7 and 9). Experiments were performed in the absence and presence of light
Karun S Arora et al.
Ophthalmology, 122(8), 1615-1624 (2015-06-21)
Determine how procedural treatments for glaucoma have changed between 1994-2012. Retrospective, observational analysis. Medicare Part B beneficiaries. We analyzed Medicare fee-for-service paid claims data between 1994-2012 to determine the number of surgical/laser procedures performed for glaucoma in the Medicare population
Giuseppe Russo et al.
Journal of medical virology, 80(12), 2100-2107 (2008-12-02)
Prostate cancer represents the second leading cause of cancer deaths in Western countries. Viral infections could play a role in prostate carcinogenesis. Human polyomavirus BK (BKV) is a possible candidate because of its transforming properties. In this study, BKV sequences
Y Q Qian et al.
Journal of molecular biology, 260(2), 224-235 (1996-07-12)
The J-domain is a highly conserved domain found in all members of the DnaJ family of molecular chaperones. The three-dimensional structure of a recombinant, uniformly 15N-labeled 77-residue polypeptide containing the complete J-domain from human Hsp40 (HDJ-1) has been determined by
Janusz K Rybakowski et al.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 144B(6), 820-823 (2007-03-22)
Both serotonin transporter and brain-derived neurotrophic factor (BDNF) genes have been previously implicated in the efficacy of lithium prophylaxis. The aim of the present study was to assess a possible interaction between serotonin transporter genotype (5HTTLPR) and BDNF Val66Met polymorphism
Axel Gerhardt et al.
Cancer letters, 208(2), 197-206 (2004-05-15)
The expression of 14 individual and two groups of tumor antigens was characterized for colorectal carcinoma by RT-PCR using 26 colorectal carcinoma specimens, eight cell lines, six samples of patients with inflammatory bowl diseases, and nine specimens from different locations
Rae-Anne Hardie et al.
Human immunology, 71(12), 1251-1254 (2010-09-30)
We report four novel KIR2DL2 alleles and two novel KIR2DL3 alleles identified from an East African population using sequence-based typing. Sequencing and molecular cloning of exon 4 confirmed that the new 2DL2 alleles were identical to 2DL2*003, except for the
Daniella Cullen et al.
The American Journal of dermatopathology, 39(1), 14-22 (2017-01-04)
Superficial acral fibromyxoma (SAF) is a benign, soft tissue neoplasm preferably located on the digits. We collected 13 cases of SAF and evaluated their clinical, histopathologic, and immunohistochemical features. This study included 9 males and 4 females, median age 54
Sandrine Chantepie et al.
PloS one, 7(11), e49336-e49336 (2012-11-29)
Cholesteryl ester transfer protein (CETP) deficiency causes elevated high-density lipoprotein-cholesterol (HDL-C) levels; its impact on HDL functionality however remains elusive. We compared functional and compositional properties of HDL derived from 9 Caucasian heterozygous CETP mutation carriers (splice-site mutation in intron
Lisbeth Gauguin et al.
The Journal of biological chemistry, 283(30), 20821-20829 (2008-05-27)
Current evidence supports a binding model in which the insulin molecule contains two binding surfaces, site 1 and site 2, which contact the two halves of the insulin receptor. The interaction of these two surfaces with the insulin receptor results
Johanna Louhimo et al.
International journal of cancer, 101(6), 545-548 (2002-09-19)
In colorectal cancer, stage is considered to be the strongest prognostic factor, but also serum tumour markers have been reported to be of prognostic value. The aim of our study was to investigate the prognostic value of serum carcinoembryonic antigen
J Sheppard Mondy et al.
Ethnicity & disease, 12(4) (2002-12-13)
The incidence of diabetic amputations is 2- to 3-fold higher in African-American patients compared to Caucasians. Vascular remodeling characterized by extracellular matrix (ECM) deposition occurs in diabetes and contributes to vascular complications. The matrix metalloproteinases (MMP) play important roles in
Spectrum and frequency of jagged1 (JAG1) mutations in Alagille syndrome patients and their families.
I D Krantz et al.
American journal of human genetics, 62(6), 1361-1369 (1998-06-19)
Alagille syndrome (AGS) is a dominantly inherited disorder characterized by liver disease in combination with heart, skeletal, ocular, facial, renal, and pancreatic abnormalities. We have recently demonstrated that Jagged1 (JAG1) is the AGS gene. JAG1 encodes a ligand in the
Ibrahim Cansaran Tanidir et al.
Artificial organs, 38(10), 838-844 (2014-01-11)
Near-infrared spectroscopy (NIRS) is a noninvasive method used to evaluate tissue oxygenation. We evaluated the relationship between cerebral and renal NIRS parameters during transcatheter intervention and adverse events in the catheterization room. Between January 1 and May 31, 2012, 123
Kenichi Tsujita et al.
Circulation, 115(14), 1904-1911 (2007-03-29)
Class A macrophage scavenger receptor (SR-A) is a macrophage-restricted multifunctional molecule that optimizes the inflammatory response by modulation of the activity of inflammatory cytokines. This study was conducted with SR-A-deficient (SR-A(-/-)) mice to evaluate the relationship between SR-A and cardiac
Valerie A Jenkins et al.
Breast care (Basel, Switzerland), 10(2), 88-93 (2015-07-22)
Appreciation of the barriers and drivers affecting enrolment in randomised clinical trials (RCTs) is important for future trial design, communication and information provision. As part of an intervention to facilitate UK multidisciplinary team communication about RCTs, women with breast cancer
Zhongyi Chen et al.
Journal of pineal research, 46(2), 235-241 (2009-01-15)
Free-radical generation is one of the primary causes of myocardial ischemia/reperfusion (I/R) injury. Melatonin is an efficient free-radical scavenger and induces the expression of antioxidant enzymes. We have previously shown that melatonin can prevent free-radical-induced myocardial injury. To date, the
Jing-Chun Han et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 115(12), 1331-1343 (2008-01-11)
The aim of the current study was to profile c-Myc, standard CD44 (CD44s), CD44v6, cyclin D1, survivin, MMP-7 and VEGF expression patterns in different gastric samples and to elucidate their relevance for Wnt, NF-kappaB and/or Stat3 activation using multiple experimental
X Estivill et al.
Lancet (London, England), 351(9100), 394-398 (1998-03-03)
Hearing impairment affects one infant in 1000 and 4% of people aged younger than 45 years. Congenital deafness is inherited or apparently sporadic. We have shown previously that DFNB1 on chromosome 13 is a major locus for recessive deafness in
Michael D Onken et al.
Investigative ophthalmology & visual science, 49(12), 5230-5234 (2008-08-23)
Early/initiating oncogenic mutations have been identified for many cancers, but such mutations remain unidentified in uveal melanoma (UM). An extensive search for such mutations was undertaken, focusing on the RAF/MEK/ERK pathway, which is often the target of initiating mutations in
C M Parsons et al.
The British journal of nutrition, 46(1), 77-86 (1981-07-01)
1. The relative potencies of three lysine, one tryptophan and six methionine analogues to their corresponding l-amino acids were determined. 2. Male poults, 9 d of age, were used in five 14 d experiments. Experimental diets were formed by adding
Filip Janku et al.
PloS one, 6(7), e22769-e22769 (2011-08-11)
Oncogenic mutations of PIK3CA, RAS (KRAS, NRAS), and BRAF have been identified in various malignancies, and activate the PI3K/AKT/mTOR and RAS/RAF/MEK pathways, respectively. Both pathways are critical drivers of tumorigenesis. Tumor tissues from 504 patients with diverse cancers referred to
S Esteban et al.
Naunyn-Schmiedeberg's archives of pharmacology, 360(2), 135-143 (1999-09-24)
The effects of antidepressant drugs on the synthesis of noradrenaline and serotonin (5-HT) were assessed using the accumulation of 3,4-dihydroxyphenylalanine (dopa) and 5-hydroxytryptophan (5-HTP) after decarboxylase inhibition as a measure of the rate of tyrosine and tryptophan hydroxylation in the
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