CN
Search Within
54-62-6
应用筛选条件
关键词:'54-62-6'
显示 1-30 共 77 条结果 关于 "54-62-6" 范围 论文
Jozaa Z ALTamimi et al.
Pharmaceutical biology, 60(1), 25-37 (2021-12-07)
Ellagic acid (EA) is used in traditional medicine to treated hyperlipidaemia. This study examined if AMPK mediates the anti-steatotic effect of ellagic acid (EA) in streptozotocin (STZ)-induced type 1 diabetes mellitus in rats. Adult male Wistar rats (130 ± 10 g) were divided
Feng Ye et al.
Journal of experimental & clinical cancer research : CR, 29, 78-78 (2010-06-23)
Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma
Jeung Il Kim et al.
Human pathology, 40(7), 934-941 (2009-04-10)
The DNA-repair protein O(6)-methylguanine-DNA methyltransferase removes alkyl adducts from the O(6)-position of guanine. The adducts can mispair with T during DNA replication, resulting in a G-to-A mutation. Epigenetic inactivation of O(6)-methylguanine-DNA methyltransferase has been found in human neoplasia and is
Jeung Il Kim et al.
Human pathology, 40(7), 934-941 (2009-04-10)
The DNA-repair protein O(6)-methylguanine-DNA methyltransferase removes alkyl adducts from the O(6)-position of guanine. The adducts can mispair with T during DNA replication, resulting in a G-to-A mutation. Epigenetic inactivation of O(6)-methylguanine-DNA methyltransferase has been found in human neoplasia and is
Martina Vendrame et al.
Pediatric neurology, 46(5), 276-280 (2012-04-24)
Retrospective review was performed of children aged <3 years with epileptic spasms at our center from 2004-2010. Short-term (<6 months) and long-term (≥6 months) outcomes were assessed. We included 173 children (104 boys; median age of onset, 6.8 months) with
Matthew S Chang et al.
Transplantation, 95(7), 960-965 (2013-04-03)
Lamivudine (LAM) has been shown to prevent de novo hepatitis B virus (HBV) infection in recipients of hepatitis B core antibody (HBcAb)-positive liver transplants (LT) but primarily in small studies with limited follow-up. We conducted a retrospective cohort study of
M Früh et al.
Lung cancer (Amsterdam, Netherlands), 146, 6-11 (2020-06-03)
Stage IV small cell lung cancer (SCLC) is associated with short survival and progression after first-line systemic therapy frequently occurs within months. Although topotecan is approved for second-line treatment, its efficacy is limited, and treatment heterogeneity exists. The decision-making patterns
Kazuya Kuraoka et al.
International journal of oncology, 23(2), 421-427 (2003-07-10)
A C/A single nucleotide polymorphism (SNP) in the E-cadherin gene promoter has been shown to affect transcriptional efficiency in vitro. In this study, we analyzed the C/A SNP in 106 gastric carcinoma cases and 90 cancer-free controls compared with clinicopathological
Helmut Gadner et al.
Blood, 121(25), 5006-5014 (2013-04-17)
Langerhans cell histiocytosis (LCH)-III tested risk-adjusted, intensified, longer treatment of multisystem LCH (MS-LCH), for which optimal therapy has been elusive. Stratified by risk organ involvement (high [RO+] or low [RO-] risk groups), > 400 patients were randomized. RO+ patients received
Piotr Kozlowski et al.
Human genetics, 121(3-4), 389-400 (2007-02-09)
Tuberous sclerosis (TSC) is an autosomal dominant disorder caused by mutations in either of two genes, TSC1 and TSC2. Point mutations and small indels account for most TSC1 and TSC2 mutations. We examined 261 TSC DNA samples (209 small-mutation-negative and
F Boutli et al.
Drugs under experimental and clinical research, 29(3), 101-105 (2004-01-08)
A 12-week double-blind randomized study was performed to compare benzoyl peroxide 5% (BP) gel and chloroxylenol 0.5% plus salicylic acid 2% (PCMX + SA) cream (Nisal cream) for efficacy and adverse reactions. Thirty-seven volunteers participated in the study, 19 in
Akemi Tsujimura et al.
International journal of oncology, 20(2), 361-365 (2002-01-15)
Preoperative differential diagnoses between uterine sarcomas and leiomyomas are difficult. As telomerase activation is thought to be essential for the immortality of malignant cells, it is considered a potentially useful diagnostic marker. The aim of the present study was to
Thorsten Fuereder et al.
European journal of clinical investigation, 44(10), 958-964 (2014-08-26)
There are no data about the efficacy of gemcitabine in combination with oxaliplatin (GEMOX) and erlotinib for the treatment of metastatic pancreatic cancer (mPC). Thus, we performed this retrospective analysis in mPC patients to investigate the activity and safety of
Karen O Klein et al.
The Journal of clinical endocrinology and metabolism, 105(10) (2020-08-02)
Gonadotropin-releasing hormone agonists (GnRHas) are standard of care for central precocious puberty (CPP). A 6-month subcutaneous injection has recently been approved by the Food and Drug Administration. Determine efficacy, pharmacokinetics, and safety of 6-month 45-mg subcutaneous leuprolide acetate for CPP.
Amalia Lamana et al.
PloS one, 10(11), e0142683-e0142683 (2015-11-17)
The T allele of rs7574865 in STAT4 confers risk of developing autoimmune disorders. However, its functional significance remains unclear. Here we analyze how rs7574865 affects the transcription of STAT4 and its protein expression. We studied 201 patients (80% female; median
S Giraud et al.
American journal of human genetics, 63(2), 455-467 (1998-07-31)
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant syndrome predisposing to tumors of the parathyroid, endocrine pancreas, anterior pituitary, adrenal glands, and diffuse neuroendocrine tissues. The MEN1 gene has been assigned, by linkage analysis and loss of heterozygosity
Nai-Kong V Cheung et al.
JAMA, 307(10), 1062-1071 (2012-03-15)
Neuroblastoma is diagnosed over a wide age range from birth through young adulthood, and older age at diagnosis is associated with a decline in survivability. To identify genetic mutations that are associated with age at diagnosis in patients with metastatic
Timothy R Fennell et al.
Xenobiotica; the fate of foreign compounds in biological systems, 48(11), 1142-1156 (2017-11-08)
1. 2-Ethylhexyl-p-methoxycinnamate (EHMC) is commonly used as an ingredient in sunscreens, resulting in potential oral and dermal exposure in humans. 2. Clearance and metabolism of EHMC in hepatocytes and disposition and metabolism of EHMC in rodents following oral (8-800 mg/kg) intravenous
P De Cruz et al.
Alimentary pharmacology & therapeutics, 42(7), 867-879 (2015-09-01)
Crohn's disease recurs in the majority of patients after intestinal resection. To compare the relative efficacy of thiopurines and anti-TNF therapy in patients at high risk of disease recurrence. As part of a larger study comparing post-operative management strategies, patients
Roger Stupp et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28(16), 2712-2718 (2010-05-05)
Invasion and migration are key processes of glioblastoma and are tightly linked to tumor recurrence. Integrin inhibition using cilengitide has shown synergy with chemotherapy and radiotherapy in vitro and promising activity in recurrent glioblastoma. This multicenter, phase I/IIa study investigated
Nurhan Güler et al.
TheScientificWorldJournal, 2012, 946060-946060 (2012-07-11)
The aim of this study was to investigate whether there is any association between inflammation and the expression of markers of cell cycle entry (Ki-67 and MCM-2) in dental follicle (DF) of asymptomatic impacted teeth and odontogenic cysts. The study
Nestor F Esnaola et al.
International journal of radiation oncology, biology, physics, 88(4), 837-844 (2014-03-13)
To evaluate, in a phase 2 study, the safety and efficacy of induction gemcitabine, oxaliplatin, and cetuximab followed by selective capecitabine-based chemoradiation in patients with borderline resectable or unresectable locally advanced pancreatic cancer (BRPC or LAPC, respectively). Patients received gemcitabine
A J Davies et al.
Leukemia, 19(8), 1459-1465 (2005-05-20)
The role of TP53 mutation in transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (t-FL) was examined in a panel of 91 lymph node biopsies derived from 29 patients pre- and post-transformation. The entire TP53 coding sequence was
Maarit Ahtiainen et al.
Age (Dordrecht, Netherlands), 34(5), 1249-1260 (2011-08-17)
A thorough understanding of the role of estrogens on aging-related muscle weakness is lacking. To clarify the molecular mechanisms underlying the effects of hormone replacement therapy (HRT) on skeletal muscle, we analyzed systemic protein and local mRNA levels of factors
C Marini et al.
Neurology, 75(7), 646-653 (2010-08-18)
To explore the causative role of PCDH19 gene (Xq22) in female patients with epilepsy. We studied a cohort of 117 female patients with febrile seizures (FS) and a wide spectrum of epilepsy phenotypes including focal and generalized forms with either
Jon Landa et al.
Neurology(R) neuroimmunology & neuroinflammation, 8(1) (2020-11-05)
To describe the clinical syndrome of 4 new patients with seizure-related 6 homolog like 2 antibodies (SEZ6L2-abs), study the antibody characteristics, and evaluate their effects on neuronal cultures. SEZ6L2-abs were initially identified in serum and CSF of a patient with
Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices.
Gabriella Nyitrai et al.
Brain research, 1309, 172-178 (2009-11-17)
A wide range of data support a role for ambient glutamate (Glu) in epilepsy, although temporal patterns associated with the cellular uptake of Glu have not been addressed in detail. We report on the effects of Glu uptake inhibitors on
Yasushi Iwasaki et al.
Clinical neuropathology, 33(5), 344-353 (2014-07-06)
We describe an autopsied case of a Japanese woman with Gerstmann-Straeussler-Scheinker disease (GSS) presenting with a rapidly progressive clinical course. Disease onset occurred at the age of 54 with dementia and gait disturbance. Her clinical course progressively deteriorated until she
Mitsuharu Kawamura et al.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 14(12), 1719-1725 (2012-05-25)
Fibrosis and inflammation may play a significant role in the pathogenesis of atrial fibrillation (AF) recurrence. Type III procollagen-N-peptide (PIIINP) may be related to atrial fibrosis and play a role in predicting the recurrence of AF. We investigated whether PIIINP
Y Aksoy et al.
Protein expression and purification, 21(2), 286-292 (2001-03-10)
Glucose-6-phosphate dehydrogenase was purified from human placenta using DEAE-Sepharose fast flow, 2',5'-ADP Sepharose 4B column chromatography, and chromatofocusing on PBE 94 with PB 74. The enzyme was purified with 62% yield and had a specific activity of 87 units per
1/3