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显示 1-27 共 27 条结果 关于 "546283" 范围 论文
Seokjoon Lee et al.
Bioorganic & medicinal chemistry letters, 16(17), 4596-4599 (2006-06-24)
A series of 7-diethylaminocoumarin compounds were synthesized and the cytotoxicities were tested against human umbilical vein endothelial cell (HUVEC) and some cancer cells. We found that the introduction of cyano groups at the 4-position will promote the bioactivity. In particular
Monitoring protein interactions in living cells with fluorescence lifetime imaging microscopy
Sun Y, et al.
Methods in Enzymology null
Daniela Chirio et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 746-758 (2014-12-03)
Paclitaxel loaded solid lipid nanoparticles (SLN) of behenic acid were prepared with the coacervation technique. Generally, spherical shaped SLN with mean diameters in the range 300–600 nm were obtained. The introduction of charged molecules, such as stearylamine and glycol chitosan
Muhammad Naeem et al.
International journal of nanomedicine, 10, 4565-4580 (2015-07-28)
Current colon-targeted drug-delivery approaches for colitis therapy often utilize single pH-triggered systems, which are less reliable due to the variation of gut pH in individuals and in disease conditions. Herein, we prepared budesonide-loaded dual-sensitive nanoparticles using enzyme-sensitive azo-polyurethane and pH-sensitive
Paul Joyce et al.
ACS applied materials & interfaces, 7(31), 17460-17470 (2015-07-17)
Biodegradable and bioactive hybrid particles composed of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles and medium-chain triglycerides were prepared by spray drying lipid-in-water emulsions stabilized by PLGA nanoparticles, to form PLGA-lipid hybrid (PLH) microparticles approximately 5 μm in mean diameter. The nanoparticle stabilizer was
Regina Won Kay Leung et al.
Biomedical optics express, 2(9), 2517-2531 (2011-10-13)
Fluorescence lifetime imaging has emerged as an important microscopy technique, where high repetition rate lasers are the primary light sources. As fluorescence lifetime becomes comparable to intervals between consecutive excitation pulses, incomplete fluorescence decay from previous pulses can superimpose onto
Xin Guan et al.
Drug delivery, 23(9), 3307-3318 (2016-04-14)
Utilization of quercetin (QT) in clinics is limited by its instability and poor solubility. To overcome these disadvantages, we prepared QT as QT-loaded PLGA-TPGS nanoparticles (QPTN) and examined its properties and therapeutic efficacy for liver cancer. QT-loaded PLGA nanoparticles (QPN)
Zhi-qiang Yuan et al.
International journal of pharmaceutics, 492(1-2), 141-151 (2015-07-19)
This study aimed to prepare efficient cRGDyK peptide-decorated micelles for the targeted therapy of non-small-cell lung cancer (NSCLC). An amphiphilic copolymer N-succinyl-palmitoyl-chitosan (SPCS) was synthesized and characterized. cRGDyK peptide is a ligand that can target tumors via specific binding integrin
Testing fluorescence lifetime standards using two-photon excitation and time-domain instrumentation: rhodamine B, coumarin 6 and lucifer yellow.
Kristoffersen AS,et al.
Journal of Fluorescence, 1015-1024 null
Monitoring protein interactions in living cells with fluorescence lifetime imaging microscopy
Sun Y, et al.
Methods in Enzymology, 371 null
Tingjie Yin et al.
Biomaterials, 61, 10-25 (2015-05-23)
In this study, a novel redox-sensitive micellar system constructed from a hyaluronic acid-based amphiphilic conjugate (HA-ss-(OA-g-bPEI), HSOP) was successfully developed for tumor-targeted co-delivery of paclitaxel (PTX) and AURKA specific siRNA (si-AURKA). HSOP exhibited excellent loading capacities for both PTX and
Daniel Haensel et al.
Cell reports, 30(11), 3932-3947 (2020-03-19)
Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and drive wound healing. Previous studies have probed basal cell heterogeneity in stem and progenitor potential, but a comprehensive
Jing Li et al.
International journal of pharmaceutics, 483(1-2), 38-48 (2015-02-07)
Tumor-targeted drug delivery and microenvironment-responsive drug release are attractive strategies in cancer treatment. Our previous study demonstrated that redox-sensitive micelles based on hyaluronic acid-deoxycholic acid (HA-ss-DOCA) conjugates exhibited excellent drug-loading capacities (34.1%) for paclitaxel (PTX) and rapid drug release in
Testing fluorescence lifetime standards using two-photon excitation and time-domain instrumentation: rhodamine B, coumarin 6 and lucifer yellow.
Kristoffersen AS,et al.
Journal of Fluorescence null
Xiaolong Tang et al.
International journal of clinical and experimental medicine, 8(4), 5150-5162 (2015-07-02)
To develop amphotericin B-loaded biodegradable TPGS-b-(PCL-ran-PGA) nanoparticles (PLGA-TPGS-AMB NPs) for fungal infection treatment, PLGA-TPGS NPs and PLGA NPs were synthesized by a modified double emulsion method and characterized in terms of size and size distribution, morphology and zeta potential. Drug
Zhuoyang Fan et al.
PloS one, 10(4), e0120129-e0120129 (2015-04-02)
Genexol-PM, produced by Samyang Company (Korea) is an excellent preparation of paclitaxel (PTX) for clinical cancer treatment. However, it cannot resolve the issue of multidrug resistance (MDR)-a significant problem in the administration of PTX to cancer patients. To increase the
Nomundelger Gankhuyag et al.
Macromolecular bioscience, 15(6), 777-787 (2015-02-07)
Delivering drugs selectively to cancer cells but not to nearby normal cells is a major obstacle in drug therapy. In this study, lithocholic acid (LCA), a potent anti-cancer drug, is converted to two forms of poly(ethyleneglycol) (PEG) conjugates, viz., PEG-LCA
Molecular light emitting heterojunctions based on fully conjugated heterocyclic aromatic rigid-rod polymer poly-p-phenylenebenzobisthiazole
Wu, C.; Cheng, H.; Wang, W.; et al.
Thin Solid Films, 477, 174-181 (2005)
Dong-Yu Gao et al.
Biomaterials, 67, 194-203 (2015-07-29)
Sorafenib, a multikinase inhibitor, has been used as an anti-angiogenic agent against highly vascular hepatocellular carcinoma (HCC) - yet associated with only moderate therapeutic effect and the high incidence of HCC recurrence. We have shown intratumoral hypoxia induced by sorafenib
Shinji Sakuma et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(5), 1227-1236 (2015-03-01)
We are investigating an imaging agent that detects early-stage primary colorectal cancer on the mucosal surface in real time under colonoscopic observation. The imaging agent, which is named the nanobeacon, is fluorescent nanospheres conjugated with peanut agglutinin and poly(N-vinylacetamide). Its
Lu Wang et al.
AAPS PharmSciTech, 15(4), 834-844 (2014-04-04)
Berberine hydrochloride (BH) is an isoquinolin alkaloid with promising anticancer efficacies. Nevertheless, further development and application of this compound had been hampered by its poor aqueous solubility, low gastrointestinal absorption, and rapid metabolism in the body. In this study, a
Sobiya Zafar et al.
International journal of pharmaceutics, 477(1-2), 454-468 (2014-12-03)
The present work describes the preparation of sterically stabilize polymeric nanoparticles of mitoxantrone dihydrochloride (MTO) along with an efflux transporter (Pgp/BCRP) inhibitor that enhance the circulation time of nanoparticles and simultaneously surmount the problem of multidrug resistance (MDR). Mitoxantrone dihydrochloride
Ofra Benny et al.
Nature biotechnology, 26(7), 799-807 (2008-07-01)
Targeting angiogenesis, the formation of blood vessels, is an important modality for cancer therapy. TNP-470, a fumagillin analog, is among the most potent and broad-spectrum angiogenesis inhibitors. However, a major clinical limitation is its poor oral availability and short half-life
Electroluminescence of doped organic thin films
Tang, C. W.; et al.
Journal of Applied Physics, 65, 3610-3610 (1989)
Huiyan Li et al.
Nanoscale, 7(30), 13075-13087 (2015-07-16)
Therapeutic angiogenesis remains the most effective method to re-establish a proper blood flow in ischemic tissues. There is a great clinical need to identify an injectable format to achieve a well accumulation following local administration and a sustained delivery of
Zilan Zhou et al.
International journal of pharmaceutics, 487(1-2), 81-90 (2015-04-14)
A dual functional nano-scaled drug carrier, comprising of a targeting ligand and pH sensitivity, has been made in order to increase the specificity and efficacy of the drug delivery system. The nanoparticles are made of a tri-block copolymer, poly(d,l lactide-co-glycolide)
Deborah D Soto-Ortega et al.
Bioorganic & medicinal chemistry, 19(8), 2596-2602 (2011-04-05)
Aggregation of the amyloid-β protein (Aβ) plays a pathogenic role in the progression of Alzheimer's disease, and small molecules that attenuate Aβ aggregation have been identified toward a therapeutic strategy that targets the disease's underlying cause. Compounds containing aromatic structures
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