54680

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Glucocorticoid-like activity of propylparaben, butylparaben, diethylhexyl phthalate and tetramethrin mixtures studied in the MDA-kb2 cell line.

Ivana Klopčič et al.

Toxicology letters, 232(2), 376-383 (2014-12-03)

Endocrine-disrupting compounds can interfere with the endocrine organs or hormone system and cause tumors, birth defects and developmental disorders in humans. The estrogen-like activity of compounds has been widely studied but little is known concerning their possible modulation of the

Comparative analysis of pathologic processes developing in mice housed in SPF vs non-SPF conditions and treated with cyclophosphamide and dsDNA preparation.

Evgeniya V Dolgova et al.

Pathology, research and practice, 211(10), 754-758 (2015-08-22)

In our earlier studies, we observed that when mice are treated with cyclophosphamide and fragmented exogenous dsDNA (18-30 h post cytostatic treatment), they develop a very characteristic set of symptoms and 80-90% of such animals succumb within 6-25 days. This

LC-MS analysis of the plasma metabolome--a novel sample preparation strategy.

Kasper Skov et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 83-88 (2014-12-23)

Blood plasma is a well-known body fluid often analyzed in studies on the effects of toxic compounds as physiological or chemical induced changes in the mammalian body are reflected in the plasma metabolome. Sample preparation prior to LC-MS based analysis

Development of eczema vaccinatum in atopic mouse models and efficacy of MVA vaccination against lethal poxviral infection.

Jarmila Knitlova et al.

PloS one, 9(12), e114374-e114374 (2014-12-09)

Smallpox vaccine based on live, replicating vaccinia virus (VACV) is associated with several potentially serious and deadly complications. Consequently, a new generation of vaccine based on non-replicating Modified vaccinia virus Ankara (MVA) has been under clinical development. MVA seems to

Parabens determination in cosmetic and personal care products exploiting a multi-syringe chromatographic (MSC) system and chemiluminescent detection.

Melisa Rodas et al.

Talanta, 143, 254-262 (2015-06-17)

Parabens are widely used in dairy products, such as in cosmetics and personal care products. Thus, in this work a multi-syringe chromatographic (MSC) system is proposed for the first time for the determination of four parabens: methylparaben (MP), ethylparaben (EP)

Marine fish oils are not equivalent with respect to B-cell membrane organization and activation.

Eric A Gurzell et al.

The Journal of nutritional biochemistry, 26(4), 369-377 (2015-01-27)

We previously reported that docosahexaenoic-acid (DHA)-enriched fish oil (DFO) feeding altered B-cell membrane organization and enhanced B-cell function. The purpose of this study was to evaluate whether menhaden oil (MO) and eicosapentaenoic-acid (EPA)-enriched fish oil (EFO) alters B-cell function/phenotype similarly.

Superbug hideout: finding MRSA in U.S.wastewater treatment plants.

Rebecca Kessler

Environmental health perspectives, 120(11), A437-A437 (2012-11-03)

Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation.

Caroline Stremnitzer et al.

The Journal of investigative dermatology, 135(7), 1790-1800 (2015-02-24)

Papain is commonly used in food, pharmaceutical, textile, and cosmetic industries and is known to induce occupational allergic asthma. We have previously shown that the papain-like cysteine protease Dermatophagoides pteronyssinus 1 from house dust mite exhibits percutaneous sensitization potential. We

Butyl paraben-induced changes in DNA methylation in rat epididymal spermatozoa.

C J Park et al.

Andrologia, 44 Suppl 1, 187-193 (2011-05-20)

Parabens have been shown to affect male rodent reproductive parameters, including testosterone levels and sperm production. In this study, we examined the effect of long-term exposure to butyl paraben (BP) on rat epididymal sperm DNA methylation. Adult male rats were

Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs.

Shigeo Hayashi et al.

Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)

Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage

Vaccine protection of chickens against antigenically diverse H5 highly pathogenic avian influenza isolates with a live HVT vector vaccine expressing the influenza hemagglutinin gene derived from a clade 2.2 avian influenza virus.

Darrell R Kapczynski et al.

Vaccine, 33(9), 1197-1205 (2015-01-24)

Vaccination is an important tool in the protection of poultry against avian influenza (AI). For field use, the overwhelming majority of AI vaccines produced are inactivated whole virus formulated into an oil emulsion. However, recombinant vectored vaccines are gaining use

Microbiota regulates type 1 diabetes through Toll-like receptors.

Michael P Burrows et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(32), 9973-9977 (2015-07-29)

Deletion of the innate immune adaptor myeloid differentiation primary response gene 88 (MyD88) in the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D) results in microbiota-dependent protection from the disease: MyD88-negative mice in germ-free (GF), but not in

Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model.

Jiahua Jiang et al.

Oncotarget, 6(17), 15639-15651 (2015-04-25)

The HuPrime® human gastric neuroendocrine carcinoma derived xenograft model GA0087 was established in this study. GA0087 PDX model showed high gene expression of vascular endothelial growth factors (VEGF)-A and B, and high potential of lung metastasis. Circulating tumor cells (CTCs)

Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model.

Thuy T B Vo et al.

Reproductive toxicology (Elmsford, N.Y.), 29(3), 306-316 (2010-02-06)

In this study, a female pubertal assay on the effects of parabens, including methyl-, ethyl-, propyl-, isopropyl-, butyl-, and isobutylparaben, was performed in a female Sprague-Dawley rat model during the juvenile-peripubertal period. The rats were orally treated with these parabens

The aqueous photosensitized degradation of butylparaben.

Dorota Gryglik et al.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 8(4), 549-555 (2009-04-02)

The photosensitized oxidation of butyl p-hydroxybenzoate (butylparaben, BP), the endocrine disrupting compound, in aqueous solution using rose bengal (RB) and aluminium phthalocyanine chloride tetrasulfonic acid (PC) as sensitizers was examined. A xenon lamp simulating solar radiation was used as a

Construction of a recombinant duck enteritis virus (DEV) expressing hemagglutinin of H5N1 avian influenza virus based on an infectious clone of DEV vaccine strain and evaluation of its efficacy in ducks and chickens.

Jichun Wang et al.

Virology journal, 12, 126-126 (2015-08-13)

Highly pathogenic avian influenza virus (AIV) subtype H5N1 remains a threat to poultry. Duck enteritis virus (DEV)-vectored vaccines expressing AIV H5N1 hemagglutinin (HA) may be viable AIV and DEV vaccine candidates. To facilitate the generation and further improvement of DEV-vectored

Effects of parabens on apoptosis induced by serum-free medium.

Mari Egawa et al.

Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 47(3), 196-204 (2012-03-02)

Alkyl esters of p-hydroxybenzoic acids (parabens), an endocrine disrupter, are used as preservatives in cosmetics and foods. In this study, to understand the relationship between parabens and differentiation in infants, the effects of parabens on apoptosis induced by serum deprivation

Cell membrane integrity in myotonic dystrophy type 1: implications for therapy.

Anchel González-Barriga et al.

PloS one, 10(3), e0121556-e0121556 (2015-03-24)

Myotonic Dystrophy type 1 (DM1) is a multisystemic disease caused by toxic RNA from a DMPK gene carrying an expanded (CTG•CAG)n repeat. Promising strategies for treatment of DM1 patients are currently being tested. These include antisense oligonucleotides and drugs for

Evaluation of stationary phases packed with superficially porous particles for the analysis of pharmaceutical compounds using supercritical fluid chromatography.

Alexandre Grand-Guillaume Perrenoud et al.

Journal of chromatography. A, 1360, 275-287 (2014-08-19)

Superficially porous particles (SPP), or core shell particles, which consist of a non-porous silica core surrounded by a thin shell of porous silica, have gained popularity as a solid support for chromatography over the last decade. In the present study

Determination and separation of bisphenol A, phthalate metabolites and structural isomers of parabens in human urine with conventional high-pressure liquid chromatography combined with electrospray ionisation tandem mass spectrometry.

Antonis Myridakis et al.

Analytical and bioanalytical chemistry, 407(9), 2509-2518 (2015-02-04)

Phthalates, bisphenol A (BPA) and parabens (PBs), organic chemicals widely used in everyday products, are considered to be endocrine disruptors. We propose a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of seven phthalate metabolites, six PBs and BPA

Solubilization of parabens in aqueous Pluronic solutions: investigating the micellar growth and interaction as a function of paraben composition.

M Khimani et al.

The journal of physical chemistry. B, 116(51), 14943-14950 (2012-12-06)

The influence of methyl paraben (MP) and butyl paraben (BP) on the aggregation characteristics of Pluronics in an aqueous medium has been investigated by DLS, SANS, viscometry, and fluorescence measurement techniques. Parabens are extensively used as preservatives in cosmetic, pharmaceutical

Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application.

James M Mathews et al.

Xenobiotica; the fate of foreign compounds in biological systems, 43(2), 169-181 (2012-07-27)

n-Butyl-p-hydroxybenzoate (n-butylparaben, BPB) is an antioxidant used in foods, pharmaceuticals and cosmetics. This study investigated the disposition of ring-labelled [(14)C]BPB in Harlan Sprague Dawley rats, and in rat and human hepatocytes. BPB was rapidly cleared in hepatocytes from rat (t(1/2)

High performance liquid chromatography column packings with deliberately broadened particle size distribution: relation between column performance and packing structure.

Anuschka Liekens et al.

Journal of chromatography. A, 1218(38), 6654-6662 (2011-08-25)

The effect of the addition of 25%, 50% and 75% (weight percent, wt%) of larger particles (resp. 3 and 5 μm) to a commercial batch of 1.9 μm particles has been investigated as an academic exercise to study the effects

Development of piperic acid derivatives from Piper nigrum as UV protection agents.

Piyapong Choochana et al.

Pharmaceutical biology, 53(4), 477-482 (2014-12-05)

There is a need for the discovery of novel natural and semi-synthetic sunscreen that is safe and effective. Piperine has a UV absorption band of 230-400 nm with high molar absorptivity. This compound has a high potential to be developed to

Detection and Genetic Characteristics of H9N2 Avian Influenza Viruses from Live Poultry Markets in Hunan Province, China.

Yiwei Huang et al.

PloS one, 10(11), e0142584-e0142584 (2015-11-12)

H9N2 avian influenza viruses (AIVs) are highly prevalent and of low pathogenicity in domestic poultry. These viruses show a high genetic compatibility with other subtypes of AIVs and have been involved in the genesis of H5N1, H7N9 and H10N8 viruses

Promotion of liver and kidney carcinogenesis by ethyl tertiary-butyl ether (ETBE) in male Wistar rats.

Akihiro Hagiwara et al.

Journal of toxicologic pathology, 28(4), 189-195 (2015-11-06)

Tumor-promoting effects of ethyl tertiary-butyl ether (ETBE) were investigated in a 2-stage carcinogenesis bioassay with regard to hepatic and renal carcinogenesis in rats. Male 6-week-old Wistar rats were given drinking water containing N-ethyl-N-(2-hydroxyethyl)nitrosamine (EHEN), as an initiator, at a dose

Synthetic approaches to parabens molecularly imprinted polymers and their applications to the solid-phase extraction of river water samples.

A Beltran et al.

Analytica chimica acta, 677(1), 72-78 (2010-09-21)

In this paper we describe the synthesis, characterisation and use of two distinct molecularly imprinted polymers (MIPs) prepared using esters of p-hydroxybenzoic acid (parabens) as templates: one MIP was synthesised by precipitation polymerisation using a semi-covalent molecularly imprinting strategy with

The consequence of the chemical composition of HPMC in matrix tablets on the release behaviour of model drug substances having different solubility.

Anna Viridén et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 77(1), 99-110 (2010-11-18)

This study investigates the effect of the chemical heterogeneity of hydroxypropyl methylcellulose (HPMC) on the release of model drug substances from hydrophilic matrix tablets. The hypothesis was that the release of drug substances could be influenced by possible interactions with

Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy.

Jie Zhao et al.

International immunopharmacology, 26(1), 221-228 (2015-04-11)

Celastrol had been proved effective in the treatment for IBD, probably with the modulation of oxidative stress, inflammatory cytokines and intestinal homeostasis. This study was aimed to investigate whether celastrol could ameliorate the inflammation of IL-10 deficient mice, a murine

Characterization of in vitro antifungal activities of small and American cranberry (Vaccinium oxycoccos L. and V. macrocarpon Aiton) and lingonberry (Vaccinium vitis-idaea L.) concentrates in sugar reduced fruit spreads.

Ertan Ermis et al.

International journal of food microbiology, 204, 111-117 (2015-04-14)

In this study, cranberry and lingonberry concentrates were added to commercial sugar-reduced fruit spreads (raspberry-Aloe vera, strawberry-guava, and strawberry-lime), and tested for their antifungal activities. Selected strains of the species Absidia glauca, Penicillium brevicompactum, Saccharomyces cerevisiae and Zygosaccharomyces bailii, as

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