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Philippe J Caron et al.
The Journal of clinical endocrinology and metabolism, 99(4), 1282-1290 (2014-01-16)
Methodological shortcomings often compromise investigations into the effects of primary somatostatin-analog treatment on tumor size in acromegaly. There are also limited data for the long-acting lanreotide formulation. The aim of the study was to better characterize the effects of primary
Andrea L Fellet et al.
American journal of physiology. Heart and circulatory physiology, 291(3), H1246-H1254 (2006-04-18)
In autonomic-blocked rats treated with NG-nitro-L-arginine methyl ester (L-NAME, 7.5 mg/kg), heart rate increased 18% and mean arterial pressure increased 48%. Thyroidectomy, along with autonomic blockade, hampered the chronotropic response but did not modify the effect on blood pressure. After
D Chilov et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15(14), 2613-2622 (2001-12-01)
The key elements of circadian clockwork and oxygen homeostasis are the PAS protein family members PER and CLOCK and hypoxia-inducible factor 1alpha (HIF-1alpha). The PAS domain serves as an interface for protein-protein interactions. We asked whether a cross-talk exists between
Jichun Yang et al.
FEBS letters, 583(18), 3009-3015 (2009-08-18)
PANDER is a cytokine co-secreted with insulin from islet beta-cells. To date, the physiological function of PANDER remains largely unknown. Here we show that PANDER binds to the liver membrane by (125)I-PANDER saturation and competitive binding assays. In HepG2 cells
Jichun Yang et al.
FEBS letters, 583(18), 3009-3015 (2009-08-18)
PANDER is a cytokine co-secreted with insulin from islet beta-cells. To date, the physiological function of PANDER remains largely unknown. Here we show that PANDER binds to the liver membrane by (125)I-PANDER saturation and competitive binding assays. In HepG2 cells
John N Fain et al.
Metabolism: clinical and experimental, 55(8), 1113-1121 (2006-07-15)
The present studies were designed to compare the relative release of interleukin 1 receptor antagonist (IL-1Ra), cathepsin S, macrophage migration inhibitory factor (MIF), nerve growth factor (NGF), and interleukin 18 (IL-18) by adipocytes as compared with the non-fat cells present
Smita Zaheer et al.
Neurobiology of disease, 40(3), 593-598 (2010-08-11)
Glia maturation factor (GMF), a primarily CNS localized protein was discovered and characterized in our laboratory. We previously demonstrated that GMF is the upstream regulator for excessive production and release of proinflammatory cytokines/chemokines in brain cells leading to the destruction
Pelin Cengiz et al.
Antioxidants & redox signaling, 14(10), 1803-1813 (2010-08-18)
We investigated the role of Na(+)/H(+) exchanger isoform 1 (NHE-1) in neonatal hypoxia/ischemia (HI). HI was induced by unilateral ligation of the left common carotid artery in postnatal day 9 (P9) mice, and subsequent exposure of animals to 8% O(2)
Punniyakotti Elumalai et al.
Preparative biochemistry & biotechnology, 49(2), 143-150 (2019-01-15)
A chemotrophic, aerobic bacterial strain, Bacillus subtilis B2, was used to produce amylase by submerged fermentation under different light sources. SDS-PAGE indicated that the 55 kDa enzyme belonged to the α-amylase group. B2 was incubated in basal media with 1% soluble
Frank I Tarazi et al.
Psychopharmacology, 198(1), 103-111 (2008-02-26)
The novel psychopharmacologic agent, asenapine, has high affinity for a range of receptors including the dopaminergic receptors. We examined the long-term effects of multiple doses of asenapine on dopamine receptor subtypes: D(1)-like (D(1) and D(5)), D(2), D(3), and D(4). Rats
Cathy J Hay et al.
The Journal of clinical endocrinology and metabolism, 90(4), 2042-2049 (2005-01-27)
The effect of a novel combination of oral etonogestrel (ENG) and im testosterone decanoate (TD) on suppression of gonadotropins and spermatogenesis as a potential lead for male contraception was investigated. Healthy male volunteers were randomized into two groups receiving 300
Valeria Barresi et al.
Neuropathology : official journal of the Japanese Society of Neuropathology, 40(1), 68-74 (2019-11-24)
Diffuse gliomas are defined on the isocitrate dehydrogenase (IDH) gene (IDH) mutational mutational status. The most frequent IDH mutation is IDH1 R132H, which is detectable by immunohistochemistry; other IDH mutations are rare (10%). IDH mutant gliomas have better prognosis. Further
Gokhan Kus et al.
In vitro cellular & developmental biology. Animal, 51(10), 1056-1063 (2015-07-15)
Ceramidases are key enzymes that decrease ceramide levels in cells. A reduction in ceramide concentration impairs ceramide signalling, and results in apoptosis resistance in cancer cells. This study investigates the potential for ceranib-2, a novel ceramidase inhibitor, to affect the
Ali A El-Emam et al.
Molecules (Basel, Switzerland), 17(3), 3475-3483 (2012-03-20)
The reaction of adamantane-1-carbohydrazide (1) with heterocyclic aldehydes, namely 5-(4-chlorophenyl)isoxazole-3-carboxaldehyde (2a), 5-(4-methylphenyl)isoxazole-3-carboxaldehyde (2b), 5-(4-methoxyphenyl)isoxazole-3-carboxaldehyde (2c), 1H-imidazole-2-carboxaldehyde and 2-butyl-4-chloro-1H-imidazole-5-carboxaldehyde, in ethanol, yielded the corresponding N'-heteroarylidene-1-adamantylcarbohydrazides 3a, 3b, 3c, 4 and 5, respectively, in good yields. The 4-acetyl-1,3,4-oxadiazoline analogues 6a‑c were prepared
Bertrand Léger et al.
Muscle & nerve, 40(1), 69-78 (2009-06-18)
Chronic complete spinal cord injury (SCI) is associated with severe skeletal muscle atrophy as well several atrophy and physical-inactivity-related comorbidity factors such as diabetes, obesity, lipid disorders, and cardiovascular diseases. Intracellular mechanisms associated with chronic complete SCI-related muscle atrophy are
Junichi Matsubara et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(10), 3022-3029 (2008-05-17)
Expression levels of insulin-like growth factor type 1 receptor (IGF-IR), epidermal growth factor receptor (EGFR), and HER2 expressions have been linked to clinical outcomes in several solid tumors. However, the clinical significance of these biomarkers in gastric cancer (GC) remains
P R Romano et al.
Journal of cell science, 111 ( Pt 6), 803-813 (1998-05-12)
We have previously identified and partially cloned Band 17, a gene expressed in growth plate chondrocytes transiting from proliferation to hypertrophy. We now rename this gene HiPER1, Histidine Phosphatase of the Endoplasmic Reticulum-1, based on the results reported here. HiPER1
Fabiana Carina Pavezzi et al.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 39(1), 108-114 (2008-01-01)
Glucoamylase is widely used in the food industry to produce high glucose syrup, and also in fermentation processes for production beer and ethanol. In this work the productivity of the glucoamylase of Aspergillus awamori expressed by the yeast Saccharomyces cerevisiae
P Prusis et al.
Journal of molecular graphics & modelling, 15(5), 307-317 (1998-06-26)
A model is presented of the melanocortin 1 receptor (MC1R), constructed by use of an unbiased, objective method. The model is created directly from data derived from multiple sequence analysis, a low-resolution EM-projection map of rhodopsin, and the approximate membrane
Jessica Moramarco et al.
Clinical endocrinology, 86(3), 332-339 (2016-10-28)
Guidelines do not currently recommend routine systematic hormonal screening for pheochromocytoma (PHEO) in all/normotensive patients with neurofibromatosis type 1 (NF1), in contrast to other PHEO-predisposing genetic syndromes such as Von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2. To characterize
B L Gwartney et al.
Journal of animal science, 70(7), 2144-2150 (1992-07-01)
The response time to cimaterol (CIM), a beta-adrenergic agonist, by broiler chickens for carcass characteristics, muscle composition, muscle fiber size, catheptic enzyme activity, and tenderness was determined. Two trials were conducted in which chickens were fed a control diet (CON)
Peter A Calabresi et al.
The Lancet. Neurology, 13(7), 657-665 (2014-05-06)
Subcutaneous pegylated interferon (peginterferon) beta-1a is being developed for treatment of relapsing multiple sclerosis, with less frequent dosing than currently available first-line injectable treatments. We assessed the safety and efficacy of peginterferon beta-1a after 48 weeks of treatment in the
Carl Jorns et al.
Cell transplantation, 23(8), 1009-1018 (2014-09-10)
Hepatocyte transplantation is an upcoming treatment for patients with metabolic liver diseases. Repeated cell infusions over 1-2 days improve clinical outcome. Isolated hepatocytes are usually cold stored in preservation solutions between repeated infusions. However, during cold storage isolated hepatocytes undergo
Zhi-Wei Niu et al.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 30(4), 269-272 (2007-07-27)
To investigate the effects of transforming growth factor (TGF)-beta(1) on fibroblasts differentiation into myofibroblasts, and the change of Egr-1 expression in the course of differentiation in BALB/c 3T3 fibroblasts. BALB/c 3T3 fibroblasts of the experiment group were treated with 10
Jacob W IJdo et al.
Infection and immunity, 72(9), 5392-5401 (2004-08-24)
The intracellular organism Anaplasma phagocytophilum causes human granulocytic ehrlichiosis and specifically infects and multiplies in neutrophilic granulocytes. Previous reports have suggested that, for its survival, this bacterium suppresses the neutrophil respiratory burst. To investigate the mechanism of survival, we first
E J Moss et al.
Toxicology and applied pharmacology, 79(3), 480-489 (1985-07-01)
The role of metabolism in 2-methoxyethanol (ME)-induced testicular toxicity has been investigated with Sprague-Dawley rats. Following administration of [14C]ME (250 mg/kg, ip) to a group of animals, there was evidence of testicular damage, identified as depletion of the spermatocyte population.
S Sood et al.
Theriogenology, 78(7), 1557-1569 (2012-09-18)
Three experiments were conducted to optimize the protocol for cryopreservation of emu sperm. Ejaculates were collected from trained male emus then diluted 1:1 and pooled before allocation to treatments and measured for sperm viability, motility, egg membrane penetration ability, membrane
I I Mustafaev et al.
Kardiologiia, 53(2), 48-54 (2013-04-04)
Aim of the study was to assess effect of monotherapy with nebivolol, bisoprolol, carvedilol for 2 months on sexual function in men with arterial hypertension (AH). Men with 1-2 degree of AH (n=75, age 35-55 years, mean age 48+/-3,5 years)
Nutjaree Jeenduang et al.
Clinica chimica acta; international journal of clinical chemistry, 442, 36-43 (2015-01-17)
Cardiovascular disease (CVD) is one of the major causes of death worldwide. Numerous genetic risk factors in lipid metabolism, including mutations of LDLR, APOB, and PCSK9, as well as polymorphisms of CETP and APOE, have been found to associate with
Soujit Sen Gupta et al.
ACS applied materials & interfaces, 4(8), 4156-4163 (2012-07-14)
This paper describes a green method for the synthesis of graphenic material from cane sugar, a common disaccharide. A suitable methodology was introduced to immobilize this material on sand without the need of any binder, resulting in a composite, referred
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